AR075291A1 - Proceso para la preparcion de derivados de l-alanina protegidos - Google Patents

Proceso para la preparcion de derivados de l-alanina protegidos

Info

Publication number
AR075291A1
AR075291A1 ARP090104133A ARP090104133A AR075291A1 AR 075291 A1 AR075291 A1 AR 075291A1 AR P090104133 A ARP090104133 A AR P090104133A AR P090104133 A ARP090104133 A AR P090104133A AR 075291 A1 AR075291 A1 AR 075291A1
Authority
AR
Argentina
Prior art keywords
preparation
protected
alanine derivatives
alanine
useful
Prior art date
Application number
ARP090104133A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41796530&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR075291(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR075291A1 publication Critical patent/AR075291A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/06—Preparation of carboxylic acid amides from nitriles by transformation of cyano groups into carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/16—Preparation of carboxylic acid nitriles by reaction of cyanides with lactones or compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/06—Zinc compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente solicitud se refiere a un proceso novedoso para la preparacion de derivados protegidos de L-alanina, utiles como intermediarios en la síntesis de compuestos utiles como moduladores opioides mu/delta.
ARP090104133A 2008-10-27 2009-10-27 Proceso para la preparcion de derivados de l-alanina protegidos AR075291A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10864908P 2008-10-27 2008-10-27

Publications (1)

Publication Number Publication Date
AR075291A1 true AR075291A1 (es) 2011-03-23

Family

ID=41796530

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090104133A AR075291A1 (es) 2008-10-27 2009-10-27 Proceso para la preparcion de derivados de l-alanina protegidos

Country Status (25)

Country Link
US (3) US8710256B2 (es)
EP (1) EP2362868B1 (es)
JP (2) JP5592893B2 (es)
KR (1) KR101690195B1 (es)
CN (2) CN107382781A (es)
AR (1) AR075291A1 (es)
AU (1) AU2009320156B2 (es)
BR (1) BRPI0920834B1 (es)
CA (1) CA2741790C (es)
CL (1) CL2011000936A1 (es)
CO (1) CO6361989A2 (es)
CR (1) CR20110286A (es)
EA (1) EA018913B1 (es)
EC (1) ECSP11011008A (es)
ES (1) ES2657676T3 (es)
HN (1) HN2011001186A (es)
HU (1) HUE038302T2 (es)
IL (1) IL212464A (es)
MX (1) MX2011004393A (es)
NI (1) NI201100078A (es)
NZ (1) NZ592415A (es)
PE (2) PE20141698A1 (es)
TW (1) TWI468375B (es)
UA (1) UA110600C2 (es)
WO (1) WO2010062590A2 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI468375B (zh) * 2008-10-27 2015-01-11 Janssen Pharmaceutica Nv 製備經保護之ｌ－丙胺酸衍生物之方法
WO2013100132A1 (ja) 2011-12-28 2013-07-04 中外製薬株式会社 ペプチド化合物の環化方法
CN106163509B (zh) 2014-02-03 2019-05-03 夸德里加生物科学公司 作为化疗剂的β-取代的β-氨基酸及类似物
CN106132406B (zh) 2014-02-03 2020-03-27 夸德里加生物科学公司 作为化疗剂的β-取代的γ-氨基酸和类似物
EP3331851A1 (en) 2015-08-03 2018-06-13 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof
WO2017043626A1 (ja) * 2015-09-11 2017-03-16 株式会社カネカ 光学活性４－カルバモイル－２，６－ジメチルフェニルアラニン誘導体の製造法
CN107129444B (zh) * 2016-02-29 2018-08-31 尚科生物医药（上海）有限公司 (s)-2-叔丁氧羰基氨基-3-(4-氨甲酰基-2,6-二甲基苯基)丙酸制备方法
CN105777584B (zh) * 2016-03-28 2018-01-02 成都伊诺达博医药科技有限公司 丙氨酸衍生物的制备方法
CN105693554B (zh) * 2016-04-06 2017-08-08 成都伊诺达博医药科技有限公司 丙氨酸衍生物的制备方法
US10479769B2 (en) 2016-09-20 2019-11-19 Sun Pharmaceutical Industries Limited Processes for the preparation of eluxadoline
CN106636241B (zh) * 2016-12-28 2020-04-03 尚科生物医药（上海）有限公司 一种酶法制备艾沙度林中间体的方法
CN106636246B (zh) * 2016-12-28 2020-03-24 尚科生物医药（上海）有限公司 生物法制备(s)-1-(5-苯基-1h-咪唑-2-基)乙胺
CN106866463B (zh) * 2017-01-24 2018-08-28 富乐马鸿凯（大连）医药有限公司 艾沙度林中间体的制备方法
US11542299B2 (en) 2017-06-09 2023-01-03 Chugai Seiyaku Kabushiki Kaisha Method for synthesizing peptide containing N-substituted amino acid
WO2019117274A1 (ja) 2017-12-15 2019-06-20 中外製薬株式会社 ペプチドの製造方法、及び塩基の処理方法
CN110092735B (zh) * 2018-01-31 2021-05-11 尚科生物医药（上海）有限公司 一种l-丙氨酸衍生物的制备方法
WO2019197274A1 (en) 2018-04-09 2019-10-17 Quimica Sintetica, S. A. Process for the preparation of opioid modulators
JP7568510B2 (ja) 2018-11-30 2024-10-16 中外製薬株式会社 ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法
EP3939962A4 (en) 2019-03-15 2022-12-28 Chugai Seiyaku Kabushiki Kaisha METHOD FOR PREPARING AN AROMATIC AMINO ACID DERIVATIVE
CN111620876B (zh) * 2020-05-07 2021-09-28 普济生物科技（台州）有限公司 瑞德西韦关键中间体的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2780372B2 (ja) 1989-08-29 1998-07-30 株式会社日立製作所 デイスク制御装置のキヤツシユ組込制御方法
JP2881473B2 (ja) * 1990-03-30 1999-04-12 日産化学工業株式会社 α―置換シクロペンテノン誘導体及びその製造法並びに該誘導体を得るための有機亜鉛試剤
US5554753A (en) * 1993-08-25 1996-09-10 Indiana University Foundation Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis
SE9402880D0 (sv) 1994-08-30 1994-08-30 Astra Ab New peptide derivatives
JP4228587B2 (ja) * 2002-05-22 2009-02-25 昭和電工株式会社 アミノメチル基含有ベンズアミド化合物の製造方法
EP1567534B1 (en) * 2002-12-04 2009-07-01 Ciba Holding Inc. Process for the synthesis of cycloorganylphosphanes and di(alkali metal/alkaline earth metal) oligophosphanediides
ME02221B (me) * 2004-03-15 2016-02-20 Janssen Pharmaceutica Nv Postupak za proizvodnju intermedijara jedinjenja korisnih kao modulatori opioidnih receptora
KR20070112255A (ko) 2005-03-14 2007-11-22 얀센 파마슈티카 엔.브이. 오피오이드 조절체의 제조 방법
TWI468375B (zh) * 2008-10-27 2015-01-11 Janssen Pharmaceutica Nv 製備經保護之ｌ－丙胺酸衍生物之方法

