BRPI0910461B8 - hormônio de estimulação do folículo recombinante, sua composição farmacêutica, seu método de produção e seu uso - Google Patents

hormônio de estimulação do folículo recombinante, sua composição farmacêutica, seu método de produção e seu uso

Info

Publication number
BRPI0910461B8
BRPI0910461B8 BRPI0910461A BRPI0910461A BRPI0910461B8 BR PI0910461 B8 BRPI0910461 B8 BR PI0910461B8 BR PI0910461 A BRPI0910461 A BR PI0910461A BR PI0910461 A BRPI0910461 A BR PI0910461A BR PI0910461 B8 BRPI0910461 B8 BR PI0910461B8
Authority
BR
Brazil
Prior art keywords
production method
stimulating hormone
follicle stimulating
pharmaceutical composition
recombinant follicle
Prior art date
Application number
BRPI0910461A
Other languages
English (en)
Inventor
Plaksin Daniel
Cottingham Ian
Boyd White Richard
Original Assignee
Ferring Int Center Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0910461(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Int Center Sa filed Critical Ferring Int Center Sa
Publication of BRPI0910461A2 publication Critical patent/BRPI0910461A2/pt
Publication of BRPI0910461A8 publication Critical patent/BRPI0910461A8/pt
Publication of BRPI0910461B1 publication Critical patent/BRPI0910461B1/pt
Publication of BRPI0910461B8 publication Critical patent/BRPI0910461B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

hormônio de estimulação do folículo (fhs) recombinante incluindo sialilação alfa 2,3 e alfa 2,6, suas preparações e composições farmacêuticas, uso dos mesmos na fabricação de medicamentos, e método de produção do rfsh. a presente invenção refere-se a preparação incluindo fsh recombinante (rfsh).
BRPI0910461A 2008-04-16 2009-04-16 hormônio de estimulação do folículo recombinante, sua composição farmacêutica, seu método de produção e seu uso BRPI0910461B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
US61/045,424 2008-04-16
EP08251528.9 2008-04-25
EP08251528 2008-04-25
PCT/GB2009/000978 WO2009127826A1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation

Publications (4)

Publication Number Publication Date
BRPI0910461A2 BRPI0910461A2 (pt) 2018-03-27
BRPI0910461A8 BRPI0910461A8 (pt) 2018-10-16
BRPI0910461B1 BRPI0910461B1 (pt) 2021-02-23
BRPI0910461B8 true BRPI0910461B8 (pt) 2021-05-25

Family

ID=39717519

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0910461A BRPI0910461B8 (pt) 2008-04-16 2009-04-16 hormônio de estimulação do folículo recombinante, sua composição farmacêutica, seu método de produção e seu uso

Country Status (29)

Country Link
US (5) US8951967B2 (pt)
EP (7) EP3045471B1 (pt)
JP (7) JP2011519359A (pt)
KR (5) KR20180095140A (pt)
CN (3) CN102066414A (pt)
AR (1) AR071479A1 (pt)
AU (5) AU2009237479B2 (pt)
BR (1) BRPI0910461B8 (pt)
CA (1) CA2725257A1 (pt)
CY (1) CY1115413T1 (pt)
DK (4) DK3144318T3 (pt)
ES (3) ES2610277T3 (pt)
FR (1) FR17C1020I2 (pt)
HK (2) HK1146284A1 (pt)
HR (3) HRP20140535T1 (pt)
HU (5) HUE030652T4 (pt)
IL (2) IL208538A (pt)
LT (4) LT3045471T (pt)
MX (3) MX2010011343A (pt)
NO (2) NO2017025I1 (pt)
NZ (1) NZ588381A (pt)
PL (4) PL2268666T3 (pt)
PT (4) PT2808340T (pt)
RU (3) RU2537268C2 (pt)
SA (1) SA109300228B1 (pt)
SI (4) SI3045471T1 (pt)
TW (1) TWI488640B (pt)
WO (1) WO2009127826A1 (pt)
ZA (1) ZA201007373B (pt)

