JPS5728052A - Novel 4-hydroxyimino-1,2,3,4-tetrahydroquinoline derivative - Google Patents

Novel 4-hydroxyimino-1,2,3,4-tetrahydroquinoline derivative

Info

Publication number
JPS5728052A
JPS5728052A JP10327280A JP10327280A JPS5728052A JP S5728052 A JPS5728052 A JP S5728052A JP 10327280 A JP10327280 A JP 10327280A JP 10327280 A JP10327280 A JP 10327280A JP S5728052 A JPS5728052 A JP S5728052A
Authority
JP
Japan
Prior art keywords
hydroxyimino
alkyl
tetrahydroquinoline
heated
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10327280A
Other languages
Japanese (ja)
Other versions
JPS6145987B2 (en
Inventor
Susumu Jinbo
Shoichi Kono
Koichi Kashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hodogaya Chemical Co Ltd
Mochida Pharmaceutical Co Ltd
Original Assignee
Hodogaya Chemical Co Ltd
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hodogaya Chemical Co Ltd, Mochida Pharmaceutical Co Ltd filed Critical Hodogaya Chemical Co Ltd
Priority to JP10327280A priority Critical patent/JPS5728052A/en
Priority to US06/281,243 priority patent/US4421919A/en
Priority to GB8120931A priority patent/GB2092130B/en
Priority to US06/281,242 priority patent/US4440770A/en
Priority to FR8114436A priority patent/FR2487346A1/en
Priority to DE19813129718 priority patent/DE3129718A1/en
Publication of JPS5728052A publication Critical patent/JPS5728052A/en
Publication of JPS6145987B2 publication Critical patent/JPS6145987B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 4-hydroxyimino-1,2,3,4-tetrahydroquinoline derivative expressed by the formula (R is H, alkyl, halogen substituted lower alkyl, phenyl substituted lower alkyl, phenylalkenyl, aromatic group containing nitrogen or alkyl or phenyl substituted amino). EXAMPLE:6-Chloro-4-hydroxyimino-1-formyl-1,2,3,4-tetrahydroquinoline. USE:An antihydrophic and a diuretic agent with almost no gastric disorder. PROCESS:p-Chloroaniline is heated with an acrylic ester in a solvent, e.g. benzene, or if desired with a base, e.g. sodium hydride, at room temperature or under heating to carry out the Michael addition reaction to obtain a 3-(p-chlorophenylamino) propionic ester. The resultant ester is hydrolyzed and then heated in the presence of a dehydrating agent to afford the compound expressed by the formula.
JP10327280A 1980-07-28 1980-07-28 Novel 4-hydroxyimino-1,2,3,4-tetrahydroquinoline derivative Granted JPS5728052A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP10327280A JPS5728052A (en) 1980-07-28 1980-07-28 Novel 4-hydroxyimino-1,2,3,4-tetrahydroquinoline derivative
US06/281,243 US4421919A (en) 1980-07-28 1981-07-07 4-Oximino-1,2,3,4-tetrahydroquinoline derivatives
GB8120931A GB2092130B (en) 1980-07-28 1981-07-07 4-oximino-1,2,3,4-tetrahydroquinoline derivatives
US06/281,242 US4440770A (en) 1980-07-28 1981-07-07 Diuretic, hypotensive and antiedemic quinoline oximes
FR8114436A FR2487346A1 (en) 1980-07-28 1981-07-24 4-OXIMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THERAPEUTIC APPLICATION THEREOF
DE19813129718 DE3129718A1 (en) 1980-07-28 1981-07-28 4-OXIMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10327280A JPS5728052A (en) 1980-07-28 1980-07-28 Novel 4-hydroxyimino-1,2,3,4-tetrahydroquinoline derivative

Publications (2)

Publication Number Publication Date
JPS5728052A true JPS5728052A (en) 1982-02-15
JPS6145987B2 JPS6145987B2 (en) 1986-10-11

Family

ID=14349749

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10327280A Granted JPS5728052A (en) 1980-07-28 1980-07-28 Novel 4-hydroxyimino-1,2,3,4-tetrahydroquinoline derivative

Country Status (1)

Country Link
JP (1) JPS5728052A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07173137A (en) * 1991-04-10 1995-07-11 Nippon Bayeragrochem Kk Tetrahydroquinolin-1-ylcarbonyl chloride derivative and its production
JP2009227624A (en) * 2008-03-24 2009-10-08 Fujifilm Corp New compound, photopolymerizable composition, photopolymerizable composition for color filter, color filter, methods for producing same, solid-state imaging device and lithographic printing original plate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07173137A (en) * 1991-04-10 1995-07-11 Nippon Bayeragrochem Kk Tetrahydroquinolin-1-ylcarbonyl chloride derivative and its production
JP2009227624A (en) * 2008-03-24 2009-10-08 Fujifilm Corp New compound, photopolymerizable composition, photopolymerizable composition for color filter, color filter, methods for producing same, solid-state imaging device and lithographic printing original plate

Also Published As

Publication number Publication date
JPS6145987B2 (en) 1986-10-11

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