JPS5455562A - Lactam compound - Google Patents

Lactam compound

Info

Publication number
JPS5455562A
JPS5455562A JP12224977A JP12224977A JPS5455562A JP S5455562 A JPS5455562 A JP S5455562A JP 12224977 A JP12224977 A JP 12224977A JP 12224977 A JP12224977 A JP 12224977A JP S5455562 A JPS5455562 A JP S5455562A
Authority
JP
Japan
Prior art keywords
formula
compound
reduction
alkoxycarbonyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12224977A
Other languages
Japanese (ja)
Inventor
Masayuki Imanishi
Yutaka Masuoka
Ryoko Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP12224977A priority Critical patent/JPS5455562A/en
Priority to AU40242/78A priority patent/AU518986B2/en
Priority to DK439878A priority patent/DK439878A/en
Priority to CA312,844A priority patent/CA1102338A/en
Priority to EP78101094A priority patent/EP0001601B1/en
Priority to DE7878101094T priority patent/DE2861210D1/en
Priority to NO783420A priority patent/NO150041C/en
Priority to IT28617/78A priority patent/IT1099358B/en
Priority to US05/950,524 priority patent/US4198514A/en
Publication of JPS5455562A publication Critical patent/JPS5455562A/en
Pending legal-status Critical Current

Links

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Lactam compounds of formula I (R1, R2 are H, acyl, alkoxycarbonyl; R3 is H, alkyl, phenyl that may be substituted; n is 1, 2).
EXAMPLE: 4-Diphenylmethyl-2-pyrrolidone.
USE: Antianxiety agent; they have extremely reduced side actions such as hypnosis and muscle relaxation activities and are observed to have antineuropasmolytic action.
PREPARATION: Cylization of a compound of formula III obained by the reduction of a compound of formula II in the presence of a mineral acid or the reduction of a compound of formula II under neutral or basic conditions with subsequent reaction of the resultant compound of formula I in which R1 is H with a reactive derivative of acid such as acetyl chloride or an alkoxycarbonyl halide forms a compound of formula I in which R1 is other than H
COPYRIGHT: (C)1979,JPO&Japio
JP12224977A 1977-10-11 1977-10-11 Lactam compound Pending JPS5455562A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP12224977A JPS5455562A (en) 1977-10-11 1977-10-11 Lactam compound
AU40242/78A AU518986B2 (en) 1977-10-11 1978-09-27 Lactams
DK439878A DK439878A (en) 1977-10-11 1978-10-04 PROCEDURE FOR PREPARING LACTAM COMPOUNDS
CA312,844A CA1102338A (en) 1977-10-11 1978-10-06 Lactam compounds
EP78101094A EP0001601B1 (en) 1977-10-11 1978-10-07 Lactam compounds and methods for their preparation
DE7878101094T DE2861210D1 (en) 1977-10-11 1978-10-07 Lactam compounds and methods for their preparation
NO783420A NO150041C (en) 1977-10-11 1978-10-10 ANALOGY PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE LACTAM COMPOUNDS
IT28617/78A IT1099358B (en) 1977-10-11 1978-10-10 ANSIOLYTIC ACTION LACTAMIC COMPOUNDS
US05/950,524 US4198514A (en) 1977-10-11 1978-10-11 Lactam compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12224977A JPS5455562A (en) 1977-10-11 1977-10-11 Lactam compound

Publications (1)

Publication Number Publication Date
JPS5455562A true JPS5455562A (en) 1979-05-02

Family

ID=14831277

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12224977A Pending JPS5455562A (en) 1977-10-11 1977-10-11 Lactam compound

Country Status (1)

Country Link
JP (1) JPS5455562A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6972341B2 (en) 2001-06-11 2005-12-06 Xeno Port, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US7423169B2 (en) 2001-06-11 2008-09-09 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs

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