IS7891A - Skiptitengd þrísýklísk gamma-karbólín sem serótónín viðtaka gerandefni og mótverkunarefni - Google Patents
Skiptitengd þrísýklísk gamma-karbólín sem serótónín viðtaka gerandefni og mótverkunarefniInfo
- Publication number
- IS7891A IS7891A IS7891A IS7891A IS7891A IS 7891 A IS7891 A IS 7891A IS 7891 A IS7891 A IS 7891A IS 7891 A IS7891 A IS 7891A IS 7891 A IS7891 A IS 7891A
- Authority
- IS
- Iceland
- Prior art keywords
- sup
- antagonists
- receptor agonists
- serotonin receptor
- novel compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43476002P | 2002-12-19 | 2002-12-19 | |
PCT/US2003/041447 WO2004056324A2 (en) | 2002-12-19 | 2003-12-19 | Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
IS7891A true IS7891A (is) | 2005-06-10 |
Family
ID=32682101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IS7891A IS7891A (is) | 2002-12-19 | 2005-06-10 | Skiptitengd þrísýklísk gamma-karbólín sem serótónín viðtaka gerandefni og mótverkunarefni |
Country Status (10)
Country | Link |
---|---|
US (1) | US7109339B2 (is) |
EP (1) | EP1581221B1 (is) |
JP (1) | JP4486505B2 (is) |
AT (1) | ATE509929T1 (is) |
AU (1) | AU2003303210A1 (is) |
ES (1) | ES2364046T3 (is) |
IS (1) | IS7891A (is) |
NO (1) | NO20052728L (is) |
PL (1) | PL377426A1 (is) |
WO (1) | WO2004056324A2 (is) |
Families Citing this family (60)
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IL156990A0 (en) * | 2001-02-16 | 2004-02-08 | Bristol Myers Squibb Co | Identification and cloning of a novel human gene ret16 |
SE0203712D0 (sv) | 2002-12-13 | 2002-12-13 | Astrazeneca Ab | Novel compounds |
JO2735B1 (en) * | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formations of balloonosterone |
US8598219B2 (en) | 2003-01-30 | 2013-12-03 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
CA2564018A1 (en) * | 2004-03-05 | 2005-10-13 | Pharma C S.A. | 8-phenoxy-.gamma. carboline derivatives |
US7592454B2 (en) * | 2004-04-14 | 2009-09-22 | Bristol-Myers Squibb Company | Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists |
US7572805B2 (en) * | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
JP5173190B2 (ja) | 2004-08-25 | 2013-03-27 | 武田薬品工業株式会社 | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
CN101094689B (zh) * | 2004-11-01 | 2013-06-12 | 安米林药品有限责任公司 | 治疗肥胖以及肥胖相关疾病和病症的方法 |
AU2005305036B2 (en) * | 2004-11-01 | 2011-03-10 | Amylin Pharmaceuticals, Llc | Treatment of obesity and related disorders |
US8394765B2 (en) | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
AR051946A1 (es) * | 2004-11-05 | 2007-02-21 | Wyeth Corp | Formulaciones de derivados de [1,4] diazepina [6,7,1-ij] quinolina |
AR052227A1 (es) * | 2004-11-05 | 2007-03-07 | Wyeth Corp | Metabolitos derivados de [1,4] diazepin [ 6,7,1-ij] quinolina, metodos de preparacion y usos de los mismos |
BRPI0614485A2 (pt) * | 2005-07-28 | 2011-03-29 | Bristol-Myers Squibb Company | tetrahidro-1h-pirido [4, 3, b] indóis substituìdos como agonistas e antagonistas receptores de serotonina |
AU2006286646B2 (en) | 2005-08-31 | 2010-09-23 | F. Hoffmann-La Roche Ag | Pyrazolone derivatives as 11-beta HSD1 inhibitors |
RU2338537C2 (ru) * | 2006-01-25 | 2008-11-20 | Сергей Олегович Бачурин | СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
EP2018863B9 (en) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
RU2329044C1 (ru) * | 2006-11-16 | 2008-07-20 | Андрей Александрович Иващенко | Лиганды 5-ht6 рецепторов, фармацевтическая композиция, способ ее получения и лекарственное средство |
IN2009DN05670A (is) | 2007-03-12 | 2015-07-24 | Intra Cellular Therapies Inc | |
RU2338745C1 (ru) * | 2007-03-21 | 2008-11-20 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
