PE20060421A1 - Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa - Google Patents

Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa

Info

Publication number
PE20060421A1
PE20060421A1 PE2005000918A PE2005000918A PE20060421A1 PE 20060421 A1 PE20060421 A1 PE 20060421A1 PE 2005000918 A PE2005000918 A PE 2005000918A PE 2005000918 A PE2005000918 A PE 2005000918A PE 20060421 A1 PE20060421 A1 PE 20060421A1
Authority
PE
Peru
Prior art keywords
compound
preparing
procedure
kinase inhibitors
ester
Prior art date
Application number
PE2005000918A
Other languages
English (en)
Inventor
Reginald O Cann
Edward J Delaney
Junying Fan
Luca Parlanti
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20060421A1 publication Critical patent/PE20060421A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR UN COMPUESTO DE FORMULA I, DONDE R1 ES ALQUILO, ARILO INFERIOR; QUE COMPRENDE: A) PROPORCIONAR UNA MEZCLA DE UNA BASE ORGANOMETALICA FUERTE TAL COMO HEXIL LITIO O n-BUTIL LITIO Y UNA AMINA DE LA ESTRUCTURA R1NH2, DONDE R1 ES ALQUILO O ARILO INFERIOR, EN UN SOLVENTE ORGANICO; B) PROPORCIONAR UN ESTER DE ESTRUCTURA A EN UN SOLVENTE ORGANICO; C) HACER REACCIONAR LA MEZCLA DE LA ETAPA A Y EL ESTER DE LA ETAPA B PARA FORMAR EL PRODUCTO DE LA AMIDA. LA REACCION ES LLAVADA A CABO A UNA TEMPERATURA ENTRE -10°C-110°C. UN COMPUESTO EMPLEANDO DICHO PROCESO ES 4[[5-[(CICLOPROPILAMINO)CARBONIL]-2-METILFENIL]AMINO]-5-METIL-N-PROPILPIRROLO[2,1-f][1,2,4]TRIAZINA-6-CARBOXAMIDA. DICHOS COMPUESTOS SON INHIBIDORES DE p38 CINASA SIENDO UTIL EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE
PE2005000918A 2004-08-12 2005-08-09 Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa PE20060421A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60093504P 2004-08-12 2004-08-12

Publications (1)

Publication Number Publication Date
PE20060421A1 true PE20060421A1 (es) 2006-06-01

Family

ID=35907758

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000918A PE20060421A1 (es) 2004-08-12 2005-08-09 Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa

Country Status (5)

Country Link
US (1) US7148348B2 (es)
AR (1) AR050519A1 (es)
PE (1) PE20060421A1 (es)
TW (1) TW200618803A (es)
WO (1) WO2006020904A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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EP2376491B1 (en) 2008-12-19 2015-03-04 Cephalon, Inc. Pyrrolotriazines as alk and jak2 inhibitors
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CA3128468A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd

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Also Published As

Publication number Publication date
AR050519A1 (es) 2006-11-01
WO2006020904A1 (en) 2006-02-23
TW200618803A (en) 2006-06-16
US7148348B2 (en) 2006-12-12
US20060035886A1 (en) 2006-02-16

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