HK1146284A1 - Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation 23-26- fsh - Google Patents

Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation 23-26- fsh

Info

Publication number
HK1146284A1
HK1146284A1 HK11100441.2A HK11100441A HK1146284A1 HK 1146284 A1 HK1146284 A1 HK 1146284A1 HK 11100441 A HK11100441 A HK 11100441A HK 1146284 A1 HK1146284 A1 HK 1146284A1
Authority
HK
Hong Kong
Prior art keywords
alpha
fsh
sialylation
recombinant
including alpha
Prior art date
Application number
HK11100441.2A
Other languages
English (en)
Chinese (zh)
Inventor
Ian Cottingham
Daniel Plaksin
Richard Boyd White
Original Assignee
Ferring Int Ct Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1146284(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Int Ct Sa filed Critical Ferring Int Ct Sa
Publication of HK1146284A1 publication Critical patent/HK1146284A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK11100441.2A 2008-04-16 2011-01-17 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation 23-26- fsh HK1146284A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
EP08251528 2008-04-25
PCT/GB2009/000978 WO2009127826A1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation

Publications (1)

Publication Number Publication Date
HK1146284A1 true HK1146284A1 (en) 2011-05-20

Family

ID=39717519

Family Applications (2)

Application Number Title Priority Date Filing Date
HK11100441.2A HK1146284A1 (en) 2008-04-16 2011-01-17 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation 23-26- fsh
HK14112411.0A HK1199039A1 (en) 2008-04-16 2014-12-10 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation 23-26- fsh

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK14112411.0A HK1199039A1 (en) 2008-04-16 2014-12-10 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation 23-26- fsh

Country Status (29)

Country Link
US (5) US8951967B2 (xx)
EP (7) EP3045471B1 (xx)
JP (7) JP2011519359A (xx)
KR (5) KR20180095140A (xx)
CN (3) CN102066414A (xx)
AR (1) AR071479A1 (xx)
AU (5) AU2009237479B2 (xx)
BR (1) BRPI0910461B8 (xx)
CA (1) CA2725257A1 (xx)
CY (1) CY1115413T1 (xx)
DK (4) DK3144318T3 (xx)
ES (3) ES2610277T3 (xx)
FR (1) FR17C1020I2 (xx)
HK (2) HK1146284A1 (xx)
HR (3) HRP20140535T1 (xx)
HU (5) HUE030652T4 (xx)
IL (2) IL208538A (xx)
LT (4) LT3045471T (xx)
MX (3) MX2010011343A (xx)
NO (2) NO2017025I1 (xx)
NZ (1) NZ588381A (xx)
PL (4) PL2268666T3 (xx)
PT (4) PT2808340T (xx)
RU (3) RU2537268C2 (xx)
SA (1) SA109300228B1 (xx)
SI (4) SI3045471T1 (xx)
TW (1) TWI488640B (xx)
WO (1) WO2009127826A1 (xx)
ZA (1) ZA201007373B (xx)

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TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
ES2547233T5 (es) 2010-09-29 2024-03-27 Ferring Bv Composición para su uso en el tratamiento de la esterilidad
WO2012050175A1 (ja) 2010-10-15 2012-04-19 日本ケミカルリサーチ株式会社 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法
US9757469B2 (en) 2011-03-31 2017-09-12 Ferring B.V. Pharmaceutical preparation
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) * 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
AU2012340501A1 (en) * 2011-12-19 2013-07-11 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
WO2013161958A1 (ja) * 2012-04-27 2013-10-31 日本ケミカルリサーチ株式会社 新規な発現ベクター
EP2824176A1 (en) * 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
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EP3237608B1 (en) * 2014-12-22 2019-10-09 F. Hoffmann-La Roche AG Cmp-dependent sialidase activity
DK3662925T3 (da) 2015-04-17 2021-06-28 Ferring Bv Sammensætning, der omfatter fsh, til behandling af infertilitet
RU2719468C2 (ru) 2015-06-26 2020-04-17 Ферринг Б.В. Способы очистки и/или вирусной инактивации
EP3205719A1 (en) * 2016-02-15 2017-08-16 CEVEC Pharmaceuticals GmbH Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
GB201603280D0 (en) 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
EP3382014A1 (en) 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
MX2020002235A (es) 2017-09-01 2020-07-20 Ferring Bv Composicion para la estimulacion ovarica controlada.
TW201945024A (zh) 2018-04-30 2019-12-01 荷蘭商菲林公司 用於經控制之卵巢刺激的組成物
TW202027780A (zh) 2018-10-17 2020-08-01 荷蘭商菲林公司 用於控制性卵巢刺激之組成物及方法
WO2021081670A1 (en) * 2019-11-01 2021-05-06 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
WO2023186331A1 (en) 2022-04-01 2023-10-05 Ferring B.V. Mixed protocol for treatment of infertility
WO2023227761A1 (en) 2022-05-26 2023-11-30 Ferring B.V. Compositions and methods for treatment of infertility in males
WO2024008971A1 (en) 2022-07-08 2024-01-11 Ferring B.V. Compositions and methods for intrauterine insemination (iui)

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TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016575A1 (en) 2010-08-03 2012-02-09 King Saud University Stoma coat
WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
ES2547233T5 (es) 2010-09-29 2024-03-27 Ferring Bv Composición para su uso en el tratamiento de la esterilidad
US9757469B2 (en) 2011-03-31 2017-09-12 Ferring B.V. Pharmaceutical preparation
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
US20170035854A1 (en) 2014-04-18 2017-02-09 Glycotope Gmbh Controlled ovarian hyperstimulation with improved recombinant human follicle-stimulating hormone

