PT3045471T - Resumo - Google Patents

Resumo

Info

Publication number
PT3045471T
PT3045471T PT161581418T PT16158141T PT3045471T PT 3045471 T PT3045471 T PT 3045471T PT 161581418 T PT161581418 T PT 161581418T PT 16158141 T PT16158141 T PT 16158141T PT 3045471 T PT3045471 T PT 3045471T
Authority
PT
Portugal
Prior art keywords
alpha
sialylation
recombinant fsh
fsh including
including alpha
Prior art date
Application number
PT161581418T
Other languages
English (en)
Inventor
Cottingham Ian
Plaksin Daniel
Boyd White Richard
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3045471(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of PT3045471T publication Critical patent/PT3045471T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT161581418T 2008-04-16 2009-04-16 Resumo PT3045471T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
EP08251528 2008-04-25

Publications (1)

Publication Number Publication Date
PT3045471T true PT3045471T (pt) 2017-06-14

Family

ID=39717519

Family Applications (4)

Application Number Title Priority Date Filing Date
PT161581418T PT3045471T (pt) 2008-04-16 2009-04-16 Resumo
PT97334973T PT2268666E (pt) 2008-04-16 2009-04-16 Recombinante fsh incluindo sialilação alfa 2,3 e alfa 2,6
PT141787291T PT2808340T (pt) 2008-04-16 2009-04-16 Resumo
PT161949250T PT3144318T (pt) 2008-04-25 2009-04-16 Fsh recombinante incluindo sialilação alfa 2,3 e alfa 2,6

Family Applications After (3)

Application Number Title Priority Date Filing Date
PT97334973T PT2268666E (pt) 2008-04-16 2009-04-16 Recombinante fsh incluindo sialilação alfa 2,3 e alfa 2,6
PT141787291T PT2808340T (pt) 2008-04-16 2009-04-16 Resumo
PT161949250T PT3144318T (pt) 2008-04-25 2009-04-16 Fsh recombinante incluindo sialilação alfa 2,3 e alfa 2,6

Country Status (29)

Country Link
US (5) US8951967B2 (pt)
EP (7) EP2808340B1 (pt)
JP (7) JP2011519359A (pt)
KR (5) KR20170110741A (pt)
CN (3) CN102066414A (pt)
AR (1) AR071479A1 (pt)
AU (5) AU2009237479B2 (pt)
BR (1) BRPI0910461B8 (pt)
CA (1) CA2725257A1 (pt)
CY (1) CY1115413T1 (pt)
DK (4) DK2808340T3 (pt)
ES (3) ES2610277T3 (pt)
FR (1) FR17C1020I2 (pt)
HK (2) HK1146284A1 (pt)
HR (3) HRP20140535T1 (pt)
HU (5) HUE030652T4 (pt)
IL (2) IL208538A (pt)
LT (4) LT2808340T (pt)
MX (3) MX2010011343A (pt)
NO (2) NO2017025I1 (pt)
NZ (1) NZ588381A (pt)
PL (4) PL2268666T3 (pt)
PT (4) PT3045471T (pt)
RU (3) RU2682270C2 (pt)
SA (1) SA109300228B1 (pt)
SI (4) SI2808340T1 (pt)
TW (1) TWI488640B (pt)
WO (1) WO2009127826A1 (pt)
ZA (1) ZA201007373B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
HRP20150968T4 (hr) 2010-09-29 2023-11-10 Ferring B.V. Pripravak za uporabu za liječenje neplodnosti
EP2628797B1 (en) 2010-10-15 2016-07-13 JCR Pharmaceuticals CO., LTD. Method for producing glycoprotein having mannose residue as non-reducing end of sugar chain
CN103619358B (zh) * 2011-03-31 2017-02-15 辉凌公司 药物制剂
WO2012168680A1 (en) 2011-06-06 2012-12-13 Ferring B.V. Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) * 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
WO2013093760A2 (en) * 2011-12-19 2013-06-27 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
JP6279466B2 (ja) * 2012-04-27 2018-02-14 Ｊｃｒファーマ株式会社 新規な発現ベクター
EP2824176A1 (en) * 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
JP6652334B2 (ja) 2014-05-31 2020-02-19 Ｊｃｒファーマ株式会社 ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地
WO2016102436A1 (en) * 2014-12-22 2016-06-30 F. Hoffmann-La Roche Ag Cmp-dependent sialidase activity
RU2704252C2 (ru) 2015-04-17 2019-10-25 Ферринг Б.В. Композиция для лечения бесплодия
WO2016207353A1 (en) 2015-06-26 2016-12-29 Ferring B.V. Methods of purification and/or viral inactivation
EP3205719A1 (en) * 2016-02-15 2017-08-16 CEVEC Pharmaceuticals GmbH Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
GB201603280D0 (en) 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
EP3382014A1 (en) 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
EP3973982B1 (en) 2017-09-01 2024-07-31 Ferring B.V. Composition for controlled ovarian stimulation
US20210038694A1 (en) 2018-04-30 2021-02-11 Ferring B.V. Composition for controlled ovarian stimulation
CN112789053A (zh) 2018-10-17 2021-05-11 辉凌公司 用于受控的卵巢刺激的组合物和方法
US20220380785A1 (en) * 2019-11-01 2022-12-01 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
WO2023186331A1 (en) 2022-04-01 2023-10-05 Ferring B.V. Mixed protocol for treatment of infertility
WO2023227761A1 (en) 2022-05-26 2023-11-30 Ferring B.V. Compositions and methods for treatment of infertility in males
WO2024008971A1 (en) 2022-07-08 2024-01-11 Ferring B.V. Compositions and methods for intrauterine insemination (iui)

