BRPI1011145A2 - anticorpo anti-axl - Google Patents
anticorpo anti-axlInfo
- Publication number
- BRPI1011145A2 BRPI1011145A2 BRPI1011145A BRPI1011145A BRPI1011145A2 BR PI1011145 A2 BRPI1011145 A2 BR PI1011145A2 BR PI1011145 A BRPI1011145 A BR PI1011145A BR PI1011145 A BRPI1011145 A BR PI1011145A BR PI1011145 A2 BRPI1011145 A2 BR PI1011145A2
- Authority
- BR
- Brazil
- Prior art keywords
- axl antibody
- axl
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009118725 | 2009-05-15 | ||
PCT/JP2010/058166 WO2010131733A1 (ja) | 2009-05-15 | 2010-05-14 | 抗axl抗体 |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI1011145A2 true BRPI1011145A2 (pt) | 2016-03-15 |
Family
ID=43085106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI1011145A BRPI1011145A2 (pt) | 2009-05-15 | 2010-05-14 | anticorpo anti-axl |
Country Status (22)
Country | Link |
---|---|
US (1) | US9340615B2 (pt) |
EP (1) | EP2431393B1 (pt) |
JP (1) | JP5669732B2 (pt) |
KR (1) | KR20120024763A (pt) |
CN (1) | CN102459344A (pt) |
AR (1) | AR076875A1 (pt) |
AU (1) | AU2010248365A1 (pt) |
BR (1) | BRPI1011145A2 (pt) |
CA (1) | CA2761891A1 (pt) |
CL (1) | CL2011002877A1 (pt) |
CO (1) | CO6460749A2 (pt) |
CR (1) | CR20110646A (pt) |
EC (1) | ECSP11011538A (pt) |
IL (1) | IL216097A0 (pt) |
MA (1) | MA33405B1 (pt) |
MX (1) | MX2011012136A (pt) |
PE (1) | PE20120562A1 (pt) |
RU (1) | RU2011151069A (pt) |
SG (1) | SG176074A1 (pt) |
TW (1) | TW201041595A (pt) |
WO (1) | WO2010131733A1 (pt) |
ZA (1) | ZA201108526B (pt) |
Families Citing this family (55)
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CA2647846C (en) | 2006-03-31 | 2016-06-21 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
CA3139492A1 (en) | 2007-09-26 | 2009-04-02 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant region |
EP4339294A2 (en) | 2007-09-26 | 2024-03-20 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
TW200936160A (en) * | 2007-11-15 | 2009-09-01 | Chugai Pharmaceutical Co Ltd | Monoclonal antibodies that bind to anexelekto and uses thereof |
KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
JP5787446B2 (ja) | 2009-03-19 | 2015-09-30 | 中外製薬株式会社 | 抗体定常領域改変体 |
EP2409991B1 (en) | 2009-03-19 | 2017-05-03 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
CA2819356C (en) | 2010-11-30 | 2023-01-24 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
EP2723377B1 (en) * | 2011-06-22 | 2018-06-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-axl antibodies and uses thereof |
EP2723376B1 (en) * | 2011-06-22 | 2018-12-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-axl antibodies and uses thereof |
WO2013033008A2 (en) | 2011-08-26 | 2013-03-07 | Merrimack Pharmaceuticals, Inc. | Tandem fc bispecific antibodies |
ES2732712T3 (es) | 2011-10-31 | 2019-11-25 | Chugai Pharmaceutical Co Ltd | Molécula de unión a antígeno que tiene una conjugación regulada entre la cadena pesada y la cadena ligera |
CA2858806A1 (en) | 2011-12-23 | 2013-06-27 | Innate Pharma | Enzymatic conjugation of polypeptides |
EP2872894B1 (en) | 2012-07-13 | 2019-04-17 | Innate Pharma | Screening of conjugated antibodies |
ES2776681T3 (es) | 2012-08-24 | 2020-07-31 | Chugai Pharmaceutical Co Ltd | Variante de la región Fc específica de FcgammaRIIb |
US11236168B2 (en) | 2012-08-24 | 2022-02-01 | Chugai Seiyaku Kabushiki Kaisha | Mouse FcγammaRII-specific Fc antibody |
US9624308B2 (en) * | 2012-11-05 | 2017-04-18 | Pierre Fabre Medicament | Antigen binding proteins |
WO2014072482A1 (en) | 2012-11-09 | 2014-05-15 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
MX2015011712A (es) | 2013-03-06 | 2016-04-04 | Merrimack Pharmaceuticals Inc | Anticerpos biespecificos fc en fila anti-c-met. |
WO2014140300A1 (en) | 2013-03-15 | 2014-09-18 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
EP3783017A1 (en) | 2013-04-02 | 2021-02-24 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
EP3010547B1 (en) | 2013-06-20 | 2021-04-21 | Innate Pharma | Enzymatic conjugation of polypeptides |
KR20160042871A (ko) | 2013-06-21 | 2016-04-20 | 이나뜨 파르마, 에스.아. | 폴리펩티드의 효소적 콘쥬게이션 |
CN104341505A (zh) * | 2013-07-29 | 2015-02-11 | 西藏海思科药业集团股份有限公司 | 对蒙古人种和高加索人种低免疫原性的、抗egfr的人鼠嵌合抗体 |
TWI522099B (zh) | 2014-06-04 | 2016-02-21 | 中國醫藥大學 | 治療胰臟癌之醫藥配方及其應用 |
GB201410826D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
