BRPI0920834A2 - processo para preparação de derivados protegidos de l-alanina - Google Patents

processo para preparação de derivados protegidos de l-alanina

Info

Publication number
BRPI0920834A2
BRPI0920834A2 BRPI0920834-8A BRPI0920834A BRPI0920834A2 BR PI0920834 A2 BRPI0920834 A2 BR PI0920834A2 BR PI0920834 A BRPI0920834 A BR PI0920834A BR PI0920834 A2 BRPI0920834 A2 BR PI0920834A2
Authority
BR
Brazil
Prior art keywords
alanine derivatives
protected
preparing protected
preparation
preparing
Prior art date
Application number
BRPI0920834-8A
Other languages
English (en)
Inventor
Feibush Penina
Anzalone Luigi
J. Villani Frank
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41796530&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0920834(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0920834A2 publication Critical patent/BRPI0920834A2/pt
Publication of BRPI0920834B1 publication Critical patent/BRPI0920834B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/06—Preparation of carboxylic acid amides from nitriles by transformation of cyano groups into carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/16—Preparation of carboxylic acid nitriles by reaction of cyanides with lactones or compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/06—Zinc compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

processo para preparação de derivados protegidos de l-alanina a presente invenção refere-se a um processo inovador destinado à preparação de derivados protegidos de l-alanina, úteis como intermediários na síntese de compostos úteis como moduladores de mu/delta opioides.
BRPI0920834-8A 2008-10-27 2009-10-27 processo para preparação de derivados protegidos de l-alanina BRPI0920834B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10864908P 2008-10-27 2008-10-27
US61/108,649 2008-10-27
PCT/US2009/062191 WO2010062590A2 (en) 2008-10-27 2009-10-27 Process for the preparation of protected l-alanine derivatives

Publications (2)

Publication Number Publication Date
BRPI0920834A2 true BRPI0920834A2 (pt) 2019-04-09
BRPI0920834B1 BRPI0920834B1 (pt) 2020-11-24

Family

ID=41796530

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0920834-8A BRPI0920834B1 (pt) 2008-10-27 2009-10-27 processo para preparação de derivados protegidos de l-alanina

Country Status (25)

Country Link
US (3) US8710256B2 (pt)
EP (1) EP2362868B1 (pt)
JP (2) JP5592893B2 (pt)
KR (1) KR101690195B1 (pt)
CN (2) CN102264691B (pt)
AR (1) AR075291A1 (pt)
AU (1) AU2009320156B2 (pt)
BR (1) BRPI0920834B1 (pt)
CA (1) CA2741790C (pt)
CL (1) CL2011000936A1 (pt)
CO (1) CO6361989A2 (pt)
CR (1) CR20110286A (pt)
EA (1) EA018913B1 (pt)
EC (1) ECSP11011008A (pt)
ES (1) ES2657676T3 (pt)
HN (1) HN2011001186A (pt)
HU (1) HUE038302T2 (pt)
IL (1) IL212464A (pt)
MX (1) MX2011004393A (pt)
NI (1) NI201100078A (pt)
NZ (1) NZ592415A (pt)
PE (2) PE20110417A1 (pt)
TW (1) TWI468375B (pt)
UA (1) UA110600C2 (pt)
WO (1) WO2010062590A2 (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI468375B (zh) * 2008-10-27 2015-01-11 Janssen Pharmaceutica Nv 製備經保護之ｌ－丙胺酸衍生物之方法
EP3974563A1 (en) 2011-12-28 2022-03-30 Chugai Seiyaku Kabushiki Kaisha Cyclic peptides
JP6271766B2 (ja) 2014-02-03 2018-01-31 クワドリガ バイオサイエンシーズ， インコーポレイテッド 化学療法剤としてのβ置換γアミノ酸および類似体
KR101900584B1 (ko) 2014-02-03 2018-09-19 콰드리가 바이오사이언시스 인코포레이티드 화학치료제로서의 베타-치환된 베타-아미노산 및 유사체
TWI665178B (zh) 2015-08-03 2019-07-11 夸德里加生物科學公司 作為化療劑的β－取代的β－氨基酸和類似物及其應用
CN108026032B (zh) * 2015-09-11 2020-09-29 株式会社钟化 光学活性4-氨基甲酰基-2,6-二甲基苯基丙氨酸衍生物的制造方法
CN107129444B (zh) * 2016-02-29 2018-08-31 尚科生物医药（上海）有限公司 (s)-2-叔丁氧羰基氨基-3-(4-氨甲酰基-2,6-二甲基苯基)丙酸制备方法
CN105777584B (zh) * 2016-03-28 2018-01-02 成都伊诺达博医药科技有限公司 丙氨酸衍生物的制备方法
CN105693554B (zh) * 2016-04-06 2017-08-08 成都伊诺达博医药科技有限公司 丙氨酸衍生物的制备方法
EP3515434A4 (en) * 2016-09-20 2020-02-26 Sun Pharmaceutical Industries Limited METHOD FOR PRODUCING ELUXADOLIN
CN106636241B (zh) * 2016-12-28 2020-04-03 尚科生物医药（上海）有限公司 一种酶法制备艾沙度林中间体的方法
CN106636246B (zh) * 2016-12-28 2020-03-24 尚科生物医药（上海）有限公司 生物法制备(s)-1-(5-苯基-1h-咪唑-2-基)乙胺
CN106866463B (zh) * 2017-01-24 2018-08-28 富乐马鸿凯（大连）医药有限公司 艾沙度林中间体的制备方法
JP7229158B2 (ja) 2017-06-09 2023-02-27 中外製薬株式会社 Ｎ－置換アミノ酸を含むペプチドの合成方法
EP3725796A4 (en) 2017-12-15 2021-09-15 Chugai Seiyaku Kabushiki Kaisha METHOD FOR MANUFACTURING PEPTIDE AND METHOD FOR PROCESSING BASES
CN110092735B (zh) * 2018-01-31 2021-05-11 尚科生物医药（上海）有限公司 一种l-丙氨酸衍生物的制备方法
WO2019197274A1 (en) 2018-04-09 2019-10-17 Quimica Sintetica, S. A. Process for the preparation of opioid modulators
KR20210098476A (ko) 2018-11-30 2021-08-10 추가이 세이야쿠 가부시키가이샤 펩티드 화합물 또는 아마이드 화합물의 탈보호법 및 고상 반응에 있어서의 탈수지 방법, 및 펩티드 화합물의 제조 방법
JP7472101B2 (ja) 2019-03-15 2024-04-22 中外製薬株式会社 芳香族アミノ酸誘導体の製造方法
CN111620876B (zh) * 2020-05-07 2021-09-28 普济生物科技（台州）有限公司 瑞德西韦关键中间体的合成方法

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JP2780372B2 (ja) 1989-08-29 1998-07-30 株式会社日立製作所 デイスク制御装置のキヤツシユ組込制御方法
JP2881473B2 (ja) * 1990-03-30 1999-04-12 日産化学工業株式会社 α―置換シクロペンテノン誘導体及びその製造法並びに該誘導体を得るための有機亜鉛試剤
US5554753A (en) 1993-08-25 1996-09-10 Indiana University Foundation Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis
SE9402880D0 (sv) 1994-08-30 1994-08-30 Astra Ab New peptide derivatives
JP4228587B2 (ja) * 2002-05-22 2009-02-25 昭和電工株式会社 アミノメチル基含有ベンズアミド化合物の製造方法
ATE435230T1 (de) * 2002-12-04 2009-07-15 Ciba Holding Inc Verfahren zur synthese von cycloorganylphosphanen und von di(alkali/erdalkalimetall)oligophosphandiiden
CN102786476B (zh) * 2004-03-15 2017-01-18 詹森药业有限公司 作为阿片受体调节剂的化合物
KR101280929B1 (ko) * 2005-03-14 2013-07-01 얀센 파마슈티카 엔.브이. 오피오이드 모듈레이터의 제조방법
TWI468375B (zh) * 2008-10-27 2015-01-11 Janssen Pharmaceutica Nv 製備經保護之ｌ－丙胺酸衍生物之方法

Also Published As

Publication number Publication date
AU2009320156B2 (en) 2014-02-13
US20140378701A1 (en) 2014-12-25
KR20110077005A (ko) 2011-07-06
CA2741790A1 (en) 2010-06-03
PE20110417A1 (es) 2011-06-22
HUE038302T2 (hu) 2018-10-29
IL212464A (en) 2014-11-30
PE20141698A1 (es) 2014-11-19
JP2012506909A (ja) 2012-03-22
CO6361989A2 (es) 2012-01-20
US8710256B2 (en) 2014-04-29
CN102264691B (zh) 2017-05-03
KR101690195B1 (ko) 2016-12-27
EP2362868B1 (en) 2017-12-20
CN102264691A (zh) 2011-11-30
ECSP11011008A (es) 2011-05-31
US20100145090A1 (en) 2010-06-10
AR075291A1 (es) 2011-03-23
ES2657676T3 (es) 2018-03-06
CL2011000936A1 (es) 2012-04-09
JP5592893B2 (ja) 2014-09-17
CA2741790C (en) 2017-09-05
AU2009320156A1 (en) 2010-06-03
EA018913B1 (ru) 2013-11-29
US8853445B2 (en) 2014-10-07
EP2362868A2 (en) 2011-09-07
IL212464A0 (en) 2011-06-30
US9187408B2 (en) 2015-11-17
NZ592415A (en) 2013-01-25
US20140135525A1 (en) 2014-05-15
TWI468375B (zh) 2015-01-11
CN107382781A (zh) 2017-11-24
JP2015013862A (ja) 2015-01-22
NI201100078A (es) 2011-10-21
CR20110286A (es) 2012-01-06
HN2011001186A (es) 2014-06-09
UA110600C2 (uk) 2016-01-25
WO2010062590A2 (en) 2010-06-03
TW201035020A (en) 2010-10-01
WO2010062590A3 (en) 2010-07-08
EA201170618A1 (ru) 2011-12-30
BRPI0920834B1 (pt) 2020-11-24
MX2011004393A (es) 2011-05-25

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/11/2020, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.