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IT1206302B (it) 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
US5541083A (en) 1989-10-24 1996-07-30 The Regents Of The University Of California Method for producing secretable glycosyltransferases and other golgi processing enzymes
EP1445322B2 (en) 1995-06-15 2012-06-06 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
JP3559652B2 (ja) * 1996-06-25 2004-09-02 グローリー工業株式会社 売上精算システムの管理装置
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
NZ336780A (en) 1997-01-16 2000-12-22 Neose Technologies Inc In vitro sialylation of glycoproteins
JPH1111665A (ja) 1997-06-28 1999-01-19 Shibuya Kogyo Co Ltd 無菌エア搬送コンベヤ装置
TWI235158B (en) * 1997-09-01 2005-07-01 Kirin Brewery Human thrombopoietin produced by human established cell lines, processes foe preparing the same, and pharmaceutical composition comprising the same
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DK1440157T3 (da) 2001-10-29 2012-05-07 Crucell Holland Bv Methods and means for producing proteins with predetermined post-translational modifications
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US20080015142A1 (en) * 2003-12-03 2008-01-17 Defrees Shawn Glycopegylated Follicle Stimulating Hormone
US8431355B2 (en) 2004-02-04 2013-04-30 Universite De Provence Aix-Marseille 1 Process for screening glycoform-specific antibodies
CA2557725C (en) 2004-02-13 2015-06-30 Glycotope Gmbh Highly active glycoproteins-process conditions and an efficient method for their production
TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
US8790322B2 (en) 2010-08-03 2014-07-29 King Saud University Stoma coat
WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
HRP20150968T4 (hr) 2010-09-29 2023-11-10 Ferring B.V. Pripravak za uporabu za liječenje neplodnosti
CN103619358B (zh) 2011-03-31 2017-02-15 辉凌公司 药物制剂
WO2012168680A1 (en) 2011-06-06 2012-12-13 Ferring B.V. Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
KR20160144480A (ko) 2014-04-18 2016-12-16 글리코토페 게엠베하 개선된 재조합 인간 난포-자극 호르몬을 이용한 조절된 난소 과다자극

