PT3144318T - Fsh recombinante incluindo sialilação alfa 2,3 e alfa 2,6 - Google Patents

Fsh recombinante incluindo sialilação alfa 2,3 e alfa 2,6

Info

Publication number
PT3144318T
PT3144318T PT161949250T PT16194925T PT3144318T PT 3144318 T PT3144318 T PT 3144318T PT 161949250 T PT161949250 T PT 161949250T PT 16194925 T PT16194925 T PT 16194925T PT 3144318 T PT3144318 T PT 3144318T
Authority
PT
Portugal
Prior art keywords
alpha
sialylation
recombinant fsh
fsh including
including alpha
Prior art date
Application number
PT161949250T
Other languages
English (en)
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3144318(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of PT3144318T publication Critical patent/PT3144318T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT161949250T 2008-04-25 2009-04-16 Fsh recombinante incluindo sialilação alfa 2,3 e alfa 2,6 PT3144318T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08251528 2008-04-25

Publications (1)

Publication Number Publication Date
PT3144318T true PT3144318T (pt) 2020-11-04

Family

ID=39717519

Family Applications (4)

Application Number Title Priority Date Filing Date
PT161949250T PT3144318T (pt) 2008-04-25 2009-04-16 Fsh recombinante incluindo sialilação alfa 2,3 e alfa 2,6
PT97334973T PT2268666E (pt) 2008-04-16 2009-04-16 Recombinante fsh incluindo sialilação alfa 2,3 e alfa 2,6
PT161581418T PT3045471T (pt) 2008-04-16 2009-04-16 Resumo
PT141787291T PT2808340T (pt) 2008-04-16 2009-04-16 Resumo

Family Applications After (3)

Application Number Title Priority Date Filing Date
PT97334973T PT2268666E (pt) 2008-04-16 2009-04-16 Recombinante fsh incluindo sialilação alfa 2,3 e alfa 2,6
PT161581418T PT3045471T (pt) 2008-04-16 2009-04-16 Resumo
PT141787291T PT2808340T (pt) 2008-04-16 2009-04-16 Resumo

Country Status (29)

Country Link
US (5) US8951967B2 (pt)
EP (7) EP2808340B1 (pt)
JP (7) JP2011519359A (pt)
KR (5) KR20160056960A (pt)
CN (3) CN105906702A (pt)
AR (1) AR071479A1 (pt)
AU (5) AU2009237479B2 (pt)
BR (1) BRPI0910461B8 (pt)
CA (1) CA2725257A1 (pt)
CY (1) CY1115413T1 (pt)
DK (4) DK3144318T3 (pt)
ES (3) ES2610277T3 (pt)
FR (1) FR17C1020I2 (pt)
HK (2) HK1146284A1 (pt)
HR (3) HRP20140535T1 (pt)
HU (5) HUE033830T2 (pt)
IL (2) IL208538A (pt)
LT (4) LT3045471T (pt)
MX (3) MX2010011343A (pt)
NO (2) NO2017025I1 (pt)
NZ (1) NZ588381A (pt)
PL (4) PL3144318T3 (pt)
PT (4) PT3144318T (pt)
RU (3) RU2537268C2 (pt)
SA (1) SA109300228B1 (pt)
SI (4) SI2268666T1 (pt)
TW (1) TWI488640B (pt)
WO (1) WO2009127826A1 (pt)
ZA (1) ZA201007373B (pt)

