PT2268666E - Recombinante fsh incluindo sialilação alfa 2,3 e alfa 2,6 - Google Patents

Recombinante fsh incluindo sialilação alfa 2,3 e alfa 2,6 Download PDF

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Publication number
PT2268666E
PT2268666E PT97334973T PT09733497T PT2268666E PT 2268666 E PT2268666 E PT 2268666E PT 97334973 T PT97334973 T PT 97334973T PT 09733497 T PT09733497 T PT 09733497T PT 2268666 E PT2268666 E PT 2268666E
Authority
PT
Portugal
Prior art keywords
alpha
sialylation
recombinant fsh
fsh including
including alpha
Prior art date
Application number
PT97334973T
Other languages
English (en)
Inventor
Ian Cottingham
Daniel Plaksin
Richard Boyd White
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2268666(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of PT2268666E publication Critical patent/PT2268666E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
PT97334973T 2008-04-16 2009-04-16 Recombinante fsh incluindo sialilação alfa 2,3 e alfa 2,6 PT2268666E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
EP08251528 2008-04-25

Publications (1)

Publication Number Publication Date
PT2268666E true PT2268666E (pt) 2014-06-25

Family

ID=39717519

Family Applications (4)

Application Number Title Priority Date Filing Date
PT97334973T PT2268666E (pt) 2008-04-16 2009-04-16 Recombinante fsh incluindo sialilação alfa 2,3 e alfa 2,6
PT141787291T PT2808340T (pt) 2008-04-16 2009-04-16 Resumo
PT161581418T PT3045471T (pt) 2008-04-16 2009-04-16 Resumo
PT161949250T PT3144318T (pt) 2008-04-25 2009-04-16 Fsh recombinante incluindo sialilação alfa 2,3 e alfa 2,6

Family Applications After (3)

Application Number Title Priority Date Filing Date
PT141787291T PT2808340T (pt) 2008-04-16 2009-04-16 Resumo
PT161581418T PT3045471T (pt) 2008-04-16 2009-04-16 Resumo
PT161949250T PT3144318T (pt) 2008-04-25 2009-04-16 Fsh recombinante incluindo sialilação alfa 2,3 e alfa 2,6

Country Status (28)

Country Link
US (5) US8951967B2 (pt)
EP (7) EP3098234A1 (pt)
JP (7) JP2011519359A (pt)
KR (5) KR20180095140A (pt)
CN (3) CN102066414A (pt)
AR (1) AR071479A1 (pt)
AU (5) AU2009237479B2 (pt)
BR (1) BRPI0910461B8 (pt)
CA (1) CA2725257A1 (pt)
CY (1) CY1115413T1 (pt)
DK (4) DK2808340T3 (pt)
ES (3) ES2610277T3 (pt)
HK (2) HK1146284A1 (pt)
HR (3) HRP20140535T1 (pt)
HU (5) HUE030652T4 (pt)
IL (2) IL208538A (pt)
LT (4) LT2808340T (pt)
MX (3) MX355457B (pt)
NO (2) NO2017025I1 (pt)
NZ (1) NZ588381A (pt)
PL (4) PL3045471T3 (pt)
PT (4) PT2268666E (pt)
RU (3) RU2537268C2 (pt)
SA (1) SA109300228B1 (pt)
SI (4) SI3144318T1 (pt)
TW (1) TWI488640B (pt)
WO (1) WO2009127826A1 (pt)
ZA (1) ZA201007373B (pt)

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TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
TWI532495B (zh) * 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
SI2621517T2 (sl) 2010-09-29 2023-11-30 Ferring B.V. Sestavek za uporabo pri zdravljenju neplodnosti
US20130224797A1 (en) 2010-10-15 2013-08-29 Jcr Pharmaceuticals Co., Ltd. Method for producing glycoprotein having mannose residue as non-reducing end of sugar chain
JP6087338B2 (ja) * 2011-03-31 2017-03-01 フェリング ベスローテン フェンノートシャップ 医薬製剤
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) * 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
AU2012340501A1 (en) * 2011-12-19 2013-07-11 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
WO2013161958A1 (ja) * 2012-04-27 2013-10-31 日本ケミカルリサーチ株式会社 新規な発現ベクター
EP2824176A1 (en) * 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
JP6652334B2 (ja) 2014-05-31 2020-02-19 Ｊｃｒファーマ株式会社 ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地
CN107429237B (zh) * 2014-12-22 2021-09-28 豪夫迈·罗氏有限公司 Cmp依赖性的唾液酸酶活性
DK3662925T3 (da) 2015-04-17 2021-06-28 Ferring Bv Sammensætning, der omfatter fsh, til behandling af infertilitet
EP3628675A1 (en) 2015-06-26 2020-04-01 Ferring B.V. Methods of purification and/or viral inactivation
EP3205719A1 (en) * 2016-02-15 2017-08-16 CEVEC Pharmaceuticals GmbH Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
GB201603280D0 (en) 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
EP3382014A1 (en) 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
AU2018326556A1 (en) 2017-09-01 2020-03-05 Ferring B.V. Composition for controlled ovarian stimulation
CN112088011A (zh) 2018-04-30 2020-12-15 辉凌公司 用于受控的卵巢刺激的组合物
TW202027780A (zh) 2018-10-17 2020-08-01 荷蘭商菲林公司 用於控制性卵巢刺激之組成物及方法
US20220380785A1 (en) * 2019-11-01 2022-12-01 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
WO2023186331A1 (en) 2022-04-01 2023-10-05 Ferring B.V. Mixed protocol for treatment of infertility
WO2023227761A1 (en) 2022-05-26 2023-11-30 Ferring B.V. Compositions and methods for treatment of infertility in males
WO2024008971A1 (en) 2022-07-08 2024-01-11 Ferring B.V. Compositions and methods for intrauterine insemination (iui)

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US5541083A (en) 1989-10-24 1996-07-30 The Regents Of The University Of California Method for producing secretable glycosyltransferases and other golgi processing enzymes
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JP3559652B2 (ja) * 1996-06-25 2004-09-02 グローリー工業株式会社 売上精算システムの管理装置
IL122732A0 (en) * 1997-01-15 1998-08-16 Akzo Nobel Nv Liquid gonadotropin-containing formulation its preparation and a device containing same
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JPH1111665A (ja) 1997-06-28 1999-01-19 Shibuya Kogyo Co Ltd 無菌エア搬送コンベヤ装置
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CA2372714A1 (en) 1999-05-07 2000-11-16 Stephen Franks The use of luteinizing hormone in the induction of pauci-or unifolliculogenesis
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TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
US8790322B2 (en) 2010-08-03 2014-07-29 King Saud University Stoma coat
WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
SI2621517T2 (sl) 2010-09-29 2023-11-30 Ferring B.V. Sestavek za uporabo pri zdravljenju neplodnosti
JP6087338B2 (ja) 2011-03-31 2017-03-01 フェリング ベスローテン フェンノートシャップ 医薬製剤
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
JP2017513853A (ja) 2014-04-18 2017-06-01 グリコトープ ゲーエムベーハー 改良された組換えヒト卵胞刺激ホルモンを用いた制御された卵巣過剰刺激

Also Published As

Publication number Publication date
US9771407B2 (en) 2017-09-26
LTPA2017018I1 (lt) 2017-06-26
CN102066414A (zh) 2011-05-18
KR20190092608A (ko) 2019-08-07
SI3045471T1 (sl) 2017-07-31
AU2017204259A1 (en) 2017-07-20
EP3045471B1 (en) 2017-03-29
RU2010141908A (ru) 2012-05-27
EP3144318A1 (en) 2017-03-22
PL2268666T3 (pl) 2014-08-29
HK1199039A1 (en) 2015-06-19
KR20110005863A (ko) 2011-01-19
TWI488640B (zh) 2015-06-21
US20110105398A1 (en) 2011-05-05
US20210332099A1 (en) 2021-10-28
AU2017204259B2 (en) 2017-08-17
JP2022031652A (ja) 2022-02-22
AR071479A1 (es) 2010-06-23
AU2014203277B2 (en) 2017-04-06
CN105906703A (zh) 2016-08-31
SI2268666T1 (sl) 2014-07-31
NZ588381A (en) 2012-05-25
HUE030652T2 (en) 2017-05-29
JP2011519359A (ja) 2011-07-07
HRP20170958T1 (hr) 2017-09-22
PT3045471T (pt) 2017-06-14
RU2745557C1 (ru) 2021-03-29
HK1146284A1 (en) 2011-05-20
MX2010011343A (es) 2011-01-20
SI3144318T1 (sl) 2020-12-31
HUE033830T2 (en) 2018-01-29
AU2009237479B2 (en) 2014-05-15
MX355457B (es) 2018-04-19
AU2017225020A1 (en) 2017-09-28
AU2017204258A1 (en) 2017-07-20
US20180079794A1 (en) 2018-03-22
LT2808340T (lt) 2016-11-10
KR20170110741A (ko) 2017-10-11
CA2725257A1 (en) 2009-10-22
KR101622944B1 (ko) 2016-05-23
RU2014141994A (ru) 2016-05-10
JP2018021037A (ja) 2018-02-08
PL3144318T3 (pl) 2021-02-08
IL208538A (en) 2014-03-31
JP2024038000A (ja) 2024-03-19
KR102108377B1 (ko) 2020-05-08
JP7316905B2 (ja) 2023-07-28
US10995128B2 (en) 2021-05-04
ES2629392T3 (es) 2017-08-09
JP2020040956A (ja) 2020-03-19
KR20180095140A (ko) 2018-08-24
DK3144318T3 (da) 2020-12-07
AU2017225020B2 (en) 2019-11-14
EP3144318B1 (en) 2020-09-23
RU2682270C2 (ru) 2019-03-18
JP6762916B2 (ja) 2020-09-30
RU2014141994A3 (pt) 2018-05-28
EP2808340A1 (en) 2014-12-03
HUS1700025I1 (hu) 2017-06-28
BRPI0910461B8 (pt) 2021-05-25
AU2014203277C1 (en) 2017-07-27
HRP20161520T1 (hr) 2016-12-30
SI2808340T1 (sl) 2016-12-30
RU2745557C3 (ru) 2021-12-10
PT2808340T (pt) 2016-11-21
US11952407B2 (en) 2024-04-09
US9546204B2 (en) 2017-01-17
DK2808340T3 (en) 2016-12-05
BRPI0910461A2 (pt) 2018-03-27
JP2015120696A (ja) 2015-07-02
ES2468318T3 (es) 2014-06-16
EP2268666B1 (en) 2014-03-12
BRPI0910461B1 (pt) 2021-02-23
IL208538A0 (en) 2010-12-30
EP2808340B1 (en) 2016-08-17
WO2009127826A1 (en) 2009-10-22
TW200948378A (en) 2009-12-01
IL230571A (en) 2015-11-30
EP4015527A1 (en) 2022-06-22
ES2610277T3 (es) 2017-04-26
HRP20140535T1 (hr) 2014-07-18
PL2808340T3 (pl) 2017-02-28
PT3144318T (pt) 2020-11-04
EP2722339A1 (en) 2014-04-23
EP2268666A1 (en) 2011-01-05
AU2017204258B2 (en) 2017-08-17
US20160347811A1 (en) 2016-12-01
DK2268666T3 (da) 2014-05-12
DK3045471T3 (en) 2017-06-26
RU2537268C2 (ru) 2014-12-27
AU2014203277A1 (en) 2014-07-24
JP2017060476A (ja) 2017-03-30
US8951967B2 (en) 2015-02-10
SA109300228B1 (ar) 2014-04-08
AU2009237479A1 (en) 2009-10-22
CN105906702A (zh) 2016-08-31
HUE030652T4 (en) 2017-09-28
MX348622B (es) 2017-06-22
CY1115413T1 (el) 2017-01-04
HUS1700036I1 (hu) 2017-10-30
NO2017025I1 (no) 2017-06-06
ZA201007373B (en) 2011-06-29
NO2017050I1 (no) 2017-09-28
EP3098234A1 (en) 2016-11-30
KR20160056960A (ko) 2016-05-20
PL3045471T3 (pl) 2017-10-31
HUS1700024I1 (hu) 2017-06-28
BRPI0910461A8 (pt) 2018-10-16
LT3045471T (lt) 2017-07-10
JP6486310B2 (ja) 2019-03-20
EP3045471A1 (en) 2016-07-20
LTPA2017029I1 (lt) 2017-10-10
US20150065695A1 (en) 2015-03-05

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