ZA201108526B - Anti-axl antibody - Google Patents
Anti-axl antibodyInfo
- Publication number
- ZA201108526B ZA201108526B ZA2011/08526A ZA201108526A ZA201108526B ZA 201108526 B ZA201108526 B ZA 201108526B ZA 2011/08526 A ZA2011/08526 A ZA 2011/08526A ZA 201108526 A ZA201108526 A ZA 201108526A ZA 201108526 B ZA201108526 B ZA 201108526B
- Authority
- ZA
- South Africa
- Prior art keywords
- axl antibody
- axl
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009118725 | 2009-05-15 | ||
PCT/JP2010/058166 WO2010131733A1 (en) | 2009-05-15 | 2010-05-14 | Anti-axl antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA201108526B true ZA201108526B (en) | 2012-11-28 |
Family
ID=43085106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA2011/08526A ZA201108526B (en) | 2009-05-15 | 2011-11-21 | Anti-axl antibody |
Country Status (22)
Country | Link |
---|---|
US (1) | US9340615B2 (en) |
EP (1) | EP2431393B1 (en) |
JP (1) | JP5669732B2 (en) |
KR (1) | KR20120024763A (en) |
CN (1) | CN102459344A (en) |
AR (1) | AR076875A1 (en) |
AU (1) | AU2010248365A1 (en) |
BR (1) | BRPI1011145A2 (en) |
CA (1) | CA2761891A1 (en) |
CL (1) | CL2011002877A1 (en) |
CO (1) | CO6460749A2 (en) |
CR (1) | CR20110646A (en) |
EC (1) | ECSP11011538A (en) |
IL (1) | IL216097A0 (en) |
MA (1) | MA33405B1 (en) |
MX (1) | MX2011012136A (en) |
PE (1) | PE20120562A1 (en) |
RU (1) | RU2011151069A (en) |
SG (1) | SG176074A1 (en) |
TW (1) | TW201041595A (en) |
WO (1) | WO2010131733A1 (en) |
ZA (1) | ZA201108526B (en) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11046784B2 (en) | 2006-03-31 | 2021-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
AU2008304778B9 (en) * | 2007-09-26 | 2014-05-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in CDR |
KR101680906B1 (en) | 2007-09-26 | 2016-11-30 | 추가이 세이야쿠 가부시키가이샤 | Modified antibody constant region |
RU2559530C2 (en) * | 2007-11-15 | 2015-08-10 | Чугаи Сейяку Кабусики Кайся | Monoclonal antibodies capable of binding with axl protein and their application |
EP2275443B1 (en) | 2008-04-11 | 2015-12-02 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
EP2826789A1 (en) | 2009-03-19 | 2015-01-21 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
WO2012073992A1 (en) | 2010-11-30 | 2012-06-07 | 中外製薬株式会社 | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
EP2723376B1 (en) * | 2011-06-22 | 2018-12-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-axl antibodies and uses thereof |
CA2839480A1 (en) * | 2011-06-22 | 2012-12-27 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Anti-axl antibodies and uses thereof |
AU2012300279A1 (en) | 2011-08-26 | 2014-04-03 | Merrimack Pharmaceuticals, Inc. | Tandem Fc bispecific antibodies |
RU2681885C2 (en) | 2011-10-31 | 2019-03-13 | Чугаи Сейяку Кабусики Кайся | Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain |
US9764038B2 (en) * | 2011-12-23 | 2017-09-19 | Innate Pharma | Enzymatic conjugation of antibodies |
EP2872894B1 (en) | 2012-07-13 | 2019-04-17 | Innate Pharma | Screening of conjugated antibodies |
EP2889376A4 (en) | 2012-08-24 | 2016-11-02 | Chugai Pharmaceutical Co Ltd | MOUSE Fc RII-SPECIFIC Fc ANTIBODY |
TW202237660A (en) | 2012-08-24 | 2022-10-01 | 日商中外製藥股份有限公司 | Fcγriib-specific fc region variant |
JP6445444B2 (en) * | 2012-11-05 | 2018-12-26 | ピエール、ファーブル、メディカマン | Novel antigen binding proteins and their use as addressing products (ADDRESSINGPRODUCT) for the treatment of cancer |
US10036010B2 (en) | 2012-11-09 | 2018-07-31 | Innate Pharma | Recognition tags for TGase-mediated conjugation |
