JPS57154168A - Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative - Google Patents

Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative

Info

Publication number
JPS57154168A
JPS57154168A JP3991081A JP3991081A JPS57154168A JP S57154168 A JPS57154168 A JP S57154168A JP 3991081 A JP3991081 A JP 3991081A JP 3991081 A JP3991081 A JP 3991081A JP S57154168 A JPS57154168 A JP S57154168A
Authority
JP
Japan
Prior art keywords
compound
heating
oximino
fluoro
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3991081A
Other languages
Japanese (ja)
Other versions
JPS6121628B2 (en
Inventor
Susumu Jinbo
Shoichi Kono
Koichi Kashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hodogaya Chemical Co Ltd
Mochida Pharmaceutical Co Ltd
Original Assignee
Hodogaya Chemical Co Ltd
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hodogaya Chemical Co Ltd, Mochida Pharmaceutical Co Ltd filed Critical Hodogaya Chemical Co Ltd
Priority to JP3991081A priority Critical patent/JPS57154168A/en
Priority to GB8120931A priority patent/GB2092130B/en
Priority to US06/281,243 priority patent/US4421919A/en
Priority to FR8114436A priority patent/FR2487346A1/en
Priority to DE19813129718 priority patent/DE3129718A1/en
Publication of JPS57154168A publication Critical patent/JPS57154168A/en
Publication of JPS6121628B2 publication Critical patent/JPS6121628B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:The compound of formula[R is H, alkyl, phenylalkenyl, (halogen substituted) phenyl or (alkyl or phenyl)-substituted amino; X is F or Br].
EXAMPLE: 6-Fluoro-4-oximino-1-propionyl-1,2,3,4-tetranhydroquinoline.
USE: Medicine. It has strong antihydropic and diuretic activities, and extremely low adverse effect to the digestive organs.
PROCESS: The compound of formula can be prepared e.g. by (1) heating p-fluoroaniline and an acrylic acid ester in a solvent, (2) heating the resultant compound in the presence of a hydrolyzed strong dehydrating agent to obtain 6- fluoro-4-oxo-1,2,3,4-tetrahydroquinoline, (3) acylating the product with a reactive derivative of a carboxylic acid which can condense the above compound (4) reacting with an amine, and (5) heating the resultant compound in the presence of hydroxylamine hydrochloride.
COPYRIGHT: (C)1982,JPO&Japio
JP3991081A 1980-07-28 1981-03-19 Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative Granted JPS57154168A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP3991081A JPS57154168A (en) 1981-03-19 1981-03-19 Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative
GB8120931A GB2092130B (en) 1980-07-28 1981-07-07 4-oximino-1,2,3,4-tetrahydroquinoline derivatives
US06/281,243 US4421919A (en) 1980-07-28 1981-07-07 4-Oximino-1,2,3,4-tetrahydroquinoline derivatives
FR8114436A FR2487346A1 (en) 1980-07-28 1981-07-24 4-OXIMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THERAPEUTIC APPLICATION THEREOF
DE19813129718 DE3129718A1 (en) 1980-07-28 1981-07-28 4-OXIMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3991081A JPS57154168A (en) 1981-03-19 1981-03-19 Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative

Publications (2)

Publication Number Publication Date
JPS57154168A true JPS57154168A (en) 1982-09-22
JPS6121628B2 JPS6121628B2 (en) 1986-05-28

Family

ID=12566098

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3991081A Granted JPS57154168A (en) 1980-07-28 1981-03-19 Novel 4-oximino-1,2,3,4-tetrahydroquinoline derivative

Country Status (1)

Country Link
JP (1) JPS57154168A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009053308A (en) * 2007-08-24 2009-03-12 Nippon Seiki Co Ltd Display device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009053308A (en) * 2007-08-24 2009-03-12 Nippon Seiki Co Ltd Display device

Also Published As

Publication number Publication date
JPS6121628B2 (en) 1986-05-28

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