SI2808340T1 - Rekombinirani FSH, ki vključuje alfa 2,3- in alfa 2,6-sialilacijo - Google Patents

Rekombinirani FSH, ki vključuje alfa 2,3- in alfa 2,6-sialilacijo

Info

Publication number
SI2808340T1
SI2808340T1 SI200931547A SI200931547A SI2808340T1 SI 2808340 T1 SI2808340 T1 SI 2808340T1 SI 200931547 A SI200931547 A SI 200931547A SI 200931547 A SI200931547 A SI 200931547A SI 2808340 T1 SI2808340 T1 SI 2808340T1
Authority
SI
Slovenia
Prior art keywords
alpha
sialylation
recombinant fsh
fsh including
including alpha
Prior art date
Application number
SI200931547A
Other languages
English (en)
Inventor
Ian Cottingham
Daniel Plaksin
Richard Boyd White
Original Assignee
Ferring B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2808340(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring B.V. filed Critical Ferring B.V.
Publication of SI2808340T1 publication Critical patent/SI2808340T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI200931547A 2008-04-16 2009-04-16 Rekombinirani FSH, ki vključuje alfa 2,3- in alfa 2,6-sialilacijo SI2808340T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
EP08251528 2008-04-25
EP14178729.1A EP2808340B1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation

Publications (1)

Publication Number Publication Date
SI2808340T1 true SI2808340T1 (sl) 2016-12-30

Family

ID=39717519

Family Applications (4)

Application Number Title Priority Date Filing Date
SI200931670A SI3045471T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH, ki vključuje alfa 2,3 in alfa 2,6-sialilacijo
SI200930931T SI2268666T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH, ki vsebuje alfa 2,3- in alfa 2,6-sialilacijo
SI200932094T SI3144318T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH, ki vsebuje alfa 2,3- in alfa 2,6-sialilacijo
SI200931547A SI2808340T1 (sl) 2008-04-16 2009-04-16 Rekombinirani FSH, ki vključuje alfa 2,3- in alfa 2,6-sialilacijo

Family Applications Before (3)

Application Number Title Priority Date Filing Date
SI200931670A SI3045471T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH, ki vključuje alfa 2,3 in alfa 2,6-sialilacijo
SI200930931T SI2268666T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH, ki vsebuje alfa 2,3- in alfa 2,6-sialilacijo
SI200932094T SI3144318T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH, ki vsebuje alfa 2,3- in alfa 2,6-sialilacijo

Country Status (29)

Country Link
US (5) US8951967B2 (sl)
EP (7) EP2722339A1 (sl)
JP (7) JP2011519359A (sl)
KR (5) KR20170110741A (sl)
CN (3) CN105906702A (sl)
AR (1) AR071479A1 (sl)
AU (5) AU2009237479B2 (sl)
BR (1) BRPI0910461B8 (sl)
CA (1) CA2725257A1 (sl)
CY (1) CY1115413T1 (sl)
DK (4) DK2268666T3 (sl)
ES (3) ES2468318T3 (sl)
FR (1) FR17C1020I2 (sl)
HK (2) HK1146284A1 (sl)
HR (3) HRP20140535T1 (sl)
HU (5) HUE030652T4 (sl)
IL (2) IL208538A (sl)
LT (5) LT3098234T (sl)
MX (3) MX2010011343A (sl)
NO (2) NO2017025I1 (sl)
NZ (1) NZ588381A (sl)
PL (4) PL2808340T3 (sl)
PT (4) PT2268666E (sl)
RU (3) RU2682270C2 (sl)
SA (1) SA109300228B1 (sl)
SI (4) SI3045471T1 (sl)
TW (1) TWI488640B (sl)
WO (1) WO2009127826A1 (sl)
ZA (1) ZA201007373B (sl)

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TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
TWI604850B (zh) * 2009-10-05 2017-11-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
US9320778B2 (en) 2010-09-29 2016-04-26 Ferring B.V. Method for controlled ovarian stimulation with combined FSH and hCG
EP2628797B1 (en) 2010-10-15 2016-07-13 JCR Pharmaceuticals CO., LTD. Method for producing glycoprotein having mannose residue as non-reducing end of sugar chain
EP2691119B1 (en) 2011-03-31 2018-08-01 Ferring B.V. Pharmaceutical preparation
AR090095A1 (es) 2011-06-06 2014-10-22 Ferring Bv Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
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US9657310B2 (en) * 2012-04-27 2017-05-23 Jcr Pharmaceuticals Co., Ltd. Expression vector
EP2824176A1 (en) * 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
JP6652334B2 (ja) 2014-05-31 2020-02-19 Ｊｃｒファーマ株式会社 ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地
JP2018500934A (ja) * 2014-12-22 2018-01-18 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｃｍｐ依存性シアリダーゼ活性
ES2784625T3 (es) 2015-04-17 2020-09-29 Ferring Bv FSH para el tratamiento de la infertilidad
AU2016282916B2 (en) * 2015-06-26 2022-01-20 Ferring B.V. Methods of purification and/or viral inactivation
EP3205719A1 (en) * 2016-02-15 2017-08-16 CEVEC Pharmaceuticals GmbH Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
GB201603280D0 (en) 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
EP3382014A1 (en) * 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
PT3675894T (pt) 2017-09-01 2022-01-25 Ferring Bv Composição para estimulação ovariana controlada
US20210038694A1 (en) 2018-04-30 2021-02-11 Ferring B.V. Composition for controlled ovarian stimulation
MX2021004383A (es) 2018-10-17 2021-06-04 Ferring Bv Composiciones y metodos para la estimulacion ovarica controlada.
US20220380785A1 (en) * 2019-11-01 2022-12-01 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
WO2023186331A1 (en) 2022-04-01 2023-10-05 Ferring B.V. Mixed protocol for treatment of infertility
WO2023227761A1 (en) 2022-05-26 2023-11-30 Ferring B.V. Compositions and methods for treatment of infertility in males
WO2024008971A1 (en) 2022-07-08 2024-01-11 Ferring B.V. Compositions and methods for intrauterine insemination (iui)

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TWI604850B (zh) * 2009-10-05 2017-11-11 菲瑞茵國際中心股份有限公司 藥學製劑
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WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
US9320778B2 (en) 2010-09-29 2016-04-26 Ferring B.V. Method for controlled ovarian stimulation with combined FSH and hCG
EP2691119B1 (en) 2011-03-31 2018-08-01 Ferring B.V. Pharmaceutical preparation
AR090095A1 (es) 2011-06-06 2014-10-22 Ferring Bv Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
JP2017513853A (ja) 2014-04-18 2017-06-01 グリコトープ ゲーエムベーハー 改良された組換えヒト卵胞刺激ホルモンを用いた制御された卵巣過剰刺激

