EA201170113A1 - Способ получения замещенных пиримидиновых производных - Google Patents

Способ получения замещенных пиримидиновых производных

Info

Publication number
EA201170113A1
EA201170113A1 EA201170113A EA201170113A EA201170113A1 EA 201170113 A1 EA201170113 A1 EA 201170113A1 EA 201170113 A EA201170113 A EA 201170113A EA 201170113 A EA201170113 A EA 201170113A EA 201170113 A1 EA201170113 A1 EA 201170113A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrimidine derivatives
substituted pyrimidine
obtaining substituted
synthesis
obtaining
Prior art date
Application number
EA201170113A
Other languages
English (en)
Other versions
EA019361B1 (ru
Inventor
Серджио Ческо-Канчиан
Хунфэн Чэнь
Джеффри С. Гримм
Неелакандха С. Мани
Кристофер М. Мейпс
Дэвид К. Палмер
Дэниел Дж. Пиппел
Кирк Л. Сорги
Тун Сяо
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41464882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201170113(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201170113A1 publication Critical patent/EA201170113A1/ru
Publication of EA019361B1 publication Critical patent/EA019361B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение направлено на создание способов получения замещенных пиримидиновых производных, которые могут найти применение в качестве промежуточных соединений при синтезе модуляторов гистаминового рецептора H, а также на новые промежуточные соединения в синтезе модуляторов Н.
EA201170113A 2008-06-30 2009-06-29 Способ получения замещенных пиримидиновых производных EA019361B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7675208P 2008-06-30 2008-06-30
PCT/US2009/049027 WO2010002774A1 (en) 2008-06-30 2009-06-29 Process for the preparation of substituted pyrimidine derivatives

Publications (2)

Publication Number Publication Date
EA201170113A1 true EA201170113A1 (ru) 2011-08-30
EA019361B1 EA019361B1 (ru) 2014-03-31

Family

ID=41464882

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170113A EA019361B1 (ru) 2008-06-30 2009-06-29 Способ получения замещенных пиримидиновых производных

Country Status (36)

Country Link
US (6) US8309720B2 (ru)
EP (5) EP2769721A3 (ru)
JP (1) JP5416768B2 (ru)
KR (1) KR101675354B1 (ru)
CN (1) CN102137672B (ru)
AR (1) AR072396A1 (ru)
AU (1) AU2009267156B2 (ru)
BR (1) BRPI0913644A2 (ru)
CA (1) CA2729733C (ru)
CO (1) CO6341560A2 (ru)
CY (1) CY1116134T1 (ru)
DK (1) DK2310012T3 (ru)
EA (1) EA019361B1 (ru)
EC (1) ECSP11010745A (ru)
ES (1) ES2538135T3 (ru)
HK (4) HK1156857A1 (ru)
HR (1) HRP20150576T1 (ru)
HU (1) HUE024949T2 (ru)
IL (4) IL210214A (ru)
JO (1) JO3043B1 (ru)
ME (1) ME02154B (ru)
MX (1) MX2011000080A (ru)
MY (1) MY150601A (ru)
NI (1) NI201000232A (ru)
NZ (1) NZ590170A (ru)
PE (1) PE20110163A1 (ru)
PL (1) PL2310012T3 (ru)
PT (1) PT2310012E (ru)
RS (1) RS53985B1 (ru)
SI (1) SI2310012T1 (ru)
SV (1) SV2011003788A (ru)
TW (3) TWI498326B (ru)
UA (1) UA106724C2 (ru)
UY (1) UY31949A (ru)
WO (1) WO2010002774A1 (ru)
ZA (1) ZA201100759B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7507737B2 (en) 2006-03-31 2009-03-24 Janssen Pharmaceutica, N.V. Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4receptor
MX2011000080A (es) 2008-06-30 2011-03-02 Janssen Pharmaceutica Nv Proceso para la preparacion de derivados de pirimidina sustituidos.
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
JP5574294B2 (ja) * 2010-11-04 2014-08-20 独立行政法人科学技術振興機構 光磁気記録媒体及び光磁気記録方法
SG11201507117XA (en) 2013-03-06 2015-10-29 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor
US10202337B2 (en) 2014-03-28 2019-02-12 Kaneka Corporation Method for producing tri-carbobenzoxy-arginine
SG11201903871TA (en) 2016-11-03 2019-05-30 Bristol Myers Squibb Co Substituted bicycle heterocyclic derivatives useful as romk channel inhibitors

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RU2276142C2 (ru) 2000-07-21 2006-05-10 Зингента Партисипейшнс Аг Способ получения 4,6-диметокси-2-метилсульфонилпиримидина (варианты) и применение
PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
AU2002258400A1 (en) 2001-02-16 2002-08-28 Tularik Inc. Methods of using pyrimidine-based antiviral agents
US20050107400A1 (en) * 2001-03-30 2005-05-19 Boyd Leslie F. Use of pyrazolopyridines as therapeutic compounds
AU2002357164A1 (en) * 2001-12-17 2003-06-30 Smithkline Beecham Corporation Pyrazolopyridazine derivatives
TWI270542B (en) 2002-02-07 2007-01-11 Sumitomo Chemical Co Method for preparing sulfone or sulfoxide compound
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EP2371954A1 (en) 2004-10-27 2011-10-05 Schering Corporation Compositions and methods for short interfering nucleic acid inhibition of NAv1.8
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JP5058159B2 (ja) * 2005-07-06 2012-10-24 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 分離マトリックスの製造方法
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US7507737B2 (en) * 2006-03-31 2009-03-24 Janssen Pharmaceutica, N.V. Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4receptor
MX2011000080A (es) 2008-06-30 2011-03-02 Janssen Pharmaceutica Nv Proceso para la preparacion de derivados de pirimidina sustituidos.
NZ599747A (en) * 2008-06-30 2013-03-28 Janssen Pharmaceutica Nv Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives

Also Published As

Publication number Publication date
TWI481603B (zh) 2015-04-21
HRP20150576T1 (hr) 2015-09-11
US20140066624A1 (en) 2014-03-06
HK1215434A1 (zh) 2016-08-26
US9079882B2 (en) 2015-07-14
EP2769721A3 (en) 2015-04-01
EP2769721A2 (en) 2014-08-27
PE20110163A1 (es) 2011-03-28
NZ590170A (en) 2012-04-27
EA019361B1 (ru) 2014-03-31
UY31949A (es) 2010-01-29
WO2010002774A1 (en) 2010-01-07
US8309720B2 (en) 2012-11-13
US9079883B2 (en) 2015-07-14
IL210214A0 (en) 2011-03-31
US9079884B2 (en) 2015-07-14
PT2310012E (pt) 2015-04-02
EP2310012B1 (en) 2015-03-04
US9359327B2 (en) 2016-06-07
BRPI0913644A2 (pt) 2015-11-24
NI201000232A (es) 2011-09-07
IL235570A (en) 2016-08-31
ECSP11010745A (es) 2011-02-28
US20130225816A1 (en) 2013-08-29
JP5416768B2 (ja) 2014-02-12
AR072396A1 (es) 2010-08-25
US9006432B2 (en) 2015-04-14
CN102137672B (zh) 2014-03-26
CY1116134T1 (el) 2017-02-08
JO3043B1 (ar) 2016-09-05
PL2310012T3 (pl) 2015-08-31
SI2310012T1 (sl) 2015-06-30
TW201420583A (zh) 2014-06-01
CA2729733C (en) 2016-10-25
TW201012810A (en) 2010-04-01
CN102137672A (zh) 2011-07-27
US20100004450A1 (en) 2010-01-07
HUE024949T2 (en) 2016-02-29
AU2009267156B2 (en) 2015-05-28
DK2310012T3 (da) 2015-03-30
US20140073795A1 (en) 2014-03-13
EP2924035A1 (en) 2015-09-30
ZA201100759B (en) 2012-07-25
EP2310012A1 (en) 2011-04-20
AU2009267156A1 (en) 2010-01-07
US20140121374A1 (en) 2014-05-01
HK1201441A1 (en) 2015-09-04
SV2011003788A (es) 2011-02-08
CA2729733A1 (en) 2010-01-07
TWI498326B (zh) 2015-09-01
TW201433568A (zh) 2014-09-01
HK1214590A1 (zh) 2016-07-29
US20130053561A1 (en) 2013-02-28
IL235572A (en) 2016-09-29
CO6341560A2 (es) 2011-11-21
IL235571A (en) 2016-09-29
EP2310012A4 (en) 2012-06-20
RS53985B1 (en) 2015-10-30
ES2538135T3 (es) 2015-06-17
EP2924023A1 (en) 2015-09-30
ME02154B (me) 2015-10-20
EP2924025A1 (en) 2015-09-30
JP2011526910A (ja) 2011-10-20
MY150601A (en) 2014-01-30
KR101675354B1 (ko) 2016-11-11
IL210214A (en) 2016-07-31
KR20110023901A (ko) 2011-03-08
UA106724C2 (ru) 2014-10-10
MX2011000080A (es) 2011-03-02
HK1156857A1 (en) 2012-06-22

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Designated state(s): AM AZ BY KZ KG MD TJ TM RU