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TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
ES2547233T5 (es) 2010-09-29 2024-03-27 Ferring Bv Composición para su uso en el tratamiento de la esterilidad
WO2012050175A1 (ja) 2010-10-15 2012-04-19 日本ケミカルリサーチ株式会社 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法
US9757469B2 (en) 2011-03-31 2017-09-12 Ferring B.V. Pharmaceutical preparation
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
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DK3662925T3 (da) 2015-04-17 2021-06-28 Ferring Bv Sammensætning, der omfatter fsh, til behandling af infertilitet
RU2719468C2 (ru) 2015-06-26 2020-04-17 Ферринг Б.В. Способы очистки и/или вирусной инактивации
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EP3382014A1 (en) 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
MX2020002235A (es) 2017-09-01 2020-07-20 Ferring Bv Composicion para la estimulacion ovarica controlada.
TW201945024A (zh) 2018-04-30 2019-12-01 荷蘭商菲林公司 用於經控制之卵巢刺激的組成物
TW202027780A (zh) 2018-10-17 2020-08-01 荷蘭商菲林公司 用於控制性卵巢刺激之組成物及方法
WO2021081670A1 (en) * 2019-11-01 2021-05-06 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
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WO2023227761A1 (en) 2022-05-26 2023-11-30 Ferring B.V. Compositions and methods for treatment of infertility in males
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ES2547233T5 (es) 2010-09-29 2024-03-27 Ferring Bv Composición para su uso en el tratamiento de la esterilidad
US9757469B2 (en) 2011-03-31 2017-09-12 Ferring B.V. Pharmaceutical preparation
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
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Publication number Publication date
SI3045471T1 (sl) 2017-07-31
EP3144318B1 (en) 2020-09-23
US9546204B2 (en) 2017-01-17
US20150065695A1 (en) 2015-03-05
HUS1700024I1 (hu) 2017-06-28
US20110105398A1 (en) 2011-05-05
JP6486310B2 (ja) 2019-03-20
AU2017204259B2 (en) 2017-08-17
PL2808340T3 (pl) 2017-02-28
US20180079794A1 (en) 2018-03-22
FR17C1020I2 (fr) 2020-04-10
HK1199039A1 (en) 2015-06-19
PT3045471T (pt) 2017-06-14
EP2808340A1 (en) 2014-12-03
EP4015527A1 (en) 2022-06-22
HRP20161520T1 (hr) 2016-12-30
IL208538A (en) 2014-03-31
NZ588381A (en) 2012-05-25
LT2808340T (lt) 2016-11-10
US9771407B2 (en) 2017-09-26
RU2537268C2 (ru) 2014-12-27
EP2808340B1 (en) 2016-08-17
IL230571A (en) 2015-11-30
US10995128B2 (en) 2021-05-04
WO2009127826A1 (en) 2009-10-22
US20210332099A1 (en) 2021-10-28
TW200948378A (en) 2009-12-01
BRPI0910461B1 (pt) 2021-02-23
KR20160056960A (ko) 2016-05-20
SI2808340T1 (sl) 2016-12-30
JP2018021037A (ja) 2018-02-08
NO2017025I1 (no) 2017-06-06
US11952407B2 (en) 2024-04-09
AU2017225020A1 (en) 2017-09-28
KR20190092608A (ko) 2019-08-07
ZA201007373B (en) 2011-06-29
PT2268666E (pt) 2014-06-25
DK3045471T3 (en) 2017-06-26
AU2017204258A1 (en) 2017-07-20
RU2014141994A (ru) 2016-05-10
ES2629392T3 (es) 2017-08-09
AU2017225020B2 (en) 2019-11-14
TWI488640B (zh) 2015-06-21
KR20170110741A (ko) 2017-10-11
EP2722339A1 (en) 2014-04-23
RU2745557C3 (ru) 2021-12-10
PT2808340T (pt) 2016-11-21
JP7316905B2 (ja) 2023-07-28
HUE030652T4 (en) 2017-09-28
DK2268666T3 (da) 2014-05-12
PT3144318T (pt) 2020-11-04
CA2725257A1 (en) 2009-10-22
SI2268666T1 (sl) 2014-07-31
JP2020040956A (ja) 2020-03-19
JP2015120696A (ja) 2015-07-02
JP6762916B2 (ja) 2020-09-30
AU2009237479A1 (en) 2009-10-22
RU2014141994A3 (pt) 2018-05-28
LTPA2017018I1 (lt) 2017-06-26
MX355457B (es) 2018-04-19
EP2268666B1 (en) 2014-03-12
EP3098234A1 (en) 2016-11-30
EP3045471A1 (en) 2016-07-20
JP2024038000A (ja) 2024-03-19
CY1115413T1 (el) 2017-01-04
AU2014203277A1 (en) 2014-07-24
RU2745557C1 (ru) 2021-03-29
PL2268666T3 (pl) 2014-08-29
JP2017060476A (ja) 2017-03-30
ES2468318T3 (es) 2014-06-16
JP2022031652A (ja) 2022-02-22
HRP20170958T1 (hr) 2017-09-22
RU2682270C2 (ru) 2019-03-18
AU2014203277B2 (en) 2017-04-06
SA109300228B1 (ar) 2014-04-08
LT3045471T (lt) 2017-07-10
MX348622B (es) 2017-06-22
NO2017050I1 (no) 2017-09-28
HK1146284A1 (en) 2011-05-20
EP3045471B1 (en) 2017-03-29
HUE030652T2 (en) 2017-05-29
CN105906702A (zh) 2016-08-31
EP3144318A1 (en) 2017-03-22
KR20110005863A (ko) 2011-01-19
LTPA2017029I1 (lt) 2017-10-10
SI3144318T1 (sl) 2020-12-31
US20160347811A1 (en) 2016-12-01
KR102108377B1 (ko) 2020-05-08
ES2610277T3 (es) 2017-04-26
HRP20140535T1 (hr) 2014-07-18
KR101622944B1 (ko) 2016-05-23
PL3045471T3 (pl) 2017-10-31
BRPI0910461A2 (pt) 2018-03-27
AU2014203277C1 (en) 2017-07-27
AU2009237479B2 (en) 2014-05-15
AR071479A1 (es) 2010-06-23
AU2017204258B2 (en) 2017-08-17
RU2010141908A (ru) 2012-05-27
DK2808340T3 (en) 2016-12-05
US8951967B2 (en) 2015-02-10
MX2010011343A (es) 2011-01-20
JP2011519359A (ja) 2011-07-07
PL3144318T3 (pl) 2021-02-08
CN105906703A (zh) 2016-08-31
EP2268666A1 (en) 2011-01-05
AU2017204259A1 (en) 2017-07-20
HUS1700036I1 (hu) 2017-10-30
IL208538A0 (en) 2010-12-30
CN102066414A (zh) 2011-05-18
FR17C1020I1 (pt) 2020-04-10
HUE033830T2 (en) 2018-01-29
DK3144318T3 (da) 2020-12-07
HUS1700025I1 (hu) 2017-06-28
BRPI0910461A8 (pt) 2018-10-16
KR20180095140A (ko) 2018-08-24

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