JPS57134469A - Tetrahydroisoquinoline derivative and its preparation - Google Patents
Tetrahydroisoquinoline derivative and its preparationInfo
- Publication number
- JPS57134469A JPS57134469A JP2075481A JP2075481A JPS57134469A JP S57134469 A JPS57134469 A JP S57134469A JP 2075481 A JP2075481 A JP 2075481A JP 2075481 A JP2075481 A JP 2075481A JP S57134469 A JPS57134469 A JP S57134469A
- Authority
- JP
- Japan
- Prior art keywords
- tetrahydroisoquinoline
- derivative
- chloro
- carboxylic acid
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:The tetrahydroisoquinoline derivative of formulaI(R is lower alkyl) or its salt.
EXAMPLE: ( 3S )-2[( 2S )-3-(4-Chloro-3-sulfamoylbenzoylthio)-2-methylpropionyl]- 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid.
USE: A hypotensor. It has diuretic activity and blood platelet coagulation suppressing activity as accompanied activities.
PROCESS: The compound of formulaIcan be prepared by reacting a 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative of formula II with a 4-chloro-3- sulfamoylbenzol halide of formula III (X is halogen) in a proper solvent in the presence or absence of an acid acceptor at 0W30°C.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2075481A JPS57134469A (en) | 1981-02-13 | 1981-02-13 | Tetrahydroisoquinoline derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2075481A JPS57134469A (en) | 1981-02-13 | 1981-02-13 | Tetrahydroisoquinoline derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57134469A true JPS57134469A (en) | 1982-08-19 |
Family
ID=12035971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2075481A Pending JPS57134469A (en) | 1981-02-13 | 1981-02-13 | Tetrahydroisoquinoline derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57134469A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4468396A (en) * | 1982-12-20 | 1984-08-28 | Schering Corporation | Antihypertensive benzothiadiazines |
-
1981
- 1981-02-13 JP JP2075481A patent/JPS57134469A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4468396A (en) * | 1982-12-20 | 1984-08-28 | Schering Corporation | Antihypertensive benzothiadiazines |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS57134469A (en) | Tetrahydroisoquinoline derivative and its preparation | |
JPS57118555A (en) | Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component | |
JPS5576840A (en) | New oxyacetic acid derivative, its preparation and blood- lipid depressor containing it as active principle | |
JPS57159771A (en) | Tetrahydroisoquinoline derivative and its preparation | |
JPS57165369A (en) | Pyrazole derivative and its preparation | |
JPS56100765A (en) | Pyridine derivative | |
JPS5772981A (en) | 1,8-naphthyridine derivative and its salt | |
JPS57169464A (en) | Tetrahydroisoquinoline derivative and its preparation | |
JPS5782371A (en) | Benzoquinoline derivative and its preparation | |
JPS52133973A (en) | Preparation of optically active lactam derivatives | |
JPS5551068A (en) | Novel hydantoin derivative, and antiphlogistic analgesic agent containing the same | |
JPS57122071A (en) | 1,4-benzothiazine compound | |
JPS5615270A (en) | Tetrahydroisoquinoline derivative and its preparation | |
JPS5762263A (en) | N-acylcarnosine aluminum salt and its preparation | |
JPS55147278A (en) | Nicotinoylaminotriazine derivative | |
JPS52125122A (en) | Carboxylic acids halides having halogen atoms at gamma- and epsilon-positions and method of preparing the same | |
JPS5553263A (en) | Aminothiophenol derivative, its preparation and herbicide containing the same | |
JPS5616465A (en) | Novel polydithiocarbamate, its preparation and agricultural and industrial chemical containing the same | |
JPS57192396A (en) | O-arylphosphoric ester having nitrogen-containing heterocyclic group, its preparation and insecticide containing the same | |
JPS52113970A (en) | Thiadiazoline-type organic phosphates, their preparation, and insectic ide or miticide containing the same | |
JPS56125340A (en) | Cyclohexenone derivative | |
JPS54115387A (en) | Tetrahydro-1,3,5-thiadiazine-4-one, insecticides and acaricides containing it | |
JPS545936A (en) | Phenylacetic acid ester derivatives, process for their preparation and their insecticides or miticides containing the same as active constituents | |
JPS5377081A (en) | 1,4-benzodioxepin derivative, its acid addition salt, and its preparation | |
JPS57131789A (en) | 1,7-naphthyridine derivative |