ATE518828T1 - Ein-topf-verfahren zur herstellung von 3-(2,2,2- trimethylhydrazinium)propionat-dihydrat - Google Patents

Ein-topf-verfahren zur herstellung von 3-(2,2,2- trimethylhydrazinium)propionat-dihydrat

Info

Publication number
ATE518828T1
ATE518828T1 AT09713008T AT09713008T ATE518828T1 AT E518828 T1 ATE518828 T1 AT E518828T1 AT 09713008 T AT09713008 T AT 09713008T AT 09713008 T AT09713008 T AT 09713008T AT E518828 T1 ATE518828 T1 AT E518828T1
Authority
AT
Austria
Prior art keywords
trimethylhydrazinium
producing
pot process
propionate dihydrate
propionate
Prior art date
Application number
AT09713008T
Other languages
English (en)
Inventor
Ivars Kalvins
Pugovics Osvalds
Aleksandrs Cernobrovijs
Agnija Ievina
Antons Lebedevs
Original Assignee
Grindeks Jsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LVP-08-22A external-priority patent/LV13988B/lv
Priority claimed from LVP-08-23A external-priority patent/LV13989B/lv
Application filed by Grindeks Jsc filed Critical Grindeks Jsc
Application granted granted Critical
Publication of ATE518828T1 publication Critical patent/ATE518828T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/40—Hydrazines having nitrogen atoms of hydrazine groups being quaternised

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Secondary Cells (AREA)
AT09713008T 2008-02-19 2009-02-19 Ein-topf-verfahren zur herstellung von 3-(2,2,2- trimethylhydrazinium)propionat-dihydrat ATE518828T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
LVP-08-22A LV13988B (lv) 2008-02-19 2008-02-19 3-(2,2,2-trimetilhidrazīnij)propionāta esteru sērskābes sāļi, to iegūšana un pielietošana meldonija iegūšanai
LVP-08-23A LV13989B (lv) 2008-02-19 2008-02-19 3-(2,2,2-trimetilhidrazīnij)propionāta esteru ogļskābie sāļi, to iegūšana un pielietošana meldonija iegūšanai
PCT/EP2009/051996 WO2009103773A1 (en) 2008-02-19 2009-02-19 A one-pot process for preparing 3-(2,2,2-trimethylhydrazinium)propionate dihydrate

Publications (1)

Publication Number Publication Date
ATE518828T1 true ATE518828T1 (de) 2011-08-15

Family

ID=40791202

Family Applications (2)

Application Number Title Priority Date Filing Date
AT09713024T ATE510818T1 (de) 2008-02-19 2009-02-19 Kohlensäure- und schwefelsäuresalze von 3-(2,2,2- trimethylhydrazinium)propionatestern und deren verwendung zur herstellung von 3-(2,2,2- trimethylhydrazinium)propionat-dihydrat
AT09713008T ATE518828T1 (de) 2008-02-19 2009-02-19 Ein-topf-verfahren zur herstellung von 3-(2,2,2- trimethylhydrazinium)propionat-dihydrat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT09713024T ATE510818T1 (de) 2008-02-19 2009-02-19 Kohlensäure- und schwefelsäuresalze von 3-(2,2,2- trimethylhydrazinium)propionatestern und deren verwendung zur herstellung von 3-(2,2,2- trimethylhydrazinium)propionat-dihydrat

Country Status (12)

Country Link
EP (2) EP2247572B1 (de)
CN (2) CN101952246B (de)
AT (2) ATE510818T1 (de)
DK (1) DK2247573T3 (de)
EA (2) EA016355B1 (de)
GE (2) GEP20125680B (de)
HR (1) HRP20110617T1 (de)
PL (1) PL2247573T3 (de)
PT (1) PT2247573E (de)
RS (1) RS51838B (de)
SI (1) SI2247573T1 (de)
WO (2) WO2009103772A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101654418B (zh) * 2009-09-11 2012-12-05 广东健信制药有限公司 一种米屈肼二水合物a型结晶体及其制备方法
CN101973909B (zh) * 2010-11-19 2013-03-06 绍兴文理学院 一种米屈肼的制备方法
CN103483219B (zh) * 2013-08-31 2015-03-25 济南诚汇双达化工有限公司 一种米屈肼二水合物制备方法
CN104165965B (zh) * 2014-06-12 2017-02-15 东力（南通）化工有限公司 一种非水滴定测定米屈肼原料药中间体3‑(2,2‑二甲基肼基)丙酸甲酯含量的分析方法
CN106008257A (zh) * 2016-03-16 2016-10-12 江苏悦兴药业有限公司 米屈肼的制备方法及其关键中间体
CN109369447B (zh) * 2018-11-05 2022-05-13 东力（南通）化工有限公司 一种3-（2,2,2-三甲基肼）丙酸盐二水合物的制备技术的改进方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU997646A1 (ru) * 1978-11-27 1983-02-23 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвсср Кормова добавка
LV13280B (en) * 2003-08-04 2005-11-20 Grindeks Publiska As Sustained release salts of 3-(2,2,2-trimethylhydrazinium)propionate, a method of production and pharmaceutical compositions thereof
JP4634380B2 (ja) * 2003-08-04 2011-02-16 “ジョイント ストック カンパニー グリンデクス” メルドニウム（Ｍｅｌｄｏｎｉｕｍ）塩、メルドニウム塩の調製方法、およびメルドニウム塩を主成分とする薬学的組成物
LV13484B (en) * 2005-02-25 2007-03-20 Jorge Silva Method for production of 3-(2,2,2-trimethylhydrazinium) propionate dihydrate

Also Published As

Publication number Publication date
EP2247573B1 (de) 2011-05-25
RS51838B (en) 2012-02-29
GEP20125681B (en) 2012-10-25
EA016937B1 (ru) 2012-08-30
ATE510818T1 (de) 2011-06-15
CN101952246A (zh) 2011-01-19
DK2247573T3 (da) 2011-09-05
WO2009103772A1 (en) 2009-08-27
EA201001170A1 (ru) 2011-02-28
EP2247573A1 (de) 2010-11-10
EA016355B1 (ru) 2012-04-30
GEP20125680B (en) 2012-10-25
SI2247573T1 (sl) 2011-10-28
EP2247572B1 (de) 2011-08-03
PL2247573T3 (pl) 2011-11-30
CN101952245A (zh) 2011-01-19
CN101952245B (zh) 2013-10-16
EA201001171A1 (ru) 2011-02-28
HRP20110617T1 (hr) 2011-09-30
CN101952246B (zh) 2013-06-12
WO2009103773A1 (en) 2009-08-27
PT2247573E (pt) 2011-09-02
EP2247572A1 (de) 2010-11-10

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