JPS5740474A - Piperazine derivative - Google Patents

Piperazine derivative

Info

Publication number
JPS5740474A
JPS5740474A JP11465880A JP11465880A JPS5740474A JP S5740474 A JPS5740474 A JP S5740474A JP 11465880 A JP11465880 A JP 11465880A JP 11465880 A JP11465880 A JP 11465880A JP S5740474 A JPS5740474 A JP S5740474A
Authority
JP
Japan
Prior art keywords
formula
compound
remedy
reacted
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11465880A
Other languages
Japanese (ja)
Other versions
JPH0138109B2 (en
Inventor
Hiroyoshi Hidaka
Takanori Sone
Taiji Sasaki
Tasuke Sugihara
Seiji Takagi
Kiyohide Sako
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Priority to JP11465880A priority Critical patent/JPS5740474A/en
Priority to US06/293,192 priority patent/US4510307A/en
Priority to DE8181106461T priority patent/DE3166969D1/en
Priority to EP81106461A priority patent/EP0046572B1/en
Publication of JPS5740474A publication Critical patent/JPS5740474A/en
Publication of JPH0138109B2 publication Critical patent/JPH0138109B2/ja
Granted legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A piperazine derivative of formula I (R1 and R2 are H or lower alkyl or groups together linking directly or through the O atom to form a heterocyclic ring with the adjacent N atom; R3 is cinnamyl or group of formula II; R4 is lower alkyl) and an acid addition salt thereof.
EXAMPLE: 1-( 4-Amino-6-quinazolinesulfonyl )-4-( 2-ethyoxy-2-phenylethyl )piperazine.
USE: Useful as a vasodilator, hypotensive agent, ameliorant of cerebral circulation, remedy for angina pectoris, remedy and preventing agent for thrombosis of the cerebrocardiovascular system and bronchodilator with low toxicity.
PROCESS: 3,4-Dihydro-4-oxoquinazoline-6-sulfonyl chloride of formula III is reacted with a compound of formula IV in the presence of an acid acceptor to give a compound, which is then heated in the presence of a reaction reagent, e.g. phosphorus oxychloride, to afford a compound of formula V. The resultant compound of formula V is then reacted with a compound of formula VI to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP11465880A 1980-08-20 1980-08-22 Piperazine derivative Granted JPS5740474A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP11465880A JPS5740474A (en) 1980-08-22 1980-08-22 Piperazine derivative
US06/293,192 US4510307A (en) 1980-08-20 1981-08-17 6-Quinazolinesulfonyl derivatives and process for preparation thereof
DE8181106461T DE3166969D1 (en) 1980-08-20 1981-08-19 6-quinazolinesulfonyl derivatives and process for preparation thereof
EP81106461A EP0046572B1 (en) 1980-08-20 1981-08-19 6-quinazolinesulfonyl derivatives and process for preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11465880A JPS5740474A (en) 1980-08-22 1980-08-22 Piperazine derivative

Publications (2)

Publication Number Publication Date
JPS5740474A true JPS5740474A (en) 1982-03-06
JPH0138109B2 JPH0138109B2 (en) 1989-08-11

Family

ID=14643312

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11465880A Granted JPS5740474A (en) 1980-08-20 1980-08-22 Piperazine derivative

Country Status (1)

Country Link
JP (1) JPS5740474A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000009480A1 (en) * 1998-08-11 2000-02-24 Daiichi Pharmaceutical Co., Ltd. Novel sulfonyl derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000009480A1 (en) * 1998-08-11 2000-02-24 Daiichi Pharmaceutical Co., Ltd. Novel sulfonyl derivatives

Also Published As

Publication number Publication date
JPH0138109B2 (en) 1989-08-11

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