JPS57156463A - Isoquinoline derivative - Google Patents

Isoquinoline derivative

Info

Publication number
JPS57156463A
JPS57156463A JP3955081A JP3955081A JPS57156463A JP S57156463 A JPS57156463 A JP S57156463A JP 3955081 A JP3955081 A JP 3955081A JP 3955081 A JP3955081 A JP 3955081A JP S57156463 A JPS57156463 A JP S57156463A
Authority
JP
Japan
Prior art keywords
formula
remedy
isoquinoline derivative
alkyl
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3955081A
Other languages
Japanese (ja)
Other versions
JPS6348869B2 (en
Inventor
Hiroyoshi Hidaka
Takanori Sone
Taiji Sasaki
Tasuke Sugihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Priority to JP3955081A priority Critical patent/JPS57156463A/en
Priority to US06/357,770 priority patent/US4456757A/en
Priority to EP82102291A priority patent/EP0061673B1/en
Priority to DE8282102291T priority patent/DE3261029D1/en
Publication of JPS57156463A publication Critical patent/JPS57156463A/en
Priority to US06/572,419 priority patent/US4560755A/en
Priority to US06/572,418 priority patent/US4525589A/en
Publication of JPS6348869B2 publication Critical patent/JPS6348869B2/ja
Granted legal-status Critical Current

Links

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:The isoquinoline derivative of formulaI[R1 is alkyl, aryl, aralkyl, benzoyl, cinnamyl, cinnamoyl, furoyl or group of formula IV (R2 is lower alkyl)].
EXAMPLE: 1-(5-Isoquinolinesulfonyl)-4-methylpiperazine.
USE: Vasodilator, cerebral circulation improving agent, remedy for stenocardia, and remedy and preventive for the cerebro-cardiac thrombosis. It has strong smooth muscle relaxing activity and blood flow increasing activity.
PROCESS: The compound of formulaIcan be prepared, e.g. by reacting 5-isoquinolinesulfonic acid chloride of formula II with 1-substituted piperazine of formula III in a solvent such as methanol, dichloromethane, etc. in the presence of an acid acceptor such as sodium bicarbonate.
COPYRIGHT: (C)1982,JPO&Japio
JP3955081A 1981-03-20 1981-03-20 Isoquinoline derivative Granted JPS57156463A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP3955081A JPS57156463A (en) 1981-03-20 1981-03-20 Isoquinoline derivative
US06/357,770 US4456757A (en) 1981-03-20 1982-03-12 Isoquinolinesulfonyl derivatives and process for the preparation thereof
EP82102291A EP0061673B1 (en) 1981-03-20 1982-03-19 Isoquinolinesulfonyl derivatives and process for the preparation thereof
DE8282102291T DE3261029D1 (en) 1981-03-20 1982-03-19 Isoquinolinesulfonyl derivatives and process for the preparation thereof
US06/572,419 US4560755A (en) 1981-03-20 1984-01-20 Isoquinolinesulfonyl derivatives which possess a relaxatory action
US06/572,418 US4525589A (en) 1981-03-20 1984-01-20 Isoquinolinesulfonyl derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3955081A JPS57156463A (en) 1981-03-20 1981-03-20 Isoquinoline derivative

Publications (2)

Publication Number Publication Date
JPS57156463A true JPS57156463A (en) 1982-09-27
JPS6348869B2 JPS6348869B2 (en) 1988-09-30

Family

ID=12556160

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3955081A Granted JPS57156463A (en) 1981-03-20 1981-03-20 Isoquinoline derivative

Country Status (1)

Country Link
JP (1) JPS57156463A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003171A1 (en) * 1992-08-10 1994-02-17 Asahi Kasei Kogyo Kabushiki Kaisha Cardiac protective
WO1994005290A1 (en) * 1992-09-03 1994-03-17 Asahi Kasei Kogyo Kabushiki Kaisha Platelet aggregation inhibitor
WO1997028130A1 (en) * 1996-02-02 1997-08-07 Nippon Shinyaku Co., Ltd. Isoquinoline derivatives and drugs
WO1999054306A1 (en) * 1997-03-10 1999-10-28 Hiroyoshi Hidaka Isoquinolinesulfonamide derivatives and drugs containing the same as the active ingredient
JP2008534600A (en) * 2005-03-31 2008-08-28 タケダ サン ディエゴ インコーポレイテッド Hydroxysteroid dehydrogenase inhibitor
WO2009004792A1 (en) * 2007-07-02 2009-01-08 Asahi Kasei Pharma Corporation Sulfonamide compound, and crystal thereof
US7618984B2 (en) 2005-08-30 2009-11-17 Asahi Kasei Pharma Corporation Sulfonamide compound
US7964613B2 (en) 2007-02-28 2011-06-21 Asahi Kasei Pharma Corporation Sulfonamide compound
US8415372B2 (en) 2007-02-27 2013-04-09 Asahi Kasei Pharma Corporation Sulfonamide compound

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003171A1 (en) * 1992-08-10 1994-02-17 Asahi Kasei Kogyo Kabushiki Kaisha Cardiac protective
WO1994005290A1 (en) * 1992-09-03 1994-03-17 Asahi Kasei Kogyo Kabushiki Kaisha Platelet aggregation inhibitor
WO1997028130A1 (en) * 1996-02-02 1997-08-07 Nippon Shinyaku Co., Ltd. Isoquinoline derivatives and drugs
WO1999054306A1 (en) * 1997-03-10 1999-10-28 Hiroyoshi Hidaka Isoquinolinesulfonamide derivatives and drugs containing the same as the active ingredient
JP2008534600A (en) * 2005-03-31 2008-08-28 タケダ サン ディエゴ インコーポレイテッド Hydroxysteroid dehydrogenase inhibitor
JP2012255004A (en) * 2005-03-31 2012-12-27 Takeda California Inc Hydroxysteroid dehydrogenase inhibitor
US7618984B2 (en) 2005-08-30 2009-11-17 Asahi Kasei Pharma Corporation Sulfonamide compound
US8415372B2 (en) 2007-02-27 2013-04-09 Asahi Kasei Pharma Corporation Sulfonamide compound
US7964613B2 (en) 2007-02-28 2011-06-21 Asahi Kasei Pharma Corporation Sulfonamide compound
US8232292B2 (en) 2007-07-02 2012-07-31 Asahi Kasei Pharma Corporation Sulfonamide compound and crystal thereof
JP2012236858A (en) * 2007-07-02 2012-12-06 Asahi Kasei Pharma Kk Method for producing sulfonamide compound salt
WO2009004792A1 (en) * 2007-07-02 2009-01-08 Asahi Kasei Pharma Corporation Sulfonamide compound, and crystal thereof
JP5234825B2 (en) * 2007-07-02 2013-07-10 旭化成ファーマ株式会社 Sulfonamide compounds and crystals thereof
US8664243B2 (en) 2007-07-02 2014-03-04 Asahi Kasei Pharma Corporation Sulfonamide compound and crystal thereof

Also Published As

Publication number Publication date
JPS6348869B2 (en) 1988-09-30

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