US9458245B2 (en) | 2013-03-06 | 2016-10-04 | Merrimack Pharmaceuticals, Inc. | ANTI-C-MET tandem Fc bispecific antibodies |
WO2014140300A1 (en) | 2013-03-15 | 2014-09-18 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
CN113621057A (en) | 2013-04-02 | 2021-11-09 | 中外制药株式会社 | Fc region variants |
EP3010547B1 (en) | 2013-06-20 | 2021-04-21 | Innate Pharma | Enzymatic conjugation of polypeptides |
WO2014202775A1 (en) | 2013-06-21 | 2014-12-24 | Innate Pharma | Enzymatic conjugation of polypeptides |
CN104341505A (en) * | 2013-07-29 | 2015-02-11 | 西藏海思科药业集团股份有限公司 | Anti-EGFR human-mouse chimeric antibody having low immunogenicity to Mongoloid and Caucasian |
TWI522099B (en) | 2014-06-04 | 2016-02-21 | 中國醫藥大學 | Pharmaceutical formulation for treating pancreatic cancer and uses of the same |
GB201410826D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
GB201410825D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
US10512688B2 (en) * | 2014-07-11 | 2019-12-24 | Genmab A/S | Antibodies binding AXL |
EP3229836B1 (en) * | 2014-12-09 | 2019-11-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Human monoclonal antibodies against axl |
UA127961C2 (en) | 2014-12-19 | 2024-02-28 | Чугей Сейяку Кабусікі Кайся | ANTI-MYOSTATIN ANTIBODIES, POLYPEPTIDES CONTAINING VARIANT Fc REGIONS, AND METHODS OF USE |
JP2018510842A (en) | 2015-02-05 | 2018-04-19 | 中外製薬株式会社 | Antibodies comprising ion concentration dependent antigen binding domains, Fc region variants, antibodies that bind to IL-8, and uses thereof |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201509338D0 (en) | 2015-05-29 | 2015-07-15 | Bergenbio As | Combination therapy |
PL3319993T3 (en) | 2015-07-10 | 2020-07-27 | Genmab A/S | Axl-specific antibody-drug conjugates for cancer treatment |
US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
JP2019505520A (en) * | 2016-01-13 | 2019-02-28 | ゲンマブ エー/エス | Preparation of antibodies and drug conjugates thereof |
GB201610902D0 (en) | 2016-06-22 | 2016-08-03 | Bergen Teknologioverforing As And Bergenbio As | Anti-Axl Antagonistic Antibodies |
TWI831965B (en) | 2016-08-05 | 2024-02-11 | 日商中外製藥股份有限公司 | Compositions for the treatment or prevention of IL-8 related diseases |
KR101909955B1 (en) * | 2016-11-28 | 2018-10-19 | 재단법인 목암생명과학연구소 | Novel Antibody Against AXL and Pharmaceutical Composition Comprising the Same |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
MX2019014572A (en) * | 2017-06-05 | 2020-07-29 | Janssen Biotech Inc | Methods of engineering surface charge for bispecific antibody production. |
MA52657A (en) | 2018-04-10 | 2021-02-17 | Genmab As | AXL SPECIFIC ANTIBODIES FOR CANCER TREATMENT |
CN110483639A (en) * | 2018-05-15 | 2019-11-22 | 复旦大学 | Target antibody and the antibody-drug conjugates and its preparation method and application of AXL |
CN110540592B (en) * | 2018-05-29 | 2022-08-09 | 杭州尚健生物技术有限公司 | Antibodies that bind to AXL protein and uses thereof |
CN109160941B (en) * | 2018-09-29 | 2020-09-04 | 未名生物医药有限公司 | Protein sequence 17E11 and uses thereof |
JP7506607B2 (en) * | 2018-12-28 | 2024-06-26 | 協和キリン株式会社 | Bispecific antibodies that bind to TfR |
EP3946453A4 (en) * | 2019-03-29 | 2022-12-07 | Celldex Therapeutics, Inc. | Anti-axl antibodies and methods of use thereof |
EP3999542A1 (en) | 2019-07-19 | 2022-05-25 | Genmab A/S | Axl antibody-drug conjugates for use in treating cancer |
GB201912059D0 (en) | 2019-08-22 | 2019-10-09 | Bergenbio As | Combaination therapy of a patient subgroup |
