JPS5777669A - Sulfur-containing prostaglandin and its preparation - Google Patents

Sulfur-containing prostaglandin and its preparation

Info

Publication number
JPS5777669A
JPS5777669A JP55152214A JP15221480A JPS5777669A JP S5777669 A JPS5777669 A JP S5777669A JP 55152214 A JP55152214 A JP 55152214A JP 15221480 A JP15221480 A JP 15221480A JP S5777669 A JPS5777669 A JP S5777669A
Authority
JP
Japan
Prior art keywords
configuration
formula
sulfur
reacting
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55152214A
Other languages
Japanese (ja)
Other versions
JPS6344143B2 (en
Inventor
Kenzo Watanabe
Takeshi Yu
Takeo Oba
Toshio Tanaka
Noriaki Okamura
Kiyoshi Sakauchi
Atsuo Hazato
Seiji Kurozumi
Akira Otsu
Fukuyoshi Kamimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP55152214A priority Critical patent/JPS5777669A/en
Priority to DE8181109250T priority patent/DE3168199D1/en
Priority to EP81109250A priority patent/EP0051284B1/en
Priority to US06/316,902 priority patent/US4466980A/en
Publication of JPS5777669A publication Critical patent/JPS5777669A/en
Publication of JPS6344143B2 publication Critical patent/JPS6344143B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The sulfur-containing prostaglandin of formulaI(R1 is H or lower alkyl; R2 is 1W10C alkyl or cycloalkyl; R3 is H or methyl; R4 and R5 are H or protecting group; n is 0, 1 or 2; the sign (.) represents an asymmetric carbon atom whose absolute configuration is R configuration, S configuration or their mixture), its enantiomer, their mixture, and their pharmacologically permissible cation salt when R1, R4 and R5 are H.
EXAMPLE: 6-Thiaprostaglandin E1.
USE: Remedy or preventive of thrombosis, or hypotensor. It has blood platelet coagulation inhibiting activity, vasodilating activity, etc.
PROCESS: The compound of formulaIis prepared e.g. by reacting the sulfonic acid ester of formula II (R4-1 and R5-1 are protecting groups: R6 is lower alkyl, substituted phenyl, etc.) with a base. Reacting the resultant unsaturated ketone of formula III with the thiol of formula IV in the presence of an organic base, and if necessary, elmninating the protecting groups.
COPYRIGHT: (C)1982,JPO&Japio
JP55152214A 1980-10-31 1980-10-31 Sulfur-containing prostaglandin and its preparation Granted JPS5777669A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP55152214A JPS5777669A (en) 1980-10-31 1980-10-31 Sulfur-containing prostaglandin and its preparation
DE8181109250T DE3168199D1 (en) 1980-10-31 1981-10-29 Novel thiaprostaglandin e1 derivatives, process for production thereof, and pharmaceuticals containing these compounds
EP81109250A EP0051284B1 (en) 1980-10-31 1981-10-29 Novel thiaprostaglandin e1 derivatives, process for production thereof, and pharmaceuticals containing these compounds
US06/316,902 US4466980A (en) 1980-10-31 1981-10-30 Thiaprostaglandin E1 derivatives, process for production thereof, and pharmaceutical use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55152214A JPS5777669A (en) 1980-10-31 1980-10-31 Sulfur-containing prostaglandin and its preparation

Publications (2)

Publication Number Publication Date
JPS5777669A true JPS5777669A (en) 1982-05-15
JPS6344143B2 JPS6344143B2 (en) 1988-09-02

Family

ID=15535559

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55152214A Granted JPS5777669A (en) 1980-10-31 1980-10-31 Sulfur-containing prostaglandin and its preparation

Country Status (1)

Country Link
JP (1) JPS5777669A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59175465A (en) * 1983-03-25 1984-10-04 Teijin Ltd Sulfone or sulfoxide compound of 5-thiaprostaglandin e1, and its preparation
WO1999005091A1 (en) * 1997-07-25 1999-02-04 Nippon Kayaku Kabushiki Kaisha Novel compound having effect of promoting neuron differentiation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59175465A (en) * 1983-03-25 1984-10-04 Teijin Ltd Sulfone or sulfoxide compound of 5-thiaprostaglandin e1, and its preparation
WO1999005091A1 (en) * 1997-07-25 1999-02-04 Nippon Kayaku Kabushiki Kaisha Novel compound having effect of promoting neuron differentiation
US6384063B1 (en) 1997-07-25 2002-05-07 Nippon Kayaku Kabushiki Kaisha Compound having effect of promoting neuron differentiation

Also Published As

Publication number Publication date
JPS6344143B2 (en) 1988-09-02

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