JPS54125680A - 5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same - Google Patents

5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same

Info

Publication number
JPS54125680A
JPS54125680A JP3296678A JP3296678A JPS54125680A JP S54125680 A JPS54125680 A JP S54125680A JP 3296678 A JP3296678 A JP 3296678A JP 3296678 A JP3296678 A JP 3296678A JP S54125680 A JPS54125680 A JP S54125680A
Authority
JP
Japan
Prior art keywords
acid ester
preparation
same
hypotensive agent
agent containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3296678A
Other languages
Japanese (ja)
Inventor
Takemi Koeda
Takashi Tsuruoka
Uichi Shibata
Hiroyasu Asaoka
Mitsugi Hachisu
Osamu Ito
Taiji Sekizawa
Shigeharu Inoue
Taro Niida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Priority to JP3296678A priority Critical patent/JPS54125680A/en
Priority to CA323,912A priority patent/CA1115709A/en
Priority to CH268779A priority patent/CH637941A5/en
Priority to IT48451/79A priority patent/IT1115064B/en
Priority to GB7910324A priority patent/GB2018753B/en
Priority to SE7902665A priority patent/SE446863B/en
Priority to ES478918A priority patent/ES478918A1/en
Priority to NLAANVRAGE7902306,A priority patent/NL178251C/en
Priority to FR7907345A priority patent/FR2422639A1/en
Priority to DE2911492A priority patent/DE2911492C2/en
Priority to BE0/194197A priority patent/BE875070A/en
Publication of JPS54125680A publication Critical patent/JPS54125680A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:5-Alkoxy-picolinic acid ester of formula I (R1 is 1W6C alkyl; R2 is phenyl, substituted phenyl, indanyl).
EXAMPLE: 5-n-Butyloxy-picolinic acid 5-indanyl ester.
USE: Hypotensive agent for oral administration.
PROCESS: The compound I can be prepared either by reacting 5-alkoxypicolinic acid II (M is H, metal atom) or its metal salt with phenol or substituted phenol III (R3 is H, lower alkyl, acetyl) in the presence of a condensing agent such as dicyclohexylcarbodiimide, in an organic solvent such as chloroform, dioxane, etc., at 0W40°C, or by reacting 5-alkoxy-picolinic acid halide IV (X is halogen) with the compound III in the presence of a base such as pyridine, triethylamine, etc. in an organic solvent such as chloroform.
COPYRIGHT: (C)1979,JPO&Japio
JP3296678A 1978-03-24 1978-03-24 5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same Pending JPS54125680A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP3296678A JPS54125680A (en) 1978-03-24 1978-03-24 5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same
CA323,912A CA1115709A (en) 1978-03-24 1979-03-21 5-substituted-hydroxy picolinic acid derivatives
CH268779A CH637941A5 (en) 1978-03-24 1979-03-22 DERIVATIVES OF PICOLINIC ACID SUBSTITUTED IN POSITION 5 AND ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE DERIVATIVES.
IT48451/79A IT1115064B (en) 1978-03-24 1979-03-22 5-SUBSTITUTED PICOLINIC ACID DERIVATIVES PROCEDURE FOR PREPARING THEM AND HYPERTENSIVE COMPOSITIONS CONTAINING THEM
GB7910324A GB2018753B (en) 1978-03-24 1979-03-23 5-substituted picolinic acid derivatives a process for preparation thereof and ananti-hypertensive composition containing the same
SE7902665A SE446863B (en) 1978-03-24 1979-03-23 5-SUBSTITUTED PICOLIC ACID DERIVATIVES, PROCEDURE FOR PREPARING THEREOF AND USING THE COMPOUNDS AS ACTIVE INGREDIENT IN AN ANTI-HYPERTENSIVE COMPOSITION
ES478918A ES478918A1 (en) 1978-03-24 1979-03-23 5-Substituted picolinic acid derivatives, a process for preparation thereof and an anti-hypertensive composition containing the same
NLAANVRAGE7902306,A NL178251C (en) 1978-03-24 1979-03-23 5-SUBSTITUTED PICOLIC ACIDS AND THEIR DERIVATIVES, ANTI-BLOOD EFFECTS, PROCESS FOR THEIR PREPARATION AND PREPARATIONS CONTAINING THEM.
FR7907345A FR2422639A1 (en) 1978-03-24 1979-03-23 DERIVATIVES OF PICOLINIC ACID SUBSTITUTED IN 5, PROCESS OF PREPARATION AND ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE DERIVATIVES
DE2911492A DE2911492C2 (en) 1978-03-24 1979-03-23 5-Substituted picolinic acids, their sodium, potassium, magnesium, calcium and aluminum salts, 5-indanyl esters and acid amides, processes for their preparation and antihypertensive agents containing them
BE0/194197A BE875070A (en) 1978-03-24 1979-03-23 DERIVATIVES OF PICOLINIC ACIDS SUBSTITUTED IN POSITION 5, PROCESS FOR PREPARATION OF THESE DERIVATIVES AND ANTI-HYPERTENSIVE COMPOSITION IN CONTAINER

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3296678A JPS54125680A (en) 1978-03-24 1978-03-24 5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same

Publications (1)

Publication Number Publication Date
JPS54125680A true JPS54125680A (en) 1979-09-29

Family

ID=12373644

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3296678A Pending JPS54125680A (en) 1978-03-24 1978-03-24 5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same

Country Status (2)

Country Link
JP (1) JPS54125680A (en)
BE (1) BE875070A (en)

Also Published As

Publication number Publication date
BE875070A (en) 1979-07-16

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