WO2021154156A1 (en) * | 2020-01-31 | 2021-08-05 | Agency For Science, Technology And Research | Anti-axl antibody and uses thereof |
GB202004189D0 (en) | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
CA3174740A1 (en) | 2020-04-08 | 2021-10-14 | James Bradley Lorens | Axl inhibitors for antiviral therapy |
GB202006072D0 (en) | 2020-04-24 | 2020-06-10 | Bergenbio Asa | Method of selecting patients for treatment with cmbination therapy |
GB202104037D0 (en) | 2021-03-23 | 2021-05-05 | Bergenbio Asa | Combination therapy |
IL289525B2 (en) * | 2021-12-30 | 2023-03-01 | B G Negev Technologies And Applications Ltd At Ben Gurion Univ | Antibody conjugates for the treatment of cancer |
CN117924510B (en) * | 2024-03-21 | 2024-06-04 | 北京星基贝勤生物科技有限公司 | Bispecific antibody targeting EGFR and AXL, and drug conjugate and application thereof |
Family Cites Families (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU22545A1 (en) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | OBTAINING A CHEMICAL AND HUMANIZED ANTIBODY AGAINST THE RECEPTOR OF THE EPIDERMAL GROWTH FACTOR FOR DIAGNOSTIC AND THERAPEUTIC USE |
US5156840A (en) | 1982-03-09 | 1992-10-20 | Cytogen Corporation | Amine-containing porphyrin derivatives |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5670373A (en) | 1988-01-22 | 1997-09-23 | Kishimoto; Tadamitsu | Antibody to human interleukin-6 receptor |
US5322678A (en) | 1988-02-17 | 1994-06-21 | Neorx Corporation | Alteration of pharmacokinetics of proteins by charge modification |
DE3920358A1 (en) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE |
JP3370324B2 (en) | 1991-04-25 | 2003-01-27 | 中外製薬株式会社 | Reshaped human antibodies to human interleukin-6 receptor |
US5468634A (en) * | 1991-06-24 | 1995-11-21 | The University Of North Carolina At Chapel Hill | Axl oncogene |
US6136310A (en) | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
DE69232137T2 (en) | 1991-11-25 | 2002-05-29 | Enzon Inc | MULTIVALENT ANTI-BINDING PROTEINS |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
JPH09506250A (en) | 1993-11-23 | 1997-06-24 | ジェネンテク,インコーポレイテッド | Protein tyrosine kinase named Rse |
IL107742A0 (en) | 1993-11-24 | 1994-02-27 | Yeda Res & Dev | Chemically-modified binding proteins |
US8017121B2 (en) | 1994-06-30 | 2011-09-13 | Chugai Seiyaku Kabushika Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
WO1996002576A1 (en) | 1994-07-13 | 1996-02-01 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin-8 |
CN101361972B (en) | 1994-10-07 | 2011-05-25 | 中外制药株式会社 | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
EP1884524A3 (en) | 1994-10-21 | 2008-06-25 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for treatment of diseases caused by IL-6 production |
US5977316A (en) | 1995-01-17 | 1999-11-02 | The Board Of Trustees Of The University Of Kentucky | Monoclonal antibody 1A7 and related polypeptides |
IL127872A0 (en) | 1996-07-19 | 1999-10-28 | Amgen Inc | Analogs of cationic proteins |
CN100335501C (en) | 1996-09-26 | 2007-09-05 | 中外制药株式会社 | Antibody against human parathormone related peptides |
US7365166B2 (en) | 1997-04-07 | 2008-04-29 | Genentech, Inc. | Anti-VEGF antibodies |
US20020187150A1 (en) | 1997-08-15 | 2002-12-12 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient |
ES2299241T3 (en) | 1998-03-17 | 2008-05-16 | Chugai Seiyaku Kabushiki Kaisha | PREVENTIVES OR REMEDIES FOR INFLAMMATORY INTESTINAL DISEASES CONTAINING ANTAGONIST ANTIBODIES OF THE IL-6 RECEIVER. |
