PE20060529A1 - Metodo para preparar compuestos de pirrolotriazina - Google Patents
Metodo para preparar compuestos de pirrolotriazinaInfo
- Publication number
- PE20060529A1 PE20060529A1 PE2005000761A PE2005000761A PE20060529A1 PE 20060529 A1 PE20060529 A1 PE 20060529A1 PE 2005000761 A PE2005000761 A PE 2005000761A PE 2005000761 A PE2005000761 A PE 2005000761A PE 20060529 A1 PE20060529 A1 PE 20060529A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- compound
- alkyl
- compounds
- pirrolotry
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
REFERIDA A UN METODO PARA PREPARAR UN COMPUESTO DE FORMULA V, DONDE R1 Y R3 SON H, HALOGENO, CIANO, ENTRE OTROS; X ES O, S, C(=O), ENTRE OTROS; R2 ES H, ALQUILO, S(=O), ENTRE OTROS; R6 ES H, ALQUILO, ALQUINILO, ENTRE OTROS; DONDE DICHO PROCEDIMIENTO SE CARACTERIZA PORQUE COMPRENDE: (a) HACER REACCIONAR UN COMPUESTO DE FORMULA I, DONDE R1, X, R2 Y R3 SE DEFINEN COMO ANTERIORMENTE, Y D ES C(=O)ORp, DONDE Rp ES H, ALQUILO C1-C6 O ARILO; CON UNA BENZOIL HIDROXIL AMINA DE FORMULA III EN PRESENCIA DE UNA BASE, EN DONDE R4 ES H, NITRO, CIANO, ENTRE OTROS, Y n ES 1, 2 O 3; PARA FORMAR UN COMPUESTO DE FORMULA II, DONDE R1, X, R2, R3 Y D SE DEFINEN COMO ANTERIORMENTE; Y (b) HACER REACCIONAR EL COMPUESTO DE FORMULA II CON UNA AMIDA DE FORMULA R6C(=O)NH2, DONDE R6 SE DEFINE COMO ANTERIORMENTE, PARA FORMAR EL COMPUESTO DE FORMULA V. DICHO PROCEDIMIENTO ES UTIL PARA LA PREPARACION DE COMPUESTOS DE PIRROLOTRIAZINA COMO COMPONENTES O PRECURSORES EN LA SINTESIS DE COMPUESTOS ANTICANCERIGENOS E INHIBIDORES DE CINASA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58438204P | 2004-06-30 | 2004-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060529A1 true PE20060529A1 (es) | 2006-06-21 |
Family
ID=35783307
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000761A PE20060529A1 (es) | 2004-06-30 | 2005-06-30 | Metodo para preparar compuestos de pirrolotriazina |
Country Status (9)
Country | Link |
---|---|
US (1) | US7534881B2 (es) |
EP (1) | EP1765827A4 (es) |
JP (1) | JP2008505175A (es) |
CN (1) | CN101010324A (es) |
AR (1) | AR049561A1 (es) |
NO (1) | NO20070550L (es) |
PE (1) | PE20060529A1 (es) |
TW (1) | TW200600513A (es) |
WO (1) | WO2006004724A2 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04010379A (es) * | 2002-04-23 | 2005-02-17 | Squibb Bristol Myers Co | Compuestos de pirrolo-triazina anilina utiles como inhibidores de cinasa. |
US7432373B2 (en) * | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
US20050288290A1 (en) * | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
US7504521B2 (en) * | 2004-08-05 | 2009-03-17 | Bristol-Myers Squibb Co. | Methods for the preparation of pyrrolotriazine compounds |
TW200618803A (en) | 2004-08-12 | 2006-06-16 | Bristol Myers Squibb Co | Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors |
EP2376491B1 (en) | 2008-12-19 | 2015-03-04 | Cephalon, Inc. | Pyrrolotriazines as alk and jak2 inhibitors |
WO2012031057A1 (en) | 2010-09-01 | 2012-03-08 | Bristol-Myers Squibb Company | Bms- 582949 for the treatment of resistant rheumatic disease |
WO2021094209A1 (en) | 2019-11-12 | 2021-05-20 | Bayer Aktiengesellschaft | Substituted pyrrolo triazine carboxamide derivatives as prostaglandin ep3 receptor antagonists |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL118481A (en) * | 1995-06-05 | 2000-08-31 | Rhone Poulenc Agrochimie | Sulfur compounds pesticidal compositions containing them and method of their application |
WO2000071129A1 (en) | 1999-05-21 | 2000-11-30 | Bristol-Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
US6982265B1 (en) * | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
US6906067B2 (en) * | 1999-12-28 | 2005-06-14 | Bristol-Myers Squibb Company | N-heterocyclic inhibitors of TNF-α expression |
US20020065270A1 (en) * | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
