KR850002267A - Preparation of pyridyl and quinolyl imidazolinones - Google Patents

Preparation of pyridyl and quinolyl imidazolinones Download PDF

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KR850002267A
KR850002267A KR1019830004662A KR830004662A KR850002267A KR 850002267 A KR850002267 A KR 850002267A KR 1019830004662 A KR1019830004662 A KR 1019830004662A KR 830004662 A KR830004662 A KR 830004662A KR 850002267 A KR850002267 A KR 850002267A
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hydrogen
methyl
compound
alkyl
isopropyl
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KR1019830004662A
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Korean (ko)
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KR900003399B1 (en
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죤 웨플로 피이터
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죤 제이 헤이간
아메리칸 사이아나밋드 캄파니
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Priority claimed from PCT/US1983/000722 external-priority patent/WO1983004252A1/en
Publication of KR850002267A publication Critical patent/KR850002267A/en
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Publication of KR900003399B1 publication Critical patent/KR900003399B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

피리딜 및 퀴놀릴 이미다졸리논류의 제법Preparation of pyridyl and quinolyl imidazolinones

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (10)

하기 구조식(Ⅱ)의 화합물 1－20당량을 적어도 3당량의 유황 및 하기구조식(Ⅲ)의 아미노카복사미드 적어도 1당량과 함께 승온에서 반응시키고, A가 수소, C1－C61급 또는 2급알킬, 또는 －COOR3인 경우 소망에 따라 COOH로 전환시키는 것이 합성단계의 일부를 구성하는 하기 구조식(Ⅰ)의 화합물의 제조방법.1-20 equivalents of the compound of formula (II) are reacted with at least 3 equivalents of sulfur and at least 1 equivalent of the aminocarboxamide of the following formula (III) at elevated temperature, and A is hydrogen, C 1 -C 6 primary or Process for the preparation of the compound of formula (I) wherein secondary alkyl, or -COOR 3 , if desired, converts to COOH as part of the synthesis step. 상기식들에서,In the above formulas, Z은 수소이며; Y는 수소, 염소, 불소, C1－C6알킬, C1－C6알콕시, 페닐 또는 치환된 페닐이며; A는 수소, C1－C61급 또는 2급알킬 또는 COOR3이며 여기서 R3는 C1－C12알킬이며 R2과 R2는 C1－C4알킬이거나 또는 이들은 함께 취해져 메틸에 의해 임의로 치환된 C3－C6사이클로알킬기를 나타내며; R1과 R2가 동일하지 않은 경우 그의 광학이성체이며; Y와 Z은 함께 취해질 경우 고리를 형성하며 이때 YZ은로서 여기서 L,M,Q 및 R7은 각기 수소, 염소, 불소, 메틸, 메톡시 또는 페닐로 구성된 군으로 부터 선택되며; A,R1,R2및 R3가 상기한 바와 같고 R1과 R2가 동일하지 않은 경우 그의 광학이성체가 된다.Z is hydrogen; Y is hydrogen, chlorine, fluorine, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, phenyl or substituted phenyl; A is hydrogen, C 1 -C 6 primary or secondary alkyl or COOR 3 , wherein R 3 is C 1 -C 12 alkyl and R 2 and R 2 are C 1 -C 4 alkyl or they are taken together by methyl An optionally substituted C 3 -C 6 cycloalkyl group; When R 1 and R 2 are not identical, they are optical isomers; Y and Z, when taken together, form a ring, where YZ is Wherein L, M, Q and R 7 are each selected from the group consisting of hydrogen, chlorine, fluorine, methyl, methoxy or phenyl; When A, R 1 , R 2 and R 3 are as described above and R 1 and R 2 are not the same, they are optical isomers. 