SE7902665L - 5-SUBSTITUTED PICOLIC ACID DERIVATIVES, PREPARATIONS FOR THE PREPARATION AND AN ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE - Google Patents

5-SUBSTITUTED PICOLIC ACID DERIVATIVES, PREPARATIONS FOR THE PREPARATION AND AN ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE

Info

Publication number
SE7902665L
SE7902665L SE7902665A SE7902665A SE7902665L SE 7902665 L SE7902665 L SE 7902665L SE 7902665 A SE7902665 A SE 7902665A SE 7902665 A SE7902665 A SE 7902665A SE 7902665 L SE7902665 L SE 7902665L
Authority
SE
Sweden
Prior art keywords
group
substituted
formula
image
carbon atoms
Prior art date
Application number
SE7902665A
Other languages
Swedish (sv)
Other versions
SE446863B (en
Inventor
Y Sekizawa
T Tsuruoka
M Hachisu
M Sezaki
M Miyamoto
U Shibata
K Mizutani
S Inouye
T Koeda
K Shimomura
T Niida
Original Assignee
Meiji Seika Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3296778A external-priority patent/JPS54125681A/en
Priority claimed from JP3296678A external-priority patent/JPS54125680A/en
Priority claimed from JP8048578A external-priority patent/JPS559002A/en
Application filed by Meiji Seika Kaisha filed Critical Meiji Seika Kaisha
Publication of SE7902665L publication Critical patent/SE7902665L/en
Publication of SE446863B publication Critical patent/SE446863B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A 5-substituted picolinic acid derivative of the formula (I): <IMAGE> wherein R1 represents a straight or branched chain halogen-substituted alkyl group having 2 to 6 carbon atoms or a substituted phenyl group having the formula <IMAGE> wherein each of R3 and R4, which may be the same or different, represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, an amino group, an N-alkyl-substituted amino group, an acylamino group, an acetyl group, an acyloxy group, a hydroxy group or a halogen-substituted alkyl group or wherein R3 and R4, when taken together, represent a polymethylene chain; and R2 represents an -OM group wherein M represents hydrogen, sodium, potassium, calcium, aluminium, magnesium, a straight or branched chain or cyclic alkoxy group having 1 to 6 carbon atoms, an aminoalkoxy group, a phenoxy group, a substituted phenoxy group, a 5-indanyloxy group, an acyloxyalkyloxy group having the formula <IMAGE> wherein R5 represents a hydrogen atom or a methyl group and R6 represents a lower alkyl group having 1 to 6 carbon atoms, a phenyl group or a substituted phenyl group, or an amino group represented by the formula <IMAGE> wherein each of R7 and R8, which may be the same or different, represents a hydrogen atom, a lower alkyl group, or a phenyl group. 5-Indanyl ester of 5-alkoxy-picolinic acid represented by the formula (A): <IMAGE> wherein Ra represents an alkyl group having 1 to 6 carbon atoms. The above compounds are useful as anti-hypertensive agents. There is also disclosed a process for preparing such compounds and anti-hypertensive compositions containing the same.
SE7902665A 1978-03-24 1979-03-23 5-SUBSTITUTED PICOLIC ACID DERIVATIVES, PROCEDURE FOR PREPARING THEREOF AND USING THE COMPOUNDS AS ACTIVE INGREDIENT IN AN ANTI-HYPERTENSIVE COMPOSITION SE446863B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3296778A JPS54125681A (en) 1978-03-24 1978-03-24 5-substituted picolinic acid, its preparation, and hypotensive agent containing the same
JP3296678A JPS54125680A (en) 1978-03-24 1978-03-24 5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same
JP8048578A JPS559002A (en) 1978-07-04 1978-07-04 5-substituted picolinic acid derivative, its preparation and hypotensive agent containing the same

Publications (2)

Publication Number Publication Date
SE7902665L true SE7902665L (en) 1979-09-25
SE446863B SE446863B (en) 1986-10-13

Family

ID=27287919

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7902665A SE446863B (en) 1978-03-24 1979-03-23 5-SUBSTITUTED PICOLIC ACID DERIVATIVES, PROCEDURE FOR PREPARING THEREOF AND USING THE COMPOUNDS AS ACTIVE INGREDIENT IN AN ANTI-HYPERTENSIVE COMPOSITION

Country Status (9)

Country Link
CA (1) CA1115709A (en)
CH (1) CH637941A5 (en)
DE (1) DE2911492C2 (en)
ES (1) ES478918A1 (en)
FR (1) FR2422639A1 (en)
GB (1) GB2018753B (en)
IT (1) IT1115064B (en)
NL (1) NL178251C (en)
SE (1) SE446863B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5344572A (en) * 1976-09-30 1978-04-21 Meiji Seika Kaisha Ltd 5-alkoxy-picolic acid, its preparation and hypotensives containing the same

Also Published As

Publication number Publication date
CA1115709A (en) 1982-01-05
CH637941A5 (en) 1983-08-31
DE2911492C2 (en) 1983-05-05
FR2422639B1 (en) 1983-05-20
FR2422639A1 (en) 1979-11-09
IT7948451A0 (en) 1979-03-22
DE2911492A1 (en) 1979-09-27
NL178251B (en) 1985-09-16
GB2018753A (en) 1979-10-24
GB2018753B (en) 1982-08-25
SE446863B (en) 1986-10-13
NL178251C (en) 1986-02-17
NL7902306A (en) 1979-09-26
ES478918A1 (en) 1979-12-16
IT1115064B (en) 1986-02-03

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