Also Published As

Publication number Publication date
SI3045471T1 (sl) 2017-07-31
EP3144318B1 (en) 2020-09-23
US9546204B2 (en) 2017-01-17
US20150065695A1 (en) 2015-03-05
HUS1700024I1 (hu) 2017-06-28
US20110105398A1 (en) 2011-05-05
JP6486310B2 (ja) 2019-03-20
AU2017204259B2 (en) 2017-08-17
PL2808340T3 (pl) 2017-02-28
US20180079794A1 (en) 2018-03-22
FR17C1020I2 (fr) 2020-04-10
HK1199039A1 (en) 2015-06-19
PT3045471T (pt) 2017-06-14
EP2808340A1 (en) 2014-12-03
EP4015527A1 (en) 2022-06-22
HRP20161520T1 (hr) 2016-12-30
IL208538A (en) 2014-03-31
NZ588381A (en) 2012-05-25
LT2808340T (lt) 2016-11-10
US9771407B2 (en) 2017-09-26
RU2537268C2 (ru) 2014-12-27
EP2808340B1 (en) 2016-08-17
IL230571A (en) 2015-11-30
US10995128B2 (en) 2021-05-04
WO2009127826A1 (en) 2009-10-22
US20210332099A1 (en) 2021-10-28
TW200948378A (en) 2009-12-01
BRPI0910461B1 (pt) 2021-02-23
KR20160056960A (ko) 2016-05-20
SI2808340T1 (sl) 2016-12-30
JP2018021037A (ja) 2018-02-08
NO2017025I1 (no) 2017-06-06
US11952407B2 (en) 2024-04-09
AU2017225020A1 (en) 2017-09-28
KR20190092608A (ko) 2019-08-07
ZA201007373B (en) 2011-06-29
PT2268666E (pt) 2014-06-25
DK3045471T3 (en) 2017-06-26
AU2017204258A1 (en) 2017-07-20
RU2014141994A (ru) 2016-05-10
ES2629392T3 (es) 2017-08-09
AU2017225020B2 (en) 2019-11-14
TWI488640B (zh) 2015-06-21
KR20170110741A (ko) 2017-10-11
EP2722339A1 (en) 2014-04-23
RU2745557C3 (ru) 2021-12-10
PT2808340T (pt) 2016-11-21
JP7316905B2 (ja) 2023-07-28
HUE030652T4 (en) 2017-09-28
DK2268666T3 (da) 2014-05-12
PT3144318T (pt) 2020-11-04
CA2725257A1 (en) 2009-10-22
SI2268666T1 (sl) 2014-07-31
JP2020040956A (ja) 2020-03-19
JP2015120696A (ja) 2015-07-02
JP6762916B2 (ja) 2020-09-30
AU2009237479A1 (en) 2009-10-22
RU2014141994A3 (xx) 2018-05-28
LTPA2017018I1 (lt) 2017-06-26
MX355457B (es) 2018-04-19
EP2268666B1 (en) 2014-03-12
EP3098234A1 (en) 2016-11-30
EP3045471A1 (en) 2016-07-20
JP2024038000A (ja) 2024-03-19
CY1115413T1 (el) 2017-01-04
AU2014203277A1 (en) 2014-07-24
RU2745557C1 (ru) 2021-03-29
PL2268666T3 (pl) 2014-08-29
JP2017060476A (ja) 2017-03-30
ES2468318T3 (es) 2014-06-16
JP2022031652A (ja) 2022-02-22
HRP20170958T1 (hr) 2017-09-22
RU2682270C2 (ru) 2019-03-18
AU2014203277B2 (en) 2017-04-06
SA109300228B1 (ar) 2014-04-08
LT3045471T (lt) 2017-07-10
MX348622B (es) 2017-06-22
NO2017050I1 (no) 2017-09-28
EP3045471B1 (en) 2017-03-29
HUE030652T2 (en) 2017-05-29
CN105906702A (zh) 2016-08-31
EP3144318A1 (en) 2017-03-22
KR20110005863A (ko) 2011-01-19
LTPA2017029I1 (lt) 2017-10-10
SI3144318T1 (sl) 2020-12-31
US20160347811A1 (en) 2016-12-01
KR102108377B1 (ko) 2020-05-08
ES2610277T3 (es) 2017-04-26
HRP20140535T1 (hr) 2014-07-18
KR101622944B1 (ko) 2016-05-23
PL3045471T3 (pl) 2017-10-31
BRPI0910461A2 (pt) 2018-03-27
AU2014203277C1 (en) 2017-07-27
AU2009237479B2 (en) 2014-05-15
AR071479A1 (es) 2010-06-23
AU2017204258B2 (en) 2017-08-17
RU2010141908A (ru) 2012-05-27
DK2808340T3 (en) 2016-12-05
US8951967B2 (en) 2015-02-10
MX2010011343A (es) 2011-01-20
JP2011519359A (ja) 2011-07-07
PL3144318T3 (pl) 2021-02-08
CN105906703A (zh) 2016-08-31
EP2268666A1 (en) 2011-01-05
AU2017204259A1 (en) 2017-07-20
HUS1700036I1 (hu) 2017-10-30
IL208538A0 (en) 2010-12-30
CN102066414A (zh) 2011-05-18
FR17C1020I1 (xx) 2020-04-10
HUE033830T2 (en) 2018-01-29
DK3144318T3 (da) 2020-12-07
BRPI0910461B8 (pt) 2021-05-25
HUS1700025I1 (hu) 2017-06-28
BRPI0910461A8 (pt) 2018-10-16
KR20180095140A (ko) 2018-08-24

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