제1항에 있어서 α－피콜린 1.5－10당량을 유황 3－5당당 및 아미노타복사미드 1당량과 100－200℃에서 반응시키는 방법.The method according to claim 1, wherein 1.5 to 10 equivalents of α-picolin are reacted with 3 to 5 sugars of sulfur and 1 equivalent of aminotaboxamide at 100 to 200 ° C. 제1항에 있어서 A와 Z이 수소이며; Y가 C1－C6알콕시이며; R1이 메틸이며; R2가 이소프로필인 방법.The compound of claim 1, wherein A and Z are hydrogen; Y is C 1 -C 6 alkoxy; R 1 is methyl; R 2 is isopropyl. 제1항에 있어서 Y가 C1－C6알킬이며 A와 Z이 수소이며; R1이 메틸이며; R2가 이소프로필인 방법.The compound of claim 1, wherein Y is C 1 -C 6 alkyl and A and Z are hydrogen; R 1 is methyl; R 2 is isopropyl. 제1항에 있어서 Y와 Z이 함께를 나타내며, 여기서 L,M,Q 및 R7은 각기 수소, 염소, 불소, 메틸, 메톡시 또는 페닐로 구성된 군으로 부터 선택되며; A가 제1항에 정의한 바와 같으며; R1R1이 메틸이고 R2가 이소프로필인 방법.The compound of claim 1 wherein Y and Z are Wherein L, M, Q and R 7 are each selected from the group consisting of hydrogen, chlorine, fluorine, methyl, methoxy or phenyl; A is as defined in claim 1; R 1 R 1 is methyl and R 2 is isopropyl. 제1항에 있어서 Y가 페닐이며; Z이 수소이며; A가 제1항에 정의한 바와 같으며; R1이 메틸이고 R2가 이소프로필인 방법The compound of claim 1, wherein Y is phenyl; Z is hydrogen; A is as defined in claim 1; R 1 is methyl and R 2 is isopropyl 제1항에 있어서 Y가 에틸이며; A와 Z이 수소이며, R이 메틸이며 R2가 이소프로필인 방법.The compound of claim 1, wherein Y is ethyl; A and Z are hydrogen, R is methyl and R 2 is isopropyl. 제1항에 있어서 Y와 Z이 수소이며, A가 CH3이며, R1이 CH3이며 R2가 CH(CH)2인 방법.The method of claim 1 wherein Y and Z are hydrogen, A is CH 3 , R 1 is CH 3 and R 2 is CH (CH) 2 . 제1항에 있어서 Y와 Z이 수소이며 A가 COOR3이며 R1이 CH3이며 R2가 CH(CH3)2이며, R3가 제1항에 정의한 바와 같은 방법.The method of claim 1 wherein Y and Z are hydrogen, A is COOR 3 , R 1 is CH 3 , R 2 is CH (CH 3 ) 2 , and R 3 is as defined in claim 1. 제1항에 있어서, 1,5당량의 α－피콜린 또는 퀴날딘을 유황 3당량 및 α－아미노카복사미드 1당량과 함께 100－250℃로 가열하여 바라는 피리딜 또는 퀴놀린 이미다졸리논을 얻는 방법.The pyridyl or quinoline imidazolinones of claim 1 are heated by heating 1,5 equivalents of α-picolin or quinaldine to 100-250 ° C. with 3 equivalents of sulfur and 1 equivalent of α-aminocarboxamide. How to get. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019830004662A 1983-05-12 1983-05-12 Process for preapring pyridyl and quinolyl imidazolinones KR900003399B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1983/000722 WO1983004252A1 (en) 1982-05-25 1983-05-12 Process for the preparation of pyridyl and quinolyl imidazolinones
USPCT/US83/00722 1983-05-12

Publications (2)

Publication Number Publication Date
KR850002267A true KR850002267A (en) 1985-05-10
KR900003399B1 KR900003399B1 (en) 1990-05-18

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KR1019830004662A KR900003399B1 (en) 1983-05-12 1983-05-12 Process for preapring pyridyl and quinolyl imidazolinones

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JP (1) JPS59500964A (en)
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JPH0378860B2 (en) 1991-12-17
JPS59500964A (en) 1984-05-31
KR900003399B1 (en) 1990-05-18

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