TR200002885T2 (en) | 1998-04-03 | 2000-12-21 | Chugai Seiyaku Kabushiki Kaisha | Humanized antibody against human tissue factor (TF) |
PT2180007E (en) | 1998-04-20 | 2013-11-25 | Roche Glycart Ag | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
WO2000032634A1 (en) | 1998-12-01 | 2000-06-08 | Protein Design Labs, Inc. | Humanized antibodies to gamma-interferon |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
US6972125B2 (en) | 1999-02-12 | 2005-12-06 | Genetics Institute, Llc | Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith |
CA2704600C (en) | 1999-04-09 | 2016-10-25 | Kyowa Hakko Kirin Co., Ltd. | A method for producing antibodies with increased adcc activity |
US7534605B2 (en) | 1999-06-08 | 2009-05-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
SE9903895D0 (en) | 1999-10-28 | 1999-10-28 | Active Biotech Ab | Novel compounds |
HUP0301835A2 (en) | 2000-05-03 | 2003-09-29 | Mbt Munich Biotechnology Ag | Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites |
EP3690043A1 (en) | 2000-10-06 | 2020-08-05 | Kyowa Kirin Co., Ltd. | Antibody composition-producing cell |
JP4889187B2 (en) | 2000-10-27 | 2012-03-07 | 中外製薬株式会社 | A blood MMP-3 concentration reducing agent comprising an IL-6 antagonist as an active ingredient |
WO2002072605A2 (en) | 2001-03-07 | 2002-09-19 | Merck Patent Gmbh | Expression technology for proteins containing a hybrid isotype antibody moiety |
UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
EP1383800A4 (en) | 2001-04-02 | 2004-09-22 | Idec Pharma Corp | RECOMBINANT ANTIBODIES COEXPRESSED WITH GnTIII |
CA2443903C (en) | 2001-04-13 | 2018-03-20 | Biogen, Inc. | Antibodies to vla-1 |
EP3960855A1 (en) * | 2001-12-28 | 2022-03-02 | Chugai Seiyaku Kabushiki Kaisha | Method for stabilizing proteins |
US7241444B2 (en) | 2002-01-18 | 2007-07-10 | Pierre Fabre Medicament | Anti-IGF-IR antibodies and uses thereof |
CA2488836A1 (en) | 2002-06-12 | 2003-12-24 | Genencor International, Inc. | Methods and compositions for milieu-dependent binding of a targeted agent to a target |
EP1382969A1 (en) | 2002-07-17 | 2004-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Diagnosis and prevention of cancer cell invasion |
CA2492524A1 (en) | 2002-08-15 | 2004-02-26 | Epitomics, Inc. | Humanized rabbit antibodies |
US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
EP1608684A2 (en) | 2003-02-07 | 2005-12-28 | Protein Design Labs, Inc. | Amphiregulin antibodies and their use to treat cancer and psoriasis |
GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
WO2005035753A1 (en) | 2003-10-10 | 2005-04-21 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
CA2545603A1 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto |
US20050142133A1 (en) | 2003-12-03 | 2005-06-30 | Xencor, Inc. | Optimized proteins that target the epidermal growth factor receptor |
AR048210A1 (en) | 2003-12-19 | 2006-04-12 | Chugai Pharmaceutical Co Ltd | A PREVENTIVE AGENT FOR VASCULITIS. |
MY140862A (en) | 2004-01-09 | 2010-01-29 | Pfizer | ANTIBODIES TO MAdCAM |
AR048335A1 (en) | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | THERAPEUTIC AGENTS FOR INTERNAL EAR DISORDERS CONTAINING AN IL-6 ANTAGONIST AS AN ACTIVE INGREDIENT |
AU2005227326B2 (en) | 2004-03-24 | 2009-12-03 | Xencor, Inc. | Immunoglobulin variants outside the Fc region |
AR049390A1 (en) | 2004-06-09 | 2006-07-26 | Wyeth Corp | ANTIBODIES AGAINST HUMAN INTERLEUQUINE-13 AND USES OF THE SAME |
ES2530340T3 (en) | 2004-07-15 | 2015-03-02 | Xencor Inc | Optimized Fc variants |