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Publication number Priority date Publication date Assignee Title
TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
HUE025514T2 (en) 2010-09-29 2016-02-29 Ferring Bv Preparation for use in treating infertility
US20130224797A1 (en) 2010-10-15 2013-08-29 Jcr Pharmaceuticals Co., Ltd. Method for producing glycoprotein having mannose residue as non-reducing end of sugar chain
JP6087338B2 (ja) * 2011-03-31 2017-03-01 フェリング ベスローテン フェンノートシャップ 医薬製剤
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
AU2012340501A1 (en) * 2011-12-19 2013-07-11 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
US9657310B2 (en) * 2012-04-27 2017-05-23 Jcr Pharmaceuticals Co., Ltd. Expression vector
EP2824176A1 (en) * 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
JP6652334B2 (ja) * 2014-05-31 2020-02-19 Ｊｃｒファーマ株式会社 ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地
JP2018500934A (ja) * 2014-12-22 2018-01-18 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｃｍｐ依存性シアリダーゼ活性
WO2016166288A1 (en) 2015-04-17 2016-10-20 Ferring B.V. Composition for treatment of infertility
AU2016282916B2 (en) 2015-06-26 2022-01-20 Ferring B.V. Methods of purification and/or viral inactivation
EP3205719A1 (en) * 2016-02-15 2017-08-16 CEVEC Pharmaceuticals GmbH Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
GB201603280D0 (en) 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
EP3382014A1 (en) * 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
CN111050787A (zh) 2017-09-01 2020-04-21 辉凌公司 用于受控的卵巢刺激的组合物
CN112088011A (zh) 2018-04-30 2020-12-15 辉凌公司 用于受控的卵巢刺激的组合物
TW202027780A (zh) 2018-10-17 2020-08-01 荷蘭商菲林公司 用於控制性卵巢刺激之組成物及方法
WO2021081670A1 (en) * 2019-11-01 2021-05-06 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
WO2023186331A1 (en) 2022-04-01 2023-10-05 Ferring B.V. Mixed protocol for treatment of infertility
WO2023227761A1 (en) 2022-05-26 2023-11-30 Ferring B.V. Compositions and methods for treatment of infertility in males
WO2024008971A1 (en) 2022-07-08 2024-01-11 Ferring B.V. Compositions and methods for intrauterine insemination (iui)

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IT1206302B (it) 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
US5541083A (en) 1989-10-24 1996-07-30 The Regents Of The University Of California Method for producing secretable glycosyltransferases and other golgi processing enzymes
EP0833934B2 (en) 1995-06-15 2012-08-15 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
JP3559652B2 (ja) * 1996-06-25 2004-09-02 グローリー工業株式会社 売上精算システムの管理装置
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
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JPH1111665A (ja) 1997-06-28 1999-01-19 Shibuya Kogyo Co Ltd 無菌エア搬送コンベヤ装置
TWI235158B (en) * 1997-09-01 2005-07-01 Kirin Brewery Human thrombopoietin produced by human established cell lines, processes foe preparing the same, and pharmaceutical composition comprising the same
BR0010709B1 (pt) 1999-05-07 2011-11-29 uso de lh para a produção de um medicamento para induzir a paucifoliculogênese ou unifoliculogênese em mulheres anovulatórias.
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US8609370B2 (en) * 2004-02-13 2013-12-17 Glycotope Gmbh Highly active glycoproteins-process conditions and an efficient method for their production
TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
TWI532495B (zh) * 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
US8790322B2 (en) 2010-08-03 2014-07-29 King Saud University Stoma coat
WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
HUE025514T2 (en) 2010-09-29 2016-02-29 Ferring Bv Preparation for use in treating infertility
JP6087338B2 (ja) 2011-03-31 2017-03-01 フェリング ベスローテン フェンノートシャップ 医薬製剤
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
SG11201608132UA (en) 2014-04-18 2016-11-29 Glycotope Gmbh Controlled ovarian hyperstimulation with improved recombinant human follicle-stimulating hormone

