MX348622B - Fsh recombinante que inlcuye alfa 2,3- y alfa 2,6-sialilacion. - Google Patents

Fsh recombinante que inlcuye alfa 2,3- y alfa 2,6-sialilacion.

Info

Publication number
MX348622B
MX348622B MX2014011348A MX2014011348A MX348622B MX 348622 B MX348622 B MX 348622B MX 2014011348 A MX2014011348 A MX 2014011348A MX 2014011348 A MX2014011348 A MX 2014011348A MX 348622 B MX348622 B MX 348622B
Authority
MX
Mexico
Prior art keywords
alpha
sialylation
recombinant fsh
fsh including
including alpha
Prior art date
Application number
MX2014011348A
Other languages
English (en)
Inventor
Ian Cottingham
Daniel Plaksin
Richard Boyd White
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX348622(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of MX348622B publication Critical patent/MX348622B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La presente invención se refiere a preparaciones que comprenden la FSH (FSH) recombinante. Una hormona estimuladora de folículo (FSH) recombinante caracterizada porque comprende sialilación a2,3- y sialilación a2,6-, en donde de 20% a 60% de la sialilación total es sialilación a2,3-.
MX2014011348A 2008-04-16 2009-04-16 Fsh recombinante que inlcuye alfa 2,3- y alfa 2,6-sialilacion. MX348622B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
EP08251528 2008-04-25
PCT/GB2009/000978 WO2009127826A1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation

Publications (1)

Publication Number Publication Date
MX348622B true MX348622B (es) 2017-06-22

Family

ID=39717519

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2017007881A MX355457B (es) 2008-04-16 2009-04-16 Fsh recombinante que incluye alfa, 2-3- y alfa 2,6-sialilacion.
MX2014011348A MX348622B (es) 2008-04-16 2009-04-16 Fsh recombinante que inlcuye alfa 2,3- y alfa 2,6-sialilacion.
MX2010011343A MX2010011343A (es) 2008-04-16 2009-04-16 Fsh recombinante que inlcuye alfa 2,3- y alfa 2,6-sialilacion.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017007881A MX355457B (es) 2008-04-16 2009-04-16 Fsh recombinante que incluye alfa, 2-3- y alfa 2,6-sialilacion.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2010011343A MX2010011343A (es) 2008-04-16 2009-04-16 Fsh recombinante que inlcuye alfa 2,3- y alfa 2,6-sialilacion.

Country Status (28)

Country Link
US (5) US8951967B2 (es)
EP (7) EP3098234A1 (es)
JP (7) JP2011519359A (es)
KR (5) KR20180095140A (es)
CN (3) CN102066414A (es)
AR (1) AR071479A1 (es)
AU (5) AU2009237479B2 (es)
BR (1) BRPI0910461B8 (es)
CA (1) CA2725257A1 (es)
CY (1) CY1115413T1 (es)
DK (4) DK2808340T3 (es)
ES (3) ES2610277T3 (es)
HK (2) HK1146284A1 (es)
HR (3) HRP20140535T1 (es)
HU (5) HUE030652T4 (es)
IL (2) IL208538A (es)
LT (4) LT2808340T (es)
MX (3) MX355457B (es)
NO (2) NO2017025I1 (es)
NZ (1) NZ588381A (es)
PL (4) PL3045471T3 (es)
PT (4) PT2268666E (es)
RU (3) RU2537268C2 (es)
SA (1) SA109300228B1 (es)
SI (4) SI3144318T1 (es)
TW (1) TWI488640B (es)
WO (1) WO2009127826A1 (es)
ZA (1) ZA201007373B (es)

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TWI532495B (zh) * 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
SI2621517T2 (sl) 2010-09-29 2023-11-30 Ferring B.V. Sestavek za uporabo pri zdravljenju neplodnosti
US20130224797A1 (en) 2010-10-15 2013-08-29 Jcr Pharmaceuticals Co., Ltd. Method for producing glycoprotein having mannose residue as non-reducing end of sugar chain
JP6087338B2 (ja) * 2011-03-31 2017-03-01 フェリング ベスローテン フェンノートシャップ 医薬製剤
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) * 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
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WO2013161958A1 (ja) * 2012-04-27 2013-10-31 日本ケミカルリサーチ株式会社 新規な発現ベクター
EP2824176A1 (en) * 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
JP6652334B2 (ja) 2014-05-31 2020-02-19 Ｊｃｒファーマ株式会社 ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地
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GB201603280D0 (en) 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
EP3382014A1 (en) 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
AU2018326556A1 (en) 2017-09-01 2020-03-05 Ferring B.V. Composition for controlled ovarian stimulation
CN112088011A (zh) 2018-04-30 2020-12-15 辉凌公司 用于受控的卵巢刺激的组合物
TW202027780A (zh) 2018-10-17 2020-08-01 荷蘭商菲林公司 用於控制性卵巢刺激之組成物及方法
US20220380785A1 (en) * 2019-11-01 2022-12-01 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
WO2023186331A1 (en) 2022-04-01 2023-10-05 Ferring B.V. Mixed protocol for treatment of infertility
WO2023227761A1 (en) 2022-05-26 2023-11-30 Ferring B.V. Compositions and methods for treatment of infertility in males
WO2024008971A1 (en) 2022-07-08 2024-01-11 Ferring B.V. Compositions and methods for intrauterine insemination (iui)

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JP6087338B2 (ja) 2011-03-31 2017-03-01 フェリング ベスローテン フェンノートシャップ 医薬製剤
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
JP2017513853A (ja) 2014-04-18 2017-06-01 グリコトープ ゲーエムベーハー 改良された組換えヒト卵胞刺激ホルモンを用いた制御された卵巣過剰刺激

Also Published As

Publication number Publication date
US9771407B2 (en) 2017-09-26
LTPA2017018I1 (lt) 2017-06-26
CN102066414A (zh) 2011-05-18
KR20190092608A (ko) 2019-08-07
SI3045471T1 (sl) 2017-07-31
AU2017204259A1 (en) 2017-07-20
EP3045471B1 (en) 2017-03-29
RU2010141908A (ru) 2012-05-27
EP3144318A1 (en) 2017-03-22
PL2268666T3 (pl) 2014-08-29
HK1199039A1 (en) 2015-06-19
KR20110005863A (ko) 2011-01-19
TWI488640B (zh) 2015-06-21
US20110105398A1 (en) 2011-05-05
US20210332099A1 (en) 2021-10-28
AU2017204259B2 (en) 2017-08-17
JP2022031652A (ja) 2022-02-22
AR071479A1 (es) 2010-06-23
AU2014203277B2 (en) 2017-04-06
CN105906703A (zh) 2016-08-31
SI2268666T1 (sl) 2014-07-31
NZ588381A (en) 2012-05-25
HUE030652T2 (en) 2017-05-29
JP2011519359A (ja) 2011-07-07
HRP20170958T1 (hr) 2017-09-22
PT3045471T (pt) 2017-06-14
RU2745557C1 (ru) 2021-03-29
HK1146284A1 (en) 2011-05-20
MX2010011343A (es) 2011-01-20
SI3144318T1 (sl) 2020-12-31
HUE033830T2 (en) 2018-01-29
AU2009237479B2 (en) 2014-05-15
MX355457B (es) 2018-04-19
AU2017225020A1 (en) 2017-09-28
AU2017204258A1 (en) 2017-07-20
US20180079794A1 (en) 2018-03-22
LT2808340T (lt) 2016-11-10
KR20170110741A (ko) 2017-10-11
CA2725257A1 (en) 2009-10-22
KR101622944B1 (ko) 2016-05-23
RU2014141994A (ru) 2016-05-10
JP2018021037A (ja) 2018-02-08
PL3144318T3 (pl) 2021-02-08
IL208538A (en) 2014-03-31
JP2024038000A (ja) 2024-03-19
KR102108377B1 (ko) 2020-05-08
PT2268666E (pt) 2014-06-25
JP7316905B2 (ja) 2023-07-28
US10995128B2 (en) 2021-05-04
ES2629392T3 (es) 2017-08-09
JP2020040956A (ja) 2020-03-19
KR20180095140A (ko) 2018-08-24
DK3144318T3 (da) 2020-12-07
AU2017225020B2 (en) 2019-11-14
EP3144318B1 (en) 2020-09-23
RU2682270C2 (ru) 2019-03-18
JP6762916B2 (ja) 2020-09-30
RU2014141994A3 (es) 2018-05-28
EP2808340A1 (en) 2014-12-03
HUS1700025I1 (hu) 2017-06-28
BRPI0910461B8 (pt) 2021-05-25
AU2014203277C1 (en) 2017-07-27
HRP20161520T1 (hr) 2016-12-30
SI2808340T1 (sl) 2016-12-30
RU2745557C3 (ru) 2021-12-10
PT2808340T (pt) 2016-11-21
US11952407B2 (en) 2024-04-09
US9546204B2 (en) 2017-01-17
DK2808340T3 (en) 2016-12-05
BRPI0910461A2 (pt) 2018-03-27
JP2015120696A (ja) 2015-07-02
ES2468318T3 (es) 2014-06-16
EP2268666B1 (en) 2014-03-12
BRPI0910461B1 (pt) 2021-02-23
IL208538A0 (en) 2010-12-30
EP2808340B1 (en) 2016-08-17
WO2009127826A1 (en) 2009-10-22
TW200948378A (en) 2009-12-01
IL230571A (en) 2015-11-30
EP4015527A1 (en) 2022-06-22
ES2610277T3 (es) 2017-04-26
HRP20140535T1 (hr) 2014-07-18
PL2808340T3 (pl) 2017-02-28
PT3144318T (pt) 2020-11-04
EP2722339A1 (en) 2014-04-23
EP2268666A1 (en) 2011-01-05
AU2017204258B2 (en) 2017-08-17
US20160347811A1 (en) 2016-12-01
DK2268666T3 (da) 2014-05-12
DK3045471T3 (en) 2017-06-26
RU2537268C2 (ru) 2014-12-27
AU2014203277A1 (en) 2014-07-24
JP2017060476A (ja) 2017-03-30
US8951967B2 (en) 2015-02-10
SA109300228B1 (ar) 2014-04-08
AU2009237479A1 (en) 2009-10-22
CN105906702A (zh) 2016-08-31
HUE030652T4 (en) 2017-09-28
CY1115413T1 (el) 2017-01-04
HUS1700036I1 (hu) 2017-10-30
NO2017025I1 (no) 2017-06-06
ZA201007373B (en) 2011-06-29
NO2017050I1 (no) 2017-09-28
EP3098234A1 (en) 2016-11-30
KR20160056960A (ko) 2016-05-20
PL3045471T3 (pl) 2017-10-31
HUS1700024I1 (hu) 2017-06-28
BRPI0910461A8 (pt) 2018-10-16
LT3045471T (lt) 2017-07-10
JP6486310B2 (ja) 2019-03-20
EP3045471A1 (en) 2016-07-20
LTPA2017029I1 (lt) 2017-10-10
US20150065695A1 (en) 2015-03-05

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