HK1215434A1 - 取代的嘧啶衍生物 - Google Patents

取代的嘧啶衍生物

Info

Publication number
HK1215434A1
HK1215434A1 HK16103405.5A HK16103405A HK1215434A1 HK 1215434 A1 HK1215434 A1 HK 1215434A1 HK 16103405 A HK16103405 A HK 16103405A HK 1215434 A1 HK1215434 A1 HK 1215434A1
Authority
HK
Hong Kong
Prior art keywords
pyrimidine derivatives
substituted pyrimidine
substituted
derivatives
pyrimidine
Prior art date
Application number
HK16103405.5A
Other languages
English (en)
Inventor
Cesco-Cancian Sergio
Chen Hongfeng
S Grimm Jeffrey
S Mani Neelakandha
M Mapes Christopher
C Palmer David
J Pippel Daniel
L Sorgi Kirk
Xiao Tong
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41464882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1215434(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1215434A1 publication Critical patent/HK1215434A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
HK16103405.5A 2008-06-30 2016-03-23 取代的嘧啶衍生物 HK1215434A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7675208P 2008-06-30 2008-06-30

Publications (1)

Publication Number Publication Date
HK1215434A1 true HK1215434A1 (zh) 2016-08-26

Family

ID=41464882

Family Applications (4)

Application Number Title Priority Date Filing Date
HK11111216.2A HK1156857A1 (zh) 2008-06-30 2011-10-19 取代的嘧啶衍生物的製備方法
HK15101911.7A HK1201441A1 (zh) 2008-06-30 2015-02-26 取代的嘧啶衍生物的製備方法
HK16102449.5A HK1214590A1 (zh) 2008-06-30 2016-03-03 哌啶和哌嗪衍生物
HK16103405.5A HK1215434A1 (zh) 2008-06-30 2016-03-23 取代的嘧啶衍生物

Family Applications Before (3)

Application Number Title Priority Date Filing Date
HK11111216.2A HK1156857A1 (zh) 2008-06-30 2011-10-19 取代的嘧啶衍生物的製備方法
HK15101911.7A HK1201441A1 (zh) 2008-06-30 2015-02-26 取代的嘧啶衍生物的製備方法
HK16102449.5A HK1214590A1 (zh) 2008-06-30 2016-03-03 哌啶和哌嗪衍生物

Country Status (36)

Country Link
US (6) US8309720B2 (zh)
EP (5) EP2769721A3 (zh)
JP (1) JP5416768B2 (zh)
KR (1) KR101675354B1 (zh)
CN (1) CN102137672B (zh)
AR (1) AR072396A1 (zh)
AU (1) AU2009267156B2 (zh)
BR (1) BRPI0913644A2 (zh)
CA (1) CA2729733C (zh)
CO (1) CO6341560A2 (zh)
CY (1) CY1116134T1 (zh)
DK (1) DK2310012T3 (zh)
EA (1) EA019361B1 (zh)
EC (1) ECSP11010745A (zh)
ES (1) ES2538135T3 (zh)
HK (4) HK1156857A1 (zh)
HR (1) HRP20150576T1 (zh)
HU (1) HUE024949T2 (zh)
IL (4) IL210214A (zh)
JO (1) JO3043B1 (zh)
ME (1) ME02154B (zh)
MX (1) MX2011000080A (zh)
MY (1) MY150601A (zh)
NI (1) NI201000232A (zh)
NZ (1) NZ590170A (zh)
PE (1) PE20110163A1 (zh)
PL (1) PL2310012T3 (zh)
PT (1) PT2310012E (zh)
RS (1) RS53985B1 (zh)
SI (1) SI2310012T1 (zh)
SV (1) SV2011003788A (zh)
TW (3) TW201433568A (zh)
UA (1) UA106724C2 (zh)
UY (1) UY31949A (zh)
WO (1) WO2010002774A1 (zh)
ZA (1) ZA201100759B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2007752T1 (sl) 2006-03-31 2010-12-31 Janssen Pharmaceutica Nv Benzoimidazol-2-il pirimidini in pirazini kot modulatorji histamin H4 receptorja
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
EP2769721A3 (en) * 2008-06-30 2015-04-01 Janssen Pharmaceutica N.V. Process for the preparation of substituted pyrimidine derivatives
JP5574294B2 (ja) * 2010-11-04 2014-08-20 独立行政法人科学技術振興機構 光磁気記録媒体及び光磁気記録方法
TWI617554B (zh) 2013-03-06 2018-03-11 健生藥品公司 組織胺ｈ受體之苯并咪唑－２－基嘧啶調控劑
JP6484220B2 (ja) * 2014-03-28 2019-03-13 株式会社カネカ トリ−カルボベンゾキシ−アルギニンの製造方法
CA3042380A1 (en) 2016-11-03 2018-05-24 Bristol-Myers Squibb Company Substituted bicycle heterocyclic derivatives useful as romk channel inhibitors

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US3931195A (en) * 1971-03-03 1976-01-06 Mead Johnson & Company Substituted piperidines
US4191828A (en) * 1976-04-14 1980-03-04 Richardson-Merrell Inc. Process for preparing 2-(2,2-dicyclohexylethyl)piperidine
US4190601A (en) 1978-05-31 1980-02-26 Union Carbide Corporation Production of tertiary amines by reductive alkylation
JPS5942396A (ja) * 1982-09-02 1984-03-08 Ishihara Sangyo Kaisha Ltd リン酸アミド誘導体およびそれらを含有する殺虫、殺ダニ、殺線虫剤
JPS6130576A (ja) 1984-07-24 1986-02-12 Ube Ind Ltd ２−アミノ−５−シアノピリミジンの製法
WO1994008577A1 (en) * 1992-10-14 1994-04-28 Merck & Co., Inc. Fibrinogen receptor antagonists
GB9422391D0 (en) 1994-11-05 1995-01-04 Solvay Interox Ltd Oxidation of organosulphur compounds
JP2002503662A (ja) 1998-02-17 2002-02-05 テュラリク インコーポレイテッド 抗ウイルス性ピリミジン誘導体
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
CN1377354A (zh) * 1999-09-30 2002-10-30 纽罗杰有限公司 某些亚烷基二胺一取代的吡唑并[1,5－a]－1,5－嘧啶和吡唑并[1,5－a]－1,3,5－三嗪
JP3507483B1 (ja) 2000-07-21 2004-03-15 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト ４，６−ジメトキシ−２−（メチルスルホニル）−１，３−ピリミジンの製造方法
PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
AU2002258400A1 (en) 2001-02-16 2002-08-28 Tularik Inc. Methods of using pyrimidine-based antiviral agents
WO2002078701A1 (en) * 2001-03-30 2002-10-10 Smithkline Beecham Corporation Use of pyrazolopyridines as therapeutic compounds
WO2003051886A1 (en) * 2001-12-17 2003-06-26 Smithkline Beecham Corporation Pyrazolopyridazine derivatives
TWI270542B (en) 2002-02-07 2007-01-11 Sumitomo Chemical Co Method for preparing sulfone or sulfoxide compound
EP1590338B1 (en) * 2002-12-04 2009-08-26 Ore Pharmaceuticals Inc. Modulators of melanocortin receptor
CA2523261C (en) * 2003-05-05 2009-07-07 F. Hoffmann-La Roche Ag Fused pyrimidine derivatives with crf activity
MX2007005069A (es) 2004-10-27 2007-06-25 Schering Corp Composiciones y metodos para la inhibicion del acido nucleico corto de interferencia de nav1.8.
EP1890703B1 (en) 2005-06-14 2016-05-11 Taigen Biotechnology Pyrimidine compounds as chemokine receptors inhibitors
US8309709B2 (en) * 2005-07-06 2012-11-13 Ge Healthcare Bio-Sciences Ab Method of preparing a separation matrix
TW200800201A (en) * 2005-11-18 2008-01-01 Lilly Co Eli Pyrimidinyl benzothiophene compounds
CN101032483B (zh) * 2006-03-09 2011-05-04 陈德桂 调节雄激素受体活性的乙内酰脲衍生物及其应用
CN101460168B (zh) * 2006-03-31 2013-07-17 詹森药业有限公司 作为组胺h4受体调节剂的苯并咪唑-2-基吡啶
SI2007752T1 (sl) * 2006-03-31 2010-12-31 Janssen Pharmaceutica Nv Benzoimidazol-2-il pirimidini in pirazini kot modulatorji histamin H4 receptorja
EP2769721A3 (en) 2008-06-30 2015-04-01 Janssen Pharmaceutica N.V. Process for the preparation of substituted pyrimidine derivatives
UA102855C2 (ru) * 2008-06-30 2013-08-27 Янссен Фармацевтика Нв Способ получения бензоимидазол-2-илпиримидиновых производных

Also Published As

Publication number Publication date
NI201000232A (es) 2011-09-07
CN102137672A (zh) 2011-07-27
IL210214A0 (en) 2011-03-31
TW201012810A (en) 2010-04-01
EP2769721A3 (en) 2015-04-01
ECSP11010745A (es) 2011-02-28
CO6341560A2 (es) 2011-11-21
US20140073795A1 (en) 2014-03-13
EP2924023A1 (en) 2015-09-30
IL235571A (en) 2016-09-29
UA106724C2 (uk) 2014-10-10
TW201420583A (zh) 2014-06-01
CY1116134T1 (el) 2017-02-08
DK2310012T3 (da) 2015-03-30
PL2310012T3 (pl) 2015-08-31
IL235570A (en) 2016-08-31
US20100004450A1 (en) 2010-01-07
US8309720B2 (en) 2012-11-13
EP2769721A2 (en) 2014-08-27
RS53985B1 (en) 2015-10-30
ES2538135T3 (es) 2015-06-17
EP2924025A1 (en) 2015-09-30
EA201170113A1 (ru) 2011-08-30
PE20110163A1 (es) 2011-03-28
TWI481603B (zh) 2015-04-21
US20140066624A1 (en) 2014-03-06
US9006432B2 (en) 2015-04-14
TW201433568A (zh) 2014-09-01
ZA201100759B (en) 2012-07-25
TWI498326B (zh) 2015-09-01
SV2011003788A (es) 2011-02-08
WO2010002774A1 (en) 2010-01-07
US9079882B2 (en) 2015-07-14
AR072396A1 (es) 2010-08-25
US20140121374A1 (en) 2014-05-01
AU2009267156A1 (en) 2010-01-07
JP2011526910A (ja) 2011-10-20
UY31949A (es) 2010-01-29
JO3043B1 (ar) 2016-09-05
US9359327B2 (en) 2016-06-07
MX2011000080A (es) 2011-03-02
EP2310012B1 (en) 2015-03-04
CA2729733C (en) 2016-10-25
PT2310012E (pt) 2015-04-02
KR101675354B1 (ko) 2016-11-11
US9079883B2 (en) 2015-07-14
NZ590170A (en) 2012-04-27
US20130225816A1 (en) 2013-08-29
HUE024949T2 (en) 2016-02-29
CA2729733A1 (en) 2010-01-07
KR20110023901A (ko) 2011-03-08
EA019361B1 (ru) 2014-03-31
HK1201441A1 (zh) 2015-09-04
US9079884B2 (en) 2015-07-14
JP5416768B2 (ja) 2014-02-12
BRPI0913644A2 (pt) 2015-11-24
EP2924035A1 (en) 2015-09-30
MY150601A (en) 2014-01-30
AU2009267156B2 (en) 2015-05-28
EP2310012A1 (en) 2011-04-20
HK1214590A1 (zh) 2016-07-29
SI2310012T1 (sl) 2015-06-30
CN102137672B (zh) 2014-03-26
EP2310012A4 (en) 2012-06-20
IL235572A (en) 2016-09-29
HK1156857A1 (zh) 2012-06-22
IL210214A (en) 2016-07-31
ME02154B (me) 2015-10-20
HRP20150576T1 (hr) 2015-09-11
US20130053561A1 (en) 2013-02-28

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HK1215434A1 (zh) 取代的嘧啶衍生物