JPS57171964A - 7-oxoprostaglandin e1 compound and blood platelet coagulation inhibiting agent containing said compound as active component - Google Patents

7-oxoprostaglandin e1 compound and blood platelet coagulation inhibiting agent containing said compound as active component

Info

Publication number
JPS57171964A
JPS57171964A JP56055481A JP5548181A JPS57171964A JP S57171964 A JPS57171964 A JP S57171964A JP 56055481 A JP56055481 A JP 56055481A JP 5548181 A JP5548181 A JP 5548181A JP S57171964 A JPS57171964 A JP S57171964A
Authority
JP
Japan
Prior art keywords
compound
oxoprostaglandin
blood platelet
inhibiting agent
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56055481A
Other languages
Japanese (ja)
Inventor
Toshio Tanaka
Takeshi Yu
Takeo Oba
Noriaki Okamura
Kenzo Watanabe
Kiyoshi Sakauchi
Atsuo Hazato
Akira Otsu
Fukuyoshi Kamimoto
Seiji Kurozumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP56055481A priority Critical patent/JPS57171964A/en
Publication of JPS57171964A publication Critical patent/JPS57171964A/en
Pending legal-status Critical Current

Links

Classifications

    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The compound of formulaI(R1 is H or 1W10C saturated or unsaturated hydrocarbon group; R2 and R3 are H of OH-protecting group), or non-toxic salt of the acid.
EXAMPLE: 16,17,18,19,20-Pentanoyl-15-cyclohexyl-7-oxoprostaglandin E1 methyl ester.
USE: A blood platelet coagulation inhibiting agent. Remedy and preventive for thrombosis. Agent for inhibiting the metastasis of cancer. It has low side effects (especially diarrhea).
PROCESS: The compound of formulaIwherein R1WR3 are not H can be prepared by (1) reacting the compound of formula II (R21 is OH-protecting group; * represents asymmetric carbon atom and its absolute structure is R or mixture of R and S) with the compound of formula III (R31 is OH-protecting group; Y is phenylthio, etc.; ** represents asymmetric carbon atom having an absolute structure defined in the formulaI; n is 1 or 2), and (2) reacting the resultant intermediate with an acid chloride of formula IV (R11 is 1W10C saturated or unsaturated hydrocarbon group).
COPYRIGHT: (C)1982,JPO&Japio
JP56055481A 1981-04-15 1981-04-15 7-oxoprostaglandin e1 compound and blood platelet coagulation inhibiting agent containing said compound as active component Pending JPS57171964A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56055481A JPS57171964A (en) 1981-04-15 1981-04-15 7-oxoprostaglandin e1 compound and blood platelet coagulation inhibiting agent containing said compound as active component

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56055481A JPS57171964A (en) 1981-04-15 1981-04-15 7-oxoprostaglandin e1 compound and blood platelet coagulation inhibiting agent containing said compound as active component

Publications (1)

Publication Number Publication Date
JPS57171964A true JPS57171964A (en) 1982-10-22

Family

ID=12999805

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56055481A Pending JPS57171964A (en) 1981-04-15 1981-04-15 7-oxoprostaglandin e1 compound and blood platelet coagulation inhibiting agent containing said compound as active component

Country Status (1)

Country Link
JP (1) JPS57171964A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7066492B2 (en) 2002-02-07 2006-06-27 Daihatsu Motor Co., Ltd. Impact force relieving structure in steering device of car

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7066492B2 (en) 2002-02-07 2006-06-27 Daihatsu Motor Co., Ltd. Impact force relieving structure in steering device of car

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