FI103042B1 - Menetelmä amlodipiinibentseenisulfonaatin valmistamiseksi ja tässä menetelmässä välituotteena toimiva yhdiste - Google Patents

Menetelmä amlodipiinibentseenisulfonaatin valmistamiseksi ja tässä menetelmässä välituotteena toimiva yhdiste

Info

Publication number
FI103042B1
FI103042B1 FI934882A FI934882A FI103042B1 FI 103042 B1 FI103042 B1 FI 103042B1 FI 934882 A FI934882 A FI 934882A FI 934882 A FI934882 A FI 934882A FI 103042 B1 FI103042 B1 FI 103042B1
Authority
FI
Finland
Prior art keywords
preparation
amlodipine benzenesulfonate
amlodipine
benzenesulfonate
Prior art date
Application number
FI934882A
Other languages
English (en)
Swedish (sv)
Other versions
FI934882A (fi
FI103042B (fi
FI934882A0 (fi
Inventor
Borut Furlan
Anton Copar
Alenka Jeriha
Original Assignee
Lek Tovarna Farmacevtskih
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Tovarna Farmacevtskih filed Critical Lek Tovarna Farmacevtskih
Publication of FI934882A0 publication Critical patent/FI934882A0/fi
Publication of FI934882A publication Critical patent/FI934882A/fi
Application granted granted Critical
Publication of FI103042B1 publication Critical patent/FI103042B1/fi
Publication of FI103042B publication Critical patent/FI103042B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
FI934882A 1992-11-26 1993-11-04 Menetelmä amlodipiinibentseenisulfonaatin valmistamiseksi ja tässä men etelmässä välituotteena toimiva yhdiste FI103042B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9200344A SI9200344B (sl) 1992-11-26 1992-11-26 Postopek za pripravo amlodipin benzensulfonata
SI9200344 1992-11-26

Publications (4)

Publication Number Publication Date
FI934882A0 FI934882A0 (fi) 1993-11-04
FI934882A FI934882A (fi) 1994-05-27
FI103042B1 true FI103042B1 (fi) 1999-04-15
FI103042B FI103042B (fi) 1999-04-15

Family

ID=20431051

Family Applications (1)

Application Number Title Priority Date Filing Date
FI934882A FI103042B (fi) 1992-11-26 1993-11-04 Menetelmä amlodipiinibentseenisulfonaatin valmistamiseksi ja tässä men etelmässä välituotteena toimiva yhdiste

Country Status (9)

Country Link
EP (1) EP0599220B1 (fi)
CZ (1) CZ283041B6 (fi)
DE (1) DE69304020T2 (fi)
FI (1) FI103042B (fi)
HR (1) HRP931429B1 (fi)
PL (2) PL173645B1 (fi)
RU (1) RU2105759C1 (fi)
SI (1) SI9200344B (fi)
SK (1) SK279353B6 (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU221810B1 (hu) * 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
UA72768C2 (en) * 1999-07-05 2005-04-15 Richter Gedeon Vegyeszet A method for obtaining amilodipine benzenesulphonate
EP1435954B1 (en) 2001-07-06 2010-01-13 LEK Pharmaceuticals D.D. A PROCESS FOR THE PREPARATION OF HIGHlLY PUREAMLODIPINE BENZENESULFONATE
US6680334B2 (en) 2001-08-28 2004-01-20 Pfizer Inc Crystalline material
AR037565A1 (es) * 2001-11-21 2004-11-17 Synthon Bv Formas de sales de amlodipina y procedimientos para prepararlas.
SI21233A (sl) * 2002-05-31 2003-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Kristalni hidratni obliki amlodipin benzensulfonata visoke čistote, postopki za njuno pripravo in uporaba
US6784297B2 (en) 2002-09-04 2004-08-31 Kopran Limited Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
EP1407773A1 (en) * 2002-10-08 2004-04-14 Council of Scientific and Industrial Research A process for the preparation of s (-) amlodipine salts
AU2002368531A1 (en) * 2002-12-30 2004-07-22 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Isolation of dihydropyridine derivative and preparation salts thereof
JP4539862B2 (ja) 2003-03-28 2010-09-08 日産化学工業株式会社 Ｔ型カルシウムチャネル阻害剤
WO2007131759A1 (en) * 2006-05-15 2007-11-22 Lek Pharmaceuticals D.D. A process for the preparation of amlodipine benzenesulfonate
NO2824100T3 (fi) 2008-07-08 2018-07-21
US8846012B2 (en) * 2008-12-22 2014-09-30 Pola Chemical Industries Inc. Melanin production inhibitor
CN102516159B (zh) * 2011-12-15 2013-10-09 扬子江药业集团江苏海慈生物药业有限公司 一种苯磺酸左旋氨氯地平的生产方法
US10034939B2 (en) 2012-10-26 2018-07-31 The University Of Chicago Synergistic combination of immunologic inhibitors for the treatment of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
EP0352863A3 (en) * 1988-07-29 1990-08-22 ZAMBON GROUP S.p.A. 1,4-dihydropyridine dicarboxylic acid derivatives

Also Published As

Publication number Publication date
EP0599220B1 (en) 1996-08-14
FI934882A (fi) 1994-05-27
HRP931429A2 (en) 1995-12-31
CZ283041B6 (cs) 1997-12-17
SI9200344B (sl) 1998-06-30
PL173645B1 (pl) 1998-04-30
SK112593A3 (en) 1994-11-09
SK279353B6 (sk) 1998-10-07
FI103042B (fi) 1999-04-15
PL174647B1 (pl) 1998-08-31
SI9200344A (en) 1994-06-30
HRP931429B1 (en) 1997-10-31
PL301080A1 (en) 1994-05-30
DE69304020T2 (de) 1997-03-06
EP0599220A1 (en) 1994-06-01
DE69304020D1 (de) 1996-09-19
RU2105759C1 (ru) 1998-02-27
FI934882A0 (fi) 1993-11-04
CZ216593A3 (en) 1994-06-15

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH

MM Patent lapsed