JPS56154474A - Preparation of piperazine derivative - Google Patents

Preparation of piperazine derivative

Info

Publication number
JPS56154474A
JPS56154474A JP3842881A JP3842881A JPS56154474A JP S56154474 A JPS56154474 A JP S56154474A JP 3842881 A JP3842881 A JP 3842881A JP 3842881 A JP3842881 A JP 3842881A JP S56154474 A JPS56154474 A JP S56154474A
Authority
JP
Japan
Prior art keywords
formula
trialkoxybenzylpiperazine
compound
action
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3842881A
Other languages
Japanese (ja)
Other versions
JPS6027674B2 (en
Inventor
Hiroshi Murai
Yoshiaki Aoyanagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP56038428A priority Critical patent/JPS6027674B2/en
Publication of JPS56154474A publication Critical patent/JPS56154474A/en
Publication of JPS6027674B2 publication Critical patent/JPS6027674B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An N-substituted trialkoxybenzylpiperazine derivative expressed by formula I [R is methyl or ethyl; Z is formula II (A is H, lower alkyl, hydroxymethyl, phenyl, naphthaloxymethyl, etc.)].
USE: A remedy for ischemic heart diseases having a pharmacological action on the coromary circulatory system, e.g. a coronary arterial vasodilator action or inhibitory action on the movement of heart.
PROCESS: An N-trialkoxybenzylpiperazine expressed by formula III is reacted with a compound of formula IV (X is halogen) or formula V or VI, if necessary in the presence of a suitable deacidifying agent, in an unreactive solvent, e.g. an alcohol, at room temperature to 100°C to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP56038428A 1981-03-16 1981-03-16 Production method of piperazine derivatives Expired JPS6027674B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56038428A JPS6027674B2 (en) 1981-03-16 1981-03-16 Production method of piperazine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56038428A JPS6027674B2 (en) 1981-03-16 1981-03-16 Production method of piperazine derivatives

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2744277A Division JPS53112886A (en) 1976-04-09 1977-03-12 Production of n-substituted trialkoxybenzylpiperazine derivative

Publications (2)

Publication Number Publication Date
JPS56154474A true JPS56154474A (en) 1981-11-30
JPS6027674B2 JPS6027674B2 (en) 1985-06-29

Family

ID=12525036

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56038428A Expired JPS6027674B2 (en) 1981-03-16 1981-03-16 Production method of piperazine derivatives

Country Status (1)

Country Link
JP (1) JPS6027674B2 (en)

Also Published As

Publication number Publication date
JPS6027674B2 (en) 1985-06-29

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