KR20100024951A (ko) * | 2007-05-25 | 2010-03-08 | 메디베이션 뉴롤로지 인코퍼레이티드 | 세포를 자극하기 위한 방법 및 조성물 |
JP2010531344A (ja) | 2007-06-26 | 2010-09-24 | アストラゼネカ アクチボラグ | カテプシンk阻害剤としての1−シアノシクロプロピル誘導体 |
CA2700160A1 (en) * | 2007-09-20 | 2009-03-26 | D2E, Llc | Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use |
EP2789338A3 (en) | 2007-11-15 | 2015-01-14 | Takeda Pharmaceutical Company Limited | Condensed pyridine derivate and use thereof |
US8575186B2 (en) | 2009-10-05 | 2013-11-05 | Albany Molecular Research, Inc. | Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof |
EP2510949A4 (en) | 2009-12-11 | 2013-11-13 | Astellas Pharma Inc | THERAPEUTICS FOR FIBROMYALGIA |
US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
WO2011103485A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
WO2011103433A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
WO2011133224A1 (en) * | 2010-04-22 | 2011-10-27 | Intra-Cellular Therapies, Inc. | Organic compounds |
US20130267500A1 (en) | 2010-09-01 | 2013-10-10 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
US9067949B2 (en) | 2011-01-19 | 2015-06-30 | Albany Molecular Research, Inc. | Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia |
WO2012112965A1 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
KR20140146192A (ko) | 2012-04-14 | 2014-12-24 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
PT2968320T (pt) | 2013-03-15 | 2021-01-28 | Intra Cellular Therapies Inc | Compostos orgânicos |
WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
CA2932610C (en) | 2013-12-03 | 2023-08-22 | Intra-Cellular Therapies, Inc. | Heterocycle fused gamma-carboline compounds for use in treatment of schizophrenia |
EP3125892A4 (en) | 2014-04-04 | 2017-12-27 | Intra-Cellular Therapies, Inc. | Organic compounds |
PL3125893T3 (pl) | 2014-04-04 | 2024-02-12 | Intra-Cellular Therapies, Inc. | Deuterowane gamma-karboliny w fuzji z heterocyklami jako antagoniści receptorów 5-HT2A |
CN108883111B (zh) | 2016-01-26 | 2021-10-08 | 细胞内治疗公司 | 有机化合物 |
JP6686168B2 (ja) | 2016-03-25 | 2020-04-22 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
JP2019513143A (ja) | 2016-03-28 | 2019-05-23 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規塩類および結晶 |
EP3436016B1 (en) | 2016-03-28 | 2022-04-27 | Intra-Cellular Therapies, Inc. | Novel co-crystals |
US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
CN110072518B (zh) | 2016-10-12 | 2021-10-26 | 细胞内治疗公司 | 无定形固体分散体 |
WO2018111805A1 (en) | 2016-12-13 | 2018-06-21 | St. Jude Children's Research Hospital | Tetrahydroquinoline-based bromodomain inhibitors |
WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
EP3562484B1 (en) | 2016-12-29 | 2021-08-25 | Intra-Cellular Therapies, Inc. | Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders |
JP7132939B2 (ja) | 2017-03-24 | 2022-09-07 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 新規組成物および方法 |
US11207322B2 (en) | 2017-04-28 | 2021-12-28 | Board Of Regents, The University Of Texas System | Method and composition related to combination therapy for addiction |
AU2018307479B2 (en) | 2017-07-26 | 2024-06-20 | Intra-Cellular Therapies, Inc. | Organic compounds |
MX2020000967A (es) | 2017-07-26 | 2020-09-28 | Intra Cellular Therapies Inc | Compuestos organicos. |
JPWO2019131902A1 (ja) | 2017-12-27 | 2020-12-10 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
EP3801527A4 (en) | 2018-06-08 | 2022-03-30 | Intra-Cellular Therapies, Inc. | NEW METHODS |
EP3609891A4 (en) | 2018-06-11 | 2021-04-14 | Intra-Cellular Therapies, Inc. | SYNTHESIS OF CONDENSED GAMMA CARBOLINE WITH SUBSTITUTED HETEROCYCLE |
