EA200801893A1 - Производные тетрагидронафталина, способ их получения и их применение в качестве ингибиторов воспаления - Google Patents
Производные тетрагидронафталина, способ их получения и их применение в качестве ингибиторов воспаленияInfo
- Publication number
- EA200801893A1 EA200801893A1 EA200801893A EA200801893A EA200801893A1 EA 200801893 A1 EA200801893 A1 EA 200801893A1 EA 200801893 A EA200801893 A EA 200801893A EA 200801893 A EA200801893 A EA 200801893A EA 200801893 A1 EA200801893 A1 EA 200801893A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- tetrahydronaptaline
- production
- inflammation inhibitors
- inflammation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
- C07C15/20—Polycyclic condensed hydrocarbons
- C07C15/24—Polycyclic condensed hydrocarbons containing two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
Abstract
Изобретение относится к многократно замещенным производным тетрагидронафталина формулы (Iа)к способу их получения и их применению в качестве ингибиторов воспаления.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06090031A EP1834948A1 (de) | 2006-03-15 | 2006-03-15 | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
US78444106P | 2006-03-22 | 2006-03-22 | |
PCT/EP2007/002432 WO2007104582A1 (de) | 2006-03-15 | 2007-03-15 | Tetrahydronaphthalinderivate, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200801893A1 true EA200801893A1 (ru) | 2009-04-28 |
EA015834B1 EA015834B1 (ru) | 2011-12-30 |
Family
ID=36754173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200801893A EA015834B1 (ru) | 2006-03-15 | 2007-03-15 | Производные тетрагидронафталина и их применение в качестве ингибиторов воспаления |
Country Status (35)
Country | Link |
---|---|
US (2) | US7880042B2 (ru) |
EP (2) | EP1834948A1 (ru) |
JP (1) | JP2009532337A (ru) |
KR (1) | KR20080112233A (ru) |
CN (1) | CN101553472A (ru) |
AR (1) | AR059896A1 (ru) |
AT (1) | ATE517092T1 (ru) |
AU (1) | AU2007224593A1 (ru) |
BR (1) | BRPI0708860A2 (ru) |
CA (1) | CA2637597A1 (ru) |
CR (1) | CR10286A (ru) |
CU (1) | CU23744B7 (ru) |
CY (1) | CY1111954T1 (ru) |
DK (1) | DK1994005T3 (ru) |
DO (1) | DOP2007000050A (ru) |
EA (1) | EA015834B1 (ru) |
EC (1) | ECSP088740A (ru) |
ES (1) | ES2370176T3 (ru) |
GT (1) | GT200800182A (ru) |
IL (1) | IL193155A0 (ru) |
MX (1) | MX2008011790A (ru) |
MY (1) | MY146671A (ru) |
NO (1) | NO20084301L (ru) |
NZ (1) | NZ570407A (ru) |
PA (1) | PA8718801A1 (ru) |
PE (1) | PE20071024A1 (ru) |
PL (1) | PL1994005T3 (ru) |
PT (1) | PT1994005E (ru) |
SG (1) | SG136072A1 (ru) |
SI (1) | SI1994005T1 (ru) |
TW (1) | TW200804287A (ru) |
UA (1) | UA94603C2 (ru) |
UY (1) | UY30211A1 (ru) |
WO (1) | WO2007104582A1 (ru) |
ZA (1) | ZA200808754B (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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US7638515B2 (en) * | 2003-10-08 | 2009-12-29 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US7662821B2 (en) | 2003-10-08 | 2010-02-16 | Bayer Schering Pharma Ag | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
WO2005034939A1 (de) * | 2003-10-08 | 2005-04-21 | Schering Aktiengesellschaft | Tetrahydronaphthalinderivate, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer |
US20080153859A1 (en) * | 2004-04-05 | 2008-06-26 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US20060084652A1 (en) * | 2004-09-09 | 2006-04-20 | Stefan Baeurle | Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US20060229305A1 (en) * | 2005-03-22 | 2006-10-12 | Markus Berger | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
EP2072509A1 (en) * | 2007-12-18 | 2009-06-24 | Bayer Schering Pharma Aktiengesellschaft | 1-Aryl-1H-quinoline-2-ones: process for their production and their use as anti-inflammatory agents |
WO2011146610A2 (en) * | 2010-05-19 | 2011-11-24 | Dr. Reddy's Laboratories Ltd. | An enantioselective synthesis of chiral amines for the production of rotigotine |
JP6115303B2 (ja) * | 2012-05-18 | 2017-04-19 | Jnc株式会社 | 隣接基としてカルボニル基を有するフェノール化合物およびその用途 |
PL233977B1 (pl) * | 2018-01-10 | 2019-12-31 | Politechnika Warszawska | Sposób otrzymywania 7-metoksy-1,2,3-tris(4-metoksyfenylo)- 1,2,3,4-tetrahydronaftalenu |
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JP2000256255A (ja) | 1999-03-10 | 2000-09-19 | Kuraray Co Ltd | (±)−トランス−ペルメトリン酸の光学分割法 |
SE9903930D0 (sv) | 1999-10-29 | 1999-10-29 | Astra Pharma Inc | Novel compounds and a novel process for their preparation |
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WO2005034939A1 (de) | 2003-10-08 | 2005-04-21 | Schering Aktiengesellschaft | Tetrahydronaphthalinderivate, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer |
US7638515B2 (en) * | 2003-10-08 | 2009-12-29 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US7662821B2 (en) * | 2003-10-08 | 2010-02-16 | Bayer Schering Pharma Ag | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US7179919B2 (en) | 2004-03-18 | 2007-02-20 | Boehringer Ingelheim Pharmaceuticals, Inc. | Stereoselective synthesis of certain trifluoromethyl-substituted alcohols |
US20050222154A1 (en) * | 2004-04-05 | 2005-10-06 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US20080153859A1 (en) * | 2004-04-05 | 2008-06-26 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
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DE102005014089A1 (de) | 2005-03-22 | 2006-09-28 | Schering Ag | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
US20060229305A1 (en) * | 2005-03-22 | 2006-10-12 | Markus Berger | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US20070015761A1 (en) * | 2005-04-14 | 2007-01-18 | Anne Mengel | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
US20070129359A1 (en) * | 2005-04-14 | 2007-06-07 | Christoph Huwe | Tetrahydronaphthalene derivatives, processes for their preparation and their use as antiinflammatory agents |
WO2006108699A1 (en) | 2005-04-14 | 2006-10-19 | Glaxo Group Limited | Indazoles as glucocorticoid receptor ligands |
DE102005017286B3 (de) | 2005-04-14 | 2006-12-28 | Schering Ag | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
US20070015750A1 (en) * | 2005-04-14 | 2007-01-18 | Stefan Baeurle | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
JP4980366B2 (ja) * | 2005-12-09 | 2012-07-18 | エフ.ホフマン−ラ ロシュ アーゲー | 抗炎症剤としてのグルココルチコイド受容体モジュレーター |
-
2006
- 2006-03-15 EP EP06090031A patent/EP1834948A1/de not_active Withdrawn
-
2007
- 2007-03-13 PA PA20078718801A patent/PA8718801A1/es unknown
- 2007-03-13 DO DO2007000050A patent/DOP2007000050A/es unknown
- 2007-03-14 US US11/717,782 patent/US7880042B2/en not_active Expired - Fee Related
- 2007-03-14 AR ARP070101030A patent/AR059896A1/es not_active Application Discontinuation
- 2007-03-14 UY UY30211A patent/UY30211A1/es not_active Application Discontinuation
- 2007-03-14 SG SG200701912-8A patent/SG136072A1/en unknown
- 2007-03-14 PE PE2007000278A patent/PE20071024A1/es not_active Application Discontinuation
- 2007-03-15 UA UAA200811918A patent/UA94603C2/ru unknown
- 2007-03-15 PL PL07723399T patent/PL1994005T3/pl unknown
- 2007-03-15 TW TW096108956A patent/TW200804287A/zh unknown
- 2007-03-15 SI SI200730751T patent/SI1994005T1/sl unknown
- 2007-03-15 PT PT07723399T patent/PT1994005E/pt unknown
- 2007-03-15 MY MYPI20083569A patent/MY146671A/en unknown
- 2007-03-15 JP JP2008558734A patent/JP2009532337A/ja active Pending
- 2007-03-15 KR KR1020087022516A patent/KR20080112233A/ko not_active Application Discontinuation
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- 2007-03-15 EA EA200801893A patent/EA015834B1/ru not_active IP Right Cessation
- 2007-03-15 DK DK07723399.7T patent/DK1994005T3/da active
- 2007-03-15 CN CNA2007800091776A patent/CN101553472A/zh active Pending
- 2007-03-15 CA CA002637597A patent/CA2637597A1/en not_active Abandoned
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- 2007-03-15 EP EP07723399A patent/EP1994005B9/de active Active
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2008
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- 2008-09-12 CR CR10286A patent/CR10286A/es not_active Application Discontinuation
- 2008-09-15 CU CU20080169A patent/CU23744B7/es active IP Right Grant
- 2008-09-15 EC EC2008008740A patent/ECSP088740A/es unknown
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2010
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2011
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