HUP0301228A3 - 3-azabicyclo(3.1.0)hexane derivatives having opioid receptor affinity, process for their preparation and pharmaceutical compositions containing them - Google Patents
3-azabicyclo(3.1.0)hexane derivatives having opioid receptor affinity, process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- HUP0301228A3 HUP0301228A3 HU0301228A HUP0301228A HUP0301228A3 HU P0301228 A3 HUP0301228 A3 HU P0301228A3 HU 0301228 A HU0301228 A HU 0301228A HU P0301228 A HUP0301228 A HU P0301228A HU P0301228 A3 HUP0301228 A3 HU P0301228A3
- Authority
- HU
- Hungary
- Prior art keywords
- azabicyclo
- preparation
- pharmaceutical compositions
- compositions containing
- opioid receptor
- Prior art date
Links
- 150000005228 3‐azabicyclo[3.1.0]hexanes Chemical class 0.000 title 1
- 102000003840 Opioid Receptors Human genes 0.000 title 1
- 108090000137 Opioid Receptors Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Gynecology & Obstetrics (AREA)
- Nutrition Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0015562.2A GB0015562D0 (en) | 2000-06-23 | 2000-06-23 | Heterocycles |
PCT/IB2001/001035 WO2001098267A1 (en) | 2000-06-23 | 2001-06-07 | 3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0301228A2 HUP0301228A2 (en) | 2003-08-28 |
HUP0301228A3 true HUP0301228A3 (en) | 2005-08-29 |
Family
ID=9894368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301228A HUP0301228A3 (en) | 2000-06-23 | 2001-06-07 | 3-azabicyclo(3.1.0)hexane derivatives having opioid receptor affinity, process for their preparation and pharmaceutical compositions containing them |
Country Status (34)
Country | Link |
---|---|
EP (1) | EP1292574A1 (en) |
JP (1) | JP2004512263A (en) |
KR (1) | KR20040002386A (en) |
CN (1) | CN1639121A (en) |
AP (1) | AP2002002698A0 (en) |
AR (1) | AR028969A1 (en) |
AU (1) | AU781837B2 (en) |
BG (1) | BG107329A (en) |
BR (1) | BR0111867A (en) |
CA (1) | CA2412188A1 (en) |
CZ (1) | CZ20023967A3 (en) |
DO (1) | DOP2001000187A (en) |
DZ (1) | DZ3368A1 (en) |
EA (1) | EA005117B1 (en) |
GB (1) | GB0015562D0 (en) |
HR (1) | HRP20020998A2 (en) |
HU (1) | HUP0301228A3 (en) |
IL (1) | IL153427A0 (en) |
IS (1) | IS6637A (en) |
MA (1) | MA26915A1 (en) |
MX (1) | MXPA02012878A (en) |
NO (1) | NO20026168L (en) |
NZ (1) | NZ523141A (en) |
OA (1) | OA12293A (en) |
PA (1) | PA8519401A1 (en) |
PE (1) | PE20020253A1 (en) |
PL (1) | PL365956A1 (en) |
SK (1) | SK17172002A3 (en) |
TN (1) | TNSN01094A1 (en) |
UA (1) | UA73176C2 (en) |
UY (1) | UY26787A1 (en) |
WO (1) | WO2001098267A1 (en) |
YU (1) | YU91802A (en) |
ZA (1) | ZA200210278B (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1440059E (en) * | 2001-10-22 | 2008-05-16 | Pfizer Prod Inc | 3-azabicyclo(3.1.0)hexane derivatives as opioid receptor antagonists |
PL371596A1 (en) * | 2002-05-17 | 2005-06-27 | Merck Patent Gmbh | Use of compounds that are effective as selective opiate receptor modulators |
DE10259245A1 (en) | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | Derivatives of asimadolin with covalently bound acids |
PT2060570E (en) * | 2004-02-23 | 2012-05-07 | Glaxo Group Ltd | Azabicyclo[3.1.0] hexane derivatives useful as modulators of dopamine d3 receptors |
GB0507680D0 (en) | 2005-04-15 | 2005-05-25 | Glaxo Group Ltd | Compounds |
ATE484502T1 (en) | 2005-06-14 | 2010-10-15 | Glaxo Group Ltd | NEW CONNECTIONS |
US8163927B2 (en) | 2006-04-03 | 2012-04-24 | Glaxo Group Limited | Azabicyclo [3.1.0] hexane derivatives as modulators of dopamine D3 receptors |
AU2008232954A1 (en) | 2007-03-30 | 2008-10-09 | Tioga Pharmaceuticals Inc. | Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome |
TWI423801B (en) * | 2007-08-27 | 2014-01-21 | Theravance Inc | 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu opioid receptor antagonists |
EP2995614B8 (en) * | 2010-06-11 | 2018-03-28 | Rhodes Technologies Inc. | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
JP2013542929A (en) | 2010-09-28 | 2013-11-28 | パナセア バイオテック リミテッド | New bicyclo ring compounds |
MX2016006482A (en) * | 2013-11-20 | 2016-12-09 | Sanwa Kagaku Kenkyusho Co | Novel 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purposes. |
KR20180004734A (en) | 2015-05-20 | 2018-01-12 | 가부시키가이샤산와카가쿠켄큐쇼 | Crystals of salts of novel 3-azabicyclo [3.1.0] hexane derivatives and uses thereof for medicaments |
CN110520129A (en) * | 2017-02-17 | 2019-11-29 | 特维娜有限公司 | Delta opiate receptor modulating compound and its use and preparation method containing 5 yuan of aza heterocycles |
CA3052479A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
AU2018229062A1 (en) | 2017-03-02 | 2019-09-26 | Ube Industries, Ltd. | Therapeutic agent for alcohol use disorders |
CN108250088B (en) * | 2018-01-04 | 2020-10-30 | 四川之江高新材料股份有限公司 | Preparation method of N, N, N '-trimethyl-N' -hydroxyethyl bisaminoethylether |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3065230A (en) * | 1959-03-16 | 1962-11-20 | Burroughs Wellcome Co | Azabicyclohexanes and method of preparing them |
DE3851081T2 (en) * | 1987-04-16 | 1995-02-16 | Lilly Co Eli | Piperidines as opioid antagonists. |
US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
DE4341403A1 (en) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituted 3-azabicycloalkane derivatives, their preparation and use |
PE20001420A1 (en) * | 1998-12-23 | 2000-12-18 | Pfizer | CCR5 MODULATORS |
TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
-
2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
-
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/en unknown
- 2001-06-07 IL IL15342701A patent/IL153427A0/en unknown
- 2001-06-07 PL PL01365956A patent/PL365956A1/en not_active Application Discontinuation
- 2001-06-07 YU YU91802A patent/YU91802A/en unknown
- 2001-06-07 EA EA200201269A patent/EA005117B1/en not_active IP Right Cessation
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/en not_active Application Discontinuation
- 2001-06-07 EP EP01936728A patent/EP1292574A1/en not_active Withdrawn
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/en unknown
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/en not_active Withdrawn
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/en unknown
- 2001-06-07 CN CNA018116086A patent/CN1639121A/en active Pending
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/en not_active Application Discontinuation
- 2001-06-07 CA CA002412188A patent/CA2412188A1/en not_active Abandoned
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/en not_active IP Right Cessation
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/en unknown
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/en unknown
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/en active
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/en unknown
- 2001-06-21 UY UY26787A patent/UY26787A1/en not_active Application Discontinuation
- 2001-06-21 AR ARP010102957A patent/AR028969A1/en unknown
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/en not_active Application Discontinuation
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/en unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/en unknown
-
2002
- 2002-11-28 BG BG107329A patent/BG107329A/en unknown
- 2002-11-28 IS IS6637A patent/IS6637A/en unknown
- 2002-12-12 HR HR20020998A patent/HRP20020998A2/en not_active Application Discontinuation
- 2002-12-16 MA MA26955A patent/MA26915A1/en unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/en unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/en not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |