NO2017025I1 - Rekombinant FSH (rFSH) innbefattende alfa2,3-sialylering og alfa2,6-sialylering hvor 80% eller mer av den totale sialylering er alfa2,3-sialylering og hvor fra 5% til 20% av den totale sialylering er alfa2,6- sialylering, spesielt follitropin delta. - Google Patents

Rekombinant FSH (rFSH) innbefattende alfa2,3-sialylering og alfa2,6-sialylering hvor 80% eller mer av den totale sialylering er alfa2,3-sialylering og hvor fra 5% til 20% av den totale sialylering er alfa2,6- sialylering, spesielt follitropin delta.

Info

Publication number
NO2017025I1
NO2017025I1 NO2017025C NO2017025C NO2017025I1 NO 2017025 I1 NO2017025 I1 NO 2017025I1 NO 2017025 C NO2017025 C NO 2017025C NO 2017025 C NO2017025 C NO 2017025C NO 2017025 I1 NO2017025 I1 NO 2017025I1
Authority
NO
Norway
Prior art keywords
sialylation
alpha2
total
rfsh
follitropin
Prior art date
Application number
NO2017025C
Other languages
English (en)
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2017025(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of NO2017025I1 publication Critical patent/NO2017025I1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO2017025C 2008-04-16 2017-06-06 Rekombinant FSH (rFSH) innbefattende alfa2,3-sialylering og alfa2,6-sialylering hvor 80% eller mer av den totale sialylering er alfa2,3-sialylering og hvor fra 5% til 20% av den totale sialylering er alfa2,6- sialylering, spesielt follitropin delta. NO2017025I1 (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
EP08251528 2008-04-25
EP13193214.7A EP2722339A1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation
EP14178729.1A EP2808340B1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation
EP09733497.3A EP2268666B1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation

Publications (1)

Publication Number Publication Date
NO2017025I1 true NO2017025I1 (no) 2017-06-06

Family

ID=39717519

Family Applications (2)

Application Number Title Priority Date Filing Date
NO2017025C NO2017025I1 (no) 2008-04-16 2017-06-06 Rekombinant FSH (rFSH) innbefattende alfa2,3-sialylering og alfa2,6-sialylering hvor 80% eller mer av den totale sialylering er alfa2,3-sialylering og hvor fra 5% til 20% av den totale sialylering er alfa2,6- sialylering, spesielt follitropin delta.
NO2017050C NO2017050I1 (no) 2008-04-25 2017-09-28 Rekombinant FSH (folikkel-stimulerende hormon)

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2017050C NO2017050I1 (no) 2008-04-25 2017-09-28 Rekombinant FSH (folikkel-stimulerende hormon)

Country Status (29)

Country Link
US (5) US8951967B2 (no)
EP (7) EP3098234A1 (no)
JP (7) JP2011519359A (no)
KR (5) KR20170110741A (no)
CN (3) CN105906703A (no)
AR (1) AR071479A1 (no)
AU (5) AU2009237479B2 (no)
BR (1) BRPI0910461B8 (no)
CA (1) CA2725257A1 (no)
CY (1) CY1115413T1 (no)
DK (4) DK3144318T3 (no)
ES (3) ES2468318T3 (no)
FR (1) FR17C1020I2 (no)
HK (2) HK1146284A1 (no)
HR (3) HRP20140535T1 (no)
HU (5) HUE030652T4 (no)
IL (2) IL208538A (no)
LT (4) LT2808340T (no)
MX (3) MX2010011343A (no)
NO (2) NO2017025I1 (no)
NZ (1) NZ588381A (no)
PL (4) PL3144318T3 (no)
PT (4) PT3144318T (no)
RU (3) RU2682270C2 (no)
SA (1) SA109300228B1 (no)
SI (4) SI3144318T1 (no)
TW (1) TWI488640B (no)
WO (1) WO2009127826A1 (no)
ZA (1) ZA201007373B (no)

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EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
HRP20150968T4 (hr) 2010-09-29 2023-11-10 Ferring B.V. Pripravak za uporabu za liječenje neplodnosti
CN103154243A (zh) 2010-10-15 2013-06-12 日本化学研究株式会社 糖链的非还原末端为甘露糖残基的糖蛋白的制造方法
CN103619358B (zh) * 2011-03-31 2017-02-15 辉凌公司 药物制剂
AR090095A1 (es) 2011-06-06 2014-10-22 Ferring Bv Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
AU2012340501A1 (en) * 2011-12-19 2013-07-11 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
JP6279466B2 (ja) * 2012-04-27 2018-02-14 Ｊｃｒファーマ株式会社 新規な発現ベクター
EP2824176A1 (en) * 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
JP6652334B2 (ja) 2014-05-31 2020-02-19 Ｊｃｒファーマ株式会社 ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地
CN107429237B (zh) * 2014-12-22 2021-09-28 豪夫迈·罗氏有限公司 Cmp依赖性的唾液酸酶活性
RU2704252C2 (ru) 2015-04-17 2019-10-25 Ферринг Б.В. Композиция для лечения бесплодия
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EP3205719A1 (en) * 2016-02-15 2017-08-16 CEVEC Pharmaceuticals GmbH Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
GB201603280D0 (en) 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
EP3382014A1 (en) * 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
ES2904787T3 (es) 2017-09-01 2022-04-06 Ferring Bv Composición para la estimulación ovárica controlada
EP3787667A1 (en) 2018-04-30 2021-03-10 Ferring B.V. Composition for controlled ovarian stimulation
CN112789053A (zh) 2018-10-17 2021-05-11 辉凌公司 用于受控的卵巢刺激的组合物和方法
US20220380785A1 (en) * 2019-11-01 2022-12-01 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
WO2023186331A1 (en) 2022-04-01 2023-10-05 Ferring B.V. Mixed protocol for treatment of infertility
WO2023227761A1 (en) 2022-05-26 2023-11-30 Ferring B.V. Compositions and methods for treatment of infertility in males
WO2024008971A1 (en) 2022-07-08 2024-01-11 Ferring B.V. Compositions and methods for intrauterine insemination (iui)

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TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
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CN103619358B (zh) 2011-03-31 2017-02-15 辉凌公司 药物制剂
AR090095A1 (es) 2011-06-06 2014-10-22 Ferring Bv Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
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KR20180095140A (ko) 2018-08-24
EP2808340A1 (en) 2014-12-03
AU2014203277A1 (en) 2014-07-24
KR20160056960A (ko) 2016-05-20
BRPI0910461A8 (pt) 2018-10-16
ZA201007373B (en) 2011-06-29
RU2014141994A3 (no) 2018-05-28
PT2268666E (pt) 2014-06-25
AU2017225020A1 (en) 2017-09-28
NZ588381A (en) 2012-05-25
AU2017204259B2 (en) 2017-08-17
LTPA2017029I1 (lt) 2017-10-10
RU2745557C3 (ru) 2021-12-10
LT3045471T (lt) 2017-07-10
HUE030652T4 (en) 2017-09-28
MX2010011343A (es) 2011-01-20
KR101622944B1 (ko) 2016-05-23
JP2020040956A (ja) 2020-03-19
FR17C1020I1 (no) 2020-04-10
HUE033830T2 (en) 2018-01-29
AU2014203277B2 (en) 2017-04-06
EP3144318A1 (en) 2017-03-22
EP2268666A1 (en) 2011-01-05
RU2014141994A (ru) 2016-05-10
LTPA2017018I1 (lt) 2017-06-26
PL3144318T3 (pl) 2021-02-08
IL208538A0 (en) 2010-12-30
JP2017060476A (ja) 2017-03-30
US9771407B2 (en) 2017-09-26
PT3144318T (pt) 2020-11-04
AU2017204259A1 (en) 2017-07-20
SI2268666T1 (sl) 2014-07-31
HUS1700024I1 (hu) 2017-06-28
AR071479A1 (es) 2010-06-23
US20180079794A1 (en) 2018-03-22
PL2268666T3 (pl) 2014-08-29
CA2725257A1 (en) 2009-10-22
DK2808340T3 (en) 2016-12-05
MX348622B (es) 2017-06-22
IL208538A (en) 2014-03-31
IL230571A (en) 2015-11-30
TW200948378A (en) 2009-12-01
US8951967B2 (en) 2015-02-10
DK2268666T3 (da) 2014-05-12
NO2017050I1 (no) 2017-09-28
US9546204B2 (en) 2017-01-17
ES2629392T3 (es) 2017-08-09
AU2017204258B2 (en) 2017-08-17
PL3045471T3 (pl) 2017-10-31
DK3144318T3 (da) 2020-12-07
PT3045471T (pt) 2017-06-14
CN105906703A (zh) 2016-08-31
ES2468318T3 (es) 2014-06-16
WO2009127826A1 (en) 2009-10-22
AU2009237479B2 (en) 2014-05-15
EP3098234A1 (en) 2016-11-30
HUS1700025I1 (hu) 2017-06-28
EP2808340B1 (en) 2016-08-17
KR20190092608A (ko) 2019-08-07
JP2011519359A (ja) 2011-07-07
JP7316905B2 (ja) 2023-07-28
EP3045471B1 (en) 2017-03-29
HUE030652T2 (en) 2017-05-29
CN105906702A (zh) 2016-08-31
LT2808340T (lt) 2016-11-10
HK1146284A1 (en) 2011-05-20
JP6762916B2 (ja) 2020-09-30
JP2015120696A (ja) 2015-07-02
CY1115413T1 (el) 2017-01-04
US20210332099A1 (en) 2021-10-28
US11952407B2 (en) 2024-04-09
DK3045471T3 (en) 2017-06-26
EP3045471A1 (en) 2016-07-20
AU2017225020B2 (en) 2019-11-14
US20110105398A1 (en) 2011-05-05
HRP20161520T1 (hr) 2016-12-30
RU2745557C1 (ru) 2021-03-29
AU2017204258A1 (en) 2017-07-20
KR20170110741A (ko) 2017-10-11
JP2022031652A (ja) 2022-02-22
RU2682270C2 (ru) 2019-03-18
EP4015527A1 (en) 2022-06-22
CN102066414A (zh) 2011-05-18
EP2722339A1 (en) 2014-04-23
SI3045471T1 (sl) 2017-07-31
BRPI0910461B8 (pt) 2021-05-25
HRP20170958T1 (hr) 2017-09-22
US10995128B2 (en) 2021-05-04
RU2537268C2 (ru) 2014-12-27
JP2018021037A (ja) 2018-02-08
AU2014203277C1 (en) 2017-07-27
HK1199039A1 (en) 2015-06-19
SI2808340T1 (sl) 2016-12-30
SI3144318T1 (sl) 2020-12-31
BRPI0910461A2 (pt) 2018-03-27
AU2009237479A1 (en) 2009-10-22
EP2268666B1 (en) 2014-03-12
ES2610277T3 (es) 2017-04-26
HRP20140535T1 (hr) 2014-07-18
KR20110005863A (ko) 2011-01-19
PT2808340T (pt) 2016-11-21
FR17C1020I2 (fr) 2020-04-10
PL2808340T3 (pl) 2017-02-28
SA109300228B1 (ar) 2014-04-08
KR102108377B1 (ko) 2020-05-08
EP3144318B1 (en) 2020-09-23
US20160347811A1 (en) 2016-12-01
RU2010141908A (ru) 2012-05-27
BRPI0910461B1 (pt) 2021-02-23
US20150065695A1 (en) 2015-03-05
MX355457B (es) 2018-04-19
JP6486310B2 (ja) 2019-03-20
JP2024038000A (ja) 2024-03-19
HUS1700036I1 (hu) 2017-10-30
TWI488640B (zh) 2015-06-21

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