PE20120562A1 - Anticuerpo anti-axl - Google Patents
Anticuerpo anti-axlInfo
- Publication number
- PE20120562A1 PE20120562A1 PE2011001964A PE2011001964A PE20120562A1 PE 20120562 A1 PE20120562 A1 PE 20120562A1 PE 2011001964 A PE2011001964 A PE 2011001964A PE 2011001964 A PE2011001964 A PE 2011001964A PE 20120562 A1 PE20120562 A1 PE 20120562A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- sequence
- amino acids
- cdr1
- cdr2
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN ANTICUERPO QUE RECONOCE EL DOMINIO FND1 DE AXL QUE COMPRENDE: A) UNA REGION VARIABLE DE CADENA PESADA DE SEQ ID Nº 2 A 32 QUE COMPRENDE UNA CDR1 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE CUALQUIERA DE SEQ ID Nº 33 A 37, UNA CDR2 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE CUALQUIERA DE SEQ ID Nº 38 A 48 Y UNA CDR3 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID Nº 49; Y B) UNA REGION VARIABLE DE CADENA LIVIANA DE SEQ ID Nº 65 A 83 QUE COMPRENDE UNA CDR1 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE CUALQUIERA DE SEQ ID Nº 84 A 89, UNA CDR2 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID Nº 90 Y UNA CDR3 QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID Nº 91. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA UTIL EN EL TRATAMIENTO DE ADENOCARCINOMA PANCREATICO, CANCER DE MAMA, GLIOMA, CANCER DE LAS CELULAS PULMONARES NO PEQUENAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009118725 | 2009-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20120562A1 true PE20120562A1 (es) | 2012-06-06 |
Family
ID=43085106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001964A PE20120562A1 (es) | 2009-05-15 | 2010-05-14 | Anticuerpo anti-axl |
Country Status (22)
Country | Link |
---|---|
US (1) | US9340615B2 (es) |
EP (1) | EP2431393B1 (es) |
JP (1) | JP5669732B2 (es) |
KR (1) | KR20120024763A (es) |
CN (1) | CN102459344A (es) |
AR (1) | AR076875A1 (es) |
AU (1) | AU2010248365A1 (es) |
BR (1) | BRPI1011145A2 (es) |
CA (1) | CA2761891A1 (es) |
CL (1) | CL2011002877A1 (es) |
CO (1) | CO6460749A2 (es) |
CR (1) | CR20110646A (es) |
EC (1) | ECSP11011538A (es) |
IL (1) | IL216097A0 (es) |
MA (1) | MA33405B1 (es) |
MX (1) | MX2011012136A (es) |
PE (1) | PE20120562A1 (es) |
RU (1) | RU2011151069A (es) |
SG (1) | SG176074A1 (es) |
TW (1) | TW201041595A (es) |
WO (1) | WO2010131733A1 (es) |
ZA (1) | ZA201108526B (es) |
Families Citing this family (56)
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US11046784B2 (en) | 2006-03-31 | 2021-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
AU2008304778B9 (en) * | 2007-09-26 | 2014-05-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in CDR |
KR101680906B1 (ko) | 2007-09-26 | 2016-11-30 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
RU2559530C2 (ru) * | 2007-11-15 | 2015-08-10 | Чугаи Сейяку Кабусики Кайся | Моноклональные антитела, способные связываться с белком axl, и их применение |
EP2275443B1 (en) | 2008-04-11 | 2015-12-02 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
EP2826789A1 (en) | 2009-03-19 | 2015-01-21 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
WO2012073992A1 (ja) | 2010-11-30 | 2012-06-07 | 中外製薬株式会社 | 複数分子の抗原に繰り返し結合する抗原結合分子 |
EP2723376B1 (en) * | 2011-06-22 | 2018-12-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-axl antibodies and uses thereof |
CA2839480A1 (en) * | 2011-06-22 | 2012-12-27 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Anti-axl antibodies and uses thereof |
AU2012300279A1 (en) | 2011-08-26 | 2014-04-03 | Merrimack Pharmaceuticals, Inc. | Tandem Fc bispecific antibodies |
