PE20050131A1 - Derivados de benzoimidazol como agentes antiproliferativos - Google Patents
Derivados de benzoimidazol como agentes antiproliferativosInfo
- Publication number
- PE20050131A1 PE20050131A1 PE2003000864A PE2003000864A PE20050131A1 PE 20050131 A1 PE20050131 A1 PE 20050131A1 PE 2003000864 A PE2003000864 A PE 2003000864A PE 2003000864 A PE2003000864 A PE 2003000864A PE 20050131 A1 PE20050131 A1 PE 20050131A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- antiproliferative agents
- benzoimidazole derivatives
- cr5r6
- benzoimidazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
REFERIDA A COMPUESTOS DE FORMULA I, SUS SALES, HIDRATOS Y SOLVATOS DONDE R1, R2 Y R3 SON CADA UNO H, ALQUILO C1-C6, HALO, CIANO, ENTRE OTROS; R4 ES -(CR5R6)nH, -(CR5R6)m(HETEROCICLILO DE 4 A 6 MIEMBROS); n ES 1-5; m ES 0-5. TAMBIEN REFERIDA A UN PROCESO PARA LA PREPARACION DE ESTOS COMPUESTOS CUYOS PREFERIDOS SON: 1-{2-[5-(3-MORFOLIN-4-ILPROPOXI)-BENZOIMIDAZOL-1-IL]-QUINOLIN-8-IL}PIPERIDIN-4-ILAMINA Y 1-{2-[5-(3-METIL-OXETAN-3-ILMETOXI)-BENZOIMIDAZOL-1-IL]-QUINOLIN-8-IL}PIPERIDIN-4-ILAMINA , ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE TRASTORNOS HIPERPROLIFERATIVOS COMO EL CANCER
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40652402P | 2002-08-28 | 2002-08-28 | |
| US41704702P | 2002-10-08 | 2002-10-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050131A1 true PE20050131A1 (es) | 2005-03-21 |
Family
ID=31981411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000864A PE20050131A1 (es) | 2002-08-28 | 2003-08-25 | Derivados de benzoimidazol como agentes antiproliferativos |
Country Status (41)
| Country | Link |
|---|---|
| US (1) | US7071337B2 (es) |
| EP (1) | EP1594858B1 (es) |
| JP (1) | JP4551771B2 (es) |
| KR (2) | KR20070086768A (es) |
| CN (1) | CN1319966C (es) |
| AP (1) | AP2005003237A0 (es) |
| AR (1) | AR041055A1 (es) |
| AT (1) | ATE445610T1 (es) |
| AU (1) | AU2003250499B2 (es) |
| BR (1) | BRPI0313942C1 (es) |
| CA (1) | CA2495577C (es) |
| CR (1) | CR7698A (es) |
| CU (1) | CU23413B7 (es) |
| CY (1) | CY1110580T1 (es) |
| DE (1) | DE60329715D1 (es) |
| DK (1) | DK1594858T3 (es) |
| DO (1) | DOP2003000694A (es) |
| EA (1) | EA008448B1 (es) |
| EC (1) | ECSP055633A (es) |
| ES (1) | ES2333219T3 (es) |
| GE (1) | GEP20064005B (es) |
| HK (1) | HK1078571A1 (es) |
| HN (1) | HN2003000257A (es) |
| HR (1) | HRP20050191B1 (es) |
| IL (1) | IL166832A (es) |
| IS (1) | IS2738B (es) |
| MA (1) | MA27389A1 (es) |
| MX (1) | MXPA05001256A (es) |
| MY (1) | MY139357A (es) |
| NO (1) | NO20051303L (es) |
| NZ (1) | NZ538427A (es) |
| OA (1) | OA12916A (es) |
| PA (1) | PA8580301A1 (es) |
| PE (1) | PE20050131A1 (es) |
| PL (1) | PL377678A1 (es) |
| PT (1) | PT1594858E (es) |
| RS (1) | RS20050180A (es) |
| SI (1) | SI1594858T1 (es) |
| TW (1) | TW200407131A (es) |
| UY (1) | UY27952A1 (es) |
| WO (1) | WO2004020431A2 (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1641780T3 (da) * | 2003-06-24 | 2009-02-02 | Pfizer Prod Inc | Fremgangsmåder til fremstilling af 1-[(benzimidazol-1yl)quinolin-8-yl]-piperidin-4-ylamin-derivater |
| BRPI0509580A (pt) * | 2004-03-30 | 2007-11-27 | Pfizer Prod Inc | combinações de inibidores de transdução de sinal |
| GB0411421D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
| CA2582479C (en) * | 2004-10-07 | 2011-07-12 | Pfizer Products Inc. | Benzoimidazole derivatives useful as antiproliferative agents |