Also Published As

Publication number Publication date
UA110600C2 (uk) 2016-01-25
CN107382781A (zh) 2017-11-24
EA018913B1 (ru) 2013-11-29
TW201035020A (en) 2010-10-01
CN102264691A (zh) 2011-11-30
BRPI0920834A2 (pt) 2019-04-09
CL2011000936A1 (es) 2012-04-09
JP2012506909A (ja) 2012-03-22
US8853445B2 (en) 2014-10-07
EP2362868B1 (en) 2017-12-20
KR20110077005A (ko) 2011-07-06
PE20141698A1 (es) 2014-11-19
HN2011001186A (es) 2014-06-09
US9187408B2 (en) 2015-11-17
ECSP11011008A (es) 2011-05-31
CA2741790C (en) 2017-09-05
EA201170618A1 (ru) 2011-12-30
CO6361989A2 (es) 2012-01-20
US8710256B2 (en) 2014-04-29
WO2010062590A2 (en) 2010-06-03
AU2009320156B2 (en) 2014-02-13
IL212464A0 (en) 2011-06-30
CR20110286A (es) 2012-01-06
CN102264691B (zh) 2017-05-03
AU2009320156A1 (en) 2010-06-03
PE20110417A1 (es) 2011-06-22
CA2741790A1 (en) 2010-06-03
EP2362868A2 (en) 2011-09-07
ES2657676T3 (es) 2018-03-06
TWI468375B (zh) 2015-01-11
MX2011004393A (es) 2011-05-25
US20100145090A1 (en) 2010-06-10
US20140378701A1 (en) 2014-12-25
NI201100078A (es) 2011-10-21
WO2010062590A3 (en) 2010-07-08
NZ592415A (en) 2013-01-25
JP2015013862A (ja) 2015-01-22
HUE038302T2 (hu) 2018-10-29
US20140135525A1 (en) 2014-05-15
IL212464A (en) 2014-11-30
JP5592893B2 (ja) 2014-09-17
KR101690195B1 (ko) 2016-12-27
BRPI0920834B1 (pt) 2020-11-24

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