US6867300B2 (en) * | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
US6670357B2 (en) * | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
WO2003002544A1 (en) * | 2001-06-26 | 2003-01-09 | Bristol-Myers Squibb Company | N-heterocyclic inhibitors of tnf-alpha expression |
TW200300350A (en) * | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
US7388009B2 (en) * | 2002-04-23 | 2008-06-17 | Bristol-Myers Squibb Company | Heteroaryl-substituted pyrrolo-triazine compounds useful as kinase inhibitors |
MXPA04010379A (es) * | 2002-04-23 | 2005-02-17 | Squibb Bristol Myers Co | Compuestos de pirrolo-triazina anilina utiles como inhibidores de cinasa. |
DE60325469D1 (de) * | 2002-04-23 | 2009-02-05 | Bristol Myers Squibb Co | Als kinase inhibitoren geeignete arylketonpyrrolotriazin-verbindungen |
TW200400034A (en) * | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
TWI329112B (en) | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
US6933386B2 (en) * | 2002-07-19 | 2005-08-23 | Bristol Myers Squibb Company | Process for preparing certain pyrrolotriazine compounds |
EP1543009A4 (en) * | 2002-08-02 | 2007-08-08 | Bristol Myers Squibb Co | Pyrrolotriazine KINASE INHIBITORS |
TW200407127A (en) * | 2002-08-21 | 2004-05-16 | Astrazeneca Ab | Chemical compounds |
TW200420565A (en) * | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
EP1590335A4 (en) * | 2003-02-05 | 2006-03-08 | Bristol Myers Squibb Co | PROCESS FOR THE PRODUCTION OF PYRROLOTRIAZINKINASE INHIBITORS |
US7419978B2 (en) * | 2003-10-22 | 2008-09-02 | Bristol-Myers Squibb Company | Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors |
US7102001B2 (en) * | 2003-12-12 | 2006-09-05 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine |
MY145634A (en) * | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
US7064203B2 (en) * | 2003-12-29 | 2006-06-20 | Bristol Myers Squibb Company | Di-substituted pyrrolotriazine compounds |
TWI338004B (en) | 2004-02-06 | 2011-03-01 | Bristol Myers Squibb Co | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
US7491725B2 (en) * | 2004-02-06 | 2009-02-17 | Bristol-Myers Squibb Company | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
US7459562B2 (en) * | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
US7102002B2 (en) * | 2004-06-16 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US7253167B2 (en) * | 2004-06-30 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic-heteroaryl compounds useful as kinase inhibitors |
US7102003B2 (en) * | 2004-07-01 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
US7504521B2 (en) * | 2004-08-05 | 2009-03-17 | Bristol-Myers Squibb Co. | Methods for the preparation of pyrrolotriazine compounds |
-
2005
- 2005-06-27 TW TW094121502A patent/TW200600513A/zh unknown
- 2005-06-28 US US11/168,682 patent/US7534881B2/en not_active Expired - Fee Related
- 2005-06-29 AR ARP050102707A patent/AR049561A1/es unknown
- 2005-06-30 PE PE2005000761A patent/PE20060529A1/es not_active Application Discontinuation
- 2005-06-30 CN CNA2005800289133A patent/CN101010324A/zh active Pending
- 2005-06-30 EP EP05790928A patent/EP1765827A4/en not_active Withdrawn
- 2005-06-30 JP JP2007520349A patent/JP2008505175A/ja not_active Withdrawn
- 2005-06-30 WO PCT/US2005/022882 patent/WO2006004724A2/en active Application Filing
-
2007
- 2007-01-29 NO NO20070550A patent/NO20070550L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW200600513A (en) | 2006-01-01 |
WO2006004724A2 (en) | 2006-01-12 |
EP1765827A2 (en) | 2007-03-28 |
US20060003967A1 (en) | 2006-01-05 |
NO20070550L (no) | 2007-03-26 |
EP1765827A4 (en) | 2009-07-29 |
AR049561A1 (es) | 2006-08-16 |
CN101010324A (zh) | 2007-08-01 |
US7534881B2 (en) | 2009-05-19 |
JP2008505175A (ja) | 2008-02-21 |
WO2006004724A3 (en) | 2006-04-06 |
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Legal Events
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FC | Refusal |