| BRPI0608096A2 (pt) | 2005-04-26 | 2009-11-10 | Pfizer | anticorpos p-caderina |
| UA94060C2 (ru) | 2005-09-07 | 2011-04-11 | Эмджен Фримонт Инк. | Моноклональное антитело, которое специфически связывает alk-1 |
| EA200802058A1 (ru) | 2006-05-09 | 2009-06-30 | Пфайзер Продактс Инк. | Производные циклоалкиламинокислот и их фармацевтические композиции |
| BRPI0809998B8 (pt) | 2007-04-03 | 2021-05-25 | Array Biopharma Inc | composto de imidazo[1,2-a] piridina como inibidores do receptor tirosina quinase, seus usos, seus processos de preparação e composições farmacêuticas |
| MX2010012718A (es) * | 2008-05-21 | 2011-04-04 | Incyte Corp | Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b ][1,2,4] triazin-2-il]benzamida y procesos relacionados con la preparacion de las mismas. |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| CA2809892C (en) | 2010-09-02 | 2019-05-28 | Merck Patent Gmbh | Pyrazolopyridinone derivatives as lpa receptor antagonists |
| GB201103578D0 (en) | 2011-03-02 | 2011-04-13 | Sabrepharm Ltd | Dipyridinium derivatives |
| JP6407504B2 (ja) | 2012-09-21 | 2018-10-17 | アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 恒常的に活性であるリン酸化型ｆｌｔ３キナーゼの阻害方法 |
| US10835525B2 (en) | 2012-09-26 | 2020-11-17 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| TWI599356B (zh) | 2012-09-26 | 2017-09-21 | 安羅格製藥有限責任公司 | 抑制突變型ｃ－ｋｉｔ的方法 |
| US11642340B2 (en) | 2012-09-26 | 2023-05-09 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| BR112015016282A2 (pt) | 2013-01-07 | 2017-07-11 | Arog Pharmaceuticals Inc | crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado |
| US10463658B2 (en) | 2013-10-25 | 2019-11-05 | Videra Pharmaceuticals, Llc | Method of inhibiting FLT3 kinase |
| RS58328B1 (sr) * | 2014-10-31 | 2019-03-29 | Genoscience Pharma Sas | Supstituisani 2,4 diamino-hinolini kao novi antitumorski agensi |
| GB2543550A (en) | 2015-10-21 | 2017-04-26 | Hox Therapeutics Ltd | Peptides |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| DK3452465T3 (da) | 2016-05-04 | 2021-02-08 | Genoscience Pharma | Substituerede 2,4-diaminoquinolinderivater til anvendelse til behandling af proliferative sygdomme |
| WO2018085292A1 (en) | 2016-11-02 | 2018-05-11 | Arog Pharmaceuticals, Inc. | Crenolanib for treating flt3 mutated proliferative disorders associated mutations |
| CN107382984B (zh) * | 2017-08-24 | 2020-07-10 | 扬州市三药制药有限公司 | 一种治疗白血病药物的制备方法 |
| CN107382983B (zh) * | 2017-08-24 | 2020-08-07 | 扬州市三药制药有限公司 | 一种治疗白血病药物的合成方法 |
| CN110840893A (zh) | 2018-12-13 | 2020-02-28 | 安罗格制药有限责任公司 | 含克莱拉尼的药物组合物及其用途 |
| US11471451B2 (en) | 2019-08-19 | 2022-10-18 | Arog Pharmaceuticals, Inc. | Uses of crenolanib |
| CN117447376A (zh) * | 2019-12-09 | 2024-01-26 | 苏州恩华生物医药科技有限公司 | 连双环结构sigma-1受体抑制剂 |
| WO2022019998A1 (en) * | 2020-07-20 | 2022-01-27 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| IL300205A (en) * | 2020-08-05 | 2023-03-01 | Massachusetts Gen Hospital | Salt-inducible kinase inhibitors |
| US11524006B2 (en) | 2020-09-17 | 2022-12-13 | Arog Pharmaceuticals, Inc. | Crenolanib for treating TRK kinase associated proliferative disorders |
| CN113683594B (zh) * | 2021-09-07 | 2022-12-27 | 曲靖师范学院 | 一种喹啉-苯并咪唑盐类化合物及其合成方法和应用 |
| JP2023063189A (ja) | 2021-10-22 | 2023-05-09 | アログ・ファーマシューティカルズ・インコーポレイテッド | 以前の治療に対して再発性／不応性のｆｌｔ３突然変異増殖性障害を治療するためのクレノラニブ |
| WO2023081923A1 (en) | 2021-11-08 | 2023-05-11 | Frequency Therapeutics, Inc. | Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607683D0 (en) | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