Also Published As

Publication number Publication date
IL208538A (en) 2014-03-31
RU2745557C3 (ru) 2021-12-10
RU2014141994A (ru) 2016-05-10
JP2017060476A (ja) 2017-03-30
SA109300228B1 (ar) 2014-04-08
ZA201007373B (en) 2011-06-29
US20210332099A1 (en) 2021-10-28
EP2808340A1 (en) 2014-12-03
US9546204B2 (en) 2017-01-17
AU2017204258A1 (en) 2017-07-20
SI3045471T1 (sl) 2017-07-31
PL3144318T3 (pl) 2021-02-08
TWI488640B (zh) 2015-06-21
AU2014203277B2 (en) 2017-04-06
PT3045471T (pt) 2017-06-14
EP2808340B1 (en) 2016-08-17
WO2009127826A1 (en) 2009-10-22
US20160347811A1 (en) 2016-12-01
KR20190092608A (ko) 2019-08-07
MX2010011343A (es) 2011-01-20
DK3045471T3 (en) 2017-06-26
KR101622944B1 (ko) 2016-05-23
EP3045471A1 (en) 2016-07-20
LT2808340T (lt) 2016-11-10
EP4015527A1 (en) 2022-06-22
CN102066414A (zh) 2011-05-18
RU2014141994A3 (sl) 2018-05-28
AR071479A1 (es) 2010-06-23
JP6762916B2 (ja) 2020-09-30
EP2722339A1 (en) 2014-04-23
SI2268666T1 (sl) 2014-07-31
KR20160056960A (ko) 2016-05-20
DK2268666T3 (da) 2014-05-12
RU2537268C2 (ru) 2014-12-27
AU2014203277C1 (en) 2017-07-27
HUE030652T4 (en) 2017-09-28
KR20170110741A (ko) 2017-10-11
US11952407B2 (en) 2024-04-09
AU2017204259B2 (en) 2017-08-17
NO2017025I1 (no) 2017-06-06
BRPI0910461B1 (pt) 2021-02-23
JP6486310B2 (ja) 2019-03-20
AU2017204259A1 (en) 2017-07-20
PT2808340T (pt) 2016-11-21
EP3098234A1 (en) 2016-11-30
US20180079794A1 (en) 2018-03-22
HUS1700024I1 (hu) 2017-06-28
JP2011519359A (ja) 2011-07-07
NZ588381A (en) 2012-05-25
HK1146284A1 (en) 2011-05-20
PL2268666T3 (pl) 2014-08-29
CN105906702A (zh) 2016-08-31
JP2018021037A (ja) 2018-02-08
HK1199039A1 (en) 2015-06-19
NO2017050I1 (no) 2017-09-28
LT3098234T (lt) 2024-09-10
PL3045471T3 (pl) 2017-10-31
HRP20170958T1 (hr) 2017-09-22
US20150065695A1 (en) 2015-03-05
EP3144318B1 (en) 2020-09-23
US10995128B2 (en) 2021-05-04
CN105906703A (zh) 2016-08-31
LTPA2017018I1 (lt) 2017-06-26
ES2610277T3 (es) 2017-04-26
HRP20140535T1 (hr) 2014-07-18
HUE030652T2 (en) 2017-05-29
EP2268666B1 (en) 2014-03-12
TW200948378A (en) 2009-12-01
ES2629392T3 (es) 2017-08-09
AU2017225020A1 (en) 2017-09-28
US8951967B2 (en) 2015-02-10
MX348622B (es) 2017-06-22
CY1115413T1 (el) 2017-01-04
AU2017204258B2 (en) 2017-08-17
LT3045471T (lt) 2017-07-10
LTPA2017029I1 (lt) 2017-10-10
IL208538A0 (en) 2010-12-30
AU2014203277A1 (en) 2014-07-24
HRP20161520T1 (hr) 2016-12-30
RU2682270C2 (ru) 2019-03-18
JP2022031652A (ja) 2022-02-22
DK3144318T3 (da) 2020-12-07
KR20110005863A (ko) 2011-01-19
KR102108377B1 (ko) 2020-05-08
CA2725257A1 (en) 2009-10-22
AU2009237479A1 (en) 2009-10-22
AU2009237479B2 (en) 2014-05-15
PT3144318T (pt) 2020-11-04
EP2268666A1 (en) 2011-01-05
DK2808340T3 (en) 2016-12-05
KR20180095140A (ko) 2018-08-24
ES2468318T3 (es) 2014-06-16
EP3045471B1 (en) 2017-03-29
RU2010141908A (ru) 2012-05-27
FR17C1020I2 (fr) 2020-04-10
JP2024038000A (ja) 2024-03-19
EP3144318A1 (en) 2017-03-22
PL2808340T3 (pl) 2017-02-28
EP3098234B1 (en) 2024-07-31
IL230571A (en) 2015-11-30
AU2017225020B2 (en) 2019-11-14
HUS1700025I1 (hu) 2017-06-28
SI3144318T1 (sl) 2020-12-31
BRPI0910461A8 (pt) 2018-10-16
RU2745557C1 (ru) 2021-03-29
HUS1700036I1 (hu) 2017-10-30
PT2268666E (pt) 2014-06-25
JP7316905B2 (ja) 2023-07-28
BRPI0910461A2 (pt) 2018-03-27
US9771407B2 (en) 2017-09-26
JP2015120696A (ja) 2015-07-02
FR17C1020I1 (sl) 2020-04-10
HUE033830T2 (en) 2018-01-29
MX355457B (es) 2018-04-19
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BRPI0910461B8 (pt) 2021-05-25

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