RU2681885C2 (ru) | 2011-10-31 | 2019-03-13 | Чугаи Сейяку Кабусики Кайся | Антигенсвязывающая молекула с регулируемой конъюгацией между тяжелой цепью и легкой цепью |
US9764038B2 (en) * | 2011-12-23 | 2017-09-19 | Innate Pharma | Enzymatic conjugation of antibodies |
EP2872894B1 (en) | 2012-07-13 | 2019-04-17 | Innate Pharma | Screening of conjugated antibodies |
EP2889376A4 (en) | 2012-08-24 | 2016-11-02 | Chugai Pharmaceutical Co Ltd | ANTIBODIES Fc SPECIFIC TO FCTRII OF MOUSE |
TW202237660A (zh) | 2012-08-24 | 2022-10-01 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
JP6445444B2 (ja) * | 2012-11-05 | 2018-12-26 | ピエール、ファーブル、メディカマン | 新規抗原結合タンパク質および癌の治療のためのアドレッシング産物(addressingproduct)としてのそれらの使用 |
US10036010B2 (en) | 2012-11-09 | 2018-07-31 | Innate Pharma | Recognition tags for TGase-mediated conjugation |
US9458245B2 (en) | 2013-03-06 | 2016-10-04 | Merrimack Pharmaceuticals, Inc. | ANTI-C-MET tandem Fc bispecific antibodies |
WO2014140300A1 (en) | 2013-03-15 | 2014-09-18 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
CN113621057A (zh) | 2013-04-02 | 2021-11-09 | 中外制药株式会社 | Fc区变体 |
EP3010547B1 (en) | 2013-06-20 | 2021-04-21 | Innate Pharma | Enzymatic conjugation of polypeptides |
WO2014202775A1 (en) | 2013-06-21 | 2014-12-24 | Innate Pharma | Enzymatic conjugation of polypeptides |
CN104341505A (zh) * | 2013-07-29 | 2015-02-11 | 西藏海思科药业集团股份有限公司 | 对蒙古人种和高加索人种低免疫原性的、抗egfr的人鼠嵌合抗体 |
TWI522099B (zh) | 2014-06-04 | 2016-02-21 | 中國醫藥大學 | 治療胰臟癌之醫藥配方及其應用 |
GB201410826D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
GB201410825D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
US10512688B2 (en) * | 2014-07-11 | 2019-12-24 | Genmab A/S | Antibodies binding AXL |
EP3229836B1 (en) * | 2014-12-09 | 2019-11-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Human monoclonal antibodies against axl |
UA127961C2 (uk) | 2014-12-19 | 2024-02-28 | Чугей Сейяку Кабусікі Кайся | Антитіло до латентного міостатину |
JP2018510842A (ja) | 2015-02-05 | 2018-04-19 | 中外製薬株式会社 | イオン濃度依存的抗原結合ドメインを含む抗体、Fc領域改変体、IL−8に結合する抗体、およびその使用 |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201509338D0 (en) | 2015-05-29 | 2015-07-15 | Bergenbio As | Combination therapy |
PL3319993T3 (pl) | 2015-07-10 | 2020-07-27 | Genmab A/S | Specyficzne wobec AXL koniugaty przeciwciało-lek do leczenia raka |
US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
JP2019505520A (ja) * | 2016-01-13 | 2019-02-28 | ゲンマブ エー/エス | 抗体およびその薬物コンジュゲートの製剤 |
GB201610902D0 (en) | 2016-06-22 | 2016-08-03 | Bergen Teknologioverforing As And Bergenbio As | Anti-Axl Antagonistic Antibodies |
TWI831965B (zh) | 2016-08-05 | 2024-02-11 | 日商中外製藥股份有限公司 | Il-8相關疾病之治療用或預防用組成物 |
KR101909955B1 (ko) * | 2016-11-28 | 2018-10-19 | 재단법인 목암생명과학연구소 | 신규 항-에이엑스엘 항체 및 이를 포함하는 약학적 조성물 |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
MX2019014572A (es) * | 2017-06-05 | 2020-07-29 | Janssen Biotech Inc | Métodos de ingeniería de carga superficial para la producción de anticuerpos biespecíficos. |
MA52657A (fr) | 2018-04-10 | 2021-02-17 | Genmab As | Anticorps spécifiques d'axl pour le traitement du cancer |
CN110483639A (zh) * | 2018-05-15 | 2019-11-22 | 复旦大学 | 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 |
CN110540592B (zh) * | 2018-05-29 | 2022-08-09 | 杭州尚健生物技术有限公司 | 结合axl蛋白的抗体及其应用 |
CN109160941B (zh) * | 2018-09-29 | 2020-09-04 | 未名生物医药有限公司 | 蛋白序列17e11及其用途 |
JP7506607B2 (ja) * | 2018-12-28 | 2024-06-26 | 協和キリン株式会社 | TfRに結合するバイスペシフィック抗体 |
EP3946453A4 (en) * | 2019-03-29 | 2022-12-07 | Celldex Therapeutics, Inc. | ANTI-AXL ANTIBODIES AND THEIR METHODS OF USE |
