EA200200422A1 - НЕКОТОРЫЕ АЛКИЛЕНДИАМИНОЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]-1,5-ПИРИМИДИНЫ И ПИРАЗОЛО[1,5-а]-1,3,5-ТРИАЗИНЫ - Google Patents
НЕКОТОРЫЕ АЛКИЛЕНДИАМИНОЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]-1,5-ПИРИМИДИНЫ И ПИРАЗОЛО[1,5-а]-1,3,5-ТРИАЗИНЫInfo
- Publication number
- EA200200422A1 EA200200422A1 EA200200422A EA200200422A EA200200422A1 EA 200200422 A1 EA200200422 A1 EA 200200422A1 EA 200200422 A EA200200422 A EA 200200422A EA 200200422 A EA200200422 A EA 200200422A EA 200200422 A1 EA200200422 A1 EA 200200422A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- pyrazolo
- disorders
- receptors
- alkyledinemia
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/5755—Neuropeptide Y
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Предложены соединения формулы (I), где R, R, R, R, R, Rи Х имеют указанные в описании значения. Данные соединения являются селективными модуляторами NPY1 рецепторов. Данные соединения полезны для лечения ряда заболеваний ЦНС, метаболических нарушений и периферических нарушений, особенно нарушений питания и гипертензии. Предложены также способы лечения таких нарушений, а также упакованные фармацевтические композиции. Соединения настоящего изобретения полезны в качестве зондов для локализации NPY1 рецепторов и в качестве стандартов в анализах связывания NPY1 рецепторов. Предложены способы применения данных соединений для изучения локализации рецепторов.Отчет о международном поиске был опубликован 2002.01.24.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15686999P | 1999-09-30 | 1999-09-30 | |
PCT/US2000/026887 WO2001023387A2 (en) | 1999-09-30 | 2000-09-29 | CERTAIN ALKYLENE DIAMINE-SUBSTITUTED PYRAZOLO[1,5,-a]-1,5-PYRIMIDINES AND PYRAZOLO[1,5-a]-1,3,5-TRIAZINES |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200200422A1 true EA200200422A1 (ru) | 2002-10-31 |
Family
ID=22561437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200200422A EA200200422A1 (ru) | 1999-09-30 | 2000-09-29 | НЕКОТОРЫЕ АЛКИЛЕНДИАМИНОЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]-1,5-ПИРИМИДИНЫ И ПИРАЗОЛО[1,5-а]-1,3,5-ТРИАЗИНЫ |
Country Status (17)
Country | Link |
---|---|
US (2) | US6372743B1 (ru) |
EP (1) | EP1218379A2 (ru) |
JP (1) | JP2003510325A (ru) |
KR (1) | KR20020047198A (ru) |
CN (1) | CN1377354A (ru) |
AU (1) | AU7738100A (ru) |
BG (1) | BG106506A (ru) |
CA (1) | CA2379585C (ru) |
CZ (1) | CZ20021067A3 (ru) |
EA (1) | EA200200422A1 (ru) |
HU (1) | HUP0202678A3 (ru) |
IL (1) | IL148905A0 (ru) |
NO (1) | NO20021356L (ru) |
PL (1) | PL354675A1 (ru) |
WO (1) | WO2001023387A2 (ru) |
YU (1) | YU23802A (ru) |
ZA (1) | ZA200202519B (ru) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2712196C2 (ru) * | 2015-06-24 | 2020-01-24 | Куровир Аб | Производные пиразоло[1,5-a]триазин-4-амина, применимые в терапии |
RU2770363C2 (ru) * | 2017-04-05 | 2022-04-15 | Куровир Аб | Гетероароматические соединения, пригодные в терапии |
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- 2000-09-29 US US09/676,970 patent/US6372743B1/en not_active Expired - Fee Related
- 2000-09-29 AU AU77381/00A patent/AU7738100A/en not_active Abandoned
- 2000-09-29 CA CA002379585A patent/CA2379585C/en not_active Expired - Fee Related
- 2000-09-29 JP JP2001526539A patent/JP2003510325A/ja active Pending
- 2000-09-29 PL PL00354675A patent/PL354675A1/xx not_active Application Discontinuation
- 2000-09-29 EP EP00967134A patent/EP1218379A2/en not_active Ceased
- 2000-09-29 CN CN00813623A patent/CN1377354A/zh active Pending
- 2000-09-29 EA EA200200422A patent/EA200200422A1/ru unknown
- 2000-09-29 WO PCT/US2000/026887 patent/WO2001023387A2/en not_active Application Discontinuation
- 2000-09-29 HU HU0202678A patent/HUP0202678A3/hu unknown
- 2000-09-29 KR KR1020027004151A patent/KR20020047198A/ko not_active Application Discontinuation
- 2000-09-29 CZ CZ20021067A patent/CZ20021067A3/cs unknown
- 2000-09-29 IL IL14890500A patent/IL148905A0/xx unknown
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- 2002-03-11 BG BG106506A patent/BG106506A/xx unknown
- 2002-03-19 NO NO20021356A patent/NO20021356L/no not_active Application Discontinuation
- 2002-03-28 ZA ZA200202519A patent/ZA200202519B/xx unknown
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RU2712196C2 (ru) * | 2015-06-24 | 2020-01-24 | Куровир Аб | Производные пиразоло[1,5-a]триазин-4-амина, применимые в терапии |
RU2770363C2 (ru) * | 2017-04-05 | 2022-04-15 | Куровир Аб | Гетероароматические соединения, пригодные в терапии |
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BG106506A (en) | 2002-12-29 |
US20030069246A1 (en) | 2003-04-10 |
EP1218379A2 (en) | 2002-07-03 |
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NO20021356L (no) | 2002-05-23 |
CN1377354A (zh) | 2002-10-30 |
CA2379585A1 (en) | 2001-04-05 |
CA2379585C (en) | 2006-06-20 |
IL148905A0 (en) | 2002-09-12 |
KR20020047198A (ko) | 2002-06-21 |
JP2003510325A (ja) | 2003-03-18 |
YU23802A (sh) | 2004-09-03 |
HUP0202678A3 (en) | 2004-06-28 |
AU7738100A (en) | 2001-04-30 |
PL354675A1 (en) | 2004-02-09 |
CZ20021067A3 (cs) | 2002-11-13 |
HUP0202678A2 (hu) | 2002-12-28 |
ZA200202519B (en) | 2004-01-28 |
WO2001023387A3 (en) | 2002-01-24 |
WO2001023387A2 (en) | 2001-04-05 |
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