UY31949A - Proceso para preparar derivados de pirimidina sustituidos - Google Patents

Proceso para preparar derivados de pirimidina sustituidos

Info

Publication number
UY31949A
UY31949A UY31949A UY31949A UY31949A UY 31949 A UY31949 A UY 31949A UY 31949 A UY31949 A UY 31949A UY 31949 A UY31949 A UY 31949A UY 31949 A UY31949 A UY 31949A
Authority
UY
Uruguay
Prior art keywords
pyrimidine derivatives
substituted pyrimidine
prepare substituted
intermediates
synthesis
Prior art date
Application number
UY31949A
Other languages
English (en)
Inventor
Sorgi Kirk
Jeffrey S Grimm
Mani Neelakandha
Daniel J Pippel
Sergio Cesco-Cancian
Christopher M Mapes
David C Palmer
Xiao Tong
Chen Hongfeng
Original Assignee
Janssen Pharmnaceutica N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41464882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY31949(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmnaceutica N V filed Critical Janssen Pharmnaceutica N V
Publication of UY31949A publication Critical patent/UY31949A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/22Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a procesos para preparar derivados de pirimidina sustituidos, útiles como intermediarios en la síntesis de los moduladores de los receptores de histamina H4, y a intermediarios en la síntesis de los moduladores de H4.
UY31949A 2008-06-30 2009-06-30 Proceso para preparar derivados de pirimidina sustituidos UY31949A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7675208P 2008-06-30 2008-06-30

Publications (1)

Publication Number Publication Date
UY31949A true UY31949A (es) 2010-01-29

Family

ID=41464882

Family Applications (1)

Application Number Title Priority Date Filing Date
UY31949A UY31949A (es) 2008-06-30 2009-06-30 Proceso para preparar derivados de pirimidina sustituidos

Country Status (36)

Country Link
US (6) US8309720B2 (es)
EP (5) EP2924025A1 (es)
JP (1) JP5416768B2 (es)
KR (1) KR101675354B1 (es)
CN (1) CN102137672B (es)
AR (1) AR072396A1 (es)
AU (1) AU2009267156B2 (es)
BR (1) BRPI0913644A2 (es)
CA (1) CA2729733C (es)
CO (1) CO6341560A2 (es)
CY (1) CY1116134T1 (es)
DK (1) DK2310012T3 (es)
EA (1) EA019361B1 (es)
EC (1) ECSP11010745A (es)
ES (1) ES2538135T3 (es)
HK (4) HK1156857A1 (es)
HR (1) HRP20150576T1 (es)
HU (1) HUE024949T2 (es)
IL (4) IL210214A (es)
JO (1) JO3043B1 (es)
ME (1) ME02154B (es)
MX (1) MX2011000080A (es)
MY (1) MY150601A (es)
NI (1) NI201000232A (es)
NZ (1) NZ590170A (es)
PE (1) PE20110163A1 (es)
PL (1) PL2310012T3 (es)
PT (1) PT2310012E (es)
RS (1) RS53985B1 (es)
SI (1) SI2310012T1 (es)
SV (1) SV2011003788A (es)
TW (3) TWI481603B (es)
UA (1) UA106724C2 (es)
UY (1) UY31949A (es)
WO (1) WO2010002774A1 (es)
ZA (1) ZA201100759B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2007752T3 (da) 2006-03-31 2010-11-15 Janssen Pharmaceutica Nv Benzimidazol-2-yl-pyrimidiner og -pyraziner som modulatorer af histamin H4-receptoren
ME02154B (me) 2008-06-30 2015-10-20 Janssen Pharmaceutica Nv Proces za pripremu supstituisanih derivata pirimidina
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
JP5574294B2 (ja) * 2010-11-04 2014-08-20 独立行政法人科学技術振興機構 光磁気記録媒体及び光磁気記録方法
CN105025898B (zh) 2013-03-06 2018-01-23 詹森药业有限公司 组胺h4受体的苯并咪唑‑2‑基嘧啶调节剂
US10202337B2 (en) 2014-03-28 2019-02-12 Kaneka Corporation Method for producing tri-carbobenzoxy-arginine
SG11201903871TA (en) 2016-11-03 2019-05-30 Bristol Myers Squibb Co Substituted bicycle heterocyclic derivatives useful as romk channel inhibitors

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3005852A (en) 1959-12-22 1961-10-24 Gen Aniline & Film Corp Production of sulfoxides and sulfones
US3931195A (en) * 1971-03-03 1976-01-06 Mead Johnson & Company Substituted piperidines
US4191828A (en) * 1976-04-14 1980-03-04 Richardson-Merrell Inc. Process for preparing 2-(2,2-dicyclohexylethyl)piperidine
US4190601A (en) * 1978-05-31 1980-02-26 Union Carbide Corporation Production of tertiary amines by reductive alkylation
JPS5942396A (ja) * 1982-09-02 1984-03-08 Ishihara Sangyo Kaisha Ltd リン酸アミド誘導体およびそれらを含有する殺虫、殺ダニ、殺線虫剤
JPS6130576A (ja) 1984-07-24 1986-02-12 Ube Ind Ltd 2−アミノ−5−シアノピリミジンの製法
US5786373A (en) * 1992-10-14 1998-07-28 Merck & Co., Inc. Fibrinogen receptor antagonists
GB9422391D0 (en) 1994-11-05 1995-01-04 Solvay Interox Ltd Oxidation of organosulphur compounds
JP2002503662A (ja) 1998-02-17 2002-02-05 テュラリク インコーポレイテッド 抗ウイルス性ピリミジン誘導体
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
US6372743B1 (en) 1999-09-30 2002-04-16 Neurogen Corporation Certain alkylene diamine-substituted pyrazlo (1,5-a)-1,5-pyrimidines and pyrazolo (1,5-a) 1,3,5-triazines
CA2411155C (en) 2000-07-21 2009-12-08 Syngenta Participations Ag Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine
PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
WO2002064096A2 (en) 2001-02-16 2002-08-22 Tularik Inc. Methods of using pyrimidine-based antiviral agents
US20050107400A1 (en) * 2001-03-30 2005-05-19 Boyd Leslie F. Use of pyrazolopyridines as therapeutic compounds
ATE323706T1 (de) * 2001-12-17 2006-05-15 Smithkline Beecham Corp Pyrazolopyridazinderivate
TWI270542B (en) 2002-02-07 2007-01-11 Sumitomo Chemical Co Method for preparing sulfone or sulfoxide compound
DE60329030D1 (de) * 2002-12-04 2009-10-08 Ore Pharmaceuticals Inc Melanocortin-rezeptormodulatoren
JP2006525261A (ja) * 2003-05-05 2006-11-09 エフ.ホフマン−ラ ロシュ アーゲー Crf活性を有する縮合ピリミジン誘導体
US7786291B2 (en) 2004-10-27 2010-08-31 Schering Corporation Compositions and methods for short interfering nucleic acid inhibition of Nav1.8
WO2006138304A2 (en) 2005-06-14 2006-12-28 Taigen Biotechnology Pyrimidine compounds
JP5058159B2 (ja) * 2005-07-06 2012-10-24 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 分離マトリックスの製造方法
TW200800201A (en) * 2005-11-18 2008-01-01 Lilly Co Eli Pyrimidinyl benzothiophene compounds
CN101032483B (zh) * 2006-03-09 2011-05-04 陈德桂 调节雄激素受体活性的乙内酰脲衍生物及其应用
DK2007752T3 (da) * 2006-03-31 2010-11-15 Janssen Pharmaceutica Nv Benzimidazol-2-yl-pyrimidiner og -pyraziner som modulatorer af histamin H4-receptoren
DE602007008859D1 (de) * 2006-03-31 2010-10-14 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyridine als modulatoren des histamin-h4-rezeptors
ME02154B (me) 2008-06-30 2015-10-20 Janssen Pharmaceutica Nv Proces za pripremu supstituisanih derivata pirimidina
AU2009267159B2 (en) * 2008-06-30 2014-05-15 Janssen Pharmaceutica Nv Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives

Also Published As

Publication number Publication date
EA201170113A1 (ru) 2011-08-30
JP2011526910A (ja) 2011-10-20
CA2729733C (en) 2016-10-25
DK2310012T3 (da) 2015-03-30
TW201012810A (en) 2010-04-01
ES2538135T3 (es) 2015-06-17
US20140121374A1 (en) 2014-05-01
PL2310012T3 (pl) 2015-08-31
KR101675354B1 (ko) 2016-11-11
TW201420583A (zh) 2014-06-01
EP2310012A1 (en) 2011-04-20
AU2009267156B2 (en) 2015-05-28
HK1201441A1 (en) 2015-09-04
SV2011003788A (es) 2011-02-08
NZ590170A (en) 2012-04-27
CN102137672B (zh) 2014-03-26
HK1214590A1 (zh) 2016-07-29
PT2310012E (pt) 2015-04-02
TWI481603B (zh) 2015-04-21
US9079884B2 (en) 2015-07-14
US20130225816A1 (en) 2013-08-29
EA019361B1 (ru) 2014-03-31
IL235571A (en) 2016-09-29
PE20110163A1 (es) 2011-03-28
KR20110023901A (ko) 2011-03-08
EP2924035A1 (en) 2015-09-30
ZA201100759B (en) 2012-07-25
JO3043B1 (ar) 2016-09-05
EP2924023A1 (en) 2015-09-30
HK1215434A1 (zh) 2016-08-26
US20100004450A1 (en) 2010-01-07
CA2729733A1 (en) 2010-01-07
RS53985B1 (en) 2015-10-30
IL210214A0 (en) 2011-03-31
US9079883B2 (en) 2015-07-14
CY1116134T1 (el) 2017-02-08
IL210214A (en) 2016-07-31
TW201433568A (zh) 2014-09-01
EP2924025A1 (en) 2015-09-30
ME02154B (me) 2015-10-20
UA106724C2 (uk) 2014-10-10
EP2769721A3 (en) 2015-04-01
IL235570A (en) 2016-08-31
HUE024949T2 (en) 2016-02-29
AR072396A1 (es) 2010-08-25
HK1156857A1 (en) 2012-06-22
IL235572A (en) 2016-09-29
MY150601A (en) 2014-01-30
US8309720B2 (en) 2012-11-13
EP2310012B1 (en) 2015-03-04
MX2011000080A (es) 2011-03-02
SI2310012T1 (sl) 2015-06-30
HRP20150576T1 (hr) 2015-09-11
US20140066624A1 (en) 2014-03-06
AU2009267156A1 (en) 2010-01-07
NI201000232A (es) 2011-09-07
EP2310012A4 (en) 2012-06-20
US20140073795A1 (en) 2014-03-13
BRPI0913644A2 (pt) 2015-11-24
CN102137672A (zh) 2011-07-27
US9006432B2 (en) 2015-04-14
EP2769721A2 (en) 2014-08-27
US20130053561A1 (en) 2013-02-28
WO2010002774A1 (en) 2010-01-07
US9359327B2 (en) 2016-06-07
CO6341560A2 (es) 2011-11-21
ECSP11010745A (es) 2011-02-28
US9079882B2 (en) 2015-07-14
TWI498326B (zh) 2015-09-01
JP5416768B2 (ja) 2014-02-12

Similar Documents

Publication Publication Date Title
UY31949A (es) Proceso para preparar derivados de pirimidina sustituidos
AR075291A1 (es) Proceso para la preparcion de derivados de l-alanina protegidos
NI201000233A (es) Proceso para la preparación de derivados de pirimidina benzoimidazol - 2 - il.
CR20110279A (es) Derivados de piridina y pirimidina como inhibidores de fosfodiesterasa 10
HK1194742A1 (en) Process for preparing fused pyrimidine-dione derivatives, useful as as trpa1 modulators trpa1
ECSP12011581A (es) Inhibidores de bace
CR11776A (es) Inhibidores de bace
CR20150370A (es) Compuestos antivirales
DK2736895T3 (da) 2-(2,4,5-substitueret anilin)-pyrimidinderivater som egfr-modulatorer, der er anvendelige til behandling af cancer
DK2350078T3 (da) Forbindelser, der opformerer hæmatopoietiske stamceller
BRPI0810653A2 (pt) Derivados de ácido nicotínico como moduladores do receptor metabotrópico de glutamato-5.
DK2411395T3 (da) Furopyrimidindionderivater som modulatorer for TRPA1
ECSP11011348A (es) 2-mercaptoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3
BRPI0823256A2 (pt) Uso de sacarose como substrato para produção fermentativa de 1,2-propanodiol
EA201270280A1 (ru) Соединения пиримидина в качестве ингибиторов при лечении туберкулеза
UY32517A (es) Derivados de nicotinamida, su preparación y su aplicación en terapéutica
CR20130625A (es) Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina
ECSP13012914A (es) Síntesis de derivados de 2-carboxamida-cicloamino-urea
UY32524A (es) Moduladores de sip y método para producirlos y usarlos
CO6680692A2 (es) Método y composición para producir azúcar clarificada
UY32349A (es) Derivados de biaril-bencil-amina
CL2010001635A1 (es) Derivados de pirimidinas utiles como moduladores del receptor h4; y su procedimiento de preparacion.
CU20090029A7 (es) Derivados de feniloxianilina
GT200800195A (es) Procedimiento para la preparación de derivados de ciclopropilamida
ECSP12012266A (es) Proceso para la preparación de intermedios de 1-aril-pirazol-3-ona útiles en la síntesis de inhibidores de receptores sigma