EP3999542A1 (en) | 2019-07-19 | 2022-05-25 | Genmab A/S | Axl antibody-drug conjugates for use in treating cancer |
GB201912059D0 (en) | 2019-08-22 | 2019-10-09 | Bergenbio As | Combaination therapy of a patient subgroup |
WO2021154156A1 (en) * | 2020-01-31 | 2021-08-05 | Agency For Science, Technology And Research | Anti-axl antibody and uses thereof |
GB202004189D0 (en) | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
CA3174740A1 (en) | 2020-04-08 | 2021-10-14 | James Bradley Lorens | Axl inhibitors for antiviral therapy |
GB202006072D0 (en) | 2020-04-24 | 2020-06-10 | Bergenbio Asa | Method of selecting patients for treatment with cmbination therapy |
GB202104037D0 (en) | 2021-03-23 | 2021-05-05 | Bergenbio Asa | Combination therapy |
IL289525B2 (en) * | 2021-12-30 | 2023-03-01 | B G Negev Technologies And Applications Ltd At Ben Gurion Univ | Conjugated antibodies for cancer treatment |
CN117924510B (zh) * | 2024-03-21 | 2024-06-04 | 北京星基贝勤生物科技有限公司 | 靶向egfr和axl的双特异性抗体及其药物偶联物与应用 |
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-
2010
- 2010-05-14 WO PCT/JP2010/058166 patent/WO2010131733A1/ja active Application Filing
- 2010-05-14 KR KR1020117029774A patent/KR20120024763A/ko not_active Application Discontinuation
- 2010-05-14 US US13/320,317 patent/US9340615B2/en active Active
- 2010-05-14 BR BRPI1011145A patent/BRPI1011145A2/pt not_active Application Discontinuation
- 2010-05-14 PE PE2011001964A patent/PE20120562A1/es not_active Application Discontinuation
- 2010-05-14 SG SG2011084050A patent/SG176074A1/en unknown
- 2010-05-14 AU AU2010248365A patent/AU2010248365A1/en not_active Abandoned
- 2010-05-14 MX MX2011012136A patent/MX2011012136A/es unknown
- 2010-05-14 MA MA34445A patent/MA33405B1/fr unknown
- 2010-05-14 CN CN2010800324176A patent/CN102459344A/zh not_active Withdrawn
- 2010-05-14 EP EP10774990.5A patent/EP2431393B1/en active Active
- 2010-05-14 AR ARP100101702A patent/AR076875A1/es unknown
- 2010-05-14 JP JP2011513382A patent/JP5669732B2/ja active Active
- 2010-05-14 RU RU2011151069/02A patent/RU2011151069A/ru not_active Application Discontinuation
- 2010-05-14 TW TW099115414A patent/TW201041595A/zh unknown
- 2010-05-14 CA CA2761891A patent/CA2761891A1/en not_active Abandoned
-
2011
- 2011-11-02 IL IL216097A patent/IL216097A0/en unknown
- 2011-11-11 CO CO11153892A patent/CO6460749A2/es unknown
- 2011-11-15 CL CL2011002877A patent/CL2011002877A1/es unknown
- 2011-11-21 ZA ZA2011/08526A patent/ZA201108526B/en unknown
- 2011-12-02 CR CR20110646A patent/CR20110646A/es not_active Application Discontinuation
- 2011-12-15 EC ECSP11011538 patent/ECSP11011538A/es unknown
Also Published As
Publication number | Publication date |
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CR20110646A (es) | 2012-02-09 |
JP5669732B2 (ja) | 2015-02-12 |
CL2011002877A1 (es) | 2012-05-25 |
MA33405B1 (fr) | 2012-07-03 |
EP2431393A4 (en) | 2013-07-17 |
CN102459344A (zh) | 2012-05-16 |
EP2431393A1 (en) | 2012-03-21 |
WO2010131733A1 (ja) | 2010-11-18 |
WO2010131733A9 (ja) | 2012-01-19 |
CA2761891A1 (en) | 2010-11-18 |
ECSP11011538A (es) | 2012-03-30 |
MX2011012136A (es) | 2012-04-10 |
SG176074A1 (en) | 2011-12-29 |
EP2431393B1 (en) | 2018-05-02 |
ZA201108526B (en) | 2012-11-28 |
CO6460749A2 (es) | 2012-06-15 |
BRPI1011145A2 (pt) | 2016-03-15 |
AU2010248365A1 (en) | 2011-12-22 |
RU2011151069A (ru) | 2013-06-20 |
IL216097A0 (en) | 2012-01-31 |
KR20120024763A (ko) | 2012-03-14 |
US9340615B2 (en) | 2016-05-17 |
AR076875A1 (es) | 2011-07-13 |
TW201041595A (en) | 2010-12-01 |
JPWO2010131733A1 (ja) | 2012-11-08 |
US20120121587A1 (en) | 2012-05-17 |
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