JPS57154168A - Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative - Google Patents
Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivativeInfo
- Publication number
- JPS57154168A JPS57154168A JP3991081A JP3991081A JPS57154168A JP S57154168 A JPS57154168 A JP S57154168A JP 3991081 A JP3991081 A JP 3991081A JP 3991081 A JP3991081 A JP 3991081A JP S57154168 A JPS57154168 A JP S57154168A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- heating
- oximino
- fluoro
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:The compound of formula[R is H, alkyl, phenylalkenyl, (halogen substituted) phenyl or (alkyl or phenyl)-substituted amino; X is F or Br].
EXAMPLE: 6-Fluoro-4-oximino-1-propionyl-1,2,3,4-tetranhydroquinoline.
USE: Medicine. It has strong antihydropic and diuretic activities, and extremely low adverse effect to the digestive organs.
PROCESS: The compound of formula can be prepared e.g. by (1) heating p-fluoroaniline and an acrylic acid ester in a solvent, (2) heating the resultant compound in the presence of a hydrolyzed strong dehydrating agent to obtain 6- fluoro-4-oxo-1,2,3,4-tetrahydroquinoline, (3) acylating the product with a reactive derivative of a carboxylic acid which can condense the above compound (4) reacting with an amine, and (5) heating the resultant compound in the presence of hydroxylamine hydrochloride.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3991081A JPS57154168A (en) | 1981-03-19 | 1981-03-19 | Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative |
GB8120931A GB2092130B (en) | 1980-07-28 | 1981-07-07 | 4-oximino-1,2,3,4-tetrahydroquinoline derivatives |
US06/281,243 US4421919A (en) | 1980-07-28 | 1981-07-07 | 4-Oximino-1,2,3,4-tetrahydroquinoline derivatives |
FR8114436A FR2487346A1 (en) | 1980-07-28 | 1981-07-24 | 4-OXIMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THERAPEUTIC APPLICATION THEREOF |
DE19813129718 DE3129718A1 (en) | 1980-07-28 | 1981-07-28 | 4-OXIMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3991081A JPS57154168A (en) | 1981-03-19 | 1981-03-19 | Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57154168A true JPS57154168A (en) | 1982-09-22 |
JPS6121628B2 JPS6121628B2 (en) | 1986-05-28 |
Family
ID=12566098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3991081A Granted JPS57154168A (en) | 1980-07-28 | 1981-03-19 | Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57154168A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009053308A (en) * | 2007-08-24 | 2009-03-12 | Nippon Seiki Co Ltd | Display device |
-
1981
- 1981-03-19 JP JP3991081A patent/JPS57154168A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009053308A (en) * | 2007-08-24 | 2009-03-12 | Nippon Seiki Co Ltd | Display device |
Also Published As
Publication number | Publication date |
---|---|
JPS6121628B2 (en) | 1986-05-28 |
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