| US5990146A (en) | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
| EP1017682A4 (en) | 1997-09-26 | 2000-11-08 | Merck & Co Inc | NEW ANGIOGENESIS INHIBITORS |
| UA75055C2 (uk) * | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
| CA2393026A1 (en) * | 1999-11-30 | 2001-06-07 | Paul A. Wender | Bryostatin analogues, synthetic methods and uses |
| JP2008002005A (ja) * | 2006-06-21 | 2008-01-10 | Shimada Shoji Kk | 衣服用パッド |
-
2003
- 2003-08-12 PA PA8580301A patent/PA8580301A1/es unknown
- 2003-08-14 EA EA200500174A patent/EA008448B1/ru not_active IP Right Cessation
- 2003-08-14 AU AU2003250499A patent/AU2003250499B2/en not_active Ceased
- 2003-08-14 DK DK03791110T patent/DK1594858T3/da active
- 2003-08-14 JP JP2004569727A patent/JP4551771B2/ja not_active Expired - Lifetime
- 2003-08-14 PL PL37767803A patent/PL377678A1/pl not_active Application Discontinuation
- 2003-08-14 MX MXPA05001256A patent/MXPA05001256A/es active IP Right Grant
- 2003-08-14 WO PCT/IB2003/003634 patent/WO2004020431A2/en active Application Filing
- 2003-08-14 PT PT03791110T patent/PT1594858E/pt unknown
- 2003-08-14 KR KR1020077014809A patent/KR20070086768A/ko not_active Application Discontinuation
- 2003-08-14 NZ NZ538427A patent/NZ538427A/en not_active IP Right Cessation
- 2003-08-14 SI SI200331687T patent/SI1594858T1/sl unknown
- 2003-08-14 OA OA1200500059A patent/OA12916A/en unknown
- 2003-08-14 AP AP2005003237A patent/AP2005003237A0/xx unknown
- 2003-08-14 BR BRPI0313942A patent/BRPI0313942C1/pt not_active IP Right Cessation
- 2003-08-14 EP EP20030791110 patent/EP1594858B1/en not_active Expired - Lifetime
- 2003-08-14 ES ES03791110T patent/ES2333219T3/es not_active Expired - Lifetime
- 2003-08-14 KR KR20057003493A patent/KR100816166B1/ko active IP Right Grant
- 2003-08-14 AT AT03791110T patent/ATE445610T1/de active
- 2003-08-14 DE DE60329715T patent/DE60329715D1/de not_active Expired - Lifetime
- 2003-08-14 CA CA 2495577 patent/CA2495577C/en not_active Expired - Lifetime
- 2003-08-14 CN CNB038206218A patent/CN1319966C/zh not_active Expired - Lifetime
- 2003-08-14 GE GEAU2003008665 patent/GEP20064005B/en unknown
- 2003-08-19 DO DO2003000694A patent/DOP2003000694A/es unknown
- 2003-08-25 HN HN2003000257A patent/HN2003000257A/es unknown
- 2003-08-25 PE PE2003000864A patent/PE20050131A1/es active IP Right Grant
- 2003-08-26 MY MYPI20033225 patent/MY139357A/en unknown
- 2003-08-26 AR ARP030103073 patent/AR041055A1/es unknown
- 2003-08-26 UY UY27952A patent/UY27952A1/es not_active Application Discontinuation
- 2003-08-26 US US10/648,151 patent/US7071337B2/en active Active
- 2003-08-27 TW TW92123585A patent/TW200407131A/zh unknown
-
2005
- 2005-01-20 IS IS7660A patent/IS2738B/is unknown
- 2005-02-10 IL IL166832A patent/IL166832A/en active IP Right Grant
- 2005-02-14 CU CU20050031A patent/CU23413B7/es not_active IP Right Cessation
- 2005-02-22 CR CR7698A patent/CR7698A/es unknown
- 2005-02-28 HR HRP20050191AA patent/HRP20050191B1/hr not_active IP Right Cessation
- 2005-02-28 MA MA28124A patent/MA27389A1/fr unknown
- 2005-02-28 EC ECSP055633 patent/ECSP055633A/es unknown
- 2005-03-14 NO NO20051303A patent/NO20051303L/no not_active Application Discontinuation
- 2005-08-14 RS YUP-2005/0180A patent/RS20050180A/sr unknown
- 2005-11-18 HK HK05110348A patent/HK1078571A1/xx not_active IP Right Cessation
-
2009
- 2009-11-30 CY CY20091101249T patent/CY1110580T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |