EA200201269A1 - 3-AZABICYCLO DERIVATIVES (3.1.0) OF HEXANE THAT HAVE A KIND TO THE OPIODE RECEPTOR - Google Patents

3-AZABICYCLO DERIVATIVES (3.1.0) OF HEXANE THAT HAVE A KIND TO THE OPIODE RECEPTOR

Info

Publication number
EA200201269A1
EA200201269A1 EA200201269A EA200201269A EA200201269A1 EA 200201269 A1 EA200201269 A1 EA 200201269A1 EA 200201269 A EA200201269 A EA 200201269A EA 200201269 A EA200201269 A EA 200201269A EA 200201269 A1 EA200201269 A1 EA 200201269A1
Authority
EA
Eurasian Patent Office
Prior art keywords
opiate
pharmaceutically
compounds
receptors
opiode
Prior art date
Application number
EA200201269A
Other languages
Russian (ru)
Other versions
EA005117B1 (en
Inventor
Бернард Джозеф Бэнкс
Дуглас Джеймс Критчер
Эшли Эдвард Фенвик
Дэвид Моррис Гетин
Грэхем Ланн
Стефен Пол Гибсон
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA200201269A1 publication Critical patent/EA200201269A1/en
Publication of EA005117B1 publication Critical patent/EA005117B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Соединения формулы (I), где заместители принимают значения, определенные в описании, и их фармацевтически или ветеринарно приемлемые производные или пролекарства являются фармацевтически и ветеринарно полезными, в частности они связываются с опиатными рецепторами (например, мю-, каппа и дельта-опиоидными рецепторами). Данные соединения, вероятно, могут использоваться для лечения заболеваний или состояний, модулируемых опиатными рецепторами, например синдрома воспаленной толстой кишки, запора, тошноты, рвоты, зудящих дерматозов, таких как аллергический дерматит и атопия, расстройств аппетита, опиатной передозировки, депрессии, зависимости от табака и хронического алкоголизма, половой дисфункции, удара, приступа, повреждения спинного мозга и травмы головы.Международная заявка была опубликована вместе с отчетом о международном поиске.The compounds of formula (I), where the substituents take the values defined in the description, and their pharmaceutically or veterinary acceptable derivatives or prodrugs are pharmaceutically and veterinary useful, in particular they bind to opiate receptors (for example, mu, kappa and delta-opioid receptors) . These compounds can probably be used to treat diseases or conditions modulated by opiate receptors, such as inflammatory bowel syndrome, constipation, nausea, vomiting, itchy dermatoses, such as allergic dermatitis and atopy, appetite disorders, opiate overdose, depression, tobacco dependence and chronic alcoholism, sexual dysfunction, stroke, seizure, spinal cord injury and head injury. The international application was published along with an international search report.

EA200201269A 2000-06-23 2001-06-07 3-azabicyclo (3.1.0)hexane derivatives having opioid 3-receptor affinity EA005117B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0015562.2A GB0015562D0 (en) 2000-06-23 2000-06-23 Heterocycles
PCT/IB2001/001035 WO2001098267A1 (en) 2000-06-23 2001-06-07 3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity

Publications (2)

Publication Number Publication Date
EA200201269A1 true EA200201269A1 (en) 2003-06-26
EA005117B1 EA005117B1 (en) 2004-10-28

Family

ID=9894368

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200201269A EA005117B1 (en) 2000-06-23 2001-06-07 3-azabicyclo (3.1.0)hexane derivatives having opioid 3-receptor affinity

Country Status (34)

Country Link
EP (1) EP1292574A1 (en)
JP (1) JP2004512263A (en)
KR (1) KR20040002386A (en)
CN (1) CN1639121A (en)
AP (1) AP2002002698A0 (en)
AR (1) AR028969A1 (en)
AU (1) AU781837B2 (en)
BG (1) BG107329A (en)
BR (1) BR0111867A (en)
CA (1) CA2412188A1 (en)
CZ (1) CZ20023967A3 (en)
DO (1) DOP2001000187A (en)
DZ (1) DZ3368A1 (en)
EA (1) EA005117B1 (en)
GB (1) GB0015562D0 (en)
HR (1) HRP20020998A2 (en)
HU (1) HUP0301228A3 (en)
IL (1) IL153427A0 (en)
IS (1) IS6637A (en)
MA (1) MA26915A1 (en)
MX (1) MXPA02012878A (en)
NO (1) NO20026168L (en)
NZ (1) NZ523141A (en)
OA (1) OA12293A (en)
PA (1) PA8519401A1 (en)
PE (1) PE20020253A1 (en)
PL (1) PL365956A1 (en)
SK (1) SK17172002A3 (en)
TN (1) TNSN01094A1 (en)
UA (1) UA73176C2 (en)
UY (1) UY26787A1 (en)
WO (1) WO2001098267A1 (en)
YU (1) YU91802A (en)
ZA (1) ZA200210278B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2701861C1 (en) * 2013-11-20 2019-10-02 Санва Кагаку Кенкюсо Ко., Лтд. New derivative of 3-azabicyclo[3.1.0]hexane and use thereof for medical purposes

