UY37466A - N-hidroxiamidinheterociclos sustituidos como moduladores de la indolamina 2,3-dioxigenasa - Google Patents

N-hidroxiamidinheterociclos sustituidos como moduladores de la indolamina 2,3-dioxigenasa

Info

Publication number
UY37466A
UY37466A UY0001037466A UY37466A UY37466A UY 37466 A UY37466 A UY 37466A UY 0001037466 A UY0001037466 A UY 0001037466A UY 37466 A UY37466 A UY 37466A UY 37466 A UY37466 A UY 37466A
Authority
UY
Uruguay
Prior art keywords
indolamine
dioxygenase
modulators
hydroxiamidinheterocicles
substituted
Prior art date
Application number
UY0001037466A
Other languages
English (en)
Inventor
Olaf Kinzel
Gerald Kleymann
Simon Anderhub
Martin Hornberger
Christoph Steeneck
Thomas Hoffmann
Original Assignee
Phenex Discovery Verwaltungs Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phenex Discovery Verwaltungs Gmbh filed Critical Phenex Discovery Verwaltungs Gmbh
Publication of UY37466A publication Critical patent/UY37466A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Moduladores de indolamina 2,3-dioxigenasa (IDO1) y su uso en la profilaxis y/o tratamiento de enfermedades mediadas por IDO1. Específicamente , la presente invención provee compuestos de acuerdo con la fórmula (I) un enantiómero, diastereómero, tautómero o sal farmacéuticamente aceptable del mismo.
UY0001037466A 2016-11-03 2017-11-01 N-hidroxiamidinheterociclos sustituidos como moduladores de la indolamina 2,3-dioxigenasa UY37466A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16002334 2016-11-03
EP17001467 2017-08-31

Publications (1)

Publication Number Publication Date
UY37466A true UY37466A (es) 2018-01-31

Family

ID=60191412

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037466A UY37466A (es) 2016-11-03 2017-11-01 N-hidroxiamidinheterociclos sustituidos como moduladores de la indolamina 2,3-dioxigenasa

Country Status (5)

Country Link
US (1) US11078168B2 (es)
EP (1) EP3535259A1 (es)
TW (1) TW201819362A (es)
UY (1) UY37466A (es)
WO (1) WO2018083241A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3495354A4 (en) * 2016-08-02 2020-01-15 Shandong Luye Pharmaceutical Co., Ltd. IDO1 INHIBITOR AND PRODUCTION METHOD AND APPLICATION THEREOF
CN108218807A (zh) * 2016-12-22 2018-06-29 上海长森药业有限公司 一种作为吲哚胺-2,3-双加氧酶抑制剂的砜脒及其制备方法和用途
WO2018214958A1 (zh) * 2017-05-25 2018-11-29 山东绿叶制药有限公司 Ido1抑制剂的晶型及其制备方法
CN110128367A (zh) * 2018-02-02 2019-08-16 成都海创药业有限公司 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法和用途
EP3715471A1 (en) 2019-03-29 2020-09-30 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Ahr signature marker set
EP3721894A1 (en) 2019-04-10 2020-10-14 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Interleukin-4-induced gene 1 (il4i1) as a biomarker and uses thereof
EP3835432A1 (en) 2019-12-10 2021-06-16 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Interleukin-4-induced gene 1 (il4i1) and respective metabolites as biomarkers for cancer
CN112315954A (zh) * 2020-11-24 2021-02-05 烟台大学 紫杉醇和ido1小分子抑制剂复方药物组合物及其用途
CN114409610B (zh) * 2022-03-29 2022-06-10 山东大学 噁二唑衍生物及其制备方法和用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME02461B (me) 2005-05-10 2017-02-20 Incyte Holdings Corp Modulatori indoleamina 2,3-dioksigenaze i metode za upotrebu istih
US7791595B2 (en) 2006-06-20 2010-09-07 Lutron Electronics Co., Inc. Touch screen assembly for a lighting control
US20080119491A1 (en) 2006-09-19 2008-05-22 Incyte Corporation Amidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
US20080146624A1 (en) 2006-09-19 2008-06-19 Incyte Corporation Amidines as modulators of indoleamine 2,3-dioxygenase
CA2663057C (en) 2006-09-19 2015-12-08 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
US20080182882A1 (en) 2006-11-08 2008-07-31 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
MY171866A (en) * 2008-07-08 2019-11-05 Incyte Holdings Corp 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
US10034939B2 (en) 2012-10-26 2018-07-31 The University Of Chicago Synergistic combination of immunologic inhibitors for the treatment of cancer
CN105481789B (zh) 2014-09-15 2020-05-19 中国科学院上海有机化学研究所 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法
CN106565696B (zh) * 2015-10-09 2020-07-28 江苏恒瑞医药股份有限公司 噁二唑类衍生物、其制备方法及其在医药上的应用
EP3389783B1 (en) 2015-12-15 2024-07-03 Merck Sharp & Dohme LLC Novel compounds as indoleamine 2,3-dioxygenase inhibitors
CN105646389B (zh) 2016-01-28 2019-06-28 中国科学院上海有机化学研究所 一种作为吲哚胺-2,3-双加氧酶抑制剂的氨基磺酸脂及其制备方法和用途
EP3495354A4 (en) 2016-08-02 2020-01-15 Shandong Luye Pharmaceutical Co., Ltd. IDO1 INHIBITOR AND PRODUCTION METHOD AND APPLICATION THEREOF

Also Published As

Publication number Publication date
EP3535259A1 (en) 2019-09-11
WO2018083241A1 (en) 2018-05-11
US20190292160A1 (en) 2019-09-26
US11078168B2 (en) 2021-08-03
TW201819362A (zh) 2018-06-01

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