CN112584838A (zh) | 2018-08-31 | 2021-03-30 | 细胞内治疗公司 | 新方法 |
US11957791B2 (en) | 2018-08-31 | 2024-04-16 | Intra-Cellular Therapies, Inc. | Methods |
EP3952864A4 (en) * | 2019-03-08 | 2023-05-10 | The Regents of the University of California | COMPOSITIONS AND METHODS FOR MODULATION OF LIPID AND STEROID METABOLISM |
CA3225391A1 (en) * | 2021-07-14 | 2023-01-19 | Northeastern University | Serotonin 5-ht2a, 5-ht2b, and 5-ht2c receptor inverse agonists |
CN114105985B (zh) * | 2021-12-13 | 2024-04-16 | 南方科技大学坪山生物医药研究院 | 不对称氢化构建卢美哌隆中间体的方法及卢美哌隆中间体 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4238607A (en) | 1972-06-19 | 1980-12-09 | Endo Laboratories Inc. | Pyridopyrrolo benzheterocycles |
US4115577A (en) | 1972-06-19 | 1978-09-19 | Endo Laboratories, Inc. | Pyridopyrrolobenzheterocycles |
US3914421A (en) | 1972-06-19 | 1975-10-21 | Endo Lab | Pyridopyrrolobenzheterocycles for combatting depression |
US4013652A (en) | 1972-06-19 | 1977-03-22 | Endo Laboratories, Inc. | Pyridopyrrolobenzoxazine |
US4183936A (en) | 1972-06-19 | 1980-01-15 | Endo Laboratories, Inc. | Pyridopyrrolobenzheterocycles |
US4219550A (en) | 1978-11-09 | 1980-08-26 | E. I. Du Pont De Nemours And Company | Cis- and trans- octahydropyridopyrrolobenzheterocycles |
HUT61548A (en) | 1990-08-27 | 1993-01-28 | Sandoz Ag | Process for producing indolonaphthyridine derivatives and pharmaceutical compositions comprising such compounds |
JP3108483B2 (ja) * | 1991-09-30 | 2000-11-13 | 日清製粉株式会社 | インドール誘導体およびこれを有効成分とする抗潰瘍薬 |
TW470745B (en) * | 1996-05-23 | 2002-01-01 | Janssen Pharmaceutica Nv | Hexahydro-pyrido[4,3-b]indole derivatives |
HUP0104773A3 (en) | 1998-12-17 | 2004-10-28 | Wyeth Corp | 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists, process for their preparation and medicaments containing them |
IL147109A0 (en) | 1999-06-15 | 2002-08-14 | Du Pont Pharm Co | Substtituted heterocycle fused gamma-carbolines |
SK7042003A3 (en) | 2000-12-20 | 2004-07-07 | Bristol Myers Squibb Co | Substituted pyridoindoles as serotonin agonists and antagonists |
US6849640B2 (en) * | 2001-08-08 | 2005-02-01 | Pharmacia & Upjohn Company | Therapeutic 1H-pyrido [4,3-b] indoles |
-
2003
- 2003-12-19 PL PL377426A patent/PL377426A1/pl not_active Application Discontinuation
- 2003-12-19 AU AU2003303210A patent/AU2003303210A1/en not_active Abandoned
- 2003-12-19 AT AT03808574T patent/ATE509929T1/de not_active IP Right Cessation
- 2003-12-19 US US10/743,449 patent/US7109339B2/en not_active Expired - Lifetime
- 2003-12-19 ES ES03808574T patent/ES2364046T3/es not_active Expired - Lifetime
- 2003-12-19 JP JP2004561460A patent/JP4486505B2/ja not_active Expired - Fee Related
- 2003-12-19 WO PCT/US2003/041447 patent/WO2004056324A2/en active Application Filing
- 2003-12-19 EP EP03808574A patent/EP1581221B1/en not_active Expired - Lifetime
-
2005
- 2005-06-07 NO NO20052728A patent/NO20052728L/no not_active Application Discontinuation
- 2005-06-10 IS IS7891A patent/IS7891A/is unknown
Also Published As
Publication number | Publication date |
---|---|
NO20052728L (no) | 2005-08-23 |
EP1581221A2 (en) | 2005-10-05 |
EP1581221A4 (en) | 2008-11-26 |
WO2004056324A3 (en) | 2004-09-02 |
NO20052728D0 (no) | 2005-06-07 |
US7109339B2 (en) | 2006-09-19 |
US20040180875A1 (en) | 2004-09-16 |
WO2004056324A2 (en) | 2004-07-08 |
PL377426A1 (pl) | 2006-02-06 |
AU2003303210A1 (en) | 2004-07-14 |
EP1581221B1 (en) | 2011-05-18 |
JP4486505B2 (ja) | 2010-06-23 |
ES2364046T3 (es) | 2011-08-23 |
JP2006511568A (ja) | 2006-04-06 |
ATE509929T1 (de) | 2011-06-15 |
AU2003303210A8 (en) | 2004-07-14 |
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