JPS57134469A - Tetrahydroisoquinoline derivative and its preparation - Google Patents

Tetrahydroisoquinoline derivative and its preparation

Info

Publication number
JPS57134469A
JPS57134469A JP2075481A JP2075481A JPS57134469A JP S57134469 A JPS57134469 A JP S57134469A JP 2075481 A JP2075481 A JP 2075481A JP 2075481 A JP2075481 A JP 2075481A JP S57134469 A JPS57134469 A JP S57134469A
Authority
JP
Japan
Prior art keywords
tetrahydroisoquinoline
derivative
chloro
carboxylic acid
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2075481A
Other languages
Japanese (ja)
Inventor
Keizo Kinashi
Joji Kato
Masaaki Hayashi
Naoto Yoneda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP2075481A priority Critical patent/JPS57134469A/en
Publication of JPS57134469A publication Critical patent/JPS57134469A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:The tetrahydroisoquinoline derivative of formulaI(R is lower alkyl) or its salt.
EXAMPLE: ( 3S )-2[( 2S )-3-(4-Chloro-3-sulfamoylbenzoylthio)-2-methylpropionyl]- 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid.
USE: A hypotensor. It has diuretic activity and blood platelet coagulation suppressing activity as accompanied activities.
PROCESS: The compound of formulaIcan be prepared by reacting a 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative of formula II with a 4-chloro-3- sulfamoylbenzol halide of formula III (X is halogen) in a proper solvent in the presence or absence of an acid acceptor at 0W30°C.
COPYRIGHT: (C)1982,JPO&Japio
JP2075481A 1981-02-13 1981-02-13 Tetrahydroisoquinoline derivative and its preparation Pending JPS57134469A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2075481A JPS57134469A (en) 1981-02-13 1981-02-13 Tetrahydroisoquinoline derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2075481A JPS57134469A (en) 1981-02-13 1981-02-13 Tetrahydroisoquinoline derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS57134469A true JPS57134469A (en) 1982-08-19

Family

ID=12035971

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2075481A Pending JPS57134469A (en) 1981-02-13 1981-02-13 Tetrahydroisoquinoline derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57134469A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468396A (en) * 1982-12-20 1984-08-28 Schering Corporation Antihypertensive benzothiadiazines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468396A (en) * 1982-12-20 1984-08-28 Schering Corporation Antihypertensive benzothiadiazines

Similar Documents

Publication Publication Date Title
JPS57134469A (en) Tetrahydroisoquinoline derivative and its preparation
JPS57118555A (en) Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component
JPS5576840A (en) New oxyacetic acid derivative, its preparation and blood- lipid depressor containing it as active principle
JPS57159771A (en) Tetrahydroisoquinoline derivative and its preparation
JPS57165369A (en) Pyrazole derivative and its preparation
JPS56100765A (en) Pyridine derivative
JPS5772981A (en) 1,8-naphthyridine derivative and its salt
JPS57169464A (en) Tetrahydroisoquinoline derivative and its preparation
JPS5782371A (en) Benzoquinoline derivative and its preparation
JPS52133973A (en) Preparation of optically active lactam derivatives
JPS5551068A (en) Novel hydantoin derivative, and antiphlogistic analgesic agent containing the same
JPS57122071A (en) 1,4-benzothiazine compound
JPS5615270A (en) Tetrahydroisoquinoline derivative and its preparation
JPS5762263A (en) N-acylcarnosine aluminum salt and its preparation
JPS55147278A (en) Nicotinoylaminotriazine derivative
JPS52125122A (en) Carboxylic acids halides having halogen atoms at gamma- and epsilon-positions and method of preparing the same
JPS5553263A (en) Aminothiophenol derivative, its preparation and herbicide containing the same
JPS5616465A (en) Novel polydithiocarbamate, its preparation and agricultural and industrial chemical containing the same
JPS57192396A (en) O-arylphosphoric ester having nitrogen-containing heterocyclic group, its preparation and insecticide containing the same
JPS52113970A (en) Thiadiazoline-type organic phosphates, their preparation, and insectic ide or miticide containing the same
JPS56125340A (en) Cyclohexenone derivative
JPS54115387A (en) Tetrahydro-1,3,5-thiadiazine-4-one, insecticides and acaricides containing it
JPS545936A (en) Phenylacetic acid ester derivatives, process for their preparation and their insecticides or miticides containing the same as active constituents
JPS5377081A (en) 1,4-benzodioxepin derivative, its acid addition salt, and its preparation
JPS57131789A (en) 1,7-naphthyridine derivative