BRPI0907237A2 - Anticorpo anti-cldn6 - Google Patents
Anticorpo anti-cldn6Info
- Publication number
- BRPI0907237A2 BRPI0907237A2 BRPI0907237-3A BRPI0907237A BRPI0907237A2 BR PI0907237 A2 BRPI0907237 A2 BR PI0907237A2 BR PI0907237 A BRPI0907237 A BR PI0907237A BR PI0907237 A2 BRPI0907237 A2 BR PI0907237A2
- Authority
- BR
- Brazil
- Prior art keywords
- cldn6 antibody
- cldn6
- antibody
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008004423 | 2008-01-11 | ||
| PCT/JP2009/000082 WO2009087978A1 (ja) | 2008-01-11 | 2009-01-09 | 抗cldn6抗体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0907237A2 true BRPI0907237A2 (pt) | 2015-07-14 |
Family
ID=40853092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0907237-3A BRPI0907237A2 (pt) | 2008-01-11 | 2009-01-09 | Anticorpo anti-cldn6 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9274119B2 (pt) |
| EP (3) | EP3064512B1 (pt) |
| JP (1) | JP5848863B2 (pt) |
| KR (1) | KR20100116179A (pt) |
| CN (1) | CN101918450A (pt) |
| AU (1) | AU2009203464A1 (pt) |
| BR (1) | BRPI0907237A2 (pt) |
| CA (1) | CA2711557A1 (pt) |
| MX (1) | MX2010007500A (pt) |
| RU (1) | RU2010133547A (pt) |
| SG (1) | SG187457A1 (pt) |
| WO (1) | WO2009087978A1 (pt) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9809815B2 (en) | 2009-02-20 | 2017-11-07 | Ganymed Pharmaceuticals Ag | Methods and compositions for diagnosis and treatment of cancer |
| US10288617B2 (en) | 2009-10-26 | 2019-05-14 | Externautics Spa | Ovary tumor markers and methods of use thereof |
| WO2011051271A2 (en) | 2009-10-26 | 2011-05-05 | Externautics S.P.A. | Prostate tumor markers and methods of use thereof |
| EP2322555A1 (en) | 2009-11-11 | 2011-05-18 | Ganymed Pharmaceuticals AG | Antibodies specific for claudin 6 (CLDN6) |
| NZ716587A (en) * | 2009-11-11 | 2017-10-27 | Ganymed Pharmaceuticals Ag | Antibodies specific for claudin 6 (cldn6) |
| TW202348631A (zh) | 2010-02-24 | 2023-12-16 | 美商免疫遺傳股份有限公司 | 葉酸受體１抗體類和免疫共軛物類及彼等之用途 |
| TR201807750T4 (tr) * | 2010-06-11 | 2018-06-21 | Kyowa Hakko Kirin Co Ltd | Anti-TIM-3 antikoru. |
| EP2404936A1 (en) * | 2010-07-06 | 2012-01-11 | Ganymed Pharmaceuticals AG | Cancer therapy using CLDN6 target-directed antibodies in vivo |
| HUE036172T2 (hu) | 2011-04-01 | 2018-06-28 | Immunogen Inc | Eljárások a hatékonyság növelésére a FOLR1 rákkezelésénél |
| ES2703936T3 (es) * | 2011-05-13 | 2019-03-13 | Ganymed Pharmaceuticals Gmbh | Anticuerpos para el tratamiento de un cáncer que expresa la claudina 6 |
| PL3026064T3 (pl) | 2011-05-13 | 2019-05-31 | Ganymed Pharmaceuticals Gmbh | Przeciwciała do leczenia nowotworu z ekspresją klaudyny 6 |
| CA2845884A1 (en) | 2011-08-22 | 2013-02-28 | Cangene Corporation | Clostridium difficile antibodies |
| KR102084806B1 (ko) * | 2012-02-17 | 2020-03-04 | 시애틀 지네틱스, 인크. | 인테그린 αvβ6에 대한 항체 및 암을 치료하기 위한 그의 용도 |
| NZ726258A (en) | 2012-08-31 | 2019-07-26 | Immunogen Inc | Antibodies and uses thereof to detect folate receptor 1 |
| WO2014132647A1 (ja) * | 2013-03-01 | 2014-09-04 | 公益財団法人ヒューマンサイエンス振興財団 | 抗体、フラグメント、医薬組成物、分子及び腫瘍マーカー |
| WO2015014376A1 (en) | 2013-07-31 | 2015-02-05 | Biontech Ag | Diagnosis and therapy of cancer involving cancer stem cells |
| KR102585409B1 (ko) | 2013-08-30 | 2023-10-05 | 이뮤노젠 아이엔씨 | 엽산 수용체 1의 검출을 위한 항체 및 분석 |
| RU2016122041A (ru) * | 2013-11-06 | 2017-12-11 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Новые анти-клаудин антитела и способы их применения |
| TWI652279B (zh) | 2013-11-11 | 2019-03-01 | 中外製藥股份有限公司 | 含改變的抗體可變區之抗原結合分子 |
| DK3514172T3 (da) * | 2014-04-01 | 2020-04-06 | Biontech Cell & Gene Therapies Gmbh | Claudin-6-specifikke immunoreceptorer og t-celleepitoper |
| MA40921A (fr) * | 2014-11-05 | 2017-09-12 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation |
| TW202313697A (zh) | 2014-11-11 | 2023-04-01 | 日商中外製藥股份有限公司 | 包含經改變之抗體可變區之抗原結合分子的資料庫 |
| CN106146666B (zh) * | 2015-03-26 | 2019-09-06 | 科济生物医药（上海）有限公司 | 靶向cldn6的免疫效应细胞及其制备方法和应用 |
| EP3349796A4 (en) | 2015-09-17 | 2019-05-29 | ImmunoGen, Inc. | THERAPEUTIC COMBINATIONS COMPRISING ANTI-FOLR1 IMMUNOCONJUGATES |
| US11479601B2 (en) | 2016-06-29 | 2022-10-25 | The Regents Of The University Of California | Antibodies specific to Sonic Hedgehog and method of use thereof |
| EP3567053A4 (en) * | 2016-12-28 | 2020-08-12 | Osaka University | MONOCLONAL ANTI-CLAUDIN-2 ANTIBODY |
| WO2019048040A1 (en) * | 2017-09-06 | 2019-03-14 | Ganymed Pharmaceuticals Gmbh | ANTIBODIES USEFUL IN THE DIAGNOSIS OF CANCER |
| SG11202002114RA (en) * | 2017-09-18 | 2020-04-29 | Univ California | Claudin6 antibodies and methods of treating cancer |
| CN111164208B (zh) | 2017-09-29 | 2023-08-04 | 第一三共株式会社 | 抗体－吡咯并苯并二氮杂卓衍生物偶联物 |
| US11952422B2 (en) | 2017-12-05 | 2024-04-09 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137 |
| JP2021510064A (ja) * | 2018-01-05 | 2021-04-15 | 中外製薬株式会社 | 細胞傷害誘導治療剤 |
| JP2022521723A (ja) | 2019-02-15 | 2022-04-12 | インテグラル・モレキュラー・インコーポレイテッド | クローディン６抗体及びその使用 |
| WO2020196474A1 (ja) | 2019-03-25 | 2020-10-01 | 第一三共株式会社 | 抗体－ピロロベンゾジアゼピン誘導体コンジュゲート |
| CN113950485A (zh) | 2019-07-10 | 2022-01-18 | 中外制药株式会社 | 密蛋白-6结合分子及其用途 |
| AU2020397070A1 (en) | 2019-12-05 | 2022-07-14 | Seagen Inc. | Anti-avb6 antibodies and antibody-drug conjugates |
| CN115397855A (zh) | 2020-03-31 | 2022-11-25 | 中外制药株式会社 | 密蛋白-6靶向多特异性抗原结合分子及其用途 |
| JP2023547662A (ja) * | 2020-11-06 | 2023-11-13 | アムジェン リサーチ （ミュニック） ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｌｄｎ６及びｃｄ３に選択的に結合するポリペプチド構築物 |
| CN116940377A (zh) * | 2021-03-05 | 2023-10-24 | 上海吉倍生物技术有限公司 | 抗cldn6抗体及其用途 |
| EP4305067A1 (en) | 2021-03-09 | 2024-01-17 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
| WO2023053282A1 (ja) | 2021-09-29 | 2023-04-06 | 中外製薬株式会社 | がんの治療に用いるための細胞傷害誘導治療剤 |
| WO2024022512A1 (en) * | 2022-07-29 | 2024-02-01 | Nanjing Legend Biotech Co., Ltd. | Claudin-6 binding moieties and uses thereof |
| WO2024039670A1 (en) * | 2022-08-15 | 2024-02-22 | Dana-Farber Cancer Institute, Inc. | Antibodies against cldn4 and methods of use thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58201994A (ja) | 1982-05-21 | 1983-11-25 | Hideaki Hagiwara | 抗原特異的ヒト免疫グロブリンの生産方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| DK0585287T3 (da) | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Fremgangsmåde til fremstilling af specifikke bindingsparelementer |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| WO1993012227A1 (en) | 1991-12-17 | 1993-06-24 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| DK0605522T3 (da) | 1991-09-23 | 2000-01-17 | Medical Res Council | Fremgangsmåde til fremstilling af humaniserede antistoffer |
| JPH07501451A (ja) | 1991-11-25 | 1995-02-16 | エンゾン・インコーポレイテッド | 多価抗原結合タンパク質 |
| DK1024191T3 (da) | 1991-12-02 | 2008-12-08 | Medical Res Council | Fremstilling af autoantistoffer fremvist på fag-overflader ud fra antistofsegmentbiblioteker |
| CA2131151A1 (en) | 1992-03-24 | 1994-09-30 | Kevin S. Johnson | Methods for producing members of specific binding pairs |
| ATE381614T1 (de) | 1992-07-24 | 2008-01-15 | Amgen Fremont Inc | Bildung von xenogenen antikörpern |
| US5648267A (en) | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
| CA2161351C (en) | 1993-04-26 | 2010-12-21 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
| CA2177367A1 (en) | 1993-12-03 | 1995-06-08 | Andrew David Griffiths | Recombinant binding proteins and peptides |
| AU701342B2 (en) | 1994-07-13 | 1999-01-28 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin-8 |
| AU3657899A (en) | 1998-04-20 | 1999-11-08 | James E. Bailey | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
| WO2000026360A1 (en) * | 1998-11-03 | 2000-05-11 | Adherex Technologies Inc. | Compounds and methods for modulating claudin-mediated functions |
| EP2275540B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| CA2424602C (en) | 2000-10-06 | 2012-09-18 | Kyowa Hakko Kogyo Co., Ltd. | Antibody composition-producing cell |
| US20030003097A1 (en) | 2001-04-02 | 2003-01-02 | Idec Pharmaceutical Corporation | Recombinant antibodies coexpressed with GnTIII |
| WO2003088808A2 (en) | 2002-04-16 | 2003-10-30 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| ES2326964T3 (es) | 2001-10-25 | 2009-10-22 | Genentech, Inc. | Composiciones de glicoproteina. |
| US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| CA2379661A1 (en) | 2002-03-28 | 2003-09-28 | Kursad Turksen | Paracellular drug delivery system |
| EP1514928B1 (en) | 2002-06-05 | 2013-07-31 | Chugai Seiyaku Kabushiki Kaisha | Method for producing antibodies using baculoviruses |
| PT1517921E (pt) * | 2002-06-28 | 2006-09-29 | Domantis Ltd | Ligandos duplamente especificos com semi-vida no soro aumentada |
| JP2006500009A (ja) * | 2002-07-09 | 2006-01-05 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
| BRPI0314814C1 (pt) | 2002-09-27 | 2021-07-27 | Xencor Inc | anticorpo compreendendo uma variante de fc |
| US20090061485A1 (en) | 2004-12-22 | 2009-03-05 | Chugai Seiyaku Kabushiki Kaisha | Method of Producing an Antibody Using a Cell in Which the Function of Fucose Transporter Is Inhibited |
| JP2007020155A (ja) | 2005-06-08 | 2007-01-25 | Canon Inc | 画像処理装置、画像処理方法、プログラム、及び記憶媒体 |
| EP1931709B1 (en) * | 2005-10-03 | 2016-12-07 | Xencor, Inc. | Fc variants with optimized fc receptor binding properties |
| JP5060068B2 (ja) | 2006-06-23 | 2012-10-31 | 一般財団法人ファインセラミックスセンター | 固体酸化物形燃料電池及びその製造方法 |
-
2009