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GEP20084300B (en) * 2001-10-22 2008-02-11 Pfizer Prod Inc 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
AU2003242527B2 (en) * 2002-05-17 2008-10-23 Tioga Pharmaceuticals, Inc. Use of compounds that are effective as selective opiate receptor modulators
DE10259245A1 (en) 2002-12-17 2004-07-01 Merck Patent Gmbh Derivatives of asimadolin with covalently bound acids
JP4960217B2 (en) 2004-02-23 2012-06-27 グラクソ グループ リミテッド Azabicyclo (3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors
GB0507680D0 (en) * 2005-04-15 2005-05-25 Glaxo Group Ltd Compounds
ATE484502T1 (en) * 2005-06-14 2010-10-15 Glaxo Group Ltd NEW CONNECTIONS
US8163927B2 (en) 2006-04-03 2012-04-24 Glaxo Group Limited Azabicyclo [3.1.0] hexane derivatives as modulators of dopamine D3 receptors
CN101677997B (en) 2007-03-30 2012-05-09 泰奥加制药公司 Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome
TWI423801B (en) * 2007-08-27 2014-01-21 Theravance Inc 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu opioid receptor antagonists
CA2936749C (en) 2010-06-11 2019-07-09 Joshua R. Giguere Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
US9133116B2 (en) 2010-09-28 2015-09-15 Panacea Biotec Ltd. Bicyclic compounds
US10392345B2 (en) 2015-05-20 2019-08-27 Sanwa Kagaku Kenkyusho Co., Ltd. Crystal of salt of novel 3-azabicyclo[3.1.0]hexane derivative and pharmaceutical use thereof
US11702408B2 (en) 2017-02-17 2023-07-18 Trevena, Inc. 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
CA3052479A1 (en) 2017-02-17 2018-08-23 Trevena, Inc. 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
CN110352055A (en) 2017-03-02 2019-10-18 株式会社三和化学研究所 The therapeutic agent of alcohol use disorders
CN108250088B (en) * 2018-01-04 2020-10-30 四川之江高新材料股份有限公司 Preparation method of N, N, N '-trimethyl-N' -hydroxyethyl bisaminoethylether

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AR245933A1 (en) * 1987-04-16 1994-03-30 Lilly Co Eli Piperidine opioid antagonists
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2701861C1 (en) * 2013-11-20 2019-10-02 Санва Кагаку Кенкюсо Ко., Лтд. New derivative of 3-azabicyclo[3.1.0]hexane and use thereof for medical purposes

Also Published As

Publication number Publication date
CZ20023967A3 (en) 2004-02-18
WO2001098267A1 (en) 2001-12-27
ZA200210278B (en) 2003-12-19
UA73176C2 (en) 2005-06-15
AR028969A1 (en) 2003-05-28
KR20040002386A (en) 2004-01-07
TNSN01094A1 (en) 2005-11-10
HRP20020998A2 (en) 2004-02-29
MXPA02012878A (en) 2003-05-14
SK17172002A3 (en) 2004-09-08
NO20026168L (en) 2003-02-18
DOP2001000187A (en) 2002-03-30
YU91802A (en) 2006-05-25
AU781837B2 (en) 2005-06-16
HUP0301228A3 (en) 2005-08-29
HUP0301228A2 (en) 2003-08-28
PL365956A1 (en) 2005-01-24
CA2412188A1 (en) 2001-12-27
IS6637A (en) 2002-11-28
UY26787A1 (en) 2002-01-31
AP2002002698A0 (en) 2002-12-31
BG107329A (en) 2003-07-31
WO2001098267A8 (en) 2003-02-27
NZ523141A (en) 2005-06-24
EP1292574A1 (en) 2003-03-19
NO20026168D0 (en) 2002-12-20
AU6259101A (en) 2002-01-02
PE20020253A1 (en) 2002-04-08
GB0015562D0 (en) 2000-08-16
JP2004512263A (en) 2004-04-22
EA005117B1 (en) 2004-10-28
OA12293A (en) 2004-03-18
CN1639121A (en) 2005-07-13
BR0111867A (en) 2003-07-01
DZ3368A1 (en) 2001-12-27
PA8519401A1 (en) 2002-12-30
MA26915A1 (en) 2004-12-20
IL153427A0 (en) 2003-07-06

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU