HK1215434A1 - 取代的嘧啶衍生物 - Google Patents

取代的嘧啶衍生物

Info

Publication number
HK1215434A1
HK1215434A1 HK16103405.5A HK16103405A HK1215434A1 HK 1215434 A1 HK1215434 A1 HK 1215434A1 HK 16103405 A HK16103405 A HK 16103405A HK 1215434 A1 HK1215434 A1 HK 1215434A1
Authority
HK
Hong Kong
Prior art keywords
pyrimidine derivatives
substituted pyrimidine
substituted
derivatives
pyrimidine
Prior art date
Application number
HK16103405.5A
Other languages
English (en)
Inventor
Cesco-Cancian Sergio
Chen Hongfeng
S Grimm Jeffrey
S Mani Neelakandha
M Mapes Christopher
C Palmer David
J Pippel Daniel
L Sorgi Kirk
Xiao Tong
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41464882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1215434(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1215434A1 publication Critical patent/HK1215434A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK16103405.5A 2008-06-30 2016-03-23 取代的嘧啶衍生物 HK1215434A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7675208P 2008-06-30 2008-06-30

Publications (1)

Publication Number Publication Date
HK1215434A1 true HK1215434A1 (zh) 2016-08-26

Family

ID=41464882

Family Applications (4)

Application Number Title Priority Date Filing Date
HK11111216.2A HK1156857A1 (zh) 2008-06-30 2011-10-19 取代的嘧啶衍生物的製備方法
HK15101911.7A HK1201441A1 (zh) 2008-06-30 2015-02-26 取代的嘧啶衍生物的製備方法
HK16102449.5A HK1214590A1 (zh) 2008-06-30 2016-03-03 哌啶和哌嗪衍生物
HK16103405.5A HK1215434A1 (zh) 2008-06-30 2016-03-23 取代的嘧啶衍生物

Family Applications Before (3)

Application Number Title Priority Date Filing Date
HK11111216.2A HK1156857A1 (zh) 2008-06-30 2011-10-19 取代的嘧啶衍生物的製備方法
HK15101911.7A HK1201441A1 (zh) 2008-06-30 2015-02-26 取代的嘧啶衍生物的製備方法
HK16102449.5A HK1214590A1 (zh) 2008-06-30 2016-03-03 哌啶和哌嗪衍生物

Country Status (36)

Country Link
US (6) US8309720B2 (zh)
EP (5) EP2924023A1 (zh)
JP (1) JP5416768B2 (zh)
KR (1) KR101675354B1 (zh)
CN (1) CN102137672B (zh)
AR (1) AR072396A1 (zh)
AU (1) AU2009267156B2 (zh)
BR (1) BRPI0913644A2 (zh)
CA (1) CA2729733C (zh)
CO (1) CO6341560A2 (zh)
CY (1) CY1116134T1 (zh)
DK (1) DK2310012T3 (zh)
EA (1) EA019361B1 (zh)
EC (1) ECSP11010745A (zh)
ES (1) ES2538135T3 (zh)
HK (4) HK1156857A1 (zh)
HR (1) HRP20150576T1 (zh)
HU (1) HUE024949T2 (zh)
IL (4) IL210214A (zh)
JO (1) JO3043B1 (zh)
ME (1) ME02154B (zh)
MX (1) MX2011000080A (zh)
MY (1) MY150601A (zh)
NI (1) NI201000232A (zh)
NZ (1) NZ590170A (zh)
PE (1) PE20110163A1 (zh)
PL (1) PL2310012T3 (zh)
PT (1) PT2310012E (zh)
RS (1) RS53985B1 (zh)
SI (1) SI2310012T1 (zh)
SV (1) SV2011003788A (zh)
TW (3) TW201433568A (zh)
UA (1) UA106724C2 (zh)
UY (1) UY31949A (zh)
WO (1) WO2010002774A1 (zh)
ZA (1) ZA201100759B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ571691A (en) 2006-03-31 2011-07-29 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
MX2011000080A (es) 2008-06-30 2011-03-02 Janssen Pharmaceutica Nv Proceso para la preparacion de derivados de pirimidina sustituidos.
JP5574294B2 (ja) * 2010-11-04 2014-08-20 独立行政法人科学技術振興機構 光磁気記録媒体及び光磁気記録方法
UY35370A (es) 2013-03-06 2014-09-30 Janssen Pharmaceutica Nv Moduladores benzoimidazol-2-il pirimidina del receptor de histamina h4
EP3124470B1 (en) 2014-03-28 2020-01-08 Kaneka Corporation Method for producing tri-carbobenzoxy-arginine
CN110139862B (zh) 2016-11-03 2024-01-16 百时美施贵宝公司 可用作romk通道抑制剂的经取代的二环杂环衍生物

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US3931195A (en) * 1971-03-03 1976-01-06 Mead Johnson & Company Substituted piperidines
US4191828A (en) * 1976-04-14 1980-03-04 Richardson-Merrell Inc. Process for preparing 2-(2,2-dicyclohexylethyl)piperidine
US4190601A (en) * 1978-05-31 1980-02-26 Union Carbide Corporation Production of tertiary amines by reductive alkylation
JPS5942396A (ja) * 1982-09-02 1984-03-08 Ishihara Sangyo Kaisha Ltd リン酸アミド誘導体およびそれらを含有する殺虫、殺ダニ、殺線虫剤
JPS6130576A (ja) 1984-07-24 1986-02-12 Ube Ind Ltd ２−アミノ−５−シアノピリミジンの製法
CA2144762A1 (en) * 1992-10-14 1994-04-28 George D. Hartman Fibrinogen receptor antagonists
GB9422391D0 (en) 1994-11-05 1995-01-04 Solvay Interox Ltd Oxidation of organosulphur compounds
NZ506417A (en) 1998-02-17 2003-05-30 Tularik Inc Anti-viral pyrimidine derivatives
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
WO2001023387A2 (en) * 1999-09-30 2001-04-05 Neurogen Corporation CERTAIN ALKYLENE DIAMINE-SUBSTITUTED PYRAZOLO[1,5,-a]-1,5-PYRIMIDINES AND PYRAZOLO[1,5-a]-1,3,5-TRIAZINES
RU2276142C2 (ru) 2000-07-21 2006-05-10 Зингента Партисипейшнс Аг Способ получения 4,6-диметокси-2-метилсульфонилпиримидина (варианты) и применение
PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
US20030130264A1 (en) 2001-02-16 2003-07-10 Tularik Inc. Methods of using pyrimidine-based antiviral agents
JP2004525150A (ja) * 2001-03-30 2004-08-19 スミスクライン ビーチャム コーポレーション 治療用化合物としてのピラゾロピリジン類の使用
JP2005524609A (ja) * 2001-12-17 2005-08-18 スミスクライン ビーチャム コーポレーション ピラゾロピリダジン誘導体
TWI270542B (en) 2002-02-07 2007-01-11 Sumitomo Chemical Co Method for preparing sulfone or sulfoxide compound
ATE440827T1 (de) * 2002-12-04 2009-09-15 Ore Pharmaceuticals Inc Melanocortin-rezeptormodulatoren
CA2523261C (en) * 2003-05-05 2009-07-07 F. Hoffmann-La Roche Ag Fused pyrimidine derivatives with crf activity
EP2371954A1 (en) 2004-10-27 2011-10-05 Schering Corporation Compositions and methods for short interfering nucleic acid inhibition of NAv1.8
KR101354114B1 (ko) 2005-06-14 2014-01-24 타이젠 바이오테크놀러지 컴퍼니 리미티드 피리미딘 화합물
CA2609093C (en) * 2005-07-06 2014-12-30 Ge Healthcare Bio-Sciences Ab Method of preparing a separation matrix
TW200800201A (en) * 2005-11-18 2008-01-01 Lilly Co Eli Pyrimidinyl benzothiophene compounds
CN101032483B (zh) * 2006-03-09 2011-05-04 陈德桂 调节雄激素受体活性的乙内酰脲衍生物及其应用
AU2007235577B2 (en) * 2006-03-31 2011-09-15 Janssen Pharmaceutica N.V. Benzoimidazol-2-yl pyridines as modulators of the histamine H4 receptor
NZ571691A (en) * 2006-03-31 2011-07-29 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor
PE20140592A1 (es) * 2008-06-30 2014-05-16 Janssen Pharmaceutica Nv Proceso para la preparacion de derivados de benzoimidazol-2-il pirimidina
MX2011000080A (es) 2008-06-30 2011-03-02 Janssen Pharmaceutica Nv Proceso para la preparacion de derivados de pirimidina sustituidos.

Also Published As

Publication number Publication date
AU2009267156B2 (en) 2015-05-28
EP2769721A2 (en) 2014-08-27
EP2924025A1 (en) 2015-09-30
SV2011003788A (es) 2011-02-08
US8309720B2 (en) 2012-11-13
WO2010002774A1 (en) 2010-01-07
US9359327B2 (en) 2016-06-07
EA019361B1 (ru) 2014-03-31
US9079883B2 (en) 2015-07-14
US20140073795A1 (en) 2014-03-13
US20130225816A1 (en) 2013-08-29
HRP20150576T1 (hr) 2015-09-11
US9079884B2 (en) 2015-07-14
PL2310012T3 (pl) 2015-08-31
HK1214590A1 (zh) 2016-07-29
IL210214A0 (en) 2011-03-31
TW201012810A (en) 2010-04-01
MX2011000080A (es) 2011-03-02
CN102137672A (zh) 2011-07-27
IL210214A (en) 2016-07-31
IL235572A (en) 2016-09-29
JO3043B1 (ar) 2016-09-05
US20140121374A1 (en) 2014-05-01
TWI498326B (zh) 2015-09-01
IL235570A (en) 2016-08-31
PE20110163A1 (es) 2011-03-28
CA2729733C (en) 2016-10-25
BRPI0913644A2 (pt) 2015-11-24
EP2310012A1 (en) 2011-04-20
AR072396A1 (es) 2010-08-25
US20140066624A1 (en) 2014-03-06
MY150601A (en) 2014-01-30
HUE024949T2 (en) 2016-02-29
TWI481603B (zh) 2015-04-21
TW201433568A (zh) 2014-09-01
CN102137672B (zh) 2014-03-26
US9006432B2 (en) 2015-04-14
KR20110023901A (ko) 2011-03-08
TW201420583A (zh) 2014-06-01
ZA201100759B (en) 2012-07-25
ME02154B (me) 2015-10-20
PT2310012E (pt) 2015-04-02
HK1201441A1 (zh) 2015-09-04
AU2009267156A1 (en) 2010-01-07
US20130053561A1 (en) 2013-02-28
EP2924023A1 (en) 2015-09-30
EP2310012A4 (en) 2012-06-20
KR101675354B1 (ko) 2016-11-11
UY31949A (es) 2010-01-29
SI2310012T1 (sl) 2015-06-30
ES2538135T3 (es) 2015-06-17
UA106724C2 (uk) 2014-10-10
EP2924035A1 (en) 2015-09-30
CA2729733A1 (en) 2010-01-07
NI201000232A (es) 2011-09-07
IL235571A (en) 2016-09-29
US20100004450A1 (en) 2010-01-07
HK1156857A1 (zh) 2012-06-22
EP2310012B1 (en) 2015-03-04
JP5416768B2 (ja) 2014-02-12
CY1116134T1 (el) 2017-02-08
ECSP11010745A (es) 2011-02-28
DK2310012T3 (da) 2015-03-30
RS53985B1 (en) 2015-10-30
NZ590170A (en) 2012-04-27
US9079882B2 (en) 2015-07-14
CO6341560A2 (es) 2011-11-21
JP2011526910A (ja) 2011-10-20
EP2769721A3 (en) 2015-04-01
EA201170113A1 (ru) 2011-08-30

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HK1215434A1 (zh) 取代的嘧啶衍生物