JPS5785380A - Thiazolidone derivative - Google Patents
Thiazolidone derivativeInfo
- Publication number
- JPS5785380A JPS5785380A JP16291080A JP16291080A JPS5785380A JP S5785380 A JPS5785380 A JP S5785380A JP 16291080 A JP16291080 A JP 16291080A JP 16291080 A JP16291080 A JP 16291080A JP S5785380 A JPS5785380 A JP S5785380A
- Authority
- JP
- Japan
- Prior art keywords
- compound expressed
- formula
- thiazolidone
- expressed
- reacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A thiazolidone derivative expressed by formulaI(R is H or CH3; R1 is H or lower alkyl; A is aryl or pyridyl).
EXAMPLE: 2-Phenyl-3-[trans-4-(carboxy)cyclohexylmethyl]-4-thiazolidone.
USE: A preventing agent and remedy for allergic diseases, e.g. nephritis, rheumatism, collagen diseases or autoimmune diseases, having more remarkable anticomplementary action than tranexamic acid, and an anti-inflammatory agent.
PROCESS: A compound expressed by formula II is reacted with a compound expressed by formula III in a solvent, e.g. methyl alcohol, under heating and refluxing to give a compound expressed by formula IV, which is then reacted with a compound expressed by formula V (R2 is H or ester residue) to afford the compound expressed by formulaIin high yield.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16291080A JPS5785380A (en) | 1980-11-18 | 1980-11-18 | Thiazolidone derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16291080A JPS5785380A (en) | 1980-11-18 | 1980-11-18 | Thiazolidone derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5785380A true JPS5785380A (en) | 1982-05-28 |
JPH0144707B2 JPH0144707B2 (en) | 1989-09-29 |
Family
ID=15763546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16291080A Granted JPS5785380A (en) | 1980-11-18 | 1980-11-18 | Thiazolidone derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5785380A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4992455A (en) * | 1987-05-22 | 1991-02-12 | Sumitomo Pharmaceuticals Company, Limited | Thiazolidin-4-one derivatives useful for treating diseases caused by platelet activating factor |
US5021435A (en) * | 1988-01-22 | 1991-06-04 | Sumitomo Pharmaceuticals Company, Limited | Certain pyridyl-thiazolidin-4-one having anti-ulcer activity |
EP0722729A2 (en) * | 1995-01-23 | 1996-07-24 | Eli Lilly And Company | Aryl-substituted rhodanines for treating multiple sclerosis |
US6506751B1 (en) | 1999-11-12 | 2003-01-14 | Millennium Pharmaceuticals, Inc. | Thiazolidinone compounds useful as chemokine inhibitors |
WO2004017965A1 (en) * | 2002-08-23 | 2004-03-04 | Ionix Pharmaceuticals Limited | 1,3-thiazolin-4-ones as therapeutic compounds in the treatment of pain |
-
1980
- 1980-11-18 JP JP16291080A patent/JPS5785380A/en active Granted
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4992455A (en) * | 1987-05-22 | 1991-02-12 | Sumitomo Pharmaceuticals Company, Limited | Thiazolidin-4-one derivatives useful for treating diseases caused by platelet activating factor |
US5021435A (en) * | 1988-01-22 | 1991-06-04 | Sumitomo Pharmaceuticals Company, Limited | Certain pyridyl-thiazolidin-4-one having anti-ulcer activity |
EP0722729A2 (en) * | 1995-01-23 | 1996-07-24 | Eli Lilly And Company | Aryl-substituted rhodanines for treating multiple sclerosis |
EP0722729A3 (en) * | 1995-01-23 | 1997-11-26 | Eli Lilly And Company | Aryl-substituted rhodanines for treating multiple sclerosis |
US6506751B1 (en) | 1999-11-12 | 2003-01-14 | Millennium Pharmaceuticals, Inc. | Thiazolidinone compounds useful as chemokine inhibitors |
WO2004017965A1 (en) * | 2002-08-23 | 2004-03-04 | Ionix Pharmaceuticals Limited | 1,3-thiazolin-4-ones as therapeutic compounds in the treatment of pain |
Also Published As
Publication number | Publication date |
---|---|
JPH0144707B2 (en) | 1989-09-29 |
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