WO2006030200A1 (en) | 2004-09-14 | 2006-03-23 | National Institute For Biological Standards And Control | Vaccine |
US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
WO2006047350A2 (en) | 2004-10-21 | 2006-05-04 | Xencor, Inc. | IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION |
AU2005299716B2 (en) | 2004-10-22 | 2012-09-06 | Amgen Inc. | Methods for refolding of recombinant antibodies |
AU2005335714B2 (en) | 2004-11-10 | 2012-07-26 | Macrogenics, Inc. | Engineering Fc antibody regions to confer effector function |
CA2592015A1 (en) | 2004-12-27 | 2006-07-06 | Progenics Pharmaceuticals (Nevada), Inc. | Orally deliverable and anti-toxin antibodies and methods for making and using them |
US8716451B2 (en) | 2005-01-12 | 2014-05-06 | Kyowa Hakko Kirin Co., Ltd | Stabilized human IgG2 and IgG3 antibodies |
CA2595169A1 (en) | 2005-01-12 | 2006-07-20 | Xencor, Inc. | Antibodies and fc fusion proteins with altered immunogenicity |
CA2603264C (en) | 2005-04-08 | 2017-03-21 | Chugai Seiyaku Kabushiki Kaisha | Antibody substituting for function of blood coagulation factor viii |
EP1789435B1 (en) | 2005-09-12 | 2010-02-24 | Industry Foundation of Chonnam National University | A method for production of mature natural killer cell |
WO2007041317A2 (en) | 2005-09-29 | 2007-04-12 | Viral Logic Systems Technology Corp. | Immunomodulatory compositions and uses therefor |
BRPI0617378B8 (en) | 2005-10-14 | 2022-09-20 | Chugai Pharmaceutical Co Ltd | USE OF AN IL-6 INHIBITOR TO PRODUCE A PHARMACEUTICAL COMPOSITION TO SUPPRESS DAMAGE TO AN ISLE TRANSPLANTATION AFTER ISLE TRANSPLANTATION; AND IMPROVE THE FEASIBILITY OF AN ISLAND IN AN ISLAND TRANSPLANTATION |
CN101330930B (en) | 2005-10-21 | 2011-11-23 | 中外制药株式会社 | Therapeutic agent for heart disease |
US7498142B2 (en) | 2006-01-31 | 2009-03-03 | Yeda Research And Development Co., Ltd. | Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies |
AU2007211334A1 (en) | 2006-02-01 | 2007-08-09 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders |
AU2007227963A1 (en) | 2006-03-23 | 2007-09-27 | Kyowa Hakko Kirin Co., Ltd. | Agonist antibody to human thrombopoietin receptor |
US11046784B2 (en) | 2006-03-31 | 2021-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
EP2009101B1 (en) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
WO2007116962A1 (en) | 2006-04-07 | 2007-10-18 | Osaka University | Muscle regeneration promoter |
WO2008092117A2 (en) | 2007-01-25 | 2008-07-31 | Xencor, Inc. | Immunoglobulins with modifications in the fcr binding region |
WO2008145141A1 (en) | 2007-05-31 | 2008-12-04 | Genmab A/S | Method for extending the half-life of exogenous or endogenous soluble molecules |
KR101680906B1 (en) | 2007-09-26 | 2016-11-30 | 추가이 세이야쿠 가부시키가이샤 | Modified antibody constant region |
AU2008304778B9 (en) | 2007-09-26 | 2014-05-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in CDR |
KR101561314B1 (en) | 2007-09-26 | 2015-10-16 | 추가이 세이야쿠 가부시키가이샤 | Anti-IL-6 receptor antibody |
RU2010116756A (en) | 2007-09-28 | 2011-11-10 | Чугаи Сейяку Кабусики Кайся (Jp) | ANTIBODY AGAINST GLIPICAN-3 WITH IMPROVED KINETIC INDICATORS IN PLASMA |
JO3076B1 (en) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | Immunotherapy regimes dependent on apoe status |
RU2506276C2 (en) | 2007-11-12 | 2014-02-10 | УЗ ФАРМА ГмбХ | Anti-axl antibodies |
US8898477B2 (en) * | 2007-11-12 | 2014-11-25 | Gemalto Inc. | System and method for secure firmware update of a secure token having a flash memory controller and a smart card |
