BG107329A - 3-azabicyclo(3.1.0) hexane derivatives having opioid receptor affinity - Google Patents
3-azabicyclo(3.1.0) hexane derivatives having opioid receptor affinityInfo
- Publication number
- BG107329A BG107329A BG107329A BG10732902A BG107329A BG 107329 A BG107329 A BG 107329A BG 107329 A BG107329 A BG 107329A BG 10732902 A BG10732902 A BG 10732902A BG 107329 A BG107329 A BG 107329A
- Authority
- BG
- Bulgaria
- Prior art keywords
- opiate
- azabicyclo
- pharmaceutically
- opioid receptor
- receptors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Compounds of formula where the substituents are as defined in the description, and pharmaceutically or veterinanarily acceptable derivatives or prodrugs thereof, are pharmaceutically and veterinarily useful, in particular they bind to opiate receptors (e.g. mu, kappa and delta opioid receptors). They are likely to be useful in the treatment of diseases of conditions modulated by opiate receptors, for example irritable bowel syndrome; constipation; nausea; vomiting; pruritic dermatoses, such as allergic dermatitis and atopy; eating disorders; opiate overdoses; depression; smoking and alcohol addiction; sexual dysfunction; shock; stroke; spinal damage; and head trauma. 34 claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0015562.2A GB0015562D0 (en) | 2000-06-23 | 2000-06-23 | Heterocycles |
| PCT/IB2001/001035 WO2001098267A1 (en) | 2000-06-23 | 2001-06-07 | 3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG107329A true BG107329A (en) | 2003-07-31 |
Family
ID=9894368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG107329A BG107329A (en) | 2000-06-23 | 2002-11-28 | 3-azabicyclo(3.1.0) hexane derivatives having opioid receptor affinity |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP1292574A1 (en) |
| JP (1) | JP2004512263A (en) |
| KR (1) | KR20040002386A (en) |
| CN (1) | CN1639121A (en) |
| AP (1) | AP2002002698A0 (en) |
| AR (1) | AR028969A1 (en) |
| AU (1) | AU781837B2 (en) |
| BG (1) | BG107329A (en) |
| BR (1) | BR0111867A (en) |
| CA (1) | CA2412188A1 (en) |
| CZ (1) | CZ20023967A3 (en) |
| DO (1) | DOP2001000187A (en) |
| DZ (1) | DZ3368A1 (en) |
| EA (1) | EA005117B1 (en) |
| GB (1) | GB0015562D0 (en) |
| HR (1) | HRP20020998A2 (en) |
| HU (1) | HUP0301228A3 (en) |
| IL (1) | IL153427A0 (en) |
| IS (1) | IS6637A (en) |
| MA (1) | MA26915A1 (en) |
| MX (1) | MXPA02012878A (en) |
| NO (1) | NO20026168L (en) |
| NZ (1) | NZ523141A (en) |
| OA (1) | OA12293A (en) |
| PA (1) | PA8519401A1 (en) |
| PE (1) | PE20020253A1 (en) |
| PL (1) | PL365956A1 (en) |
| SK (1) | SK17172002A3 (en) |
| TN (1) | TNSN01094A1 (en) |
| UA (1) | UA73176C2 (en) |
| UY (1) | UY26787A1 (en) |
| WO (1) | WO2001098267A1 (en) |
| YU (1) | YU91802A (en) |
| ZA (1) | ZA200210278B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0213464A (en) | 2001-10-22 | 2004-11-09 | Pfizer Prod Inc | 3-Azabicyclo [3.1.0] hexane derivatives as opioid receptor antagonists |
| EP2074997A1 (en) * | 2002-05-17 | 2009-07-01 | Tioga Pharmaceuticals, Inc. | Use of Asimadoline for the treatment of digestive disorders |
| DE10259245A1 (en) | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | Derivatives of asimadolin with covalently bound acids |
| DK1745040T3 (en) | 2004-02-23 | 2010-04-12 | Glaxo Group Ltd | Azabicyclo (3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors |
| GB0507680D0 (en) * | 2005-04-15 | 2005-05-25 | Glaxo Group Ltd | Compounds |
| JP5068747B2 (en) * | 2005-06-14 | 2012-11-07 | グラクソ グループ リミテッド | Azabicyclo [3.1.0] hexane derivatives as modulators of dopamine D3 receptors |
| WO2007113258A1 (en) * | 2006-04-03 | 2007-10-11 | Glaxo Group Limited | Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors |
| EP2561870A1 (en) | 2007-03-30 | 2013-02-27 | Tioga Pharmaceuticals, Inc. | Kappa-Opiate Agonists For The Treatment Of Diarrhea-Predominant and Alternating Irritable Bowel Syndrome |
| TWI423801B (en) * | 2007-08-27 | 2014-01-21 | Theravance Inc | 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu opioid receptor antagonists |
| AU2011263417B2 (en) | 2010-06-11 | 2014-03-27 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof |
| WO2012042539A2 (en) | 2010-09-28 | 2012-04-05 | Panacea Biotec Ltd | Novel bicyclic compounds |
| KR102305244B1 (en) * | 2013-11-20 | 2021-09-27 | 우베 고산 가부시키가이샤 | Novel 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purposes |
| JP6087035B1 (en) | 2015-05-20 | 2017-03-01 | 株式会社三和化学研究所 | Crystal of salt of novel 3-azabicyclo [3.1.0] hexane derivative and pharmaceutical use thereof |
| BR112019016827A2 (en) * | 2017-02-17 | 2020-04-07 | Trevena Inc | 5-membered azaheterocyclic delta-opioid receptor modulating compounds, methods of use and production thereof |
| CA3052479A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| AU2018229062A1 (en) | 2017-03-02 | 2019-09-26 | Ube Industries, Ltd. | Therapeutic agent for alcohol use disorders |
| CN108250088B (en) * | 2018-01-04 | 2020-10-30 | 四川之江高新材料股份有限公司 | Preparation method of N, N, N '-trimethyl-N' -hydroxyethyl bisaminoethylether |
| CN115825305B (en) * | 2022-10-21 | 2024-09-20 | 昆明理工大学 | Molecularly imprinted solid-phase microextraction fiber and preparation method and application thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3065230A (en) * | 1959-03-16 | 1962-11-20 | Burroughs Wellcome Co | Azabicyclohexanes and method of preparing them |
| ES2058265T3 (en) * | 1987-04-16 | 1994-11-01 | Lilly Co Eli | PIPERIDINES ANTAGONISTS FROM OPIACEANS. |
| US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| DE4341403A1 (en) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituted 3-azabicycloalkane derivatives, their preparation and use |
| TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| PE20001420A1 (en) * | 1998-12-23 | 2000-12-18 | Pfizer | CCR5 MODULATORS |
-
2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
-
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/en unknown
- 2001-06-07 CA CA002412188A patent/CA2412188A1/en not_active Abandoned
- 2001-06-07 YU YU91802A patent/YU91802A/en unknown
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/en unknown
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/en not_active Application Discontinuation
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/en not_active IP Right Cessation
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/en unknown
- 2001-06-07 CN CNA018116086A patent/CN1639121A/en active Pending
- 2001-06-07 EP EP01936728A patent/EP1292574A1/en not_active Withdrawn
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/en unknown
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/en not_active Withdrawn
- 2001-06-07 EA EA200201269A patent/EA005117B1/en not_active IP Right Cessation
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/en active
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/en not_active Application Discontinuation
- 2001-06-07 PL PL01365956A patent/PL365956A1/en not_active Application Discontinuation
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 IL IL15342701A patent/IL153427A0/en unknown
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/en unknown
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/en unknown
- 2001-06-21 AR ARP010102957A patent/AR028969A1/en unknown
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/en not_active Application Discontinuation
- 2001-06-21 UY UY26787A patent/UY26787A1/en not_active Application Discontinuation
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/en unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/en unknown
-
2002
- 2002-11-28 BG BG107329A patent/BG107329A/en unknown
- 2002-11-28 IS IS6637A patent/IS6637A/en unknown
- 2002-12-12 HR HR20020998A patent/HRP20020998A2/en not_active Application Discontinuation
- 2002-12-16 MA MA26955A patent/MA26915A1/en unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/en unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/en not_active Application Discontinuation
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