JPS577482A - 1,3-benzoxazine derivative and its preparation - Google Patents
1,3-benzoxazine derivative and its preparationInfo
- Publication number
- JPS577482A JPS577482A JP8202080A JP8202080A JPS577482A JP S577482 A JPS577482 A JP S577482A JP 8202080 A JP8202080 A JP 8202080A JP 8202080 A JP8202080 A JP 8202080A JP S577482 A JPS577482 A JP S577482A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- benzoxazine
- halogen
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula I (R1 is alkyl or aryl; R2 is alkyl or together with R1 forms an alkylene; R3 is H, alkyl, alkoxyl or halogen).
EXAMPLE: 2,2-Dimethyl-3-(2-pyridylthio)-4-oxo-4H-1,3-benzoxazine.
USE: An anti-inflammatory agent.
PROCESS: An imidoyl halide derivative of a 1,3-benzoxazine expressed by formula II (X is halogen) is reacted with 2-mercaptopyridine N-oxide at a molar ratio of 1:2 or equimolar amounts in the presence of a base, e.g. triethylamine, in a solvent, e.g. methylene chloride, at 30W100°C to give an intermediate product of formula III or IV, which is then heated in the absence or presence of an organic solvent, e.g. methylene chloride, at 30W100°C to afford the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8202080A JPS577482A (en) | 1980-06-17 | 1980-06-17 | 1,3-benzoxazine derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8202080A JPS577482A (en) | 1980-06-17 | 1980-06-17 | 1,3-benzoxazine derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS577482A true JPS577482A (en) | 1982-01-14 |
Family
ID=13762832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8202080A Pending JPS577482A (en) | 1980-06-17 | 1980-06-17 | 1,3-benzoxazine derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS577482A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0307226A2 (en) * | 1987-09-11 | 1989-03-15 | American Cyanamid Company | Process for the preparation of a macrolide compound |
-
1980
- 1980-06-17 JP JP8202080A patent/JPS577482A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0307226A2 (en) * | 1987-09-11 | 1989-03-15 | American Cyanamid Company | Process for the preparation of a macrolide compound |
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