PE20020253A1 - Derivados de 3-azabiciclo[3.1.0]hexano como ligandos de receptores opiaceos - Google Patents

Derivados de 3-azabiciclo[3.1.0]hexano como ligandos de receptores opiaceos

Info

Publication number
PE20020253A1
PE20020253A1 PE2001000604A PE2001000604A PE20020253A1 PE 20020253 A1 PE20020253 A1 PE 20020253A1 PE 2001000604 A PE2001000604 A PE 2001000604A PE 2001000604 A PE2001000604 A PE 2001000604A PE 20020253 A1 PE20020253 A1 PE 20020253A1
Authority
PE
Peru
Prior art keywords
alkyl
ethyl
hexane
derivatives
halo
Prior art date
Application number
PE2001000604A
Other languages
English (en)
Inventor
Bernard Joseph Banks
Douglas James Critcher
Stephen Paul Gibson
David Morris Gethin
Ashley Edward Fenwick
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20020253A1 publication Critical patent/PE20020253A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS 3-AZABICICLO[3.1.0]HEXANO DE FORMULA I DONDE Ar ES FENILO OPCIONALMENTE CONDENSADO CON BENCENO O UN ANILLO HETEROARILO DE 5 A 6 MIEMBROS; R1 ES H, HALO, NO2, NH2, NY2WY1, HET, AD, OE, ENTRE OTROS; Y2 ES H, ALQUILO C1-C6, ALQUENILO C3-C6, ENTRE OTROS; W ES SO2, CO, C(O)O, P(Y1)=S, ENTRE OTROS; Y1 ES ALQUILO C1-C10 CON HALOGENO, OH, ALCOXI C1-C4, ALCANOILOXI C1-C6, ENTRE OTROS; HET ES HETEROCICLICO CON 4 HETEROATOMOS SELECCIONADOS DE N, O, S QUE PUEDE COMPRENDER HASTA 3 ANILLOS SUSTITUIDOS CON ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS; A ES ALQUILENO C1-C4, ALQUENILENO C2-C4, ALQUINILENO C2-C4 CON ALQUILO C1-C4, ALCOXI C1-C4, HALOGENO, OH; D ES H, OH, CN, ENTRE OTROS; E ES H, CONR23R23, ENTRE OTROS. R23 ES H, ALQUILO C1-C4, HALOALQUILO C1-C4; R2 ES H, HALO; R3 ES H, CN, HALO; R4 ES ALQUILO C1-C10, ALQUENILO; R5 Y R8 SON H, ALQUILO C1-C6; R6, R7, R9 Y R10 SON H; n ES 0-2; q ES 0-1. SON COMPUESTOS PREFERIDOS N-(3-{6-ETIL-3-[2-(2-HIDROXIETOXI)-ETIL]-3-AZABICICLO-[3.1.0]HEX-6-IL}-FENIL)METANOSULFONAMIDA, N-(3-{3-{2-[2-(DIMETILAMINO)ETOXI)-ETIL]-6-ETIL-3-AZABICICLO-[3.1.0]HEX-6-IL}-FENIL)METANOSULFONAMIDA, ENTRE OTROS. LOS DERIVADOS DE 3-AZABICICLO[3.1.0]HEXANO SON LIGANDOS DE RECEPTORES OPIACEOS Y SON UTILES PARA EL TRATAMIENTO DEL SINDROME DEL INTESTINO IRRITABLE, ESTRENIMIENTO, NAUSEAS, VOMITOS
PE2001000604A 2000-06-23 2001-06-21 Derivados de 3-azabiciclo[3.1.0]hexano como ligandos de receptores opiaceos PE20020253A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0015562.2A GB0015562D0 (en) 2000-06-23 2000-06-23 Heterocycles

Publications (1)

Publication Number Publication Date
PE20020253A1 true PE20020253A1 (es) 2002-04-08

Family

ID=9894368

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000604A PE20020253A1 (es) 2000-06-23 2001-06-21 Derivados de 3-azabiciclo[3.1.0]hexano como ligandos de receptores opiaceos

Country Status (34)

