CO6361989A2 - Proceso para la preparacion de derivados de l-alanina protegidos - Google Patents
Proceso para la preparacion de derivados de l-alanina protegidosInfo
- Publication number
- CO6361989A2 CO6361989A2 CO11051582A CO11051582A CO6361989A2 CO 6361989 A2 CO6361989 A2 CO 6361989A2 CO 11051582 A CO11051582 A CO 11051582A CO 11051582 A CO11051582 A CO 11051582A CO 6361989 A2 CO6361989 A2 CO 6361989A2
- Authority
- CO
- Colombia
- Prior art keywords
- protected
- preparation
- alanine derivatives
- alanine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/06—Preparation of carboxylic acid amides from nitriles by transformation of cyano groups into carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/16—Preparation of carboxylic acid nitriles by reaction of cyanides with lactones or compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
- C07F3/06—Zinc compounds
Abstract
La presente invención se encuentra dirigida a un proceso para la preparación de derivados de L-alanina protegidos de fórmula donde los sustituyentes R0, PG1, R4 y R6 son como se definen en la reivindicación 1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10864908P | 2008-10-27 | 2008-10-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6361989A2 true CO6361989A2 (es) | 2012-01-20 |
Family
ID=41796530
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO11051582A CO6361989A2 (es) | 2008-10-27 | 2011-04-27 | Proceso para la preparacion de derivados de l-alanina protegidos |
Country Status (25)
Country | Link |
---|---|
US (3) | US8710256B2 (es) |
EP (1) | EP2362868B1 (es) |
JP (2) | JP5592893B2 (es) |
KR (1) | KR101690195B1 (es) |
CN (2) | CN102264691B (es) |
AR (1) | AR075291A1 (es) |
AU (1) | AU2009320156B2 (es) |
BR (1) | BRPI0920834B1 (es) |
CA (1) | CA2741790C (es) |
CL (1) | CL2011000936A1 (es) |
CO (1) | CO6361989A2 (es) |
CR (1) | CR20110286A (es) |
EA (1) | EA018913B1 (es) |
EC (1) | ECSP11011008A (es) |
ES (1) | ES2657676T3 (es) |
HN (1) | HN2011001186A (es) |
HU (1) | HUE038302T2 (es) |
IL (1) | IL212464A (es) |
MX (1) | MX2011004393A (es) |
NI (1) | NI201100078A (es) |
NZ (1) | NZ592415A (es) |
PE (2) | PE20141698A1 (es) |
TW (1) | TWI468375B (es) |
UA (1) | UA110600C2 (es) |
WO (1) | WO2010062590A2 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI468375B (zh) * | 2008-10-27 | 2015-01-11 | Janssen Pharmaceutica Nv | 製備經保護之l-丙胺酸衍生物之方法 |
TWI640541B (zh) | 2011-12-28 | 2018-11-11 | 中外製藥股份有限公司 | Peptide compound having an annular portion and pharmaceutical composition thereof |
BR112016017997A2 (pt) | 2014-02-03 | 2017-08-08 | Quadriga Biosciences Inc | Beta aminoácidos beta-substituídos e análogos como agentes quimioterapêuticos |
BR112016017993A2 (pt) | 2014-02-03 | 2017-08-08 | Quadriga Biosciences Inc | Gama-aminoácidos beta-substituídos e análogos como agentes quimioterapêuticos |
KR20180035894A (ko) | 2015-08-03 | 2018-04-06 | 콰드리가 바이오사이언시스 인코포레이티드 | 화학치료제로서의 베타-치환된 베타-아미노산 및 유사체 및 이들의 용도 |
CN108026032B (zh) * | 2015-09-11 | 2020-09-29 | 株式会社钟化 | 光学活性4-氨基甲酰基-2,6-二甲基苯基丙氨酸衍生物的制造方法 |
CN107129444B (zh) * | 2016-02-29 | 2018-08-31 | 尚科生物医药(上海)有限公司 | (s)-2-叔丁氧羰基氨基-3-(4-氨甲酰基-2,6-二甲基苯基)丙酸制备方法 |
CN105777584B (zh) * | 2016-03-28 | 2018-01-02 | 成都伊诺达博医药科技有限公司 | 丙氨酸衍生物的制备方法 |
CN105693554B (zh) * | 2016-04-06 | 2017-08-08 | 成都伊诺达博医药科技有限公司 | 丙氨酸衍生物的制备方法 |
EP3515434A4 (en) | 2016-09-20 | 2020-02-26 | Sun Pharmaceutical Industries Limited | METHOD FOR PRODUCING ELUXADOLIN |
CN106636246B (zh) * | 2016-12-28 | 2020-03-24 | 尚科生物医药(上海)有限公司 | 生物法制备(s)-1-(5-苯基-1h-咪唑-2-基)乙胺 |
CN106636241B (zh) * | 2016-12-28 | 2020-04-03 | 尚科生物医药(上海)有限公司 | 一种酶法制备艾沙度林中间体的方法 |
CN106866463B (zh) * | 2017-01-24 | 2018-08-28 | 富乐马鸿凯(大连)医药有限公司 | 艾沙度林中间体的制备方法 |
KR20230169447A (ko) | 2017-06-09 | 2023-12-15 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
US11492369B2 (en) | 2017-12-15 | 2022-11-08 | Chugai Seiyaku Kabushiki Kaisha | Method for producing peptide, and method for processing bases |
CN110092735B (zh) * | 2018-01-31 | 2021-05-11 | 尚科生物医药(上海)有限公司 | 一种l-丙氨酸衍生物的制备方法 |
WO2019197274A1 (en) | 2018-04-09 | 2019-10-17 | Quimica Sintetica, S. A. | Process for the preparation of opioid modulators |
EP3889164A4 (en) | 2018-11-30 | 2022-11-02 | Chugai Seiyaku Kabushiki Kaisha | DEPROTECTION METHODS AND RESIN REMOVAL METHODS IN THE SOLID PHASE REACTION FOR PEPTIDE COMPOUND OR AMIDE COMPOUND AND METHODS FOR PRODUCTION OF A PEPTIDE COMPOUND |
WO2020189540A1 (ja) | 2019-03-15 | 2020-09-24 | 中外製薬株式会社 | 芳香族アミノ酸誘導体の製造方法 |
CN111620876B (zh) * | 2020-05-07 | 2021-09-28 | 普济生物科技(台州)有限公司 | 瑞德西韦关键中间体的合成方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2780372B2 (ja) | 1989-08-29 | 1998-07-30 | 株式会社日立製作所 | デイスク制御装置のキヤツシユ組込制御方法 |
JP2881473B2 (ja) * | 1990-03-30 | 1999-04-12 | 日産化学工業株式会社 | α―置換シクロペンテノン誘導体及びその製造法並びに該誘導体を得るための有機亜鉛試剤 |
US5554753A (en) | 1993-08-25 | 1996-09-10 | Indiana University Foundation | Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis |
SE9402880D0 (sv) | 1994-08-30 | 1994-08-30 | Astra Ab | New peptide derivatives |
JP4228587B2 (ja) * | 2002-05-22 | 2009-02-25 | 昭和電工株式会社 | アミノメチル基含有ベンズアミド化合物の製造方法 |
DE60328219D1 (de) | 2002-12-04 | 2009-08-13 | Ciba Holding Inc | Verfahren zur synthese von cycloorganylphosphanen und von di(alkali/erdalkalimetall)oligophosphandiiden |
ATE516274T1 (de) * | 2004-03-15 | 2011-07-15 | Janssen Pharmaceutica Nv | Neue verbindungen als modulatoren des opioidrezeptors |
EP1863764A1 (en) | 2005-03-14 | 2007-12-12 | Janssen Pharmaceutica, N.V. | Process for the preparation of opioid modulators |
TWI468375B (zh) * | 2008-10-27 | 2015-01-11 | Janssen Pharmaceutica Nv | 製備經保護之l-丙胺酸衍生物之方法 |
-
2009
- 2009-10-26 TW TW98136147A patent/TWI468375B/zh not_active IP Right Cessation
- 2009-10-27 HU HUE09752026A patent/HUE038302T2/hu unknown
- 2009-10-27 MX MX2011004393A patent/MX2011004393A/es active IP Right Grant
- 2009-10-27 AR ARP090104133A patent/AR075291A1/es active IP Right Grant
- 2009-10-27 CA CA2741790A patent/CA2741790C/en active Active
- 2009-10-27 PE PE2014000876A patent/PE20141698A1/es not_active Application Discontinuation
- 2009-10-27 CN CN200980153642.2A patent/CN102264691B/zh active Active
- 2009-10-27 NZ NZ592415A patent/NZ592415A/xx unknown
- 2009-10-27 BR BRPI0920834-8A patent/BRPI0920834B1/pt active IP Right Grant
- 2009-10-27 AU AU2009320156A patent/AU2009320156B2/en active Active
- 2009-10-27 JP JP2011534675A patent/JP5592893B2/ja active Active
- 2009-10-27 CN CN201710219076.7A patent/CN107382781A/zh active Pending
- 2009-10-27 ES ES09752026.6T patent/ES2657676T3/es active Active
- 2009-10-27 EP EP09752026.6A patent/EP2362868B1/en active Active
- 2009-10-27 PE PE2011000939A patent/PE20110417A1/es active IP Right Grant
- 2009-10-27 WO PCT/US2009/062191 patent/WO2010062590A2/en active Application Filing
- 2009-10-27 US US12/606,730 patent/US8710256B2/en active Active
- 2009-10-27 UA UAA201106621A patent/UA110600C2/uk unknown
- 2009-10-27 KR KR1020117011699A patent/KR101690195B1/ko active IP Right Grant
- 2009-10-27 EA EA201170618A patent/EA018913B1/ru unknown
-
2011
- 2011-04-26 CL CL2011000936A patent/CL2011000936A1/es unknown
- 2011-04-26 IL IL212464A patent/IL212464A/en active IP Right Grant
- 2011-04-27 NI NI201100078A patent/NI201100078A/es unknown
- 2011-04-27 HN HN2011001186A patent/HN2011001186A/es unknown
- 2011-04-27 EC EC2011011008A patent/ECSP11011008A/es unknown
- 2011-04-27 CO CO11051582A patent/CO6361989A2/es active IP Right Grant
- 2011-05-27 CR CR20110286A patent/CR20110286A/es unknown
-
2014
- 2014-01-23 US US14/162,150 patent/US8853445B2/en active Active
- 2014-07-31 JP JP2014155710A patent/JP2015013862A/ja active Pending
- 2014-09-05 US US14/478,253 patent/US9187408B2/en active Active
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