EA200201269A1 - Производные 3-азабицикло(3.1.0)гексана, обладающие сродством к опиодному рецептору - Google Patents

Производные 3-азабицикло(3.1.0)гексана, обладающие сродством к опиодному рецептору

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Publication number
EA200201269A1
EA200201269A1 EA200201269A EA200201269A EA200201269A1 EA 200201269 A1 EA200201269 A1 EA 200201269A1 EA 200201269 A EA200201269 A EA 200201269A EA 200201269 A EA200201269 A EA 200201269A EA 200201269 A1 EA200201269 A1 EA 200201269A1
Authority
EA
Eurasian Patent Office
Prior art keywords
opiate
pharmaceutically
compounds
receptors
opiode
Prior art date
Application number
EA200201269A
Other languages
English (en)
Other versions
EA005117B1 (ru
Inventor
Бернард Джозеф Бэнкс
Дуглас Джеймс Критчер
Эшли Эдвард Фенвик
Дэвид Моррис Гетин
Грэхем Ланн
Стефен Пол Гибсон
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA200201269A1 publication Critical patent/EA200201269A1/ru
Publication of EA005117B1 publication Critical patent/EA005117B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Otolaryngology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Соединения формулы (I), где заместители принимают значения, определенные в описании, и их фармацевтически или ветеринарно приемлемые производные или пролекарства являются фармацевтически и ветеринарно полезными, в частности они связываются с опиатными рецепторами (например, мю-, каппа и дельта-опиоидными рецепторами). Данные соединения, вероятно, могут использоваться для лечения заболеваний или состояний, модулируемых опиатными рецепторами, например синдрома воспаленной толстой кишки, запора, тошноты, рвоты, зудящих дерматозов, таких как аллергический дерматит и атопия, расстройств аппетита, опиатной передозировки, депрессии, зависимости от табака и хронического алкоголизма, половой дисфункции, удара, приступа, повреждения спинного мозга и травмы головы.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200201269A 2000-06-23 2001-06-07 Производные 3-азабицикло(3.1.0)гексана, обладающие сродством к опиодному рецептору EA005117B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0015562.2A GB0015562D0 (en) 2000-06-23 2000-06-23 Heterocycles
PCT/IB2001/001035 WO2001098267A1 (en) 2000-06-23 2001-06-07 3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity

Publications (2)

Publication Number Publication Date
EA200201269A1 true EA200201269A1 (ru) 2003-06-26
EA005117B1 EA005117B1 (ru) 2004-10-28

Family

ID=9894368

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200201269A EA005117B1 (ru) 2000-06-23 2001-06-07 Производные 3-азабицикло(3.1.0)гексана, обладающие сродством к опиодному рецептору

Country Status (34)

Country Link
EP (1) EP1292574A1 (ru)
JP (1) JP2004512263A (ru)
KR (1) KR20040002386A (ru)
CN (1) CN1639121A (ru)
AP (1) AP2002002698A0 (ru)
AR (1) AR028969A1 (ru)
AU (1) AU781837B2 (ru)
BG (1) BG107329A (ru)
BR (1) BR0111867A (ru)
CA (1) CA2412188A1 (ru)
CZ (1) CZ20023967A3 (ru)
DO (1) DOP2001000187A (ru)
DZ (1) DZ3368A1 (ru)
EA (1) EA005117B1 (ru)
GB (1) GB0015562D0 (ru)
HR (1) HRP20020998A2 (ru)
HU (1) HUP0301228A3 (ru)
IL (1) IL153427A0 (ru)
IS (1) IS6637A (ru)
MA (1) MA26915A1 (ru)
MX (1) MXPA02012878A (ru)
NO (1) NO20026168L (ru)
NZ (1) NZ523141A (ru)
OA (1) OA12293A (ru)
PA (1) PA8519401A1 (ru)
PE (1) PE20020253A1 (ru)
PL (1) PL365956A1 (ru)
SK (1) SK17172002A3 (ru)
TN (1) TNSN01094A1 (ru)
UA (1) UA73176C2 (ru)
UY (1) UY26787A1 (ru)
WO (1) WO2001098267A1 (ru)
YU (1) YU91802A (ru)
ZA (1) ZA200210278B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2701861C1 (ru) * 2013-11-20 2019-10-02 Санва Кагаку Кенкюсо Ко., Лтд. Новое производное 3-азабицикло[3.1.0]гексана и его применение в медицинских целях

