JPS57171964A - 7-oxoprostaglandin e1 compound and blood platelet coagulation inhibiting agent containing said compound as active component - Google Patents
7-oxoprostaglandin e1 compound and blood platelet coagulation inhibiting agent containing said compound as active componentInfo
- Publication number
- JPS57171964A JPS57171964A JP56055481A JP5548181A JPS57171964A JP S57171964 A JPS57171964 A JP S57171964A JP 56055481 A JP56055481 A JP 56055481A JP 5548181 A JP5548181 A JP 5548181A JP S57171964 A JPS57171964 A JP S57171964A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- oxoprostaglandin
- blood platelet
- inhibiting agent
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:The compound of formulaI(R1 is H or 1W10C saturated or unsaturated hydrocarbon group; R2 and R3 are H of OH-protecting group), or non-toxic salt of the acid.
EXAMPLE: 16,17,18,19,20-Pentanoyl-15-cyclohexyl-7-oxoprostaglandin E1 methyl ester.
USE: A blood platelet coagulation inhibiting agent. Remedy and preventive for thrombosis. Agent for inhibiting the metastasis of cancer. It has low side effects (especially diarrhea).
PROCESS: The compound of formulaIwherein R1WR3 are not H can be prepared by (1) reacting the compound of formula II (R21 is OH-protecting group; * represents asymmetric carbon atom and its absolute structure is R or mixture of R and S) with the compound of formula III (R31 is OH-protecting group; Y is phenylthio, etc.; ** represents asymmetric carbon atom having an absolute structure defined in the formulaI; n is 1 or 2), and (2) reacting the resultant intermediate with an acid chloride of formula IV (R11 is 1W10C saturated or unsaturated hydrocarbon group).
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56055481A JPS57171964A (en) | 1981-04-15 | 1981-04-15 | 7-oxoprostaglandin e1 compound and blood platelet coagulation inhibiting agent containing said compound as active component |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56055481A JPS57171964A (en) | 1981-04-15 | 1981-04-15 | 7-oxoprostaglandin e1 compound and blood platelet coagulation inhibiting agent containing said compound as active component |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57171964A true JPS57171964A (en) | 1982-10-22 |
Family
ID=12999805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56055481A Pending JPS57171964A (en) | 1981-04-15 | 1981-04-15 | 7-oxoprostaglandin e1 compound and blood platelet coagulation inhibiting agent containing said compound as active component |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57171964A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7066492B2 (en) | 2002-02-07 | 2006-06-27 | Daihatsu Motor Co., Ltd. | Impact force relieving structure in steering device of car |
-
1981
- 1981-04-15 JP JP56055481A patent/JPS57171964A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7066492B2 (en) | 2002-02-07 | 2006-06-27 | Daihatsu Motor Co., Ltd. | Impact force relieving structure in steering device of car |
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