JPS57200366A - Isoquinoline compound - Google Patents
Isoquinoline compoundInfo
- Publication number
- JPS57200366A JPS57200366A JP56082559A JP8255981A JPS57200366A JP S57200366 A JPS57200366 A JP S57200366A JP 56082559 A JP56082559 A JP 56082559A JP 8255981 A JP8255981 A JP 8255981A JP S57200366 A JPS57200366 A JP S57200366A
- Authority
- JP
- Japan
- Prior art keywords
- formulai
- remedy
- compound
- cerebral
- isoquinoline compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An isoquinoline compound of formulaI(R1 and R2 are H, lower alkyl or directly link or through O or N to form a heterocyclic ring with the adjacent N) and an acid addition salt thereof.
EXAMPLE: 5-Isoquinolinesulfonamide.
USE: Useful as a vasodilator, ameliorant of the cerebral circulation, remedy for angina pectoris, and preventing agent and remedy for thrombosis in cerebral and cardiovascular systems having powerful relaxing action on smooth muscles and increasing action on the blood stream.
PROCESS: A 5-isoquinolinesulfonyl chloride of formula II is reacted with an amine of formula III, preferably in the presence of an acid acceptor, e.g. sodium bicarbonate or sodium hydroxide, in a solvent, e.g. methanol, to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56082559A JPS57200366A (en) | 1981-06-01 | 1981-06-01 | Isoquinoline compound |
US06/357,770 US4456757A (en) | 1981-03-20 | 1982-03-12 | Isoquinolinesulfonyl derivatives and process for the preparation thereof |
EP82102291A EP0061673B1 (en) | 1981-03-20 | 1982-03-19 | Isoquinolinesulfonyl derivatives and process for the preparation thereof |
DE8282102291T DE3261029D1 (en) | 1981-03-20 | 1982-03-19 | Isoquinolinesulfonyl derivatives and process for the preparation thereof |
US06/572,419 US4560755A (en) | 1981-03-20 | 1984-01-20 | Isoquinolinesulfonyl derivatives which possess a relaxatory action |
US06/572,418 US4525589A (en) | 1981-03-20 | 1984-01-20 | Isoquinolinesulfonyl derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56082559A JPS57200366A (en) | 1981-06-01 | 1981-06-01 | Isoquinoline compound |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57200366A true JPS57200366A (en) | 1982-12-08 |
JPS6361942B2 JPS6361942B2 (en) | 1988-11-30 |
Family
ID=13777844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56082559A Granted JPS57200366A (en) | 1981-03-20 | 1981-06-01 | Isoquinoline compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57200366A (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61227581A (en) * | 1985-04-02 | 1986-10-09 | Asahi Chem Ind Co Ltd | Isoquinoline derivative bearing sulfone group |
WO1998006433A1 (en) | 1996-08-12 | 1998-02-19 | Yoshitomi Pharmaceutical Industries, Ltd. | MEDICINES COMPRISING Rho KINASE INHIBITOR |
WO2000064478A1 (en) | 1999-04-27 | 2000-11-02 | Mitsubishi Pharma Corporation | Preventives/remedies for liver diseases |
JP2006063018A (en) * | 2004-08-27 | 2006-03-09 | Asahi Kasei Fainkemu Kk | Method for producing isoquinolinesulfonyl chloride |
JP2006076932A (en) * | 2004-09-10 | 2006-03-23 | Asahi Kasei Fainkemu Kk | Method for producing isoquinolinesulfonyl chloride |
WO2009004792A1 (en) * | 2007-07-02 | 2009-01-08 | Asahi Kasei Pharma Corporation | Sulfonamide compound, and crystal thereof |
US7618984B2 (en) | 2005-08-30 | 2009-11-17 | Asahi Kasei Pharma Corporation | Sulfonamide compound |
US7964613B2 (en) | 2007-02-28 | 2011-06-21 | Asahi Kasei Pharma Corporation | Sulfonamide compound |
US8415372B2 (en) | 2007-02-27 | 2013-04-09 | Asahi Kasei Pharma Corporation | Sulfonamide compound |
-
1981
- 1981-06-01 JP JP56082559A patent/JPS57200366A/en active Granted
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH053851B2 (en) * | 1985-04-02 | 1993-01-18 | Asahi Kasei Kogyo Kk | |
JPS61227581A (en) * | 1985-04-02 | 1986-10-09 | Asahi Chem Ind Co Ltd | Isoquinoline derivative bearing sulfone group |
WO1998006433A1 (en) | 1996-08-12 | 1998-02-19 | Yoshitomi Pharmaceutical Industries, Ltd. | MEDICINES COMPRISING Rho KINASE INHIBITOR |
CZ301044B6 (en) * | 1996-08-12 | 2009-10-21 | Mitsubishi Tanabe Pharma | Medicaments comprising Rho kinase inhibiting amide derivatives |
WO2000064478A1 (en) | 1999-04-27 | 2000-11-02 | Mitsubishi Pharma Corporation | Preventives/remedies for liver diseases |
JP4707350B2 (en) * | 2004-08-27 | 2011-06-22 | 旭化成ファインケム株式会社 | Process for producing isoquinolinesulfonyl chloride |
JP2006063018A (en) * | 2004-08-27 | 2006-03-09 | Asahi Kasei Fainkemu Kk | Method for producing isoquinolinesulfonyl chloride |
JP2006076932A (en) * | 2004-09-10 | 2006-03-23 | Asahi Kasei Fainkemu Kk | Method for producing isoquinolinesulfonyl chloride |
JP4707355B2 (en) * | 2004-09-10 | 2011-06-22 | 旭化成ファインケム株式会社 | Process for producing isoquinolinesulfonyl chloride |
US7618984B2 (en) | 2005-08-30 | 2009-11-17 | Asahi Kasei Pharma Corporation | Sulfonamide compound |
US8415372B2 (en) | 2007-02-27 | 2013-04-09 | Asahi Kasei Pharma Corporation | Sulfonamide compound |
US7964613B2 (en) | 2007-02-28 | 2011-06-21 | Asahi Kasei Pharma Corporation | Sulfonamide compound |
WO2009004792A1 (en) * | 2007-07-02 | 2009-01-08 | Asahi Kasei Pharma Corporation | Sulfonamide compound, and crystal thereof |
US8232292B2 (en) | 2007-07-02 | 2012-07-31 | Asahi Kasei Pharma Corporation | Sulfonamide compound and crystal thereof |
JP2012236858A (en) * | 2007-07-02 | 2012-12-06 | Asahi Kasei Pharma Kk | Method for producing sulfonamide compound salt |
JP5234825B2 (en) * | 2007-07-02 | 2013-07-10 | 旭化成ファーマ株式会社 | Sulfonamide compounds and crystals thereof |
US8664243B2 (en) | 2007-07-02 | 2014-03-04 | Asahi Kasei Pharma Corporation | Sulfonamide compound and crystal thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS6361942B2 (en) | 1988-11-30 |
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