Also Published As

Publication number Publication date
RU2010141908A (ru) 2012-05-27
PL3045471T3 (pl) 2017-10-31
RU2014141994A (ru) 2016-05-10
US10995128B2 (en) 2021-05-04
EP3098234A1 (en) 2016-11-30
KR20180095140A (ko) 2018-08-24
MX348622B (es) 2017-06-22
BRPI0910461A2 (pt) 2018-03-27
AU2014203277A1 (en) 2014-07-24
ES2629392T3 (es) 2017-08-09
HUS1700036I1 (hu) 2017-10-30
FR17C1020I2 (fr) 2020-04-10
DK3144318T3 (da) 2020-12-07
KR101622944B1 (ko) 2016-05-23
SI2808340T1 (sl) 2016-12-30
EP3144318B1 (en) 2020-09-23
AU2009237479B2 (en) 2014-05-15
RU2014141994A3 (pt) 2018-05-28
FR17C1020I1 (pt) 2020-04-10
HUE033830T2 (en) 2018-01-29
BRPI0910461A8 (pt) 2018-10-16
HRP20161520T1 (hr) 2016-12-30
PL2268666T3 (pl) 2014-08-29
US11952407B2 (en) 2024-04-09
IL208538A (en) 2014-03-31
ZA201007373B (en) 2011-06-29
AU2017225020A1 (en) 2017-09-28
AU2017204258A1 (en) 2017-07-20
TW200948378A (en) 2009-12-01
HUE030652T2 (en) 2017-05-29
KR20160056960A (ko) 2016-05-20
RU2537268C2 (ru) 2014-12-27
PT3045471T (pt) 2017-06-14
US20160347811A1 (en) 2016-12-01
NO2017050I1 (no) 2017-09-28
JP2011519359A (ja) 2011-07-07
PL3144318T3 (pl) 2021-02-08
AU2017204258B2 (en) 2017-08-17
EP2808340B1 (en) 2016-08-17
EP2268666B1 (en) 2014-03-12
AR071479A1 (es) 2010-06-23
HUE030652T4 (en) 2017-09-28
JP6486310B2 (ja) 2019-03-20
KR20110005863A (ko) 2011-01-19
IL230571A (en) 2015-11-30
RU2682270C2 (ru) 2019-03-18
KR102108377B1 (ko) 2020-05-08
TWI488640B (zh) 2015-06-21
KR20170110741A (ko) 2017-10-11
EP2808340A1 (en) 2014-12-03
US8951967B2 (en) 2015-02-10
US20150065695A1 (en) 2015-03-05
AU2017225020B2 (en) 2019-11-14
JP6762916B2 (ja) 2020-09-30
SI3045471T1 (sl) 2017-07-31
MX355457B (es) 2018-04-19
BRPI0910461B8 (pt) 2021-05-25
HK1146284A1 (en) 2011-05-20
MX2010011343A (es) 2011-01-20
CY1115413T1 (el) 2017-01-04
DK3045471T3 (en) 2017-06-26
LTPA2017029I1 (lt) 2017-10-10
LTPA2017018I1 (lt) 2017-06-26
NO2017025I1 (no) 2017-06-06
AU2017204259A1 (en) 2017-07-20
US20110105398A1 (en) 2011-05-05
PT2808340T (pt) 2016-11-21
AU2009237479A1 (en) 2009-10-22
ES2468318T3 (es) 2014-06-16
US9546204B2 (en) 2017-01-17
BRPI0910461B1 (pt) 2021-02-23
EP2268666A1 (en) 2011-01-05
DK2268666T3 (da) 2014-05-12
HUS1700025I1 (hu) 2017-06-28
CN105906703A (zh) 2016-08-31
DK2808340T3 (en) 2016-12-05
EP4015527A1 (en) 2022-06-22
HK1199039A1 (en) 2015-06-19
US20180079794A1 (en) 2018-03-22
US9771407B2 (en) 2017-09-26
SI2268666T1 (sl) 2014-07-31
CN102066414A (zh) 2011-05-18
SI3144318T1 (sl) 2020-12-31
EP2722339A1 (en) 2014-04-23
EP3045471A1 (en) 2016-07-20
WO2009127826A1 (en) 2009-10-22
JP2018021037A (ja) 2018-02-08
CN105906702A (zh) 2016-08-31
LT3045471T (lt) 2017-07-10
HRP20170958T1 (hr) 2017-09-22
JP2017060476A (ja) 2017-03-30
HUS1700024I1 (hu) 2017-06-28
JP7316905B2 (ja) 2023-07-28
CA2725257A1 (en) 2009-10-22
JP2024038000A (ja) 2024-03-19
IL208538A0 (en) 2010-12-30
JP2015120696A (ja) 2015-07-02
EP3045471B1 (en) 2017-03-29
EP3144318A1 (en) 2017-03-22
JP2022031652A (ja) 2022-02-22
PL2808340T3 (pl) 2017-02-28
LT2808340T (lt) 2016-11-10
RU2745557C1 (ru) 2021-03-29
AU2017204259B2 (en) 2017-08-17
ES2610277T3 (es) 2017-04-26
HRP20140535T1 (hr) 2014-07-18
PT2268666E (pt) 2014-06-25
SA109300228B1 (ar) 2014-04-08
US20210332099A1 (en) 2021-10-28
RU2745557C3 (ru) 2021-12-10
NZ588381A (en) 2012-05-25
AU2014203277C1 (en) 2017-07-27
KR20190092608A (ko) 2019-08-07
AU2014203277B2 (en) 2017-04-06
JP2020040956A (ja) 2020-03-19

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GB0807658D0 (en) Sebaforce 2
GB0808845D0 (en) 10000003
GB0808846D0 (en) 10000002
GB0808847D0 (en) 10000001
GB0808958D0 (en) 10000004