GB201410825D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
CN107074948B (zh) | 2014-07-11 | 2022-01-28 | 根马布股份公司 | 结合axl的抗体 |
EP3229836B1 (en) * | 2014-12-09 | 2019-11-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Human monoclonal antibodies against axl |
EP3240804A4 (en) | 2014-12-19 | 2019-01-09 | Chugai Seiyaku Kabushiki Kaisha | ANTI-MYOSTATIN ANTIBODIES, POLYPEPTIDES WITH DEVIANT FC REGIONS AND METHOD OF USE |
CN114773470A (zh) | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用 |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201509338D0 (en) | 2015-05-29 | 2015-07-15 | Bergenbio As | Combination therapy |
HUE049072T2 (hu) | 2015-07-10 | 2020-09-28 | Genmab As | AXL-specifikus ellenanyag-drog konjugátumok rák kezelésére |
JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
EP3402465B1 (en) | 2016-01-13 | 2024-03-13 | Genmab A/S | Formulation for antibody and drug conjugate thereof |
GB201610902D0 (en) * | 2016-06-22 | 2016-08-03 | Bergen Teknologioverforing As And Bergenbio As | Anti-Axl Antagonistic Antibodies |
CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
KR101909955B1 (ko) * | 2016-11-28 | 2018-10-19 | 재단법인 목암생명과학연구소 | 신규 항-에이엑스엘 항체 및 이를 포함하는 약학적 조성물 |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
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CN112218895A (zh) | 2018-04-10 | 2021-01-12 | 健玛保 | 用于癌症治疗的axl特异性抗体 |
CN110483639A (zh) * | 2018-05-15 | 2019-11-22 | 复旦大学 | 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 |
CN110540592B (zh) * | 2018-05-29 | 2022-08-09 | 杭州尚健生物技术有限公司 | 结合axl蛋白的抗体及其应用 |
CN109160941B (zh) * | 2018-09-29 | 2020-09-04 | 未名生物医药有限公司 | 蛋白序列17e11及其用途 |
AU2019413278A1 (en) * | 2018-12-28 | 2021-07-15 | Kyowa Kirin Co., Ltd. | Bispecific antibody binding to TfR |
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-
2010
- 2010-05-14 WO PCT/JP2010/058166 patent/WO2010131733A1/ja active Application Filing
- 2010-05-14 EP EP10774990.5A patent/EP2431393B1/en active Active
- 2010-05-14 RU RU2011151069/02A patent/RU2011151069A/ru not_active Application Discontinuation
- 2010-05-14 AR ARP100101702A patent/AR076875A1/es unknown
- 2010-05-14 MX MX2011012136A patent/MX2011012136A/es unknown
- 2010-05-14 KR KR1020117029774A patent/KR20120024763A/ko not_active Application Discontinuation
- 2010-05-14 BR BRPI1011145A patent/BRPI1011145A2/pt not_active Application Discontinuation
- 2010-05-14 US US13/320,317 patent/US9340615B2/en active Active
- 2010-05-14 SG SG2011084050A patent/SG176074A1/en unknown
- 2010-05-14 MA MA34445A patent/MA33405B1/fr unknown
- 2010-05-14 PE PE2011001964A patent/PE20120562A1/es not_active Application Discontinuation
- 2010-05-14 CN CN2010800324176A patent/CN102459344A/zh not_active Withdrawn
- 2010-05-14 JP JP2011513382A patent/JP5669732B2/ja active Active
- 2010-05-14 TW TW099115414A patent/TW201041595A/zh unknown
- 2010-05-14 CA CA2761891A patent/CA2761891A1/en not_active Abandoned
- 2010-05-14 AU AU2010248365A patent/AU2010248365A1/en not_active Abandoned
-
2011
- 2011-11-02 IL IL216097A patent/IL216097A0/en unknown
- 2011-11-11 CO CO11153892A patent/CO6460749A2/es unknown
- 2011-11-15 CL CL2011002877A patent/CL2011002877A1/es unknown
- 2011-11-21 ZA ZA2011/08526A patent/ZA201108526B/en unknown
- 2011-12-02 CR CR20110646A patent/CR20110646A/es not_active Application Discontinuation
- 2011-12-15 EC ECSP11011538 patent/ECSP11011538A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ECSP11011538A (es) | 2012-03-30 |
CN102459344A (zh) | 2012-05-16 |
JP5669732B2 (ja) | 2015-02-12 |
EP2431393A4 (en) | 2013-07-17 |
CO6460749A2 (es) | 2012-06-15 |
ZA201108526B (en) | 2012-11-28 |
AU2010248365A1 (en) | 2011-12-22 |
EP2431393A1 (en) | 2012-03-21 |
US9340615B2 (en) | 2016-05-17 |
WO2010131733A9 (ja) | 2012-01-19 |
WO2010131733A1 (ja) | 2010-11-18 |
MA33405B1 (fr) | 2012-07-03 |
PE20120562A1 (es) | 2012-06-06 |
SG176074A1 (en) | 2011-12-29 |
RU2011151069A (ru) | 2013-06-20 |
AR076875A1 (es) | 2011-07-13 |
CL2011002877A1 (es) | 2012-05-25 |
CR20110646A (es) | 2012-02-09 |
JPWO2010131733A1 (ja) | 2012-11-08 |
KR20120024763A (ko) | 2012-03-14 |
EP2431393B1 (en) | 2018-05-02 |
CA2761891A1 (en) | 2010-11-18 |
MX2011012136A (es) | 2012-04-10 |
TW201041595A (en) | 2010-12-01 |
IL216097A0 (en) | 2012-01-31 |
US20120121587A1 (en) | 2012-05-17 |
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