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60226161T2 (de) * 2001-10-22 2009-07-02 Pfizer Products Inc., Groton 3-azabicyclo[3.1.0]hexan derivative als antagonisten der opioid rezeptoren
KR101108014B1 (ko) * 2002-05-17 2012-01-25 티오가 파마슈티칼스, 인코포레이티드 선택성 아편제 수용체 조절인자로서 효과적인 화합물의 용도
DE10259245A1 (de) 2002-12-17 2004-07-01 Merck Patent Gmbh Derivate des Asimadolins mit kovalent gebundenen Säuren
SI1745040T1 (sl) 2004-02-23 2010-04-30 Venue Glaxo Group Ltd Derivati azabiciklo(3.1.0)heksana, uporabni kot modulatorji dopaminskih receptorjev d3
GB0507680D0 (en) 2005-04-15 2005-05-25 Glaxo Group Ltd Compounds
EP1891056B1 (en) 2005-06-14 2010-10-13 Glaxo Group Limited Novel compounds
DE602007012531D1 (de) * 2006-04-03 2011-03-31 Glaxo Group Ltd Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptoren
WO2008121496A1 (en) 2007-03-30 2008-10-09 Tioga Pharmaceuticals Inc. Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
AU2011263417B2 (en) 2010-06-11 2014-03-27 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
WO2012042539A2 (en) 2010-09-28 2012-04-05 Panacea Biotec Ltd Novel bicyclic compounds
RU2017144548A (ru) 2015-05-20 2019-06-20 Санва Кагаку Кенкюсо Ко., Лтд. Кристаллическая соль нового производного 3-азабицикло[3.1.0]гексана и ее применение в медицине
CN110446495B (zh) 2017-02-17 2023-09-05 特维娜有限公司 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法
KR20190129867A (ko) * 2017-02-17 2019-11-20 트레베나, 인코포레이티드. 5-원 아자-헤테로고리 함유 델타-오피오이드 수용체 조절 화합물, 및 그의 사용 및 제조 방법
CA3054122A1 (en) 2017-03-02 2018-09-07 Sanwa Kagaku Kenkyusho Co., Ltd. Therapeutic agent for alcohol use disorders
CN108250088B (zh) * 2018-01-04 2020-10-30 四川之江高新材料股份有限公司 N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法

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US3065230A (en) * 1959-03-16 1962-11-20 Burroughs Wellcome Co Azabicyclohexanes and method of preparing them
IL86061A (en) * 1987-04-16 1992-07-15 Lilly Co Eli Derivatives of trans-3,4-isomer of 4-methyl-4-phenyl-piperidines,process for their preparation and pharmaceutical compositions containing them
US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
TWI244481B (en) * 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
PE20001420A1 (es) * 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2701861C1 (ru) * 2013-11-20 2019-10-02 Санва Кагаку Кенкюсо Ко., Лтд. Новое производное 3-азабицикло[3.1.0]гексана и его применение в медицинских целях

Also Published As

Publication number Publication date
AU6259101A (en) 2002-01-02
IL153427A0 (en) 2003-07-06
BG107329A (en) 2003-07-31
NO20026168L (no) 2003-02-18
HRP20020998A2 (en) 2004-02-29
PL365956A1 (en) 2005-01-24
AP2002002698A0 (en) 2002-12-31
BR0111867A (pt) 2003-07-01
UA73176C2 (en) 2005-06-15
GB0015562D0 (en) 2000-08-16
SK17172002A3 (sk) 2004-09-08
MA26915A1 (fr) 2004-12-20
EP1292574A1 (en) 2003-03-19
IS6637A (is) 2002-11-28
TNSN01094A1 (fr) 2005-11-10
YU91802A (sh) 2006-05-25
NZ523141A (en) 2005-06-24
ZA200210278B (en) 2003-12-19
OA12293A (en) 2004-03-18
PA8519401A1 (es) 2002-12-30
HUP0301228A3 (en) 2005-08-29
KR20040002386A (ko) 2004-01-07
DOP2001000187A (es) 2002-03-30
CN1639121A (zh) 2005-07-13
DZ3368A1 (fr) 2001-12-27
CZ20023967A3 (cs) 2004-02-18
AR028969A1 (es) 2003-05-28
MXPA02012878A (es) 2003-05-14
HUP0301228A2 (hu) 2003-08-28
WO2001098267A1 (en) 2001-12-27
JP2004512263A (ja) 2004-04-22
EA005117B1 (ru) 2004-10-28
CA2412188A1 (en) 2001-12-27
PE20020253A1 (es) 2002-04-08
UY26787A1 (es) 2002-01-31
AU781837B2 (en) 2005-06-16
WO2001098267A8 (en) 2003-02-27
NO20026168D0 (no) 2002-12-20

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