PL3045471T3 - Rekombinowany FSH zawierający alfa 2,3- i alfa 2,6-sialilację - Google Patents

Rekombinowany FSH zawierający alfa 2,3- i alfa 2,6-sialilację

Info

Publication number
PL3045471T3
PL3045471T3 PL16158141T PL16158141T PL3045471T3 PL 3045471 T3 PL3045471 T3 PL 3045471T3 PL 16158141 T PL16158141 T PL 16158141T PL 16158141 T PL16158141 T PL 16158141T PL 3045471 T3 PL3045471 T3 PL 3045471T3
Authority
PL
Poland
Prior art keywords
alpha
sialylation
recombinant fsh
fsh containing
containing alpha
Prior art date
Application number
PL16158141T
Other languages
English (en)
Inventor
Ian Cottingham
Daniel Plaksin
Richard Boyd White
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3045471(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of PL3045471T3 publication Critical patent/PL3045471T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL16158141T 2008-04-16 2009-04-16 Rekombinowany FSH zawierający alfa 2,3- i alfa 2,6-sialilację PL3045471T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
EP08251528 2008-04-25
EP16158141.8A EP3045471B1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation
EP13193214.7A EP2722339A1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation
EP09733497.3A EP2268666B1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation

Publications (1)

Publication Number Publication Date
PL3045471T3 true PL3045471T3 (pl) 2017-10-31

Family

ID=39717519

Family Applications (6)

Application Number Title Priority Date Filing Date
PL09733497T PL2268666T3 (pl) 2008-04-16 2009-04-16 Rekombinowany FSH zawierający alfa 2,3- i alfa 2,6-sialilację
PL16158141T PL3045471T3 (pl) 2008-04-16 2009-04-16 Rekombinowany FSH zawierający alfa 2,3- i alfa 2,6-sialilację
PL14178729T PL2808340T3 (pl) 2008-04-16 2009-04-16 Rekombinowany FSH zawierający alfa 2,3- i alfa 2,6-sialilację
PL21212873.0T PL4015527T3 (pl) 2008-04-16 2009-04-16 Rekombinowany fsh zawierający alfa 2,3- i alfa 2,6-sialilację
PL16194925T PL3144318T3 (pl) 2008-04-16 2009-04-16 Rekombinowany fsh obejmujący alfa 2,3- oraz alfa 2,6-sialilację
PL16179121.5T PL3098234T3 (pl) 2008-04-16 2009-04-16 Rekombinowany fsh zawierający alfa 2,3- i alfa 2,6-sialilację

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL09733497T PL2268666T3 (pl) 2008-04-16 2009-04-16 Rekombinowany FSH zawierający alfa 2,3- i alfa 2,6-sialilację

Family Applications After (4)

Application Number Title Priority Date Filing Date
PL14178729T PL2808340T3 (pl) 2008-04-16 2009-04-16 Rekombinowany FSH zawierający alfa 2,3- i alfa 2,6-sialilację
PL21212873.0T PL4015527T3 (pl) 2008-04-16 2009-04-16 Rekombinowany fsh zawierający alfa 2,3- i alfa 2,6-sialilację
PL16194925T PL3144318T3 (pl) 2008-04-16 2009-04-16 Rekombinowany fsh obejmujący alfa 2,3- oraz alfa 2,6-sialilację
PL16179121.5T PL3098234T3 (pl) 2008-04-16 2009-04-16 Rekombinowany fsh zawierający alfa 2,3- i alfa 2,6-sialilację

Country Status (29)

Country Link
US (6) US8951967B2 (pl)
EP (7) EP2722339A1 (pl)
JP (7) JP2011519359A (pl)
KR (5) KR101622944B1 (pl)
CN (3) CN105906702A (pl)
AR (1) AR071479A1 (pl)
AU (5) AU2009237479B2 (pl)
BR (1) BRPI0910461B8 (pl)
CA (1) CA2725257A1 (pl)
CY (1) CY1115413T1 (pl)
DK (6) DK3144318T3 (pl)
ES (5) ES2629392T3 (pl)
FI (4) FI3098234T3 (pl)
FR (3) FR17C1020I2 (pl)
HR (5) HRP20140535T1 (pl)
HU (9) HUE033830T2 (pl)
IL (2) IL208538A (pl)
LT (8) LT3045471T (pl)
MX (3) MX2010011343A (pl)
NO (4) NO2017025I1 (pl)
NZ (1) NZ588381A (pl)
PL (6) PL2268666T3 (pl)
PT (6) PT3144318T (pl)
RU (3) RU2537268C2 (pl)
SA (1) SA109300228B1 (pl)
SI (6) SI3098234T1 (pl)
TW (1) TWI488640B (pl)
WO (1) WO2009127826A1 (pl)
ZA (1) ZA201007373B (pl)

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TWI532495B (zh) * 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
EP2621517B2 (en) 2010-09-29 2023-10-11 Ferring B.V. Composition for use in treating infertility
CN103154243A (zh) 2010-10-15 2013-06-12 日本化学研究株式会社 糖链的非还原末端为甘露糖残基的糖蛋白的制造方法
US9757469B2 (en) 2011-03-31 2017-09-12 Ferring B.V. Pharmaceutical preparation
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
AU2012340501A1 (en) * 2011-12-19 2013-07-11 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
JP6279466B2 (ja) * 2012-04-27 2018-02-14 Ｊｃｒファーマ株式会社 新規な発現ベクター
EP2824176A1 (en) 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
JP6652334B2 (ja) 2014-05-31 2020-02-19 Ｊｃｒファーマ株式会社 ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地
CN107429237B (zh) * 2014-12-22 2021-09-28 豪夫迈·罗氏有限公司 Cmp依赖性的唾液酸酶活性
HUE054300T2 (hu) 2015-04-17 2021-08-30 Ferring Bv FSH-t tartalmazó, meddõség kezelésére szolgáló készítmény
CA2990311A1 (en) 2015-06-26 2016-12-29 Ferring B.V. Methods of purification and/or viral inactivation
EP3205719A1 (en) * 2016-02-15 2017-08-16 CEVEC Pharmaceuticals GmbH Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
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EP3382014A1 (en) * 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
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EP4427806A3 (en) 2017-09-01 2024-10-09 Ferring B.V. Composition for controlled ovarian stimulation
RS66871B1 (sr) 2018-04-30 2025-06-30 Ferring Bv Kompozicija za kontrolisanu stimulaciju jajnika
TWI846743B (zh) 2018-10-17 2024-07-01 荷蘭商菲林公司 用於控制性卵巢刺激之組成物及方法
WO2021081670A1 (en) * 2019-11-01 2021-05-06 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
CN118922201A (zh) 2022-04-01 2024-11-08 辉凌公司 治疗不育症的混合方案
JP2025516966A (ja) 2022-05-26 2025-05-30 フェリング ベスローテン フェンノートシャップ 男性の不妊症の治療のための組成物及び方法
US20250367262A1 (en) 2022-07-08 2025-12-04 Ferring B.V. Compositions and methods for intrauterine insemination (iui)
WO2025017533A1 (en) 2023-07-20 2025-01-23 Ferring B.V. Extended release drug-loaded microparticles

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TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
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WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
EP2621517B2 (en) 2010-09-29 2023-10-11 Ferring B.V. Composition for use in treating infertility
US9757469B2 (en) 2011-03-31 2017-09-12 Ferring B.V. Pharmaceutical preparation
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
CA2945883A1 (en) 2014-04-18 2015-10-22 Glycotope Gmbh Controlled ovarian hyperstimulation with improved recombinant human follicle-stimulating hormone

Also Published As

Publication number Publication date
EP3144318B1 (en) 2020-09-23
SI2268666T1 (sl) 2014-07-31
PT2808340T (pt) 2016-11-21
HUS2500029I1 (hu) 2025-07-28
ZA201007373B (en) 2011-06-29
LTPA2025505I1 (pl) 2025-02-10
JP2011519359A (ja) 2011-07-07
US20150065695A1 (en) 2015-03-05
DK2268666T3 (da) 2014-05-12
SI3144318T1 (sl) 2020-12-31
AU2009237479B2 (en) 2014-05-15
KR101622944B1 (ko) 2016-05-23
TWI488640B (zh) 2015-06-21
DK4015527T3 (da) 2025-04-14
PL3144318T3 (pl) 2021-02-08
ES2468318T3 (es) 2014-06-16
IL230571A (en) 2015-11-30
DK3144318T3 (da) 2020-12-07
PT3045471T (pt) 2017-06-14
NO2025032I1 (no) 2025-07-14
CN105906703A (zh) 2016-08-31
ES2989729T3 (es) 2024-11-27
RU2014141994A (ru) 2016-05-10
RU2010141908A (ru) 2012-05-27
SI2808340T1 (sl) 2016-12-30
KR20190092608A (ko) 2019-08-07
JP2017060476A (ja) 2017-03-30
FR25C1003I1 (fr) 2025-02-28
HUE030652T4 (en) 2017-09-28
RU2745557C3 (ru) 2021-12-10
HRP20250313T1 (hr) 2025-05-09
KR20160056960A (ko) 2016-05-20
US9546204B2 (en) 2017-01-17
MX348622B (es) 2017-06-22
AR071479A1 (es) 2010-06-23
CN105906702A (zh) 2016-08-31
AU2017204258B2 (en) 2017-08-17
US12516094B2 (en) 2026-01-06
NO2025006I1 (no) 2025-01-16
RU2537268C2 (ru) 2014-12-27
JP6486310B2 (ja) 2019-03-20
WO2009127826A1 (en) 2009-10-22
PT4015527T (pt) 2025-04-10
FR17C1020I1 (pl) 2020-04-10
HUE071059T2 (hu) 2025-07-28
EP4015527B1 (en) 2025-01-22
IL208538A (en) 2014-03-31
EP2808340A1 (en) 2014-12-03
AU2014203277B2 (en) 2017-04-06
EP2808340B1 (en) 2016-08-17
AU2017204259B2 (en) 2017-08-17
LTPA2025525I1 (pl) 2025-07-25
HRP20140535T1 (hr) 2014-07-18
CY1115413T1 (el) 2017-01-04
US20160347811A1 (en) 2016-12-01
US9771407B2 (en) 2017-09-26
RU2682270C2 (ru) 2019-03-18
US20210332099A1 (en) 2021-10-28
CN102066414A (zh) 2011-05-18
NO2017025I1 (no) 2017-06-06
EP4015527A1 (en) 2022-06-22
AU2017225020A1 (en) 2017-09-28
SI4015527T1 (sl) 2025-05-30
AU2017204259A1 (en) 2017-07-20
HUE068565T2 (hu) 2025-01-28
RU2745557C1 (ru) 2021-03-29
HRP20241187T1 (hr) 2024-12-06
EP2268666B1 (en) 2014-03-12
HRP20170958T1 (hr) 2017-09-22
EP3098234B1 (en) 2024-07-31
BRPI0910461B8 (pt) 2021-05-25
FI3098234T3 (fi) 2024-10-31
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