Country Link
EP (1) EP1292574A1 (es)
JP (1) JP2004512263A (es)
KR (1) KR20040002386A (es)
CN (1) CN1639121A (es)
AP (1) AP2002002698A0 (es)
AR (1) AR028969A1 (es)
AU (1) AU781837B2 (es)
BG (1) BG107329A (es)
BR (1) BR0111867A (es)
CA (1) CA2412188A1 (es)
CZ (1) CZ20023967A3 (es)
DO (1) DOP2001000187A (es)
DZ (1) DZ3368A1 (es)
EA (1) EA005117B1 (es)
GB (1) GB0015562D0 (es)
HR (1) HRP20020998A2 (es)
HU (1) HUP0301228A3 (es)
IL (1) IL153427A0 (es)
IS (1) IS6637A (es)
MA (1) MA26915A1 (es)
MX (1) MXPA02012878A (es)
NO (1) NO20026168L (es)
NZ (1) NZ523141A (es)
OA (1) OA12293A (es)
PA (1) PA8519401A1 (es)
PE (1) PE20020253A1 (es)
PL (1) PL365956A1 (es)
SK (1) SK17172002A3 (es)
TN (1) TNSN01094A1 (es)
UA (1) UA73176C2 (es)
UY (1) UY26787A1 (es)
WO (1) WO2001098267A1 (es)
YU (1) YU91802A (es)
ZA (1) ZA200210278B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0213464A (pt) 2001-10-22 2004-11-09 Pfizer Prod Inc Derivados de 3-azabiciclo[3.1.0]hexano como antagonistas receptores de opióide
EP2074997A1 (en) * 2002-05-17 2009-07-01 Tioga Pharmaceuticals, Inc. Use of Asimadoline for the treatment of digestive disorders
DE10259245A1 (de) 2002-12-17 2004-07-01 Merck Patent Gmbh Derivate des Asimadolins mit kovalent gebundenen Säuren
DK1745040T3 (da) 2004-02-23 2010-04-12 Glaxo Group Ltd Som modulatorer af dopamin-D3-receptorer anvendelige azabicyclo(3.1.0)hexanederivater
GB0507680D0 (en) * 2005-04-15 2005-05-25 Glaxo Group Ltd Compounds
JP5068747B2 (ja) * 2005-06-14 2012-11-07 グラクソ グループ リミテッド ドーパミンｄ３受容体のモジュレーターとしてのアザビシクロ［３．１．０］ヘキサン誘導体
WO2007113258A1 (en) * 2006-04-03 2007-10-11 Glaxo Group Limited Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors
EP2561870A1 (en) 2007-03-30 2013-02-27 Tioga Pharmaceuticals, Inc. Kappa-Opiate Agonists For The Treatment Of Diarrhea-Predominant and Alternating Irritable Bowel Syndrome
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
AU2011263417B2 (en) 2010-06-11 2014-03-27 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
WO2012042539A2 (en) 2010-09-28 2012-04-05 Panacea Biotec Ltd Novel bicyclic compounds
KR102305244B1 (ko) * 2013-11-20 2021-09-27 우베 고산 가부시키가이샤 신규 3-아자비사이클로[3.1.0]헥산 유도체 및 그 의약 용도
JP6087035B1 (ja) 2015-05-20 2017-03-01 株式会社三和化学研究所 新規３−アザビシクロ［３．１．０］ヘキサン誘導体の塩の結晶及びその医薬用途
BR112019016827A2 (pt) * 2017-02-17 2020-04-07 Trevena Inc compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 5 membros, métodos de uso e produção dos mesmos
CA3052479A1 (en) 2017-02-17 2018-08-23 Trevena, Inc. 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
AU2018229062A1 (en) 2017-03-02 2019-09-26 Ube Industries, Ltd. Therapeutic agent for alcohol use disorders
CN108250088B (zh) * 2018-01-04 2020-10-30 四川之江高新材料股份有限公司 N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法
CN115825305B (zh) * 2022-10-21 2024-09-20 昆明理工大学 一种分子印迹固相微萃取纤维及其制备方法与应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065230A (en) * 1959-03-16 1962-11-20 Burroughs Wellcome Co Azabicyclohexanes and method of preparing them
ES2058265T3 (es) * 1987-04-16 1994-11-01 Lilly Co Eli Piperidinas antagonistas de opiaceos.
US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
TWI244481B (en) * 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
PE20001420A1 (es) * 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5

Also Published As

Publication number Publication date
AR028969A1 (es) 2003-05-28
BG107329A (en) 2003-07-31
HUP0301228A2 (hu) 2003-08-28
HUP0301228A3 (en) 2005-08-29
YU91802A (sh) 2006-05-25
PL365956A1 (en) 2005-01-24
IS6637A (is) 2002-11-28
UY26787A1 (es) 2002-01-31
EA200201269A1 (ru) 2003-06-26
DZ3368A1 (fr) 2001-12-27
IL153427A0 (en) 2003-07-06
SK17172002A3 (sk) 2004-09-08
AU6259101A (en) 2002-01-02
BR0111867A (pt) 2003-07-01
NO20026168L (no) 2003-02-18
MXPA02012878A (es) 2003-05-14
ZA200210278B (en) 2003-12-19
EA005117B1 (ru) 2004-10-28
AP2002002698A0 (en) 2002-12-31
HRP20020998A2 (en) 2004-02-29
PA8519401A1 (es) 2002-12-30
DOP2001000187A (es) 2002-03-30
WO2001098267A1 (en) 2001-12-27
OA12293A (en) 2004-03-18
NZ523141A (en) 2005-06-24
EP1292574A1 (en) 2003-03-19
CZ20023967A3 (cs) 2004-02-18
GB0015562D0 (en) 2000-08-16
KR20040002386A (ko) 2004-01-07
UA73176C2 (en) 2005-06-15
WO2001098267A8 (en) 2003-02-27
MA26915A1 (fr) 2004-12-20
JP2004512263A (ja) 2004-04-22
CN1639121A (zh) 2005-07-13
TNSN01094A1 (fr) 2005-11-10
CA2412188A1 (en) 2001-12-27
NO20026168D0 (no) 2002-12-20
AU781837B2 (en) 2005-06-16

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