- 2009-01-09 EP EP16165434.8A patent/EP3064512B1/en active Active
- 2009-01-09 EP EP23193707.9A patent/EP4282428A3/en active Pending
- 2009-01-09 CN CN2009801019661A patent/CN101918450A/zh active Pending
- 2009-01-09 CA CA2711557A patent/CA2711557A1/en not_active Abandoned
- 2009-01-09 JP JP2009548907A patent/JP5848863B2/ja active Active
- 2009-01-09 EP EP09700588.8A patent/EP2241578B1/en not_active Revoked
- 2009-01-09 SG SG2013002365A patent/SG187457A1/en unknown
- 2009-01-09 WO PCT/JP2009/000082 patent/WO2009087978A1/ja active Application Filing
- 2009-01-09 BR BRPI0907237-3A patent/BRPI0907237A2/pt not_active IP Right Cessation
- 2009-01-09 RU RU2010133547/10A patent/RU2010133547A/ru not_active Application Discontinuation
- 2009-01-09 AU AU2009203464A patent/AU2009203464A1/en not_active Abandoned
- 2009-01-09 US US12/735,359 patent/US9274119B2/en active Active
- 2009-01-09 KR KR1020107017001A patent/KR20100116179A/ko not_active Application Discontinuation
- 2009-01-09 MX MX2010007500A patent/MX2010007500A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP3064512C0 (en) | 2023-08-30 |
| EP2241578A4 (en) | 2012-09-12 |
| CA2711557A1 (en) | 2009-07-16 |
| EP4282428A3 (en) | 2024-03-20 |
| EP3064512A3 (en) | 2016-10-19 |
| CN101918450A (zh) | 2010-12-15 |
| EP2241578A1 (en) | 2010-10-20 |
| JP5848863B2 (ja) | 2016-01-27 |
| EP3064512A2 (en) | 2016-09-07 |
| WO2009087978A1 (ja) | 2009-07-16 |
| US9274119B2 (en) | 2016-03-01 |
| SG187457A1 (en) | 2013-02-28 |
| KR20100116179A (ko) | 2010-10-29 |
| AU2009203464A1 (en) | 2009-07-16 |
| EP2241578B1 (en) | 2016-04-20 |
| EP4282428A2 (en) | 2023-11-29 |
| US20110059469A1 (en) | 2011-03-10 |
| RU2010133547A (ru) | 2012-02-20 |
| EP3064512B1 (en) | 2023-08-30 |
| MX2010007500A (es) | 2010-10-20 |
| JPWO2009087978A1 (ja) | 2011-05-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY2019004I1 (el) | Τροποποιημενα αντισωματα αντι-ιl-23ρ19 | |
| BRPI0907237A2 (pt) | Anticorpo anti-cldn6 | |
| BRPI0906877A2 (pt) | Anticorpos anti-trkb aperfeiçoados | |
| DK3072906T3 (da) | Antistofformulering | |
| DK2370462T3 (da) | Glucagon-analoger | |
| BRPI0907376A2 (pt) | Fotobiorretador | |
| DK2342317T3 (da) | Hængende-dråbe-plade | |
| DE602009000234D1 (de) | msignals | |
| BRPI0914649A2 (pt) | Piprazolo-quinazolinas | |
| DE602008003972D1 (de) | Sitzrücklehnungsmechanismus | |
| DE602008003521D1 (de) | Sitzrücklehnungsmechanismus | |
| DK2336132T3 (da) | Morpholinpurinderivat | |
| DK2342454T3 (da) | Vindkraftanlæg | |
| DK2335031T3 (da) | In-line-måler | |
| BRPI0817427A2 (pt) | Anticorpo anti-bst2 | |
| BRPI0909633A2 (pt) | anticorpos anti-tyrp1 | |
| DE602008003970D1 (de) | Strahlstromkalibriersystem | |
| DK2271613T3 (da) | Hydroxymethylcyklohexylaminer | |
| BRPI0907522A2 (pt) | biarlamidas | |
| DE112009001946A5 (de) | Mobelauszugsführung | |
| DE602009000488D1 (de) | Obstvereinzelvorrichtung | |
| BRPI0907863A2 (pt) | pirrolopirimidinacarboxamidas | |
| BRPI0909634A2 (pt) | 2-aminoquinolinas | |
| DE112009000183A5 (de) | Sicherheitsvorreiber | |
| BRPI0912769A2 (pt) | anticorpos anti-pirb |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |