CL2011000936A1 - Proceso de preparacion de compuestos derivados de l-alanina protegidos, utiles como intermediarios de la sintesis de compuestos moduladores opioides mu/delta. - Google Patents
Proceso de preparacion de compuestos derivados de l-alanina protegidos, utiles como intermediarios de la sintesis de compuestos moduladores opioides mu/delta.Info
- Publication number
- CL2011000936A1 CL2011000936A1 CL2011000936A CL2011000936A CL2011000936A1 CL 2011000936 A1 CL2011000936 A1 CL 2011000936A1 CL 2011000936 A CL2011000936 A CL 2011000936A CL 2011000936 A CL2011000936 A CL 2011000936A CL 2011000936 A1 CL2011000936 A1 CL 2011000936A1
- Authority
- CL
- Chile
- Prior art keywords
- intermediaries
- opioid
- alanine
- delta
- synthesis
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/06—Preparation of carboxylic acid amides from nitriles by transformation of cyano groups into carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/16—Preparation of carboxylic acid nitriles by reaction of cyanides with lactones or compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/06—Zinc compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Catalysts (AREA)
Abstract
Proceso de preparación de compuestos derivados de l-alanina protegidos, útiles como intermediarios de la síntesis de compuestos moduladores opioides mu/delta.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10864908P | 2008-10-27 | 2008-10-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2011000936A1 true CL2011000936A1 (es) | 2012-04-09 |
Family
ID=41796530
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2011000936A CL2011000936A1 (es) | 2008-10-27 | 2011-04-26 | Proceso de preparacion de compuestos derivados de l-alanina protegidos, utiles como intermediarios de la sintesis de compuestos moduladores opioides mu/delta. |
Country Status (25)
Country | Link |
---|---|
US (3) | US8710256B2 (es) |
EP (1) | EP2362868B1 (es) |
JP (2) | JP5592893B2 (es) |
KR (1) | KR101690195B1 (es) |
CN (2) | CN102264691B (es) |
AR (1) | AR075291A1 (es) |
AU (1) | AU2009320156B2 (es) |
BR (1) | BRPI0920834B1 (es) |
CA (1) | CA2741790C (es) |
CL (1) | CL2011000936A1 (es) |
CO (1) | CO6361989A2 (es) |
CR (1) | CR20110286A (es) |
EA (1) | EA018913B1 (es) |
EC (1) | ECSP11011008A (es) |
ES (1) | ES2657676T3 (es) |
HN (1) | HN2011001186A (es) |
HU (1) | HUE038302T2 (es) |
IL (1) | IL212464A (es) |
MX (1) | MX2011004393A (es) |
NI (1) | NI201100078A (es) |
NZ (1) | NZ592415A (es) |
PE (2) | PE20110417A1 (es) |
TW (1) | TWI468375B (es) |
UA (1) | UA110600C2 (es) |
WO (1) | WO2010062590A2 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI468375B (zh) * | 2008-10-27 | 2015-01-11 | Janssen Pharmaceutica Nv | 製備經保護之l-丙胺酸衍生物之方法 |
TWI713889B (zh) | 2011-12-28 | 2020-12-21 | 中外製藥股份有限公司 | 胜肽化合物之環化方法 |
CN106132406B (zh) | 2014-02-03 | 2020-03-27 | 夸德里加生物科学公司 | 作为化疗剂的β-取代的γ-氨基酸和类似物 |
AU2015210638B2 (en) | 2014-02-03 | 2017-07-20 | Quadriga Biosciences, Inc. | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents |
AR105592A1 (es) | 2015-08-03 | 2017-10-18 | Quadriga Biosciences Inc | b-AMINOÁCIDOS b-SUSTITUIDOS Y ANÁLOGOS COMO AGENTES QUIMIOTERAPÉUTICOS Y USOS DE LOS MISMOS |
JPWO2017043626A1 (ja) * | 2015-09-11 | 2018-06-21 | 株式会社カネカ | 光学活性4−カルバモイル−2,6−ジメチルフェニルアラニン誘導体の製造法 |
CN107129444B (zh) * | 2016-02-29 | 2018-08-31 | 尚科生物医药(上海)有限公司 | (s)-2-叔丁氧羰基氨基-3-(4-氨甲酰基-2,6-二甲基苯基)丙酸制备方法 |
CN105777584B (zh) * | 2016-03-28 | 2018-01-02 | 成都伊诺达博医药科技有限公司 | 丙氨酸衍生物的制备方法 |
CN105693554B (zh) * | 2016-04-06 | 2017-08-08 | 成都伊诺达博医药科技有限公司 | 丙氨酸衍生物的制备方法 |
EP3515434A4 (en) | 2016-09-20 | 2020-02-26 | Sun Pharmaceutical Industries Limited | METHOD FOR PRODUCING ELUXADOLIN |
CN106636246B (zh) * | 2016-12-28 | 2020-03-24 | 尚科生物医药(上海)有限公司 | 生物法制备(s)-1-(5-苯基-1h-咪唑-2-基)乙胺 |
CN106636241B (zh) * | 2016-12-28 | 2020-04-03 | 尚科生物医药(上海)有限公司 | 一种酶法制备艾沙度林中间体的方法 |
CN106866463B (zh) * | 2017-01-24 | 2018-08-28 | 富乐马鸿凯(大连)医药有限公司 | 艾沙度林中间体的制备方法 |
WO2018225851A1 (ja) | 2017-06-09 | 2018-12-13 | 中外製薬株式会社 | N-置換アミノ酸を含むペプチドの合成方法 |
WO2019117274A1 (ja) | 2017-12-15 | 2019-06-20 | 中外製薬株式会社 | ペプチドの製造方法、及び塩基の処理方法 |
CN110092735B (zh) * | 2018-01-31 | 2021-05-11 | 尚科生物医药(上海)有限公司 | 一种l-丙氨酸衍生物的制备方法 |
WO2019197274A1 (en) | 2018-04-09 | 2019-10-17 | Quimica Sintetica, S. A. | Process for the preparation of opioid modulators |
JPWO2020111238A1 (ja) | 2018-11-30 | 2021-10-21 | 中外製薬株式会社 | ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法 |
KR20210139366A (ko) | 2019-03-15 | 2021-11-22 | 추가이 세이야쿠 가부시키가이샤 | 방향족 아미노산 유도체의 제조 방법 |
CN111620876B (zh) * | 2020-05-07 | 2021-09-28 | 普济生物科技(台州)有限公司 | 瑞德西韦关键中间体的合成方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2780372B2 (ja) | 1989-08-29 | 1998-07-30 | 株式会社日立製作所 | デイスク制御装置のキヤツシユ組込制御方法 |
JP2881473B2 (ja) * | 1990-03-30 | 1999-04-12 | 日産化学工業株式会社 | α―置換シクロペンテノン誘導体及びその製造法並びに該誘導体を得るための有機亜鉛試剤 |
US5554753A (en) * | 1993-08-25 | 1996-09-10 | Indiana University Foundation | Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis |
SE9402880D0 (sv) | 1994-08-30 | 1994-08-30 | Astra Ab | New peptide derivatives |
JP4228587B2 (ja) * | 2002-05-22 | 2009-02-25 | 昭和電工株式会社 | アミノメチル基含有ベンズアミド化合物の製造方法 |
JP4599169B2 (ja) * | 2002-12-04 | 2010-12-15 | チバ ホールディング インコーポレーテッド | シクロオルガニルホスファンおよびジ(アルカリ金属/アルカリ土類金属)オリゴホスファンジイドの合成方法 |
ME01601B (me) * | 2004-03-15 | 2014-09-20 | Janssen Pharmaceutica Nv | Modulatori opioidnog receptora |
US7629488B2 (en) * | 2005-03-14 | 2009-12-08 | Janssen Pharmaceutica N.V. | Process for the preparation of opioid modulators |
TWI468375B (zh) * | 2008-10-27 | 2015-01-11 | Janssen Pharmaceutica Nv | 製備經保護之l-丙胺酸衍生物之方法 |
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2009
- 2009-10-26 TW TW98136147A patent/TWI468375B/zh not_active IP Right Cessation
- 2009-10-27 CA CA2741790A patent/CA2741790C/en active Active
- 2009-10-27 HU HUE09752026A patent/HUE038302T2/hu unknown
- 2009-10-27 AU AU2009320156A patent/AU2009320156B2/en not_active Ceased
- 2009-10-27 MX MX2011004393A patent/MX2011004393A/es active IP Right Grant
- 2009-10-27 JP JP2011534675A patent/JP5592893B2/ja not_active Expired - Fee Related
- 2009-10-27 ES ES09752026.6T patent/ES2657676T3/es active Active
- 2009-10-27 PE PE2011000939A patent/PE20110417A1/es active IP Right Grant
- 2009-10-27 KR KR1020117011699A patent/KR101690195B1/ko active IP Right Grant
- 2009-10-27 NZ NZ592415A patent/NZ592415A/xx unknown
- 2009-10-27 PE PE2014000876A patent/PE20141698A1/es not_active Application Discontinuation
- 2009-10-27 EP EP09752026.6A patent/EP2362868B1/en active Active
- 2009-10-27 BR BRPI0920834-8A patent/BRPI0920834B1/pt active IP Right Grant
- 2009-10-27 US US12/606,730 patent/US8710256B2/en active Active
- 2009-10-27 CN CN200980153642.2A patent/CN102264691B/zh active Active
- 2009-10-27 EA EA201170618A patent/EA018913B1/ru unknown
- 2009-10-27 AR ARP090104133A patent/AR075291A1/es active IP Right Grant
- 2009-10-27 WO PCT/US2009/062191 patent/WO2010062590A2/en active Application Filing
- 2009-10-27 UA UAA201106621A patent/UA110600C2/uk unknown
- 2009-10-27 CN CN201710219076.7A patent/CN107382781A/zh active Pending
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2011
- 2011-04-26 CL CL2011000936A patent/CL2011000936A1/es unknown
- 2011-04-26 IL IL212464A patent/IL212464A/en active IP Right Grant
- 2011-04-27 HN HN2011001186A patent/HN2011001186A/es unknown
- 2011-04-27 EC EC2011011008A patent/ECSP11011008A/es unknown
- 2011-04-27 CO CO11051582A patent/CO6361989A2/es active IP Right Grant
- 2011-04-27 NI NI201100078A patent/NI201100078A/es unknown
- 2011-05-27 CR CR20110286A patent/CR20110286A/es unknown
-
2014
- 2014-01-23 US US14/162,150 patent/US8853445B2/en active Active
- 2014-07-31 JP JP2014155710A patent/JP2015013862A/ja active Pending
- 2014-09-05 US US14/478,253 patent/US9187408B2/en active Active
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