RU2559530C2 (en) * | 2007-11-15 | 2015-08-10 | Чугаи Сейяку Кабусики Кайся | Monoclonal antibodies capable of binding with axl protein and their application |
MX2010008578A (en) | 2008-02-08 | 2010-11-10 | Medimmune Llc | Anti-ifnar1 antibodies with reduced fc ligand affinity. |
EP2275443B1 (en) | 2008-04-11 | 2015-12-02 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
EP2826789A1 (en) | 2009-03-19 | 2015-01-21 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
US10150808B2 (en) | 2009-09-24 | 2018-12-11 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant regions |
US10435458B2 (en) | 2010-03-04 | 2019-10-08 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variants with reduced Fcgammar binding |
KR20120138241A (en) | 2010-03-11 | 2012-12-24 | 화이자 인코포레이티드 | Antibodies with ph dependent antigen binding |
-
2010
- 2010-05-14 WO PCT/JP2010/058166 patent/WO2010131733A1/en active Application Filing
- 2010-05-14 KR KR1020117029774A patent/KR20120024763A/en not_active Application Discontinuation
- 2010-05-14 US US13/320,317 patent/US9340615B2/en active Active
- 2010-05-14 BR BRPI1011145A patent/BRPI1011145A2/en not_active Application Discontinuation
- 2010-05-14 PE PE2011001964A patent/PE20120562A1/en not_active Application Discontinuation
- 2010-05-14 SG SG2011084050A patent/SG176074A1/en unknown
- 2010-05-14 AU AU2010248365A patent/AU2010248365A1/en not_active Abandoned
- 2010-05-14 MX MX2011012136A patent/MX2011012136A/en unknown
- 2010-05-14 MA MA34445A patent/MA33405B1/en unknown
- 2010-05-14 CN CN2010800324176A patent/CN102459344A/en not_active Withdrawn
- 2010-05-14 EP EP10774990.5A patent/EP2431393B1/en active Active
- 2010-05-14 AR ARP100101702A patent/AR076875A1/en unknown
- 2010-05-14 JP JP2011513382A patent/JP5669732B2/en active Active
- 2010-05-14 RU RU2011151069/02A patent/RU2011151069A/en not_active Application Discontinuation
- 2010-05-14 TW TW099115414A patent/TW201041595A/en unknown
- 2010-05-14 CA CA2761891A patent/CA2761891A1/en not_active Abandoned
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2011
- 2011-11-02 IL IL216097A patent/IL216097A0/en unknown
- 2011-11-11 CO CO11153892A patent/CO6460749A2/en unknown
- 2011-11-15 CL CL2011002877A patent/CL2011002877A1/en unknown
- 2011-11-21 ZA ZA2011/08526A patent/ZA201108526B/en unknown
- 2011-12-02 CR CR20110646A patent/CR20110646A/en not_active Application Discontinuation
- 2011-12-15 EC ECSP11011538 patent/ECSP11011538A/en unknown
Also Published As
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CR20110646A (en) | 2012-02-09 |
JP5669732B2 (en) | 2015-02-12 |
CL2011002877A1 (en) | 2012-05-25 |
MA33405B1 (en) | 2012-07-03 |
PE20120562A1 (en) | 2012-06-06 |
EP2431393A4 (en) | 2013-07-17 |
CN102459344A (en) | 2012-05-16 |
EP2431393A1 (en) | 2012-03-21 |
WO2010131733A1 (en) | 2010-11-18 |
WO2010131733A9 (en) | 2012-01-19 |
CA2761891A1 (en) | 2010-11-18 |
ECSP11011538A (en) | 2012-03-30 |
MX2011012136A (en) | 2012-04-10 |
SG176074A1 (en) | 2011-12-29 |
EP2431393B1 (en) | 2018-05-02 |
CO6460749A2 (en) | 2012-06-15 |
BRPI1011145A2 (en) | 2016-03-15 |
AU2010248365A1 (en) | 2011-12-22 |
RU2011151069A (en) | 2013-06-20 |
IL216097A0 (en) | 2012-01-31 |
KR20120024763A (en) | 2012-03-14 |
US9340615B2 (en) | 2016-05-17 |
AR076875A1 (en) | 2011-07-13 |
TW201041595A (en) | 2010-12-01 |
JPWO2010131733A1 (en) | 2012-11-08 |
US20120121587A1 (en) | 2012-05-17 |
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