Also Published As

Publication number Publication date
US20210332099A1 (en) 2021-10-28
JP2022031652A (ja) 2022-02-22
JP6486310B2 (ja) 2019-03-20
JP2020040956A (ja) 2020-03-19
EP2722339A1 (en) 2014-04-23
HRP20170958T1 (hr) 2017-09-22
BRPI0910461A2 (pt) 2018-03-27
RU2537268C2 (ru) 2014-12-27
WO2009127826A1 (en) 2009-10-22
EP2268666A1 (en) 2011-01-05
TWI488640B (zh) 2015-06-21
CN105906703A (zh) 2016-08-31
HUE030652T4 (en) 2017-09-28
FR17C1020I1 (pt) 2020-04-10
HUE033830T2 (en) 2018-01-29
DK2268666T3 (da) 2014-05-12
HUS1700036I1 (hu) 2017-10-30
EP3098234A1 (en) 2016-11-30
NZ588381A (en) 2012-05-25
AU2017225020B2 (en) 2019-11-14
MX2010011343A (es) 2011-01-20
ES2468318T3 (es) 2014-06-16
DK2808340T3 (en) 2016-12-05
PT3144318T (pt) 2020-11-04
NO2017050I1 (no) 2017-09-28
AU2009237479B2 (en) 2014-05-15
US20150065695A1 (en) 2015-03-05
SI2808340T1 (sl) 2016-12-30
PT2808340T (pt) 2016-11-21
RU2014141994A3 (pt) 2018-05-28
HUS1700024I1 (hu) 2017-06-28
LTPA2017029I1 (lt) 2017-10-10
US11952407B2 (en) 2024-04-09
JP2017060476A (ja) 2017-03-30
US20180079794A1 (en) 2018-03-22
DK3144318T3 (da) 2020-12-07
DK3045471T3 (en) 2017-06-26
EP3144318A1 (en) 2017-03-22
SI3045471T1 (sl) 2017-07-31
EP2808340B1 (en) 2016-08-17
ZA201007373B (en) 2011-06-29
IL208538A0 (en) 2010-12-30
AU2017225020A1 (en) 2017-09-28
EP4015527A1 (en) 2022-06-22
HRP20161520T1 (hr) 2016-12-30
JP6762916B2 (ja) 2020-09-30
US20110105398A1 (en) 2011-05-05
IL230571A (en) 2015-11-30
EP2808340A1 (en) 2014-12-03
AU2017204259A1 (en) 2017-07-20
NO2017025I1 (no) 2017-06-06
AU2014203277B2 (en) 2017-04-06
US10995128B2 (en) 2021-05-04
AU2014203277A1 (en) 2014-07-24
EP3045471A1 (en) 2016-07-20
KR20160056960A (ko) 2016-05-20
CY1115413T1 (el) 2017-01-04
SA109300228B1 (ar) 2014-04-08
AU2009237479A1 (en) 2009-10-22
KR101622944B1 (ko) 2016-05-23
JP2015120696A (ja) 2015-07-02
RU2745557C3 (ru) 2021-12-10
HUE030652T2 (en) 2017-05-29
TW200948378A (en) 2009-12-01
JP2018021037A (ja) 2018-02-08
US20160347811A1 (en) 2016-12-01
CN102066414A (zh) 2011-05-18
PL2268666T3 (pl) 2014-08-29
US8951967B2 (en) 2015-02-10
EP3098234B1 (en) 2024-07-31
AU2017204258A1 (en) 2017-07-20
AU2017204259B2 (en) 2017-08-17
IL208538A (en) 2014-03-31
HK1146284A1 (en) 2011-05-20
JP2011519359A (ja) 2011-07-07
HK1199039A1 (en) 2015-06-19
RU2682270C2 (ru) 2019-03-18
BRPI0910461B1 (pt) 2021-02-23
LT2808340T (lt) 2016-11-10
BRPI0910461A8 (pt) 2018-10-16
MX355457B (es) 2018-04-19
FR17C1020I2 (fr) 2020-04-10
BRPI0910461B8 (pt) 2021-05-25
ES2629392T3 (es) 2017-08-09
JP2024038000A (ja) 2024-03-19
KR102108377B1 (ko) 2020-05-08
AR071479A1 (es) 2010-06-23
LT3045471T (lt) 2017-07-10
CN105906702A (zh) 2016-08-31
US9546204B2 (en) 2017-01-17
HUS1700025I1 (hu) 2017-06-28
KR20180095140A (ko) 2018-08-24
LTPA2017018I1 (lt) 2017-06-26
ES2610277T3 (es) 2017-04-26
HRP20140535T1 (hr) 2014-07-18
EP3045471B1 (en) 2017-03-29
CA2725257A1 (en) 2009-10-22
AU2017204258B2 (en) 2017-08-17
KR20190092608A (ko) 2019-08-07
RU2014141994A (ru) 2016-05-10
RU2010141908A (ru) 2012-05-27
AU2014203277C1 (en) 2017-07-27
EP3144318B1 (en) 2020-09-23
RU2745557C1 (ru) 2021-03-29
SI2268666T1 (sl) 2014-07-31
EP2268666B1 (en) 2014-03-12
PT2268666E (pt) 2014-06-25
JP7316905B2 (ja) 2023-07-28
KR20110005863A (ko) 2011-01-19
PL2808340T3 (pl) 2017-02-28
MX348622B (es) 2017-06-22
SI3144318T1 (sl) 2020-12-31
KR20170110741A (ko) 2017-10-11
PL3144318T3 (pl) 2021-02-08
PL3045471T3 (pl) 2017-10-31
US9771407B2 (en) 2017-09-26

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