EA199900559A1 - Замещенные, азотсодержащие гетероциклы в качестве ингибиторов протеинкиназы p38 - Google Patents

Замещенные, азотсодержащие гетероциклы в качестве ингибиторов протеинкиназы p38

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Publication number
EA199900559A1
EA199900559A1 EA199900559A EA199900559A EA199900559A1 EA 199900559 A1 EA199900559 A1 EA 199900559A1 EA 199900559 A EA199900559 A EA 199900559A EA 199900559 A EA199900559 A EA 199900559A EA 199900559 A1 EA199900559 A1 EA 199900559A1
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EA
Eurasian Patent Office
Prior art keywords
inhibitors
substituted
nitrogen
containing heterocycles
methods
Prior art date
Application number
EA199900559A
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English (en)
Other versions
EA002855B1 (ru
Inventor
Гай В. Бемис
Франческо Джеральд Салитуро
Джон Патрик Даффи
Джон Е. Кочран
Эдмунд Мартин Харрингтон
Марк А. Мёрко
Кейт П. Уилсон
Майкл Су
Винсент П. Галулло
Original Assignee
Вертекс Фармасьютикалз Инкорпорейтед
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Priority claimed from US08/822,373 external-priority patent/US5945418A/en
Application filed by Вертекс Фармасьютикалз Инкорпорейтед filed Critical Вертекс Фармасьютикалз Инкорпорейтед
Publication of EA199900559A1 publication Critical patent/EA199900559A1/ru
Publication of EA002855B1 publication Critical patent/EA002855B1/ru

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

Данное изобретение касается ингибиторов p38, протеинкиназы млекопитающих, вовлечённой в процесс пролиферации клеток, клеточной гибели и в ответную реакцию на внеклеточный раздражитель. Изобретение касается способов получения этих ингибиторов. Изобретение касается также фармацевтических композиций, содержащих ингибиторы согласно изобретению, и способов применения этих композиций в лечении и профилактике различных заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900559A 1996-12-18 1997-12-17 ЗАМЕЩЕННЫЕ, АЗОТСОДЕРЖАЩИЕ ГЕТЕРОЦИКЛЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗЫ р38 EA002855B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3428896P 1996-12-18 1996-12-18
US08/822,373 US5945418A (en) 1996-12-18 1997-03-20 Inhibitors of p38
US08/862,925 US6147080A (en) 1996-12-18 1997-06-10 Inhibitors of p38
PCT/US1997/023392 WO1998027098A1 (en) 1996-12-18 1997-12-17 SUBSTITUTED NITROGEN CONTAINING HETEROCYCLES AS INHIBITORS OF p38 PROTEIN KINASE

Publications (2)

Publication Number Publication Date
EA199900559A1 true EA199900559A1 (ru) 2000-02-28
EA002855B1 EA002855B1 (ru) 2002-10-31

Family

ID=27364615

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900559A EA002855B1 (ru) 1996-12-18 1997-12-17 ЗАМЕЩЕННЫЕ, АЗОТСОДЕРЖАЩИЕ ГЕТЕРОЦИКЛЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗЫ р38

Country Status (29)

Country Link
US (1) US6147080A (ru)
EP (1) EP0951467B1 (ru)
JP (1) JP4171072B2 (ru)
CN (2) CN1153770C (ru)
AP (1) AP1136A (ru)
AT (1) ATE236165T1 (ru)
AU (1) AU738000B2 (ru)
BG (1) BG64533B1 (ru)
BR (1) BR9714415A (ru)
CA (1) CA2274825C (ru)
CZ (1) CZ299600B6 (ru)
DE (1) DE69720522T2 (ru)
DK (1) DK0951467T3 (ru)
EA (1) EA002855B1 (ru)
EE (1) EE04191B1 (ru)
ES (1) ES2202658T3 (ru)
HK (1) HK1023340A1 (ru)
HU (1) HUP0001125A3 (ru)
ID (1) ID21919A (ru)
IL (1) IL130349A0 (ru)
IS (1) IS5069A (ru)
NO (1) NO315047B1 (ru)
NZ (1) NZ336146A (ru)
PL (1) PL202464B1 (ru)
PT (1) PT951467E (ru)
SK (1) SK284578B6 (ru)
TR (1) TR199902194T2 (ru)
TW (1) TW521071B (ru)
WO (1) WO1998027098A1 (ru)

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